Optimization in Drug Discovery: In Vitro Methods
Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and...
Saved in:
| Other Authors: | , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Totowa, NJ
Humana Press
2014
|
| Edition: | 2nd ed. 2014 |
| Series: | Methods in Pharmacology and Toxicology
|
| Subjects: | |
| Online Access: | UBR01 TUM01 Volltext |
| Summary: | Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development |
| Physical Description: | 1 Online-Ressource (XVII, 597 p. 113 illus., 49 illus. in color) |
| ISBN: | 9781627037426 |
| DOI: | 10.1007/978-1-62703-742-6 |
Staff View
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| spelling | Optimization in Drug Discovery In Vitro Methods edited by Gary W. Caldwell, Zhengyin Yan 2nd ed. 2014 Totowa, NJ Humana Press 2014 1 Online-Ressource (XVII, 597 p. 113 illus., 49 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Pharmacology and Toxicology Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve "drug-like" characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development Biomedicine Pharmacology/Toxicology Medicine Pharmacology Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf In vitro (DE-588)4250701-7 gnd rswk-swf Arzneimittelforschung (DE-588)4003120-2 gnd rswk-swf Arzneimittelforschung (DE-588)4003120-2 s Arzneimittelentwicklung (DE-588)4143176-5 s In vitro (DE-588)4250701-7 s 1\p DE-604 Caldwell, Gary W. edt Yan, Zhengyin edt Erscheint auch als Druck-Ausgabe 9781627037419 https://doi.org/10.1007/978-1-62703-742-6 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Optimization in Drug Discovery In Vitro Methods Biomedicine Pharmacology/Toxicology Medicine Pharmacology Arzneimittelentwicklung (DE-588)4143176-5 gnd In vitro (DE-588)4250701-7 gnd Arzneimittelforschung (DE-588)4003120-2 gnd |
| subject_GND | (DE-588)4143176-5 (DE-588)4250701-7 (DE-588)4003120-2 |
| title | Optimization in Drug Discovery In Vitro Methods |
| title_auth | Optimization in Drug Discovery In Vitro Methods |
| title_exact_search | Optimization in Drug Discovery In Vitro Methods |
| title_full | Optimization in Drug Discovery In Vitro Methods edited by Gary W. Caldwell, Zhengyin Yan |
| title_fullStr | Optimization in Drug Discovery In Vitro Methods edited by Gary W. Caldwell, Zhengyin Yan |
| title_full_unstemmed | Optimization in Drug Discovery In Vitro Methods edited by Gary W. Caldwell, Zhengyin Yan |
| title_short | Optimization in Drug Discovery |
| title_sort | optimization in drug discovery in vitro methods |
| title_sub | In Vitro Methods |
| topic | Biomedicine Pharmacology/Toxicology Medicine Pharmacology Arzneimittelentwicklung (DE-588)4143176-5 gnd In vitro (DE-588)4250701-7 gnd Arzneimittelforschung (DE-588)4003120-2 gnd |
| topic_facet | Biomedicine Pharmacology/Toxicology Medicine Pharmacology Arzneimittelentwicklung In vitro Arzneimittelforschung |
| url | https://doi.org/10.1007/978-1-62703-742-6 |
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