Holdings: Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht

Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht: = Role of prenatal testosterone exposure in the development of alcohol addiction

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Bibliographic Details
Main Author:	Huber, Sabine E. 1987- (Author)
Format:	Thesis Book
Language:	English
Published:	Erlangen ; Nürnberg [2018]
Subjects:	Hochschulschrift
Online Access:	Inhaltsverzeichnis Inhaltsverzeichnis
Physical Description:	183 Seiten Diagramme 21 cm

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MARC


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adam_text	TABLE OF CONTENTS ABSTRACT.........................................................................................................................1 ZUSAMMENFASSUNG..................................................................................................... 3 1. INTRODUCTION...............................................................................................................5 1.1 ALCOHOL AND ALCOHOL USE DISORDER..................................................................6 1.2 RISK FACTORS.........................................................................................................8 1.3 NON-ADDICTIVE USE OF DRUGS........................................................................... 13 1.4 TRANSITION FROM CONTROLLED TO COMPULSIVE USE........................................ 14 1.5 MODE OF ACTION................................................................................................. 16 1.5.1 PRIMARY TARGETS......................................................................................... 18 1.5.2 THE DOPAMINE SYSTEM ............................................................................ 20 1.5.3 THE SEROTONIN SYSTEM ............................................................................. 22 1.5.4 INVOLVEMENT OF ENDOCANNABINOIDS AND OPIOIDS ................................. 23 1.5.5 SIGNALING PATHWAYS..................................................................................24 1.5.6 SYNAPTIC PLASTICITY.................................................................................... 27 1.6 SEX HORMONE ACTIVITY ...................................................................................... 26 1.6.1 ACTIVATIONAL EFFECTS................................................................................... 33 1.6.2 ORGANIZATIONAL EFFECTS............................................................................. 34 1.7 THE 2D:4D RATIO................................................................................................35 1.6 AIM OF THE STUDY .............................................................................................. 37 2. MATERIAL & METHODS .............................................................................................. 36 2.1 ANIMALS............................................................................................................. 36 2.1.1 BREEDING AND PRENATAL TREATMENT..........................................................36 2.1.2 HOUSING...................................................................................................... 39 2.2 BEHAVIORAL TESTS.............................................................................................. 40 2.2.1 EMOTIONAL BEHAVIOR..................................................................................40 2.2.1.1 OPEN FIELD..........................................................................................40 2.2.1.2 ELEVATED-PLUS-MAZE.........................................................................41 2.2.1.3 DARK-LIGHT-BOX.................................................................................... 41 2.2.2 SOCIAL BEHAVIOR.........................................................................................41 2.2.2.1 SOCIAL APPROACH TEST.........................................................................42 2.2.2.2 NOVEL OBJECT RECOGNITION TEST..........................................................42 2.2.3 HANDEDNESS.............................................................................................. 43 2.2.4 DRINKING STUDY...........................................................................................44 2.2.4.1 TWO-BOTTLE FREE-CHOICE DRINKING ...................................................... 44 2.2.4.2 BASELINE DRINKING AND ALCOHOL DEPRIVATION EFFECT ....................... 44 2.2.4.3 TASTE PREFERENCE...............................................................................45 2.3 BODY MORPHOLOGY.............................................................................................45 2.3.1 DIGIT MEASUREMENTS.................................................................................45 2.3.2 BODY MEASUREMENTS................................................................................46 2.4 MOLECULAR BIOLOGICAL METHODS.......................................................................46 2.4.1 ADULT HORMONE LEVELS...............................................................................46 2.4.1.1 DIHYDROTESTOSTERONE.........................................................................46 2.4.1.2 CORTICOSTERONE................................................................................... 47 2.4.2 BRAIN MONOAMINE LEVELS.......................................................................... 47 2.4.2.1 HOMOGENIZATION OF BRAIN TISSUE ..................................................... 46 2.4.2.2. PREPARATION FOR ANALYSIS..................................................................48 2.4.3. RNA-SEQUENCING .................................................................................... 48 2.4.3.1 RNA EXTRACTION.................................................................................. 49 2.4.3.2 RNA-SEQUENCING...............................................................................50 2.5 STATISTICAL ANALYSIS........................................................................................... 