Neurobiology of the placebo effect: Part 1
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cambridge, MA ; San Diego, CA ; Oxford ; London
Academic Press
2018
|
| Edition: | First edition |
| Series: | International review of neurobiology
volume 138 |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | xx, 357 Seiten Illustrationen |
| ISBN: | 9780128143254 |
Staff View
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Record in the Search Index
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| adam_text | CONTENTS
Contributors xi
Preface xv
1. Placebo Analgesia in Rodents: Current and
Future Research 1
Asaf Keller, Titilóla Akintola, and Luana ColJoca
1. Introduction 2
2. Placebo Analgesia and Acute Pain in Rodents; Pioneering
Attempts 2
3. Pavlovian Conditioning and Acute Pain 3
4. An Operant Conditioning Model 6
5. Placebo-Conditioned Responses in Chronic Pain Models 7
6. Future Directions 8
7. Conclusions 11
Acknowledgments 11
References 12
Further Reading 15
2. Expectancy Modulation of Opioid Neurotransmission 17
Marta Pecina and Jon-Kar Zubieta
1. Expectation Modulation of Opioid Neurotransmission 18
2. Opioid Neurotransmission and Function 19
3. Opioid Pharmacological and Neuroimaging Studies of Placebo Effects 21
4. Placebo Effects and p-Opioid Neurotransmission 22
5. Opioid-Mediated Personality Predictors of Placebo Effects 25
6. Genetic Modulation of Placebo Effects: Al 18G Asn40Asp and FAAH
Pro129Thr 27
7. Opioid-Mediated Predictors of Placebo Effects in Major Depression 29
8. Future Directions 31
9. Conclusions 33
References 34
v
vi Contents
3. Placebo Effects in the Immune System 39
Martin Hadamitzky, Wiebke Sondermann, Sven Benson,
and Manfred Schedlowski
1. Introduction 40
2. Conditioning of Immune Responses—Approaches and Paradigms
Across Species 40
3. Behaviorally Conditioned Immunosuppression 43
4. Translational Aspects and Clinical Relevance of Associative
Learning Protocols 46
5. Persistence of Conditioned Placebo Effects 48
6. Future Directions and Limitations 50
Acknowledgments 53
References 53
4. Human Pharmacological Conditioning of the Immune and
Endocrine System: Challenges and Opportunities 61
Judith Tekampe, Henriet van Middendorp, Fred C.GJ. Sweep,
Sean H.P.P. Roerink, Ad R.M.M. Flermus, and Andrea W.M. Evers
1. Pharmacological Conditioning of Immune and Endocrine Responses 64
2. Challenges 69
3. Opportunities for Research and Clinical Practice 71
4. Bridging the Gap Between Lab and Practice: Increasing the External
Validity of Laboratory Studies by Using Real-World Challenges 74
5. General Conclusion and Discussion 75
References 77
5. Response Expectancy and the Placebo Effect 81
Irving Kirsch
Introduction 81
1. Response Expectancy vs Stimulus Expectancy 82
2. Overgeneralization From Stimulus Expectancy to Response
Expectancy Effects 84
3. Dimensions of Response Expectancies 86
4. Measuring Expectations 87
5. How Placebos Work: An Integrative Model 88
6. Clinical Implications 90
References 91
Contents
vii
6. A Functional-Cognitive Perspective on the Relation Between
Conditioning and Placebo Research 95
Jan De Houwer
1. Conditioning as an Effect 96
2. A Brief History of Conditioning Models 98
3. Different Ways in Which Conditioning Might Be Involved
in the Placebo Effect 103
4. What Are Placebo Effects? 108
Acknowledgments 109
References 109
7. The Application of Persuasion Theory to Placebo Effects 113
Andrew L. Geers, Pablo Brihol, Erin A. Vogel, Olivia Aspiras,
Fawn C. Caplandies, and Richard E. Petty
1. Research on Placebo Effects 116
