Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Gießen, Lahn
VVB Laufersweiler Verlag
2016
|
| Series: | Edition Scientifique
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 151 Seiten 21 cm x 14.6 cm, 201 g |
| ISBN: | 9783835964877 3835964879 |
Staff View
MARC
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| 245 | 1 | 0 | |a Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection |c by Gopala Krishna Mannala, Nidigallu(Indien) |
| 264 | 1 | |a Gießen, Lahn |b VVB Laufersweiler Verlag |c 2016 | |
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Record in the Search Index
| _version_ | 1804178475705171968 |
|---|---|
| adam_text | 1. LIST OF PUBLICATIONS,
1
2.
INTRODUCTION................................................................................................................................
2
2.1. DISCOVERY OF NON-CODING
RNAS..............................................................................................2
2.2. ROLE OF NON-CODING RNAS IN HOST-PATHOGEN
INTERACTIONS..................................................3
2.3. EUKARYOTIC NON-CODING
RNAS.................................................................................................
4
2.3.1. CLASSES OF EUKARYOTIC NON-CODING R NA
S.......................................................................................................
4
2.3.2. MICRORNA BIOGENESIS AND FUNCTIONAL
MECHANISM........................................................................................
5
2.3.3. MICRORNA RESPONSE TO INFECTION OF BACTERIAL
PATHOGENS...........................................................................
6
2.3.4. MICRORNAS INVOLVED IN IMMUNE REGULATION DURING BACTERIAL
INFECTIONS..................................................9
2.3.5. OVERVIEW OF INSECT IMMUNE SYSTEM AND ITS REGULATION BY M IR N A S
......................................................
11
2.4. BACTERIAL NON-CODING
RNAS..................................................................................................
14
2.4.1. DIFFERENT CLASSES OF BACTERIAL NON-CODING RNAS IN L M
ONOCYTOGENES................................................14
2.4.2 ROLE OF NON-CODING RNAS IN OTHER BACTERIAL
PATHOGENS.......................................................................
18
2.5. THE FACULTATIVE INTRACELLULAR PATHOGEN LISTERIA MONOCYTOGENES
....................................
19
2.5.1. THE SPECIES L.
MONOCYTOGENES......................................................................................................................
19
2.5.2. INTERACTIONS OF L MONOCYTOGENES WITH ITS
HOST..........................................................................................
20
2.6. HOST RESPONSE TO L. MONOCYTOGENES INFECTION
.................................................................
24
2.6.1 INNATE IMMUNE
RESPONSE...................................................................................................................................24
2.6.1.1. INNATE IMMUNE
CELLS.................................................................................................................................................24
2.6.1.2. TOLL LIKE RECEPTORS, NOD-LIKE RECEPTORS AND RIG-1-LIKE
RECEPTORS
................................................................
25
2.6.1.3.
CYTOKINES...................................................................................................................................................................
27
1.7 OBJECTIVES OF THE
STUDY...........................................................................................................29
3. CHAPTER I MICRORNA RESPONSE TO LISTERIA MONOCYTOGENES INFECTION IN
EPITHELIAL
C E LLS
.................................................................................................................................................30
3.1
PUBLICATION................................................................................................................................30
3.2
CONTRIBUTION..............................................................................................................................30
3.3
ABSTRACT.....................................................................................................................................30
3.4 RESULTS AND
DISCUSSION..........................................................................................................
31
3.4.1 L. MONOCYTOGENES INFECTION ALTERS MIRNA PROFILE DEPENDENT ON ITS
CELLULAR LOCALIZATION
..................
31
3.4.2 PURIFIED LISTERIOLYSIN (LLO) LEADS TO INDUCTION OF MIR-146B,
MIR-16 AND MIR-155 IN CACO-2 CELLS .33
3.4.3 TARGET GENE EXPRESSION
ANALYSIS.....................................................................................................................35
3.5 CONCLUSION
36
4. CHAPTER N LISTERIA MONOCYTOGENES INDUCES A VIRULENCE-DEPENDENT
MICRORNA
SIGNATURE THAT REGULATES THE IMMUNE RESPONSE IN GAILERIA M E LLO N E
LLA.......................37
4.1
PUBLICATION.................................................................................................................................37
4.2
CONTRIBUTION...............................................................................................................................37
4.3
ABSTRACT......................................................................................................................................
