Tissue-Protective Cytokines: Methods and Protocols
While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of in...
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| Other Authors: | , |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Totowa, NJ
Humana Press
2013
|
| Series: | Methods in Molecular Biology, Methods and Protocols
982 |
| Subjects: | |
| Online Access: | UBR01 TUM01 Volltext |
| Summary: | While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines. In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs |
| Physical Description: | 1 Online-Ressource (XI, 328 p. 55 illus., 18 illus. in color) |
| ISBN: | 9781627033084 |
| DOI: | 10.1007/978-1-62703-308-4 |
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| 520 | |a While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines. In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs | ||
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| spelling | Tissue-Protective Cytokines Methods and Protocols edited by Pietro Ghezzi, Anthony Cerami Totowa, NJ Humana Press 2013 1 Online-Ressource (XI, 328 p. 55 illus., 18 illus. in color) txt rdacontent c rdamedia cr rdacarrier Methods in Molecular Biology, Methods and Protocols 982 While many cytokines are known for their inflammatory action, there is a growing interest in the tissue-protective effects of some cytokines. The prototypic tissue-protective cytokine is EPO. Initially described as neuro-protective, it is beneficial in animal models of ischemic and other types of injury. Scientists had to overcome the notion that EPO had only erythropoietic actions, was only produced by the kidney, and that its receptor was only present in erythroid progenitor cells. The use of in vitro and in vivo disease models was essential to demonstrate the protective effects of EPO. Reproducible models will be needed for the further study of the mechanism of action of EPO and for the identification of other tissue-protective cytokines. In Tissue-Protective Cytokines: Methods and Protocols, expert researchers in the field detail the key models that have been used to characterize the tissue-protective actions of cytokines. Written in the highly successful Methods in Molecular Biology™ series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, provide step-by-step laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Thorough and intuitive, Tissue Protective Cytokines: Methods and Protocols aids scientists in continuing to study tissue-protection that will be a new field of interest of cytokine biology, both in discovering novel actions of known cytokines and in developing new drugs Life Sciences Biochemistry, general Human Physiology Life sciences Human physiology Biochemistry Ghezzi, Pietro edt Cerami, Anthony edt Erscheint auch als Druck-Ausgabe 9781627033077 https://doi.org/10.1007/978-1-62703-308-4 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Tissue-Protective Cytokines Methods and Protocols Life Sciences Biochemistry, general Human Physiology Life sciences Human physiology Biochemistry |
| title | Tissue-Protective Cytokines Methods and Protocols |
| title_auth | Tissue-Protective Cytokines Methods and Protocols |
| title_exact_search | Tissue-Protective Cytokines Methods and Protocols |
| title_full | Tissue-Protective Cytokines Methods and Protocols edited by Pietro Ghezzi, Anthony Cerami |
| title_fullStr | Tissue-Protective Cytokines Methods and Protocols edited by Pietro Ghezzi, Anthony Cerami |
| title_full_unstemmed | Tissue-Protective Cytokines Methods and Protocols edited by Pietro Ghezzi, Anthony Cerami |
| title_short | Tissue-Protective Cytokines |
| title_sort | tissue protective cytokines methods and protocols |
| title_sub | Methods and Protocols |
| topic | Life Sciences Biochemistry, general Human Physiology Life sciences Human physiology Biochemistry |
| topic_facet | Life Sciences Biochemistry, general Human Physiology Life sciences Human physiology Biochemistry |
| url | https://doi.org/10.1007/978-1-62703-308-4 |
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