G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols
This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkabl...
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| Other Authors: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY
Springer New York
2015
|
| Edition: | 2nd ed. 2015 |
| Series: | Methods in Molecular Biology
1335 |
| Subjects: | |
| Online Access: | UBR01 TUM01 Volltext |
| Summary: | This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical, and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists, and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets |
| Physical Description: | 1 Online-Ressource (XII, 327 p. 71 illus., 50 illus. in color) |
| ISBN: | 9781493929146 |
| DOI: | 10.1007/978-1-4939-2914-6 |
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| spelling | G Protein-Coupled Receptors in Drug Discovery Methods and Protocols edited by Marta Filizola 2nd ed. 2015 New York, NY Springer New York 2015 1 Online-Ressource (XII, 327 p. 71 illus., 50 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 1335 This detailed volume provides an overview of recent techniques employed in the field of G protein-coupled receptors (GPCRs) to screen for new drugs and to derive information about their receptor structure, dynamics, and function for the purpose of developing improved therapeutics. Owing to remarkable recent advances in the structural, biophysical, and biochemical analyses of these receptors, as well as a growing body of evidence hinting at the possible relevance of allosteric modulators, biased agonists, and oligomer-selective ligands as improved therapeutic agents, drug discovery for GPCRs has recently taken a completely new direction. For this book, expert contributors have shared their protocols and views on the impact of these methodologies on modern drug discovery. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and fully updated, G Protein-Coupled Receptors in Drug Discovery: Methods and Protocols, Second Edition serves as an ideal guide for a diverse audience from structural and molecular biologists to pharmacologists and drug designers who wish to explore this extensive class of key drug targets Biomedicine Pharmacology/Toxicology Proteomics Medicine Pharmacology Filizola, Marta edt Erscheint auch als Druck-Ausgabe 9781493929139 https://doi.org/10.1007/978-1-4939-2914-6 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | G Protein-Coupled Receptors in Drug Discovery Methods and Protocols Biomedicine Pharmacology/Toxicology Proteomics Medicine Pharmacology |
| title | G Protein-Coupled Receptors in Drug Discovery Methods and Protocols |
| title_auth | G Protein-Coupled Receptors in Drug Discovery Methods and Protocols |
| title_exact_search | G Protein-Coupled Receptors in Drug Discovery Methods and Protocols |
| title_full | G Protein-Coupled Receptors in Drug Discovery Methods and Protocols edited by Marta Filizola |
| title_fullStr | G Protein-Coupled Receptors in Drug Discovery Methods and Protocols edited by Marta Filizola |
| title_full_unstemmed | G Protein-Coupled Receptors in Drug Discovery Methods and Protocols edited by Marta Filizola |
| title_short | G Protein-Coupled Receptors in Drug Discovery |
| title_sort | g protein coupled receptors in drug discovery methods and protocols |
| title_sub | Methods and Protocols |
| topic | Biomedicine Pharmacology/Toxicology Proteomics Medicine Pharmacology |
| topic_facet | Biomedicine Pharmacology/Toxicology Proteomics Medicine Pharmacology |
| url | https://doi.org/10.1007/978-1-4939-2914-6 |
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