Allostery: Methods and Protocols
Despite considerable variability within the scientific community, allosteric regulation can best be defined functionally as how a macromolecule binds one ligand differently when a second ligand is or is not pre-bound to the macromolecule, which constitutes a vital aspect of protein structure/functio...
Gespeichert in:
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
New York, NY
Springer New York
2012
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| Schriftenreihe: | Methods in Molecular Biology, Methods and Protocols
796 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 Volltext |
| Zusammenfassung: | Despite considerable variability within the scientific community, allosteric regulation can best be defined functionally as how a macromolecule binds one ligand differently when a second ligand is or is not pre-bound to the macromolecule, which constitutes a vital aspect of protein structure/function. In Allostery: Methods and Protocols, expert researchers in the field provide key techniques to investigate this biological phenomenon. Focusing on heterotropic systems with some coverage of homotropic systems, this volume covers the monitoring of allosteric function, allosteric conformational changes, and allosteric changes in protein dynamics/sub-population distribution, as well as topics such as macromolecular and ligand engineering of allosteric functions and computational aids in the study of allostery. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Allostery: Methods and Protocols aids scientists in continuing to study ligand-induced, through-protein effects on protein function (ligand binding/catalysis), a phenomenon that is well recognized through the history of the life sciences and very poorly understood at the molecular level |
| Beschreibung: | 1 Online-Ressource (XVIII, 439 p. 134 illus) |
| ISBN: | 9781617793349 |
| DOI: | 10.1007/978-1-61779-334-9 |
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Datensatz im Suchindex
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| discipline | Biologie |
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| spelling | Allostery Methods and Protocols edited by Aron W. Fenton New York, NY Springer New York 2012 1 Online-Ressource (XVIII, 439 p. 134 illus) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology, Methods and Protocols 796 Despite considerable variability within the scientific community, allosteric regulation can best be defined functionally as how a macromolecule binds one ligand differently when a second ligand is or is not pre-bound to the macromolecule, which constitutes a vital aspect of protein structure/function. In Allostery: Methods and Protocols, expert researchers in the field provide key techniques to investigate this biological phenomenon. Focusing on heterotropic systems with some coverage of homotropic systems, this volume covers the monitoring of allosteric function, allosteric conformational changes, and allosteric changes in protein dynamics/sub-population distribution, as well as topics such as macromolecular and ligand engineering of allosteric functions and computational aids in the study of allostery. Written in the highly successful Methods in Molecular Biology™ series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Thorough and intuitive, Allostery: Methods and Protocols aids scientists in continuing to study ligand-induced, through-protein effects on protein function (ligand binding/catalysis), a phenomenon that is well recognized through the history of the life sciences and very poorly understood at the molecular level Life Sciences Protein Science Protein Structure Life sciences Proteins Untersuchungsmethode (DE-588)4324907-3 gnd rswk-swf Allosterie (DE-588)4477780-2 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Allosterie (DE-588)4477780-2 s Untersuchungsmethode (DE-588)4324907-3 s 2\p DE-604 Fenton, Aron W. edt Erscheint auch als Druck-Ausgabe 9781617793332 https://doi.org/10.1007/978-1-61779-334-9 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Allostery Methods and Protocols Life Sciences Protein Science Protein Structure Life sciences Proteins Untersuchungsmethode (DE-588)4324907-3 gnd Allosterie (DE-588)4477780-2 gnd |
| subject_GND | (DE-588)4324907-3 (DE-588)4477780-2 (DE-588)4143413-4 |
| title | Allostery Methods and Protocols |
| title_auth | Allostery Methods and Protocols |
| title_exact_search | Allostery Methods and Protocols |
| title_full | Allostery Methods and Protocols edited by Aron W. Fenton |
| title_fullStr | Allostery Methods and Protocols edited by Aron W. Fenton |
| title_full_unstemmed | Allostery Methods and Protocols edited by Aron W. Fenton |
| title_short | Allostery |
| title_sort | allostery methods and protocols |
| title_sub | Methods and Protocols |
| topic | Life Sciences Protein Science Protein Structure Life sciences Proteins Untersuchungsmethode (DE-588)4324907-3 gnd Allosterie (DE-588)4477780-2 gnd |
| topic_facet | Life Sciences Protein Science Protein Structure Life sciences Proteins Untersuchungsmethode Allosterie Aufsatzsammlung |
| url | https://doi.org/10.1007/978-1-61779-334-9 |
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