DNA Topoisomerase Protocols: Volume I: DNA Topology and Enzymes
DNA Topoisomerase Protocols, I: DNA Topology and Enzymes brings together an unprecedented collection of cutting-edge experimental protocols for investigating DNA structure, topology, and DNA topoisomerase function. Described by expert experimentalists who have perfected the techniques, these unfaili...
Saved in:
| Other Authors: | , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Totowa, NJ
Humana Press
1999
|
| Series: | Methods in Molecular Biology™
94 |
| Subjects: | |
| Online Access: | UBR01 Volltext |
| Summary: | DNA Topoisomerase Protocols, I: DNA Topology and Enzymes brings together an unprecedented collection of cutting-edge experimental protocols for investigating DNA structure, topology, and DNA topoisomerase function. Described by expert experimentalists who have perfected the techniques, these unfailingly reproducible methods utilize new approaches to study changes in DNA topology (linking number, knotting, catenation, and relaxation) and DNA structure (bending), as well as to assess chromosome structure through FLP-mediated recombination and to analyze bacterial nucleoid structure. State-of-the-art protocols also detail the expression and purification of bacterial, viral, and eukaryotic DNA topoisomerases from a variety of sources, including baculovirus, and bacterial, yeast and mammalian expression systems. A companion volume, DNA Topoisomerase Protocols, v. 2: Enzymology and Drugs, provides detailed protocols to study the catalytic activities of DNA topoisomerases, as well as their specific interactions with topoisomerase-targeted antitumor and antibacterial drugs. DNA Topoisomerase Protocols, I: DNA Topology and Enzymes will be of immense value to the many basic scientists and clinicians who want better to understand and to exploit proficiently the wealth of recent discoveries about chromatin structure and its relation to gene expression, about DNA topoisomerases as the targets of antitumor and antibacterial agents, and about DNA repair |
| Physical Description: | 1 Online-Ressource (XV, 327 p) |
| ISBN: | 9781592592593 |
| DOI: | 10.1385/1592592597 |
Staff View
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| isbn | 9781592592593 |
| language | English |
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| spelling | DNA Topoisomerase Protocols Volume I: DNA Topology and Enzymes edited by Mary-Ann Bjornsti, Neil Osheroff Totowa, NJ Humana Press 1999 1 Online-Ressource (XV, 327 p) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology™ 94 DNA Topoisomerase Protocols, I: DNA Topology and Enzymes brings together an unprecedented collection of cutting-edge experimental protocols for investigating DNA structure, topology, and DNA topoisomerase function. Described by expert experimentalists who have perfected the techniques, these unfailingly reproducible methods utilize new approaches to study changes in DNA topology (linking number, knotting, catenation, and relaxation) and DNA structure (bending), as well as to assess chromosome structure through FLP-mediated recombination and to analyze bacterial nucleoid structure. State-of-the-art protocols also detail the expression and purification of bacterial, viral, and eukaryotic DNA topoisomerases from a variety of sources, including baculovirus, and bacterial, yeast and mammalian expression systems. A companion volume, DNA Topoisomerase Protocols, v. 2: Enzymology and Drugs, provides detailed protocols to study the catalytic activities of DNA topoisomerases, as well as their specific interactions with topoisomerase-targeted antitumor and antibacterial drugs. DNA Topoisomerase Protocols, I: DNA Topology and Enzymes will be of immense value to the many basic scientists and clinicians who want better to understand and to exploit proficiently the wealth of recent discoveries about chromatin structure and its relation to gene expression, about DNA topoisomerases as the targets of antitumor and antibacterial agents, and about DNA repair Life Sciences Cell Biology Life sciences Cell biology Methode (DE-588)4038971-6 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf DNS-Gyrase (DE-588)4285125-7 gnd rswk-swf DNS-Gyrase (DE-588)4285125-7 s Molekularbiologie (DE-588)4039983-7 s Methode (DE-588)4038971-6 s DE-604 Bjornsti, Mary-Ann edt Osheroff, Neil edt Erscheint auch als Druck-Ausgabe 9780896034440 https://doi.org/10.1385/1592592597 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | DNA Topoisomerase Protocols Volume I: DNA Topology and Enzymes Life Sciences Cell Biology Life sciences Cell biology Methode (DE-588)4038971-6 gnd Molekularbiologie (DE-588)4039983-7 gnd DNS-Gyrase (DE-588)4285125-7 gnd |
| subject_GND | (DE-588)4038971-6 (DE-588)4039983-7 (DE-588)4285125-7 |
| title | DNA Topoisomerase Protocols Volume I: DNA Topology and Enzymes |
| title_auth | DNA Topoisomerase Protocols Volume I: DNA Topology and Enzymes |
| title_exact_search | DNA Topoisomerase Protocols Volume I: DNA Topology and Enzymes |
| title_full | DNA Topoisomerase Protocols Volume I: DNA Topology and Enzymes edited by Mary-Ann Bjornsti, Neil Osheroff |
| title_fullStr | DNA Topoisomerase Protocols Volume I: DNA Topology and Enzymes edited by Mary-Ann Bjornsti, Neil Osheroff |
| title_full_unstemmed | DNA Topoisomerase Protocols Volume I: DNA Topology and Enzymes edited by Mary-Ann Bjornsti, Neil Osheroff |
| title_short | DNA Topoisomerase Protocols |
| title_sort | dna topoisomerase protocols volume i dna topology and enzymes |
| title_sub | Volume I: DNA Topology and Enzymes |
| topic | Life Sciences Cell Biology Life sciences Cell biology Methode (DE-588)4038971-6 gnd Molekularbiologie (DE-588)4039983-7 gnd DNS-Gyrase (DE-588)4285125-7 gnd |
| topic_facet | Life Sciences Cell Biology Life sciences Cell biology Methode Molekularbiologie DNS-Gyrase |
| url | https://doi.org/10.1385/1592592597 |
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