Mitochondrial DNA: Methods and Protocols
Mutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authori...
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2002
|
| Schriftenreihe: | Methods in Molecular Biology™
197 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | Mutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Each readily reproducible protocol includes step-by-step instructions, tips on avoiding pitfalls and extending the method to other situation, and introductory material explaining the theory behind the process. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial dysfunction and disease |
| Beschreibung: | 1 Online-Ressource (XIV, 414 p. 128 illus., 8 illus. in color) |
| ISBN: | 9781592592845 |
| DOI: | 10.1385/1592592848 |
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Datensatz im Suchindex
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| spelling | Mitochondrial DNA Methods and Protocols edited by William C. Copeland Totowa, NJ Humana Press 2002 1 Online-Ressource (XIV, 414 p. 128 illus., 8 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology™ 197 Mutations within mitochondrial DNA (mtDNA) and the nuclear genes involved in the maintenance of mitochondrial DNA have been linked to a wide range of human diseases, including several of the most common diseases of aging. In Mitochondrial DNA: Methods and Protocols internationally recognized authorities describe in great detail the methods they have perfected to analyze mtDNA and the proteins involved in its maintenance. The analytical techniques cover the purification of mtDNA from a variety of sources and the analysis of DNA for both deletions, point mutations, and damage, for replication intermediates, and for following the fate of mtDNA outside of the mitochondria. Additional analytical methods are presented for analyzing the proteins and enzymes that maintain mtDNA. Each readily reproducible protocol includes step-by-step instructions, tips on avoiding pitfalls and extending the method to other situation, and introductory material explaining the theory behind the process. Comprehensive and timely, Mitochondrial DNA: Methods and Protocols offers both basic and clinical researchers proven cutting-edge methods for analyzing the role mtDNA plays in the aging process, apoptosis, and possibly some cancers, and for investigating the cause of mitochondrial dysfunction and disease Life Sciences Cell Biology Life sciences Cell biology Labortechnik (DE-588)4123602-6 gnd rswk-swf Genanalyse (DE-588)4200230-8 gnd rswk-swf Mitochondriale DNS (DE-588)4202301-4 gnd rswk-swf Mitochondriopathie (DE-588)4280150-3 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Mitochondriale DNS (DE-588)4202301-4 s Labortechnik (DE-588)4123602-6 s DE-604 Mitochondriopathie (DE-588)4280150-3 s Genanalyse (DE-588)4200230-8 s Copeland, William C. edt Erscheint auch als Druck-Ausgabe 9780896039728 https://doi.org/10.1385/1592592848 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Mitochondrial DNA Methods and Protocols Life Sciences Cell Biology Life sciences Cell biology Labortechnik (DE-588)4123602-6 gnd Genanalyse (DE-588)4200230-8 gnd Mitochondriale DNS (DE-588)4202301-4 gnd Mitochondriopathie (DE-588)4280150-3 gnd |
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| title | Mitochondrial DNA Methods and Protocols |
| title_auth | Mitochondrial DNA Methods and Protocols |
| title_exact_search | Mitochondrial DNA Methods and Protocols |
| title_full | Mitochondrial DNA Methods and Protocols edited by William C. Copeland |
| title_fullStr | Mitochondrial DNA Methods and Protocols edited by William C. Copeland |
| title_full_unstemmed | Mitochondrial DNA Methods and Protocols edited by William C. Copeland |
| title_short | Mitochondrial DNA |
| title_sort | mitochondrial dna methods and protocols |
| title_sub | Methods and Protocols |
| topic | Life Sciences Cell Biology Life sciences Cell biology Labortechnik (DE-588)4123602-6 gnd Genanalyse (DE-588)4200230-8 gnd Mitochondriale DNS (DE-588)4202301-4 gnd Mitochondriopathie (DE-588)4280150-3 gnd |
| topic_facet | Life Sciences Cell Biology Life sciences Cell biology Labortechnik Genanalyse Mitochondriale DNS Mitochondriopathie Aufsatzsammlung |
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