51 3. RESULTS..................................................................................................................52 3.1 BEHAVIORAL TESTS...............................................................................................52 3.1.1 EMOTIONAL BEHAVIOR.................................................................................. 52 3.1.1.1 OPEN FIELD.......................................................................................... 52 3.1.1.2 ELEVATED-PLUS-MAZE.......................................................................... 55 3.1.1.3 DARK-LIGHT-BOX .................................................................................... 60 3.1.2 SOCIAL BEHAVIOR......................................................................................... 62 3.1.2.1 SOCIAL APPROACH TEST.........................................................................62 3.1.2.2 OBJECT RECOGNITION ............................................................................. 65 3.1.3 HANDEDNESS...............................................................................................65 3.1.4 DRINKING STUDY........................................................................................... 67 3.1.4.1 TWO-BOTTLE FREE-CHOICE DRINKING ...................................................... 67 3.1.4.2 BASELINE DRINKING AND ALCOHOL DEPRIVATION EFFECT ....................... 72 3.1.4.4 TASTE PREFERENCE...............................................................................75 3.2 BODY MEASUREMENTS.......................................................................................76 3.2.1 DIGIT MEASUREMENTS.................................................................................76 3.2.2 BODY MEASUREMENTS................................................................................65 3.3 MOLECULAR BIOLOGICAL METHODS........................................................................87 3.3.1 ADULT HORMONE LEVELS (ELISA)................................................................87 3.3.1.1 DIHYDROTESTOSTERONE.........................................................................67 3.3.1.2 CORTICOSTERONE................................................................................... 66 3.3.2 BRAIN MONOAMINE LEVELS..........................................................................89 3.3.3 RNA-SEQUENCING ..................................................................................... 95 4. DISCUSSION...............................................................................................................96 5. REFERENCES............................................................................................................114 6. ABBREVIATIONS.......................................................................................................136 PUBLICATIONS...............................................................................................................139 APPENDIX....................................................................................................................141 ACKNOWLEDGEMENTS................................................................................................. 180 CURRICULUM VITAE.......................................................................................................162
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author	Huber, Sabine E. 1987-
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spelling	Huber, Sabine E. 1987- Verfasser (DE-588)1158608098 aut Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht = Role of prenatal testosterone exposure in the development of alcohol addiction vorgelegt von Sabine E. Huber aus Tirschenreuth Role of prenatal testosterone exposure in the development of alcohol addiction Erlangen ; Nürnberg [2018] 183 Seiten Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Alexander-Universität Erlangen-Nürnberg 2018 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1158607695/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030351564&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Huber, Sabine E. 1987- Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht = Role of prenatal testosterone exposure in the development of alcohol addiction
subject_GND	(DE-588)4113937-9
title	Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht = Role of prenatal testosterone exposure in the development of alcohol addiction
title_alt	Role of prenatal testosterone exposure in the development of alcohol addiction
title_auth	Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht = Role of prenatal testosterone exposure in the development of alcohol addiction
title_exact_search	Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht = Role of prenatal testosterone exposure in the development of alcohol addiction
title_full	Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht = Role of prenatal testosterone exposure in the development of alcohol addiction vorgelegt von Sabine E. Huber aus Tirschenreuth
title_fullStr	Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht = Role of prenatal testosterone exposure in the development of alcohol addiction vorgelegt von Sabine E. Huber aus Tirschenreuth
title_full_unstemmed	Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht = Role of prenatal testosterone exposure in the development of alcohol addiction vorgelegt von Sabine E. Huber aus Tirschenreuth
title_short	Die Rolle der pränatalen Testosteronexposition in der Entstehung von Alkoholsucht
title_sort	die rolle der pranatalen testosteronexposition in der entstehung von alkoholsucht role of prenatal testosterone exposure in the development of alcohol addiction
title_sub	= Role of prenatal testosterone exposure in the development of alcohol addiction
topic_facet	Hochschulschrift
url	http://d-nb.info/1158607695/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030351564&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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