iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases:
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Ulm
2016
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | 228 Bläter Illustrationen 30 cm |
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Datensatz im Suchindex
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|---|---|
| adam_text | TABLE OF CONTENTS
4
ABBREVIATIONS.....................................................................................................................................
6
1
INTRODUCTION...........................................................................................................................
18
1.1 INDUCED PLURIPOTENT STEM CELLS
(IPSCS)...........................................................................18
1.2 GENE EDITING
TECHNOLOGIES.................................................................................................22
1.3 DISEASE MODELING USING
IPSCS...........................................................................................25
1.4 AIM OF THIS
STUDY..................................................................................................................34
2 MATERIALS AND
METHODS.......................................................................................................36
2.1 GENERATION AND CULTURE OF INDUCED PLURIPOTENT STEM CELLS (IPSCS)
.........................
36
2.2 QUALITY CONTROL AND CHARACTERIZATION OF IPSC LINES
......................................................
38
2.3 GENE EDITING OF IPSC
LINES..................................................................................................42
2.4 ESTABLISHMENT OF IPSC-DERIVED CELL CULTURE M
ODELS..................................................... 51
2.5 CHARACTERIZATION OF IPSC-DERIVED CELL CULTURE M ODELS
................................................
55
2.6 STATISTICAL
ANALYSIS...............................................................................................................
69
3
RESULTS........................................................................................................................................
70
3.1 GENERATION OF HUMAN INDUCED PLURIPOTENT STEM CELLS (IPSCS)
.................................
70
3.2 GENE EDITING OF IPSC
LINES..................................................................................................85
3.3 IPSC-DERIVED CELL CULTURE M
ODELS.....................................................................................
91
4 DISCUSSION
149
4.1 GENERATION AND USAGE OF IPSCS AS RESEARCH TOOLS 149
4.2 DISEASE MODELING USING IPSC-DERIVED CELL CULTURE M ODELS
.....................................
154
4.3 CHANGES AND CHALLENGES OF FUTURE IPSC STUDIES
........................................................
173
5 SUM M
ARY..................................................................................................................................177
6 LIST OF
REFERENCES.................................................................................................................178
7
ACKNOWLEDGEMENTS............................................................................................................
226
8 STATUTORY
DECLARATION.....................................................................................................
228
|
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| author | Speidel, Anna Katharina 1986- |
| author_GND | (DE-588)1141695235 |
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| bvnumber | BV044792009 |
| ctrlnum | (OCoLC)1017029182 (DE-599)DNB1144192471 |
| discipline | Psychologie Medizin |
| format | Thesis Book |
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| indexdate | 2024-07-10T08:01:50Z |
| institution | BVB |
| language | English |
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| spelling | Speidel, Anna Katharina 1986- Verfasser (DE-588)1141695235 aut iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases Anna Kathaina Speidel Ulm 2016 228 Bläter Illustrationen 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Ulm University 2017 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030187199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Speidel, Anna Katharina 1986- iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases |
| subject_GND | (DE-588)4113937-9 |
| title | iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases |
| title_auth | iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases |
| title_exact_search | iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases |
| title_full | iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases Anna Kathaina Speidel |
| title_fullStr | iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases Anna Kathaina Speidel |
| title_full_unstemmed | iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases Anna Kathaina Speidel |
| title_short | iPSC-derived cell culture models to study neuropsychiatric and neurodegenerative diseases |
| title_sort | ipsc derived cell culture models to study neuropsychiatric and neurodegenerative diseases |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030187199&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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