Glycobiology Protocols:
Glycobiology involves studies of complex carbohydrates and posttrans- tional modifications of proteins, and has become an important interdiscip- nary field encompassing chemistry, biochemistry, biology, physiology, and pathology. Although initial research was directed toward elucidation of the diffe...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2007
|
| Schriftenreihe: | Methods in Molecular Biology
347 |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBR01 Volltext |
| Zusammenfassung: | Glycobiology involves studies of complex carbohydrates and posttrans- tional modifications of proteins, and has become an important interdiscip- nary field encompassing chemistry, biochemistry, biology, physiology, and pathology. Although initial research was directed toward elucidation of the different carbohydrate structures and the enzymes synthesizing them, the field has now moved toward identifying the functions of carbohydrates. The pro- cols described in Glycobiology Protocols form a solid basis for investigations of glycan functions in health and disease. The cloning of many of the genes participating in glycosylation processes has helped to enhance our knowledge of how glycosylation is controlled, but has also added another dimension of complexity to the great heterogeneous variety of the structures of the oligos- charides of glycoproteins, proteoglycans, and glycolipids. A family of similar enzyme proteins exists for each glycosylation step. Glycosyltransferases are extremely specific for both the nucleotide sugar donor and the acceptor s- strate, but many other factors control sugar transfer, including the locali- tion and topology of enzymes, cofactors, possible chaperone proteins, and the availability of sugar acceptor substrates. The analysis of the intracellular organization of glycosylation and of the factors controlling the activities of the participating enzymes in the cell are important areas that need more research efforts. Another challenge for future research is to understand the glycodynamics of a cell, that is, how the cell responds to stimuli leading to biological and pathological changes in terms of alterations in glycosylation, and how this affects the biology of the cell |
| Beschreibung: | 1 Online-Ressource (XVIII, 382 p. 112 illus) |
| ISBN: | 9781597451673 |
| DOI: | 10.1385/1597451673 |
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| 520 | |a Glycobiology involves studies of complex carbohydrates and posttrans- tional modifications of proteins, and has become an important interdiscip- nary field encompassing chemistry, biochemistry, biology, physiology, and pathology. Although initial research was directed toward elucidation of the different carbohydrate structures and the enzymes synthesizing them, the field has now moved toward identifying the functions of carbohydrates. The pro- cols described in Glycobiology Protocols form a solid basis for investigations of glycan functions in health and disease. The cloning of many of the genes participating in glycosylation processes has helped to enhance our knowledge of how glycosylation is controlled, but has also added another dimension of complexity to the great heterogeneous variety of the structures of the oligos- charides of glycoproteins, proteoglycans, and glycolipids. A family of similar enzyme proteins exists for each glycosylation step. Glycosyltransferases are extremely specific for both the nucleotide sugar donor and the acceptor s- strate, but many other factors control sugar transfer, including the locali- tion and topology of enzymes, cofactors, possible chaperone proteins, and the availability of sugar acceptor substrates. The analysis of the intracellular organization of glycosylation and of the factors controlling the activities of the participating enzymes in the cell are important areas that need more research efforts. Another challenge for future research is to understand the glycodynamics of a cell, that is, how the cell responds to stimuli leading to biological and pathological changes in terms of alterations in glycosylation, and how this affects the biology of the cell | ||
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| isbn | 9781597451673 |
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| spelling | Glycobiology Protocols edited by Inka Brockhausen Totowa, NJ Humana Press 2007 1 Online-Ressource (XVIII, 382 p. 112 illus) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 347 Glycobiology involves studies of complex carbohydrates and posttrans- tional modifications of proteins, and has become an important interdiscip- nary field encompassing chemistry, biochemistry, biology, physiology, and pathology. Although initial research was directed toward elucidation of the different carbohydrate structures and the enzymes synthesizing them, the field has now moved toward identifying the functions of carbohydrates. The pro- cols described in Glycobiology Protocols form a solid basis for investigations of glycan functions in health and disease. The cloning of many of the genes participating in glycosylation processes has helped to enhance our knowledge of how glycosylation is controlled, but has also added another dimension of complexity to the great heterogeneous variety of the structures of the oligos- charides of glycoproteins, proteoglycans, and glycolipids. A family of similar enzyme proteins exists for each glycosylation step. Glycosyltransferases are extremely specific for both the nucleotide sugar donor and the acceptor s- strate, but many other factors control sugar transfer, including the locali- tion and topology of enzymes, cofactors, possible chaperone proteins, and the availability of sugar acceptor substrates. The analysis of the intracellular organization of glycosylation and of the factors controlling the activities of the participating enzymes in the cell are important areas that need more research efforts. Another challenge for future research is to understand the glycodynamics of a cell, that is, how the cell responds to stimuli leading to biological and pathological changes in terms of alterations in glycosylation, and how this affects the biology of the cell Life Sciences Biochemistry, general Life sciences Biochemistry Proteine (DE-588)4076388-2 gnd rswk-swf Labortechnik (DE-588)4123602-6 gnd rswk-swf Glykosylierung (DE-588)4269099-7 gnd rswk-swf Glykoproteine (DE-588)4071905-4 gnd rswk-swf Glykoproteine (DE-588)4071905-4 s Labortechnik (DE-588)4123602-6 s DE-604 Proteine (DE-588)4076388-2 s Glykosylierung (DE-588)4269099-7 s b DE-604 Brockhausen, Inka 1944- (DE-588)173090052 edt Erscheint auch als Druck-Ausgabe 9781588295538 https://doi.org/10.1385/1597451673 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Glycobiology Protocols Life Sciences Biochemistry, general Life sciences Biochemistry Proteine (DE-588)4076388-2 gnd Labortechnik (DE-588)4123602-6 gnd Glykosylierung (DE-588)4269099-7 gnd Glykoproteine (DE-588)4071905-4 gnd |
| subject_GND | (DE-588)4076388-2 (DE-588)4123602-6 (DE-588)4269099-7 (DE-588)4071905-4 |
| title | Glycobiology Protocols |
| title_auth | Glycobiology Protocols |
| title_exact_search | Glycobiology Protocols |
| title_full | Glycobiology Protocols edited by Inka Brockhausen |
| title_fullStr | Glycobiology Protocols edited by Inka Brockhausen |
| title_full_unstemmed | Glycobiology Protocols edited by Inka Brockhausen |
| title_short | Glycobiology Protocols |
| title_sort | glycobiology protocols |
| topic | Life Sciences Biochemistry, general Life sciences Biochemistry Proteine (DE-588)4076388-2 gnd Labortechnik (DE-588)4123602-6 gnd Glykosylierung (DE-588)4269099-7 gnd Glykoproteine (DE-588)4071905-4 gnd |
| topic_facet | Life Sciences Biochemistry, general Life sciences Biochemistry Proteine Labortechnik Glykosylierung Glykoproteine |
| url | https://doi.org/10.1385/1597451673 |
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