Verfügbarkeit: Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD)

Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD):

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Bibliographische Detailangaben
1. Verfasser:	Meßmann, Joanna Julia (VerfasserIn)
Format:	Abschlussarbeit Buch
Sprache:	English
Veröffentlicht:	Ulm 2017
Schlagworte:	Hochschulschrift
Online-Zugang:	Inhaltsverzeichnis Inhaltsverzeichnis
Beschreibung:	155 Blätter Illustrationen, Diagramme 30 cm

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adam_text	TABLE OF CONTENTS ABBREVIATIONS 5 1 INTRODUCTION 10 1.1 BONE MARROW TRANSPLANTATION 10 1.2 GRAFT-VERSUS-HOST DISEASE 10 1.3 MANAGING COMPLICATIONS IN BMT 18 1.3 MYELOID-DERIVED SUPPRESSOR CELLS 22 1.4 AIM OF THE STUDY 31 2 MATERIALS AND METHODS 32 2.1 MATERIALS 32 2.2 METHODS 41 3 RESULTS 53 3.1 CHARACTERIZATION OF IN V/TRO-GENERATED MDSCS 53 3.2 IN VITRO- GENERATED MDSCS SUPPRESS GVHD IN TWO DISTINCT MURINE BMT 57 MODELS 3.3 MDSC-MEDIATED SUPPRESSION IS ANTIGEN-INDEPENDENT 62 3.4 GVT EFFECT IS MAINTAINED AFTER MDSC TRANSPLANTATION 65 3.5 IN V/TRO-GENERATED MDSCS PROLIFERATE IN VIVO AND HOME TO LYMPHOID 73 AND GVHD-TARGET ORGANS 3.6 IN VITRO- GENERATED MDSCS DO NOT IMPAIR ALLOGENEIC T CELL HOMING, 76 PHENOTYPE AND ONLY INSUBSTANTIALLY DECREASE ALLOGENEIC T CELL PROLIFERATION 3.7 MDSC-MEDIATED GVHD SUPPRESSION IS DEPENDENT ON TYPE 2 81 POLARIZATION OF ALLOGENEIC T CELLS 3.8 APC-LIKE MDSCS EXPAND UNDER GVHD CONDITIONS IN VITRO 93 3.9 GVHD-INDUCED MDSCS 97 4 DISCUSSION 107 4.1 IN VITRO -GENERATED MDSCS PREVENT GVHD 108 4.2 MDSC-MEDIATED TYPE 2 POLARIZATION OF T CELLS PREVENT GVHD BUT 110 DOES NOT ABROGATE THE GVT EFFECT 4.3 DIFFERENTIATION OF IN VITRO -GENERATED MDSCS UNDER GVHD CONDITIONS 113 IN VITRO 4.3 MDSCS ARE ENDOGENOUSLY INDUCED IN GVHD-DEVELOPING ANIMALS 114 4.4 GVHD PREVENTION BY ACTIVATION OF GVHD-INDUCED MDSCS 116 5 SUMMARY 119 REFERENCES 121 STATUTORY DECLARATION 154 ACKNOWLEDGEMENTS 155
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spelling	Meßmann, Joanna Julia Verfasser (DE-588)1148955976 aut Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD) Joanna Julia Meßmann Ulm 2017 155 Blätter Illustrationen, Diagramme 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation International Graduate School in Molecular Medicine Ulm 2017 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1151740365/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030187131&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Meßmann, Joanna Julia Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD)
subject_GND	(DE-588)4113937-9
title	Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD)
title_auth	Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD)
title_exact_search	Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD)
title_full	Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD) Joanna Julia Meßmann
title_fullStr	Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD) Joanna Julia Meßmann
title_full_unstemmed	Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD) Joanna Julia Meßmann
title_short	Myeloid-derived suppressor cells (MDSCs) as modulators of graft-versus-host disease (GVHD)
title_sort	myeloid derived suppressor cells mdscs as modulators of graft versus host disease gvhd
topic_facet	Hochschulschrift
url	http://d-nb.info/1151740365/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030187131&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
work_keys_str_mv	AT meßmannjoannajulia myeloidderivedsuppressorcellsmdscsasmodulatorsofgraftversushostdiseasegvhd

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