Holdings: Protein Tyrosine Phosphatases

Protein Tyrosine Phosphatases: Structure, Signaling and Drug Discovery

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Bibliographic Details
Main Author:	Ahuja, Lalima G. (Author)
Format:	Book
Language:	English
Published:	Berlin/Boston De Gruyter [2018]
Subjects:	Proteintyrosinphosphatase Medizinische Chemie Biochemie Wirkstoffdesign Signalproteine
Online Access:	http://www.degruyter.com/search?f_0=isbnissn&q_0=9783110426434&searchTitles=true Inhaltsverzeichnis
Physical Description:	XIV, 282 Seiten Illustrationen 24 cm x 17 cm
ISBN:	9783110426434 3110426439

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MARC


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adam_text	CONTENTS PREFACE* V ABOUT THE AUTHOR * IX 1 TYROSINE PHOSPHORYLATION IN CELL SIGNALING: DISCOVERY AND BEYOND * 1 1.1 PROTEIN PHOSPHORYLATION * 1 1.2 ORIGINS AND EARLY WORK * 4 1.3 TYROSINE PHOSPHORYLATION: DISCOVERY AND BEGINNINGS * 5 1.4 TYROSINE PHOSPHORYLATION: CURRENT SIGNIFICANCE * 8 1.5 THE PROTEIN TYROSINE KINASES * 9 1.5.1 THE PROTEIN TYROSINE KINASE CATALYTIC DOMAIN * 12 1.5.2 PROTEIN TYROSINE KINASES: SRC AS A MODEL * 15 1.5.3 REGULATION OF SRC TYROSINE KINASE * 16 1.6 PHOSPHOTYROSINE RECOGNITION DOMAINS * 18 1.6.1 SH2 DOMAINS: DISCOVERY AND SELECTIVITY * 19 1.6.2 SH2 DOMAINS: STRUCTURE AND FUNCTION * 20 1.6.3 PTB DOMAINS: DISCOVERY AND SELECTIVITY * 22 1.6.4 PTB DOMAINS: STRUCTURE AND FUNCTION * 23 1.6.5 SH2 DOMAINS VERSUS PTB DOMAINS * 25 1.6.6 ATYPICAL PHOSPHOTYROSINE RECOGNITION DOMAINS: HYB DOMAIN * 26 1.6.7 ATYPICAL PHOSPHOTYROSINE RECOGNITION DOMAINS: PKCOE AND PKC0 C2 DOMAINS * 26 REFERENCES * 26 2 PROTEIN PHOSPHATASES: CLASSIFICATION AND DOMAIN ARCHITECTURE * 35 2.1 THE PROTEIN PHOSPHATASES * 35 2.2 THE PHOSPHOPROTEIN PHOSPHATASES * 36 2.2.1 PROTEIN PHOSPHATASE 1 * 37 2.2.2 PROTEIN PHOSPHATASE 2A * 40 2.2.3 PROTEIN PHOSPHATASE 2B * 44 2.2.4 PROTEIN PHOSPHATASE 5 * 45 2.2.5 NATURAL TOXINS AS INHIBITORS OF PPP CATALYTIC SUBUNITS * 47 2.3 THE METAL-DEPENDENT PROTEIN PHOSPHATASES * 48 2.4 FCP/SCP PHOSPHATASES * 51 2.5 PROTEIN TYROSINE PHOSPHATASES * 54 2.5.1 THE DUAL-SPECIFICITY PHOSPHATASES * 55 2.5.2 THE CLASS II PROTEIN TYROSINE PHOSPHATASES * 65 2.5.3 THE CLASS III PROTEIN TYROSINE PHOSPHATASES * 67 2.5.4 THE CLASS IV PROTEIN TYROSINE PHOSPHATASES * 68 REFERENCES * 70 3 PROTEIN TYROSINE PHOSPHATASES: MOLECULAR STRUCTURE AND MECHANISM * 89 3.1 THE PROTEIN TYROSINE PHOSPHATASES * 89 3.2 THE PTP CATALYTIC DOMAIN * 92 3.2.1 THE P-LOOP ----- 96 3.2.2 THE WPD-LOOP * 97 3.2.3 THE Q-LOOP * 99 3.2.4 THE PY-RECOGNITION LOOP * 99 3.2.5 THE E-LOOP ----- 100 3.3 CATALYTIC DOMAINS OF DIFFERENT PTP CLASSES * 101 3.4 THE CATALYTIC MECHANISM * 103 3.5 DIFFERENCES IN THE MECHANICS OF CLASS I, II AND III PTPS * 105 3.6 CRYSTALLOGRAPHIC STRATEGIES TO STUDY PTP STRUCTURE * 105 3.7 ACTIVE SITE DETERMINANTS * 106 3.8 