2. Placebo Effects and Persuasive Communication 119
3. Modern Models of Persuasion 121
4. Main Postulates of the ELM 122
5. Multiple Processes: Beyond Elaboration and Validation 126
6. The ELM and Placebo Effects 127
7. When and Why Do Characteristics of a Provider Alter
Placebo Effects? 128
8. When and Why Do Placebo Effects Endure Over Time? 130
9. Summary and Conclusions 132
References 133
8. Mindsets Matter: A New Framework for Harnessing
the Placebo Effect in Modern Medicine 137
Sean R. Zion and Alia J. Crum
1. Introduction 138
2. The Treatment Effect: Drug Plus Placebo Effects 140
3. Psychological Processes Activate Neurobiological Mechanisms 142
4. Social and Contextual Factors Inform Psychological Processes 148
5. Discussion 155
Acknowledgments 156
References 156
viii
Contents
9. The Role of Social and Interpersonal Factors in Placebo Analgesia 161
Elizabeth A. Necka and Lauren Y. Atlas
1. Patient-Provider Interactions and Placebo Effects 163
2. Loneliness as a Potential Determinant of Placebo Effects 166
3. What Loneliness and the Study of Individual Differences in Social
Perceptions Can Tell Us About Placebo 173
Acknowledgment 174
References 174
10. What Is Minimally Required to Elicit Placebo Effects? 181
Karin B. Jensen
1. Introduction 182
2. Placebo and Basic Brain Function 183
3. Placebo and Conscious Awareness 186
4. Placebo Effects Among Patients With Intellectual Disability 193
5. Future Topics 195
References 195
Further Reading 199
11. Critical Life Functions: Can Placebo Replace Oxygen? 201
Fabrizio Benedetti, Diletta Barbiani, and Eleonora Camerone
1. Introduction 202
2. Critical Life Functions: What They Are and How They Can Be Studied 203
3. The High Altitude Model of Oxygen Shortage 204
4. Placebo Effects at High Altitude: Can Oxygen Be Replaced by Placebo? 207
5. Nocebo Effects at High Altitude 214
6. Conclusions and Future Challenges 215
References 216
12. Placebos Without Deception: Outcomes,
Mechanisms, and Ethics 219
Luana Colloca and Jeremy Howick
1. Introduction 220
2. Do Placebos Require Deception? The Mysterious Case of
Open-Label Placebos 220
3. Clinical Open-Label Placebo Trials 221
4. Laboratory (Open-Label) Placebo Studies 224
5. Dose-Extending (Open-Label) Placebos 225
Contents
ix
6. Potential Mechanisms 227
7. Clinical Implications 230
8. Ethical implications 232
9. Conclusions 235
Acknowledgments 235
References 235
13. Placebo and Psychotherapy: Differences, Similarities, and
Implications 241
Jens Gaab7 Cosima Locher, and Charlotte Blease
t. Psychotherapy and Placebo: Definitions and Distinctions 242
2. Empirical Approaches to Control for Incidental Treatment Constituents
in Psychotherapy 244
3. Placebo and Psychotherapy: Unwanted Proximity 247
4. The Implications of the Relationship Between Placebo and Psychotherapy 249
Conflict of Interest 251
References 252
14. Expectation-Focused Psychotherapy to Improve Clinical
Outcomes 257
Bettina K. Doering, Julia A. Glombiewski, and Winfried Rief
1. Introduction 258
2. Formation, Persistence, and Change of Expectations 260
3. The Medical Context: Optimization of Patient Expectations 262
4. Expectation-Focused Psychotherapy 265
5. Future Directions 267
6. Conclusions 268
References 268
15. Nocebo Effects: Neurobiological Mechanisms and Strategies
for Prevention and Optimizing Treatment 271
Julian Kleine-Borgmann and Ulrike Bingel
1. Introduction 271
2. Psychosocial Mechanisms 272
3. Neurobiological Correlates 273
4. Symptom Development 275
5. Treatment Efficacy and Course of Disease 276
6. Unwanted/Adverse Events 278
