MHC Protocols:
Many of the genes found in the human major histocompatibility complex (MHC:HLA region) are subject to extreme polymorphism. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. Many MHC genes also have significant disease associati...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2003
|
| Schriftenreihe: | Methods in Molecular Biology™
210 |
| Schlagworte: | |
| Online-Zugang: | DE-355 DE-91 URL des Erstveröffentlichers |
| Zusammenfassung: | Many of the genes found in the human major histocompatibility complex (MHC:HLA region) are subject to extreme polymorphism. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. Many MHC genes also have significant disease association and play a pivotal role in the control of immune response. In MHC Protocols, leading experts detail readily reproducible methods for identifying these polymorphisms in the human MHC. Described in step-by-step detail to ensure robust and successful experimental results, these techniques provide DNA-based protocols for the study of polymorphism in HLA class I and II genes and in non-HLA HMC genes associated with human disease (TAP1, TAP2, C2, C4, and TNF-a). The authors also describe methods for accessing HLA sequence data from electronic databases designed to catalog HLA-region genes and their alleles. Each method is written by an investigator who has used the technique extensively and includes troubleshooting tips and notes on pitfalls to avoid. Comprehensive and highly practical, MHC Protocols offers both experienced and novice investigators not only a state-of-the-art overview of this dramatically evolving area of immunology, but also a reliable guide to the identification of MHC gene polymorphisms |
| Beschreibung: | 1 Online-Ressource (XII, 340 p) |
| ISBN: | 9781592592913 |
| DOI: | 10.1385/1592592910 |
Internformat
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| 520 | |a Many of the genes found in the human major histocompatibility complex (MHC:HLA region) are subject to extreme polymorphism. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. Many MHC genes also have significant disease association and play a pivotal role in the control of immune response. In MHC Protocols, leading experts detail readily reproducible methods for identifying these polymorphisms in the human MHC. Described in step-by-step detail to ensure robust and successful experimental results, these techniques provide DNA-based protocols for the study of polymorphism in HLA class I and II genes and in non-HLA HMC genes associated with human disease (TAP1, TAP2, C2, C4, and TNF-a). The authors also describe methods for accessing HLA sequence data from electronic databases designed to catalog HLA-region genes and their alleles. Each method is written by an investigator who has used the technique extensively and includes troubleshooting tips and notes on pitfalls to avoid. Comprehensive and highly practical, MHC Protocols offers both experienced and novice investigators not only a state-of-the-art overview of this dramatically evolving area of immunology, but also a reliable guide to the identification of MHC gene polymorphisms | ||
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| id | DE-604.BV044951718 |
| illustrated | Not Illustrated |
| indexdate | 2024-12-06T17:00:49Z |
| institution | BVB |
| isbn | 9781592592913 |
| language | English |
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| publishDate | 2003 |
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| spelling | MHC Protocols edited by Stephen H. Powis, Robert W. Vaughan Totowa, NJ Humana Press 2003 1 Online-Ressource (XII, 340 p) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology™ 210 Many of the genes found in the human major histocompatibility complex (MHC:HLA region) are subject to extreme polymorphism. HLA polymorphism has been used extensively in solid organ and bone marrow transplantation to match donors and recipients. Many MHC genes also have significant disease association and play a pivotal role in the control of immune response. In MHC Protocols, leading experts detail readily reproducible methods for identifying these polymorphisms in the human MHC. Described in step-by-step detail to ensure robust and successful experimental results, these techniques provide DNA-based protocols for the study of polymorphism in HLA class I and II genes and in non-HLA HMC genes associated with human disease (TAP1, TAP2, C2, C4, and TNF-a). The authors also describe methods for accessing HLA sequence data from electronic databases designed to catalog HLA-region genes and their alleles. Each method is written by an investigator who has used the technique extensively and includes troubleshooting tips and notes on pitfalls to avoid. Comprehensive and highly practical, MHC Protocols offers both experienced and novice investigators not only a state-of-the-art overview of this dramatically evolving area of immunology, but also a reliable guide to the identification of MHC gene polymorphisms Biomedicine Immunology Medicine Genanalyse (DE-588)4200230-8 gnd rswk-swf Genetische Variabilität (DE-588)4264352-1 gnd rswk-swf MHC (DE-588)4169760-1 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content MHC (DE-588)4169760-1 s Genetische Variabilität (DE-588)4264352-1 s DE-604 Genanalyse (DE-588)4200230-8 s Powis, Stephen H. edt Vaughan, Robert W. edt Erscheint auch als Druck-Ausgabe 9780896035485 https://doi.org/10.1385/1592592910 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | MHC Protocols Biomedicine Immunology Medicine Genanalyse (DE-588)4200230-8 gnd Genetische Variabilität (DE-588)4264352-1 gnd MHC (DE-588)4169760-1 gnd |
| subject_GND | (DE-588)4200230-8 (DE-588)4264352-1 (DE-588)4169760-1 (DE-588)4143413-4 |
| title | MHC Protocols |
| title_auth | MHC Protocols |
| title_exact_search | MHC Protocols |
| title_full | MHC Protocols edited by Stephen H. Powis, Robert W. Vaughan |
| title_fullStr | MHC Protocols edited by Stephen H. Powis, Robert W. Vaughan |
| title_full_unstemmed | MHC Protocols edited by Stephen H. Powis, Robert W. Vaughan |
| title_short | MHC Protocols |
| title_sort | mhc protocols |
| topic | Biomedicine Immunology Medicine Genanalyse (DE-588)4200230-8 gnd Genetische Variabilität (DE-588)4264352-1 gnd MHC (DE-588)4169760-1 gnd |
| topic_facet | Biomedicine Immunology Medicine Genanalyse Genetische Variabilität MHC Aufsatzsammlung |
| url | https://doi.org/10.1385/1592592910 |
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