ACCESSORY SUBSTRATE BINDING DETERMINANTS * 107 3.9 THE UNIQUE CLASS IV PTPS * 110 3.10 AN ALTERNATE MECHANISM FOR THE CLASS IV PTPS * 112 REFERENCES * 113 4 THE RECEPTOR PROTEIN TYROSINE PHOSPHATASES: STRUCTURE AND FUNCTION * 119 4.1 CLASSIFICATION OF PROTEIN TYROSINE PHOSPHATASES * 119 4.2 THE R1/R6 SUBTYPE * 119 4.3 THE R2A SUBTYPE * 126 4.4 THE R2B SUBTYPE * 130 4.5 THE R3 SUBTYPE ----- 133 4.6 THE R4 SUBTYPE ----- 134 4.7 THE R5 SUBTYPE * 136 4.8 THE R7 SUBTYPE * 139 4.9 THE R8 SUBTYPE * 141 REFERENCES * 142 5 THE DOUBLE-DOMAIN RECEPTOR PROTEIN TYROSINE PHOSPHATASES * 155 5.1 TANDEM PTP DOMAINS IN RECEPTOR PTPS * 155 5.2 INTERDOMAIN INTERACTIONS HOLDING THE TANDEM PTP DOMAINS * 157 5.3 LINKER CONNECTING THE TWO DOMAINS * 158 5.4 EVOLUTION OF THE D2 DOMAIN * 158 5.4.1 THE D2A SUBCLASS OF D2 DOMAINS * 160 5.4.2 THE D2B SUBCLASS OF D2 DOMAINS * 161 5.5 D2 DOMAINS AFFECT SUBSTRATE SELECTION OF THE COGNATE D1 DOMAINS * 162 5.6 D2 MODULATES THE ACTIVITY OF ITS COGNATE D1 DOMAIN * 162 5.7 ROLE OF INTER- AND INTRADOMAIN AMINO ACID NETWORKS * 166 5.8 ROLE OF D2 DOMAIN AS A REDOX PROTECTOR * 167 5.9 DIMERIZATION IN DOUBLE-DOMAIN RECEPTOR RTFS * 172 5.10 ROLE OF D2 DOMAIN IN RECEPTOR CROSS TALK * 174 REFERENCES * 175 6 THE NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASES: PART I * 179 6.1 CLASSIFICATION OF NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASES * 179 6.2 THE NT1 SUBCLASS * 179 6.3 PTP1B: STRUCTURE AND CATALYTIC FUNCTION * 181 6.3.1 PTP1B: SUBSTRATE IDENTIFICATION * 184 6.3.2 PTP1B: REGULATION OF FUNCTION ----- 186 6.3.3 PTP1B: ROLE IN DISEASE * 187 6.3.4 PTP1B: ROLE IN CANCER * 189 6.3.5 PTP1B AS A THERAPEUTIC TARGET * 190 6.4 T-CELL PROTEIN TYROSINE PHOSPHATASE * 192 6.4.1 BIOLOGICAL ROLE OF TCPTP * 193 6.5 TCPTP AND PTP1B * 194 REFERENCES * 195 7 THE NON-RECEPTOR PROTEIN TYROSINE PHOSPHATASES: PART II * 203 7.1 THE NT2 SUBTYPE OF NON-RECEPTOR PTPS * 203 7.1.1 STRUCTURE AND REGULATION OF SHPS * 203 7.1.2 PHYSIOLOGICAL ROLE OF SHP1 * 207 7.1.3 SHP2 SIGNALING AND FUNCTION * 208 7.2 THE NT3 SUBTYPE OF NON-RECEPTOR PTPS * 210 7.3 THE NT4 SUBTYPE OF NON-RECEPTOR PTPS * 212 7.3.1 THE PTP-PEST ----- 213 7.3.2 STRUCTURAL ARCHITECTURE OF PTP-PEST * 213 7.3.3 PTP-PEST: MODE OF PHYSIOLOGICAL FUNCTION * 215 7.3.4 THE PTP-PEP/LYP TYROSINE PHOSPHATASE * 215 7.3.5 ROLE OF THE TYROSINE PHOSPHATASE DOMAIN OF LYP * 216 7.3.6 MODE OF ACTION OF LYP * 217 7.3.7 PTP HSCF/BDP1 ----- 218 7.4 THE NT5 SUBTYPE OF NON-RECEPTOR PTPS * 218 7.5 THE NT6 SUBTYPE OF NON-RECEPTOR PTPS * 220 7.5.1 PTPD1 NON-RECEPTOR PTP * 220 7.5.2 PTPD2 NON-RECEPTOR PTP * 222 7.6 THE NT7 SUBTYPE OF NON-RECEPTOR PTPS * 223 7.7 THE NT8 SUBTYPE OF NON-RECEPTOR PTPS * 225 7.8 7.9 8 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 INDEX THE NT9 SUBTYPE OF NON-RECEPTOR PTPS * 226 THE PTPN5 RR SUBFAMILY OF PTPS * 228 REFERENCES * 229 PROTEIN TYROSINE PHOSPHATASES: STRATEGIES FOR DRUG DEVELOPMENT * NATURAL PRODUCTS AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS * NATURAL PRODUCT ANALOGUES AS PROTEIN TYROSINE PHOSPHATASE INHIBITORS ----- 259 REVERSIBLE ORTHOSTERIC INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES * 261 IRREVERSIBLE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES * 263 BIDENTATE INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES * 264 ALLOSTERIC INHIBITORS OF PROTEIN TYROSINE PHOSPHATASES * 266 BIOLOGICS-BASED THERAPEUTIC INTERVENTION OF PROTEIN TYROSINE PHOSPHATASES * 268 CONCLUDING REMARKS * 270 REFERENCES * 270 * 279 2 W
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author	Ahuja, Lalima G.
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physical	XIV, 282 Seiten Illustrationen 24 cm x 17 cm
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publisher	De Gruyter
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spelling	Ahuja, Lalima G. Verfasser (DE-588)1170084710 aut Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Lalima G. Ahuja Berlin/Boston De Gruyter [2018] XIV, 282 Seiten Illustrationen 24 cm x 17 cm txt rdacontent n rdamedia nc rdacarrier Proteintyrosinphosphatase (DE-588)4311372-2 gnd rswk-swf Medizinische Chemie Biochemie Proteintyrosinphosphatase Wirkstoffdesign Signalproteine Proteintyrosinphosphatase (DE-588)4311372-2 s DE-604 Walter de Gruyter GmbH & Co. KG (DE-588)10095502-2 pbl Erscheint auch als Online-Ausgabe 978-3-11-042177-4 Erscheint auch als Online-Ausgabe, EPUB 978-3-11-042184-2 X:MVB http://www.degruyter.com/search?f_0=isbnissn&q_0=9783110426434&searchTitles=true DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030465340&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Ahuja, Lalima G. Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Proteintyrosinphosphatase (DE-588)4311372-2 gnd
subject_GND	(DE-588)4311372-2
title	Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery
title_auth	Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery
title_exact_search	Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery
title_full	Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Lalima G. Ahuja
title_fullStr	Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Lalima G. Ahuja
title_full_unstemmed	Protein Tyrosine Phosphatases Structure, Signaling and Drug Discovery Lalima G. Ahuja
title_short	Protein Tyrosine Phosphatases
title_sort	protein tyrosine phosphatases structure signaling and drug discovery
title_sub	Structure, Signaling and Drug Discovery
topic	Proteintyrosinphosphatase (DE-588)4311372-2 gnd
topic_facet	Proteintyrosinphosphatase
url	http://www.degruyter.com/search?f_0=isbnissn&q_0=9783110426434&searchTitles=true http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030465340&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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