References 282
X
Contents
16. Nocebo Effects and Experimental Models in Visceral Pain 285
Sigrid Elsenbruch and Franziska labrenz
1. Introduction 286
2. Visceral Pain and Placebo Research 287
3. Negative Suggestions 288
4. Conditioning: From Pain-Related Fear to Nocebo Hyperalgesia? 293
5. Brain Mechanisms 294
6. Future Directions 296
7. Conclusions 301
Acknowledgments 301
References 301
17. Using Learning Strategies to Inhibit the Nocebo Effect 307
Veronica F. Quinn and Ben Colagiuri
1. Introduction 308
2. Learning as a Mechanism of the Nocebo Effect 308
3. Learning Strategies to Inhibit the Nocebo Effect 311
4. Limitations of the Current Research 322
5. Conclusion and Future Research Directions 324
References 325
18. Can knowledge of Placebo and Nocebo Mechanisms
Help Improve Randomized Clinical Trials? 329
Elisa Carlino and Lene Vase
1. Current Challenges of the RCTs 330
2. How Are the Challenges Currently Met? 337
3. Can Knowledge of Placebo/Nocebo Mechanisms Point
to a New Approach? 344
References 348
CONTENTS
Contributors xi
Preface xv
1. Placebo Analgesia in Rodents: Current and
Future Research 1
Asaf Keller, Titilóla Akintola, and Luana ColJoca
1. Introduction 2
2. Placebo Analgesia and Acute Pain in Rodents; Pioneering
Attempts 2
3. Pavlovian Conditioning and Acute Pain 3
4. An Operant Conditioning Model 6
5. Placebo-Conditioned Responses in Chronic Pain Models 7
6. Future Directions 8
7. Conclusions 11
Acknowledgments 11
References 12
Further Reading 15
2. Expectancy Modulation of Opioid Neurotransmission 17
Marta Pecina and Jon-Kar Zubieta
1. Expectation Modulation of Opioid Neurotransmission 18
2. Opioid Neurotransmission and Function 19
3. Opioid Pharmacological and Neuroimaging Studies of Placebo Effects 21
4. Placebo Effects and p-Opioid Neurotransmission 22
5. Opioid-Mediated Personality Predictors of Placebo Effects 25
6. Genetic Modulation of Placebo Effects: Al 18G Asn40Asp and FAAH
Pro129Thr 27
7. Opioid-Mediated Predictors of Placebo Effects in Major Depression 29
8. Future Directions 31
9. Conclusions 33
References 34
v
vi Contents
3. Placebo Effects in the Immune System 39
Martin Hadamitzky, Wiebke Sondermann, Sven Benson,
and Manfred Schedlowski
1. Introduction 40
2. Conditioning of Immune Responses—Approaches and Paradigms
Across Species 40
3. Behaviorally Conditioned Immunosuppression 43
4. Translational Aspects and Clinical Relevance of Associative
Learning Protocols 46
5. Persistence of Conditioned Placebo Effects 48
6. Future Directions and Limitations 50
Acknowledgments 53
References 53
4. Human Pharmacological Conditioning of the Immune and
Endocrine System: Challenges and Opportunities 61
Judith Tekampe, Henriet van Middendorp, Fred C.GJ. Sweep,
Sean H.P.P. Roerink, Ad R.M.M. Flermus, and Andrea W.M. Evers
1. Pharmacological Conditioning of Immune and Endocrine Responses 64
2. Challenges 69
3. Opportunities for Research and Clinical Practice 71
4. Bridging the Gap Between Lab and Practice: Increasing the External
Validity of Laboratory Studies by Using Real-World Challenges 74
5. General Conclusion and Discussion 75
References 77
5. Response Expectancy and the Placebo Effect 81
Irving Kirsch
Introduction 81
1. Response Expectancy vs Stimulus Expectancy 82
2. Overgeneralization From Stimulus Expectancy to Response
Expectancy Effects 84
3. Dimensions of Response Expectancies 86
4. Measuring Expectations 87
5. How Placebos Work: An Integrative Model 88
6. Clinical Implications 90
References 91
Contents
vii
6. A Functional-Cognitive Perspective on the Relation Between
