Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides:
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Göttingen, Niedersachs
Cuvillier, E
2015
|
| Edition: | 1., Aufl. |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | 280 Seiten |
| ISBN: | 9783736990852 3736990855 |
Staff View
MARC
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| 245 | 1 | 0 | |a Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides |c Cornelia Panse |
| 250 | |a 1., Aufl. | ||
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Record in the Search Index
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|---|---|
| adam_text | CONTENTS
1 INTRODUCTION 1
2 DESIGN AND SYNTHESIS OF IHF MIMICKING PEPTIDES CONTAINING TWO DNA
RECOGNITION UNITS 5
2.1 THE INTEGRATION HOST FACTOR 5
2.2 RECOGNITION AND BENDING OF DOUBLE STRANDED DNA 7
2.3 GENERAL DESIGN OF A SMALL PEPTIDE MIMICKING IHF-LIKE DNA BINDING AND
BENDING 10
2.4 IHF MIMICKING PEPTIDES CONTAINING TWO DNA RECOGNITION UNITS 12
2.5 SYNTHESIS OF ARTIFICIAL AMINO ACIDS TO PARTICIPATE IN THE LIGATION
14
2.6 SYNTHESIS OF DIMERIC IHF MIMICKING PEPTIDES BY APPLYING
[3+2] CYCLOADDITION 17
2.7 IHF HOMODIMER BASED ON AMIDE BONDS 22
3 NOVEL PHOTOCLEAVABLE AUXILIARIES FOR APPLICATION IN PNA/PNA MEDIATED
LIGATION STRATEGY 29
3.1 PRINCIPLES OF PNA/PNA MEDIATED LIGATION STRATEGY
29
3.2 NUCLEOBASE TEMPLATED REACTIONS 31
3.3 PEPTIDE NUCLEIC ACID 33
3.4 CHEMICAL STRATEGIES TO LIGATE AND FUNCTIONALIZE PEPTIDES 35
3.5 PHOTOLABILE O-NITROBENZENE DERIVATIVES 37
3.6 SYNTHESIS OF A PHOTOCLEAVABLE AUXILIARY BASED ON O-NITROBENZENE 40
3.7 SYNTHESIS OF A PHOTOLABILE AUXILIARY BASED ON 6-NITROVALERATE 44
3.8 SYNTHESIS OF A PHOTOLABILE AUXILIARY BEARING AN AZIDE RESIDUE 54
3.9 CAGED PNA/PEPTIDE CONJUGATES FOR SELECTIVE LIGATION VIA
DISULFIDEBRIDGE
FORMATION 61
3.10 LIGHT INDUCIBLE NANOPARTICLE DELIVERY INTO CELLS 74
3.11 APPLICATION OF THE PHOTOSENSITIVE G-AZIDO NITROVERATRYL LINKER IN
SPPS .... 81
4 TARGETING SUBSTRATE-KINASE PAIRS BY COVALENT LIGATION WITH AN ATP
MIMICKING
CROSSLINKER 87
4.1 SELECTIVE CROSSLINKERS FOR IDENTIFYING NEW SUBSTRATE-KINASE PAIRS 87
HTTP://D-NB.INFO/1076019870
CONTENTS
4.2 SYNTHESIS OF SUBSTRATE-KINASE CROSSLIRIKER 90
4.3 CROSSLINKING EXPERIMENTS 93
5 CONCLUSION 95
6 EXPERIMENTAL PART 101
6.1 MATERIALS AND GENERAL METHODS 101
6.2 SPECTROSCOPIC METHODS 104
6.3 SOLID PHASE SYNTHESIS 106
6.4 SYNTHESIS OF MODIFIED AMINO ACIDS AND PEPTIDES FOR IHF MIMICKING
PEPTIDES . ILL
6.4.1 IHF MIMICKING PEPTIDE VIA [3+2] CYDOADDITION ILL
6.4.2 IHF MIMICKING PEPTIDE BASED ON AMIDE BONDS 135
6.5 DEVELOPMENT OF NOVEL PHOTOCLEAVABLE AUXILIARIES 152
6.5.1 SYNTHESIS OF PHOTOLABILE AUXILIARIES FOR APPLICATION IN A NOVEL
LIGATION STRATEGY 152
6.5.2 SYNTHESIS OF CAGED COSS NANOPARTICLE 224
6.5.3 APPLICATION OF PHOTOSENSITIVE P-AZIDO NITROVERATRYL LINKER IN SPPS
. . 229
6.6 SYNTHESIS OF SUBSTRATE-KINASE CROSSLINKER 234
7 ABBREVIATIONS 241
8 APPENDAGES 245
REFERENCES 247
ACKNOWLEDGMENTS 263
|
| any_adam_object | 1 |
| author | Panse, Cornelia Hannah 1985- |
| author_GND | (DE-588)1077581378 |
| author_facet | Panse, Cornelia Hannah 1985- |
| author_role | aut |
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| bvnumber | BV044873791 |
| ctrlnum | (OCoLC)1029451305 (DE-599)DNB1076019870 |
| dewey-full | 540 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 540 - Chemistry and allied sciences |
| dewey-raw | 540 |
| dewey-search | 540 |
| dewey-sort | 3540 |
| dewey-tens | 540 - Chemistry and allied sciences |
| discipline | Chemie / Pharmazie |
| edition | 1., Aufl. |
| format | Thesis Book |
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| illustrated | Not Illustrated |
| indexdate | 2024-07-10T08:03:28Z |
| institution | BVB |
| isbn | 9783736990852 3736990855 |
| language | English |
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| physical | 280 Seiten |
| publishDate | 2015 |
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| spelling | Panse, Cornelia Hannah 1985- Verfasser (DE-588)1077581378 aut Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides Cornelia Panse 1., Aufl. Göttingen, Niedersachs Cuvillier, E 2015 280 Seiten txt rdacontent n rdamedia nc rdacarrier Dissertation Cuvillier Verlag 2014 Peptidsynthese (DE-588)4173715-5 gnd rswk-swf Ligation (DE-588)4723826-4 gnd rswk-swf Proteins Ligation Strategy chemical strategies (DE-588)4113937-9 Hochschulschrift gnd-content Peptidsynthese (DE-588)4173715-5 s Ligation (DE-588)4723826-4 s DE-604 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030268173&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Panse, Cornelia Hannah 1985- Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides Peptidsynthese (DE-588)4173715-5 gnd Ligation (DE-588)4723826-4 gnd |
| subject_GND | (DE-588)4173715-5 (DE-588)4723826-4 (DE-588)4113937-9 |
| title | Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides |
| title_auth | Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides |
| title_exact_search | Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides |
| title_full | Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides Cornelia Panse |
| title_fullStr | Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides Cornelia Panse |
| title_full_unstemmed | Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides Cornelia Panse |
| title_short | Development of Functionalized Derivatives for the Application in a Novel Bioorthogonal Ligation Strategy and for the Design of IHF Mimicking Peptides |
| title_sort | development of functionalized derivatives for the application in a novel bioorthogonal ligation strategy and for the design of ihf mimicking peptides |
| topic | Peptidsynthese (DE-588)4173715-5 gnd Ligation (DE-588)4723826-4 gnd |
| topic_facet | Peptidsynthese Ligation Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030268173&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pansecorneliahannah developmentoffunctionalizedderivativesfortheapplicationinanovelbioorthogonalligationstrategyandforthedesignofihfmimickingpeptides |