The Inflammasome: Methods and Protocols
Inflammasomes have a seemingly simple architecture. A sensor molecule of the NLR or PYHIN protein family recruits the common adapter molecule apoptosis-associated speck-like protein containing a CARD (ASC). Even so, inflammasome activation is highly regulated at multiple steps and precise details o...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Totowa, NJ
Humana Press
2013
|
| Schriftenreihe: | Methods in Molecular Biology, Methods and Protocols
1040 |
| Schlagworte: | |
| Online-Zugang: | UBR01 TUM01 URL des Erstveröffentlichers |
| Zusammenfassung: | Inflammasomes have a seemingly simple architecture. A sensor molecule of the NLR or PYHIN protein family recruits the common adapter molecule apoptosis-associated speck-like protein containing a CARD (ASC). Even so, inflammasome activation is highly regulated at multiple steps and precise details of how inflammasomes are activated at the molecular level remain largely unknown. In The Inflammasome: Methods and Protocols, expert researchers in the field detail methods and protocols to study multiple aspects of inflammasome function. These methods include the generation of inflammasome stimuli, perturbance of cellular homeostasis, assessment of ASC speck formation, monitoring of caspase-1 activity and processing, activation of IL-1β cytokines, and analysis of inflammasome assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls |
| Beschreibung: | 1 Online-Ressource (XI, 225 p. 44 illus., 21 illus. in color) |
| ISBN: | 9781627035231 |
| DOI: | 10.1007/978-1-62703-523-1 |
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| 520 | |a Inflammasomes have a seemingly simple architecture. A sensor molecule of the NLR or PYHIN protein family recruits the common adapter molecule apoptosis-associated speck-like protein containing a CARD (ASC). Even so, inflammasome activation is highly regulated at multiple steps and precise details of how inflammasomes are activated at the molecular level remain largely unknown. In The Inflammasome: Methods and Protocols, expert researchers in the field detail methods and protocols to study multiple aspects of inflammasome function. These methods include the generation of inflammasome stimuli, perturbance of cellular homeostasis, assessment of ASC speck formation, monitoring of caspase-1 activity and processing, activation of IL-1β cytokines, and analysis of inflammasome assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls | ||
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| discipline | Medizin |
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| spelling | The Inflammasome Methods and Protocols edited by Christine M. De Nardo, Eicke Latz Totowa, NJ Humana Press 2013 1 Online-Ressource (XI, 225 p. 44 illus., 21 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology, Methods and Protocols 1040 Inflammasomes have a seemingly simple architecture. A sensor molecule of the NLR or PYHIN protein family recruits the common adapter molecule apoptosis-associated speck-like protein containing a CARD (ASC). Even so, inflammasome activation is highly regulated at multiple steps and precise details of how inflammasomes are activated at the molecular level remain largely unknown. In The Inflammasome: Methods and Protocols, expert researchers in the field detail methods and protocols to study multiple aspects of inflammasome function. These methods include the generation of inflammasome stimuli, perturbance of cellular homeostasis, assessment of ASC speck formation, monitoring of caspase-1 activity and processing, activation of IL-1β cytokines, and analysis of inflammasome assembly. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls Biomedicine Immunology Cytokines and Growth Factors Medicine Cytokines Growth factors De Nardo, Christine M. edt Latz, Eicke edt Erscheint auch als Druck-Ausgabe 9781627035224 https://doi.org/10.1007/978-1-62703-523-1 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | The Inflammasome Methods and Protocols Biomedicine Immunology Cytokines and Growth Factors Medicine Cytokines Growth factors |
| title | The Inflammasome Methods and Protocols |
| title_auth | The Inflammasome Methods and Protocols |
| title_exact_search | The Inflammasome Methods and Protocols |
| title_full | The Inflammasome Methods and Protocols edited by Christine M. De Nardo, Eicke Latz |
| title_fullStr | The Inflammasome Methods and Protocols edited by Christine M. De Nardo, Eicke Latz |
| title_full_unstemmed | The Inflammasome Methods and Protocols edited by Christine M. De Nardo, Eicke Latz |
| title_short | The Inflammasome |
| title_sort | the inflammasome methods and protocols |
| title_sub | Methods and Protocols |
| topic | Biomedicine Immunology Cytokines and Growth Factors Medicine Cytokines Growth factors |
| topic_facet | Biomedicine Immunology Cytokines and Growth Factors Medicine Cytokines Growth factors |
| url | https://doi.org/10.1007/978-1-62703-523-1 |
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