Conditioning and Placebo Research 95
Jan De Houwer
1. Conditioning as an Effect 96
2. A Brief History of Conditioning Models 98
3. Different Ways in Which Conditioning Might Be Involved
in the Placebo Effect 103
4. What Are Placebo Effects? 108
Acknowledgments 109
References 109
7. The Application of Persuasion Theory to Placebo Effects 113
Andrew L. Geers, Pablo Brihol, Erin A. Vogel, Olivia Aspiras,
Fawn C. Caplandies, and Richard E. Petty
1. Research on Placebo Effects 116
2. Placebo Effects and Persuasive Communication 119
3. Modern Models of Persuasion 121
4. Main Postulates of the ELM 122
5. Multiple Processes: Beyond Elaboration and Validation 126
6. The ELM and Placebo Effects 127
7. When and Why Do Characteristics of a Provider Alter
Placebo Effects? 128
8. When and Why Do Placebo Effects Endure Over Time? 130
9. Summary and Conclusions 132
References 133
8. Mindsets Matter: A New Framework for Harnessing
the Placebo Effect in Modern Medicine 137
Sean R. Zion and Alia J. Crum
1. Introduction 138
2. The Treatment Effect: Drug Plus Placebo Effects 140
3. Psychological Processes Activate Neurobiological Mechanisms 142
4. Social and Contextual Factors Inform Psychological Processes 148
5. Discussion 155
Acknowledgments 156
References 156
viii
Contents
9. The Role of Social and Interpersonal Factors in Placebo Analgesia 161
Elizabeth A. Necka and Lauren Y. Atlas
1. Patient-Provider Interactions and Placebo Effects 163
2. Loneliness as a Potential Determinant of Placebo Effects 166
3. What Loneliness and the Study of Individual Differences in Social
Perceptions Can Tell Us About Placebo 173
Acknowledgment 174
References 174
10. What Is Minimally Required to Elicit Placebo Effects? 181
Karin B. Jensen
1. Introduction 182
2. Placebo and Basic Brain Function 183
3. Placebo and Conscious Awareness 186
4. Placebo Effects Among Patients With Intellectual Disability 193
5. Future Topics 195
References 195
Further Reading 199
11. Critical Life Functions: Can Placebo Replace Oxygen? 201
Fabrizio Benedetti, Diletta Barbiani, and Eleonora Camerone
1. Introduction 202
2. Critical Life Functions: What They Are and How They Can Be Studied 203
3. The High Altitude Model of Oxygen Shortage 204
4. Placebo Effects at High Altitude: Can Oxygen Be Replaced by Placebo? 207
5. Nocebo Effects at High Altitude 214
6. Conclusions and Future Challenges 215
References 216
12. Placebos Without Deception: Outcomes,
Mechanisms, and Ethics 219
Luana Colloca and Jeremy Howick
1. Introduction 220
2. Do Placebos Require Deception? The Mysterious Case of
Open-Label Placebos 220
3. Clinical Open-Label Placebo Trials 221
4. Laboratory (Open-Label) Placebo Studies 224
5. Dose-Extending (Open-Label) Placebos 225
Contents
ix
6. Potential Mechanisms 227
7. Clinical Implications 230
8. Ethical implications 232
9. Conclusions 235
Acknowledgments 235
References 235
13. Placebo and Psychotherapy: Differences, Similarities, and
Implications 241
Jens Gaab7 Cosima Locher, and Charlotte Blease
t. Psychotherapy and Placebo: Definitions and Distinctions 242
2. Empirical Approaches to Control for Incidental Treatment Constituents
in Psychotherapy 244
3. Placebo and Psychotherapy: Unwanted Proximity 247
4. The Implications of the Relationship Between Placebo and Psychotherapy 249
Conflict of Interest 251
References 252
14. Expectation-Focused Psychotherapy to Improve Clinical
Outcomes 257
Bettina K. Doering, Julia A. Glombiewski, and Winfried Rief
1. Introduction 258
2. Formation, Persistence, and Change of Expectations 260
