Membrane Transporters: Methods and Protocols
Membrane transporters and channels play key roles in drug absorption and distribution, influence drug efficacy and toxicity, and are the target of about 30% of currently marketed drugs. In Membrane Transporters: Methods and Protocols, a panel of recognized basic and clinical investigators-many world...
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2003
|
| Schriftenreihe: | Methods in Molecular Biology
227 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 URL des Erstveröffentlichers |
| Zusammenfassung: | Membrane transporters and channels play key roles in drug absorption and distribution, influence drug efficacy and toxicity, and are the target of about 30% of currently marketed drugs. In Membrane Transporters: Methods and Protocols, a panel of recognized basic and clinical investigators-many world-famous-describe their proven, cutting-edge methodologies for studying these important proteins. Treated in step-by-step detail, these techniques take advantage of all the latest developments in biomedical research, including pharmacogenomics, bioinformatics, and microarray technologies. The authors explain databases and tools for bioinformatics analysis, provide practical guidelines for microarray experiments and data analysis, and illustrate the use of small-angle X-ray scattering, nuclear magnetic resonance (NMR), and molecular modeling to study the structural biology of membrane transporters. Methods for exploring structure-function correlation, such as site-directed mutagenesis, immunocytochemistry, and confocal microscopy, are also described, along with several methods that may help in the development of novel therapeutics. Each technique contains hands-on instructions, many notes on avoiding the problems that one may encounter, and suggestions for variant procedures. Comprehensive and highly practical, Membrane Transporters: Methods and Protocols offers investigators working in biopharmaceutical science, drug discovery, and drug delivery both an array of powerful tools for work on membrane transporters and an essential guide to the state-of-the-art in the membrane transporter field today |
| Beschreibung: | 1 Online-Ressource (XII, 372 p) |
| ISBN: | 9781592593873 |
| DOI: | 10.1385/1592593879 |
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| spelling | Membrane Transporters Methods and Protocols edited by Qing Yan Totowa, NJ Humana Press 2003 1 Online-Ressource (XII, 372 p) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 227 Membrane transporters and channels play key roles in drug absorption and distribution, influence drug efficacy and toxicity, and are the target of about 30% of currently marketed drugs. In Membrane Transporters: Methods and Protocols, a panel of recognized basic and clinical investigators-many world-famous-describe their proven, cutting-edge methodologies for studying these important proteins. Treated in step-by-step detail, these techniques take advantage of all the latest developments in biomedical research, including pharmacogenomics, bioinformatics, and microarray technologies. The authors explain databases and tools for bioinformatics analysis, provide practical guidelines for microarray experiments and data analysis, and illustrate the use of small-angle X-ray scattering, nuclear magnetic resonance (NMR), and molecular modeling to study the structural biology of membrane transporters. Methods for exploring structure-function correlation, such as site-directed mutagenesis, immunocytochemistry, and confocal microscopy, are also described, along with several methods that may help in the development of novel therapeutics. Each technique contains hands-on instructions, many notes on avoiding the problems that one may encounter, and suggestions for variant procedures. Comprehensive and highly practical, Membrane Transporters: Methods and Protocols offers investigators working in biopharmaceutical science, drug discovery, and drug delivery both an array of powerful tools for work on membrane transporters and an essential guide to the state-of-the-art in the membrane transporter field today Life Sciences Cell Biology Life sciences Cell biology Untersuchungsmethode (DE-588)4324907-3 gnd rswk-swf Carrier-Proteine (DE-588)4213127-3 gnd rswk-swf Membrantransport (DE-588)4038575-9 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Membrantransport (DE-588)4038575-9 s Untersuchungsmethode (DE-588)4324907-3 s DE-604 Carrier-Proteine (DE-588)4213127-3 s Yan, Qing edt Erscheint auch als Druck-Ausgabe 9781588291042 https://doi.org/10.1385/1592593879 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Membrane Transporters Methods and Protocols Life Sciences Cell Biology Life sciences Cell biology Untersuchungsmethode (DE-588)4324907-3 gnd Carrier-Proteine (DE-588)4213127-3 gnd Membrantransport (DE-588)4038575-9 gnd |
| subject_GND | (DE-588)4324907-3 (DE-588)4213127-3 (DE-588)4038575-9 (DE-588)4143413-4 |
| title | Membrane Transporters Methods and Protocols |
| title_auth | Membrane Transporters Methods and Protocols |
| title_exact_search | Membrane Transporters Methods and Protocols |
| title_full | Membrane Transporters Methods and Protocols edited by Qing Yan |
| title_fullStr | Membrane Transporters Methods and Protocols edited by Qing Yan |
| title_full_unstemmed | Membrane Transporters Methods and Protocols edited by Qing Yan |
| title_short | Membrane Transporters |
| title_sort | membrane transporters methods and protocols |
| title_sub | Methods and Protocols |
| topic | Life Sciences Cell Biology Life sciences Cell biology Untersuchungsmethode (DE-588)4324907-3 gnd Carrier-Proteine (DE-588)4213127-3 gnd Membrantransport (DE-588)4038575-9 gnd |
| topic_facet | Life Sciences Cell Biology Life sciences Cell biology Untersuchungsmethode Carrier-Proteine Membrantransport Aufsatzsammlung |
| url | https://doi.org/10.1385/1592593879 |
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