37
4.4 RESULTS AND
DISCUSSION...........................................................................................................
38
4.4.1 MIRNA MICROARRAY ANALYSIS IN INVERTEBRATE
G.
MELLONELLA DUING INFECTION............................................38
4.4.2 VALIDATION OF MIRNA MICROARRAY RESULTS AND PATHOGEN/NON-PATHOGEN
SPECIFIC MIRNA RESPONSE... 39
4.4.3 MIRNA REGULATE GENE TARGETS THAT ARE INVOLVED IN IMMUNE RESPONSE
AGAINST BACTERIAL INFECTION ...41
4.5
CONCLUSION.................................................................................................................................44
5. CHAPTER HI DETECTION OF ANTISENSE TRANSCRIPTS AND THEIR ROLE DURING
INTRACELLULAR
SURVIVAL OF L. MONOCYTOGENES IN P388D1 MACROPHAGES
.................................................
45
5.1.
PUBLICATIONS.............................................................................................................................
45
5.2
CONTRIBUTION..............................................................................................................................
45
5.3
ABSTRACT......................................................................................................................................46
5.4 RESULTS AND
DISCUSSION...........................................................................................................
46
5.4.1 IDENTIFICATION OF NEW ANTISENSE RNAS USING SOLID SEQUENCING
TECHNOLOGY
......................................
46
5.4.2 DETECTION OF VERY LONG ANTISENSE USING ION TORRENT
TECHNOLOGY...............................................................48
5.5
CONCLUSION.................................................................................................................................51
6. SUM M
ARY....................................................................................................................................
52
7. ZUSAM M
ENFASSUNG.................................................................................................................
54
8.
REFERENCES.................................................................................................................................57
10. ACKNOWLEDGM
ENTS................................................................................................................
74
11. D
ECLARATION..............................................................................................................................76
12. CURRICULUM V ITA E
....................................................................................................................77
13. SUPPLEMENTARY MATERIAL .80
|
| any_adam_object | 1 |
| author | Mannala, Gopala Krishna |
| author_facet | Mannala, Gopala Krishna |
| author_role | aut |
| author_sort | Mannala, Gopala Krishna |
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| bvnumber | BV044912565 |
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| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| format | Thesis Book |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:04:34Z |
| institution | BVB |
| institution_GND | (DE-588)1065553803 |
| isbn | 9783835964877 3835964879 |
| language | English |
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| physical | 151 Seiten 21 cm x 14.6 cm, 201 g |
| publishDate | 2016 |
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| spelling | Mannala, Gopala Krishna Verfasser aut Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection by Gopala Krishna Mannala, Nidigallu(Indien) Gießen, Lahn VVB Laufersweiler Verlag 2016 151 Seiten 21 cm x 14.6 cm, 201 g txt rdacontent n rdamedia nc rdacarrier Edition Scientifique Dissertation Justus-Liebig-Universität 2016 bacteria cabt listeria monocytogenes cabt infection cabt immune competence cabt Doktorarbeit Uni Wissenschaft (DE-588)4113937-9 Hochschulschrift gnd-content VVB LAUFERSWEILER Verlag (DE-588)1065553803 pbl DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030306051&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Mannala, Gopala Krishna Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection bacteria cabt listeria monocytogenes cabt infection cabt immune competence cabt |
| subject_GND | (DE-588)4113937-9 |
| title | Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection |
| title_auth | Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection |
| title_exact_search | Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection |
| title_full | Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection by Gopala Krishna Mannala, Nidigallu(Indien) |
| title_fullStr | Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection by Gopala Krishna Mannala, Nidigallu(Indien) |
| title_full_unstemmed | Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection by Gopala Krishna Mannala, Nidigallu(Indien) |
| title_short | Dual non-coding RNA profiles of host and bacteria and their role in the regulation of innate immune response during Listeria monocytogenes infection |
| title_sort | dual non coding rna profiles of host and bacteria and their role in the regulation of innate immune response during listeria monocytogenes infection |
| topic | bacteria cabt listeria monocytogenes cabt infection cabt immune competence cabt |
| topic_facet | bacteria listeria monocytogenes infection immune competence Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030306051&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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