3. The Medical Context: Optimization of Patient Expectations 262
4. Expectation-Focused Psychotherapy 265
5. Future Directions 267
6. Conclusions 268
References 268
15. Nocebo Effects: Neurobiological Mechanisms and Strategies
for Prevention and Optimizing Treatment 271
Julian Kleine-Borgmann and Ulrike Bingel
1. Introduction 271
2. Psychosocial Mechanisms 272
3. Neurobiological Correlates 273
4. Symptom Development 275
5. Treatment Efficacy and Course of Disease 276
6. Unwanted/Adverse Events 278
References 282
X
Contents
16. Nocebo Effects and Experimental Models in Visceral Pain 285
Sigrid Elsenbruch and Franziska labrenz
1. Introduction 286
2. Visceral Pain and Placebo Research 287
3. Negative Suggestions 288
4. Conditioning: From Pain-Related Fear to Nocebo Hyperalgesia? 293
5. Brain Mechanisms 294
6. Future Directions 296
7. Conclusions 301
Acknowledgments 301
References 301
17. Using Learning Strategies to Inhibit the Nocebo Effect 307
Veronica F. Quinn and Ben Colagiuri
1. Introduction 308
2. Learning as a Mechanism of the Nocebo Effect 308
3. Learning Strategies to Inhibit the Nocebo Effect 311
4. Limitations of the Current Research 322
5. Conclusion and Future Research Directions 324
References 325
18. Can knowledge of Placebo and Nocebo Mechanisms
Help Improve Randomized Clinical Trials? 329
Elisa Carlino and Lene Vase
1. Current Challenges of the RCTs 330
2. How Are the Challenges Currently Met? 337
3. Can Knowledge of Placebo/Nocebo Mechanisms Point
to a New Approach? 344
References 348
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| spelling | Neurobiology of the placebo effect Part 1 edited by Luana Colloca First edition Cambridge, MA ; San Diego, CA ; Oxford ; London Academic Press 2018 xx, 357 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier International review of neurobiology volume 138 International review of neurobiology Neurobiologie (DE-588)4041871-6 gnd rswk-swf Placebo (DE-588)4046191-9 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Neurobiologie (DE-588)4041871-6 s Placebo (DE-588)4046191-9 s DE-604 Colloca, Luana edt (DE-604)BV044961447 1 International review of neurobiology volume 138 (DE-604)BV002534817 138 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030353988&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030353988&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Neurobiology of the placebo effect International review of neurobiology Neurobiologie (DE-588)4041871-6 gnd Placebo (DE-588)4046191-9 gnd |
| subject_GND | (DE-588)4041871-6 (DE-588)4046191-9 (DE-588)4143413-4 |
| title | Neurobiology of the placebo effect |
| title_auth | Neurobiology of the placebo effect |
| title_exact_search | Neurobiology of the placebo effect |
| title_full | Neurobiology of the placebo effect Part 1 edited by Luana Colloca |
| title_fullStr | Neurobiology of the placebo effect Part 1 edited by Luana Colloca |
| title_full_unstemmed | Neurobiology of the placebo effect Part 1 edited by Luana Colloca |
| title_short | Neurobiology of the placebo effect |
| title_sort | neurobiology of the placebo effect |
| topic | Neurobiologie (DE-588)4041871-6 gnd Placebo (DE-588)4046191-9 gnd |
| topic_facet | Neurobiologie Placebo Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030353988&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030353988&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV044961447 (DE-604)BV002534817 |
| work_keys_str_mv | AT collocaluana neurobiologyoftheplaceboeffectpart1 |
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