Drug Safety Evaluation: Methods and Protocols
This second edition provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pedia...
Saved in:
| Other Authors: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY
Springer New York
2017
|
| Edition: | 2nd ed. 2017 |
| Series: | Methods in Molecular Biology
1641 |
| Subjects: | |
| Online Access: | UBR01 TUM01 Volltext |
| Summary: | This second edition provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls. Authoritative and practical, Drug Safety Evaluation: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field |
| Physical Description: | 1 Online-Ressource (XI, 427 p. 58 illus., 28 illus. in color) |
| ISBN: | 9781493971725 |
| DOI: | 10.1007/978-1-4939-7172-5 |
Staff View
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| edition | 2nd ed. 2017 |
| format | Electronic eBook |
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| spelling | Drug Safety Evaluation Methods and Protocols edited by Jean-Charles Gautier 2nd ed. 2017 New York, NY Springer New York 2017 1 Online-Ressource (XI, 427 p. 58 illus., 28 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 1641 This second edition provides up-to-date chapters and new chapters focusing on the most recent advances in the field of drug safety evaluation. Divided into seven parts, chapters detail specific aspects related to the experimental design of preclinical studies conducted to support the safety of pediatric and combination drugs, necropsy and histopathology evaluation, mass spectrometry imaging, genetic toxicology protocols including the Pig-a mutation assay, safety pharmacology methods such as automatization of patch-clamp procedures, target safety assessment for investigative toxicology, screening assays for developmental toxicology, and methods to characterize novel translational safety biomarkers like microRNAs. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting to avoid known pitfalls. Authoritative and practical, Drug Safety Evaluation: Methods and Protocols, Second Edition aims to ensure successful results in the further study of this vital field Biomedicine Pharmacology/Toxicology Medicine Pharmacology Arzneimittelsicherheit (DE-588)4143182-0 gnd rswk-swf Arzneimittelsicherheit (DE-588)4143182-0 s 1\p DE-604 Gautier, Jean-Charles edt Erscheint auch als Druck-Ausgabe 9781493971701 https://doi.org/10.1007/978-1-4939-7172-5 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Drug Safety Evaluation Methods and Protocols Biomedicine Pharmacology/Toxicology Medicine Pharmacology Arzneimittelsicherheit (DE-588)4143182-0 gnd |
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| title | Drug Safety Evaluation Methods and Protocols |
| title_auth | Drug Safety Evaluation Methods and Protocols |
| title_exact_search | Drug Safety Evaluation Methods and Protocols |
| title_full | Drug Safety Evaluation Methods and Protocols edited by Jean-Charles Gautier |
| title_fullStr | Drug Safety Evaluation Methods and Protocols edited by Jean-Charles Gautier |
| title_full_unstemmed | Drug Safety Evaluation Methods and Protocols edited by Jean-Charles Gautier |
| title_short | Drug Safety Evaluation |
| title_sort | drug safety evaluation methods and protocols |
| title_sub | Methods and Protocols |
| topic | Biomedicine Pharmacology/Toxicology Medicine Pharmacology Arzneimittelsicherheit (DE-588)4143182-0 gnd |
| topic_facet | Biomedicine Pharmacology/Toxicology Medicine Pharmacology Arzneimittelsicherheit |
| url | https://doi.org/10.1007/978-1-4939-7172-5 |
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