Computational Methods for GPCR Drug Discovery:
This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure...
Saved in:
| Other Authors: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY
Springer New York
2018
|
| Series: | Methods in Molecular Biology
1705 |
| Subjects: | |
| Online Access: | UBR01 TUM01 Volltext |
| Summary: | This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modelling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique,Computational Methods for GPCR Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers |
| Physical Description: | 1 Online-Ressource (XI, 436 p. 111 illus., 102 illus. in color) |
| ISBN: | 9781493974658 |
| DOI: | 10.1007/978-1-4939-7465-8 |
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| spelling | Computational Methods for GPCR Drug Discovery edited by Alexander Heifetz New York, NY Springer New York 2018 1 Online-Ressource (XI, 436 p. 111 illus., 102 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology 1705 This volume looks at modern computational strategies and techniques used in GPCR drug discovery including structure and ligand-based approaches and cheminformatics. The chapters in this book describe how these approaches can be applied to address key drug discovery issues, such as receptor structure modelling, function and dynamics, prediction of protein-water-ligand interactions and binding kinetics, free energy of binding, interconversion between agonists and antagonists, deorphanization of GPCRs, and the discovery of biased and allosteric modulators. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary software and tools, step-by-step, readily reproducible modelling protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and unique,Computational Methods for GPCR Drug Discovery is a valuable resource for structural and molecular biologists, computational and medicinal chemists, pharmacologists, and drug designers Biomedicine Pharmacology/Toxicology Medicine Pharmacology Heifetz, Alexander edt Erscheint auch als Druck-Ausgabe 9781493974641 https://doi.org/10.1007/978-1-4939-7465-8 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Computational Methods for GPCR Drug Discovery Biomedicine Pharmacology/Toxicology Medicine Pharmacology |
| title | Computational Methods for GPCR Drug Discovery |
| title_auth | Computational Methods for GPCR Drug Discovery |
| title_exact_search | Computational Methods for GPCR Drug Discovery |
| title_full | Computational Methods for GPCR Drug Discovery edited by Alexander Heifetz |
| title_fullStr | Computational Methods for GPCR Drug Discovery edited by Alexander Heifetz |
| title_full_unstemmed | Computational Methods for GPCR Drug Discovery edited by Alexander Heifetz |
| title_short | Computational Methods for GPCR Drug Discovery |
| title_sort | computational methods for gpcr drug discovery |
| topic | Biomedicine Pharmacology/Toxicology Medicine Pharmacology |
| topic_facet | Biomedicine Pharmacology/Toxicology Medicine Pharmacology |
| url | https://doi.org/10.1007/978-1-4939-7465-8 |
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