3D cell culture: fundamentals and applications in tissue engineering and regenerative medicine
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Singapore
Pan Standford Publishing
[2018]
|
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | xiv, 211 Seiten Illustrationen |
| ISBN: | 9789814774536 |
Internformat
MARC
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| 245 | 1 | 0 | |a 3D cell culture |b fundamentals and applications in tissue engineering and regenerative medicine |c Ranjna C. Dutta, Aroop K. Dutta |
| 264 | 1 | |a Singapore |b Pan Standford Publishing |c [2018] | |
| 300 | |a xiv, 211 Seiten |b Illustrationen | ||
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Datensatz im Suchindex
| _version_ | 1804178289561960448 |
|---|---|
| adam_text | Contents
Preface ix
Acknowledgements xi
Synopsis xiii
1 Introduction 1
1.1 Cell Culture: Historical Perspective 1
1.2 Cell Culture: 2D vs. 3D 3
2
Significance of Tissue-Specific Extracellular
Microenvironment (ECM) 13
2.1 Introduction 13
2.1.1 What Is ECM? 15
2.1.2 Tissue Specificity of ECM 20
2.1.3 Essential/Representative Components of ECM 22
2.1.3,1 Collagens (fibrillar and structural] 27
2.1.3.2 Elastin (elastic) 36
2.1.3.3 Microfibril associated macromolecules
(fibrillar) 38
2.1.3.4 Laminin (adhesive) 43
2.1.3.5 Fibronectin (adhesive) 45
2.1.3.6 Matricellular (anti-adhesive) 49
2.1.3.7 Matrikines and matricryptins 52
2.1.3.8 Proteoglycans 53
2.1.3.9 Glycosaminoglycans (GAGs) 61
2.1.3.10 Hyaluronan (hyaluronic acid) 61
2.2 Cell-Cell Interaction 64
2.3 Cell-Effecter Interaction 65
2.4 Cell-ECM Interaction 66
2.4.1 Protrusive Contacts 66
vi
Contents
2.4.2 Contractile Contacts 70
2.4.3 Mechanically Supportive Contacts 70
2.5 ECM Related Disorders 74
2.6 Conclusion 79
2.6.1 Classification 79
2.6.2 Inter Intramolecular ECM Interactions 80
2.6.3 Implications 81
ECM Mimicking for 3D Cell Culture 103
3.1 3D Cell Culture (Introduction) 103
3.1.1 Significance of ECM Mimicking 104
3.1.2 ECM Mimicking/Reconstitution 107
3.1.2.1 Physical mimicking 108
3.1.2.2 Biochemical mimicking 110
3.1.2.3 Mechanical mimicking 110
3.1.2.4 ECM mimicking through organ/tissue
decellularization 113
3.1.3 Need for Compatible Cell-Types 114
3.2 Models for 3D Cell Culture 115
3.2.1 Spheroids 115
3.2.2 Hydrogels 116
3.2.3 Scaffolds and Matrices 118
3.3 Materials for 3D Cell Culture 119
3.3.1 Natural 120
3.3.2 Synthetic 121
3.3.3 Hybrid 122
3.3.3.1 Physical blends 123
3.3.3.2 Chemical blends 125
3.4 Methods of Creating Scaffold/Matrices for
3D Culture 125
3.4.1 Conventional Techniques 126
3.4.1.1 Solvent casting/melt molding 126
3.4.1.2 Extrusion 126
3.4.1.3 Molding with particle leaching 127
3.4.1.4 Gel casting and freeze drying 127
3.4.1.5 Thermally induced phase
transition/gas foaming 128
3.4.1.6 Fiber bonding 128
Contents
vii
3.4.1.7 Microsphere sintering 128
3.4.1.8 Micro-contact printing 128
3.4.2 Advanced Techniques 128
3.4.2.1 Electrospinning 129
3.4.2.2 Rapid prototyping or solid free form
fabrication 130
3.4.2.3 Emulsion templating 132
3.4.2.4 Micromolding 133
3.4.2.5 Photoplating/photolithography 133
3.4.2.6 Designed self-assembly 134
3.5 Applications of 3D Scaffolds/Matrices 138
3.5.1 In Research and Development 138
3.5.2 Diagnostics 139
3.5.3 Cell-Based Sensors 140
3.5.4 High Throughput Screening 141
3.5.5 Biotech Industry 141
3.5.6 Drug Delivery 142
3.5.7 Biochemical Replacement 142
3.5.8 In Tissue Engineering (TE) 142
3.5.8.1 Ex vivo organ model 143
3.5.8.2 Tissue explants 144
3.5.8.3 In vivo tissue regeneration 144
3.5.9 Human-Organoid Models for Physiology 145
Scaffolds/Matrices for 3D Cell/Tissue Culture 159
4.1 Introduction 159
4.2 Non-specific in vitro 3D Culture 165
4.3 Tissue Engineering 165
4.4 Regenerative Medicine 167
4.4.1 In situ 167
4.4.2 Ex situ 167
4.5 Available Technologies 168
4.5.1 Matrigel 170
4.5.2 Alvetex® 171
4.5.3 3D-Biotek® 172
4.5.4 AlgiMatrix® 3D Cell Culture System 172
4.5.5 PuraMatrix® 173
4.5.6 Integra® 174
viii Contents
4.5.7 PriMatrix 176
4.5.8 Hyalubrix® /Hyalgan 176
4.5.9 Extracel™ 177
4.5.10 Mebiol 178
4.5.11 Up Cell™ 179
4.5.12 BioVaSc-TERM® 180
4.5.13 Corgel® 180
4.5.14 Opsite, Biobrane and Oasis® Wound Matrix 181
4.5.15 Cyto-Matrix 182
4.5.16 AmnioGraft® 182
4.5.17 Artiss/Tisseel 183
4.5.18 ECM Analog® 185
4.6 Future Trends/Challenges Ahead 187
Recommended Reading
Glossary
Index
197
199
203
Contents
Preface ix
Acknowledgements xi
Synopsis xiii
1 Introduction 1
1.1 Cell Culture: Historical Perspective 1
1.2 Cell Culture: 2D vs. 3D 3
2
Significance of Tissue-Specific Extracellular
Microenvironment (ECM) 13
2.1 Introduction 13
2.1.1 What Is ECM? 15
2.1.2 Tissue Specificity of ECM 20
2.1.3 Essential/Representative Components of ECM 22
2.1.3,1 Collagens (fibrillar and structural] 27
2.1.3.2 Elastin (elastic) 36
2.1.3.3 Microfibril associated macromolecules
(fibrillar) 38
2.1.3.4 Laminin (adhesive) 43
2.1.3.5 Fibronectin (adhesive) 45
2.1.3.6 Matricellular (anti-adhesive) 49
2.1.3.7 Matrikines and matricryptins 52
2.1.3.8 Proteoglycans 53
2.1.3.9 Glycosaminoglycans (GAGs) 61
2.1.3.10 Hyaluronan (hyaluronic acid) 61
2.2 Cell-Cell Interaction 64
2.3 Cell-Effecter Interaction 65
2.4 Cell-ECM Interaction 66
2.4.1 Protrusive Contacts 66
vi
Contents
2.4.2 Contractile Contacts 70
2.4.3 Mechanically Supportive Contacts 70
2.5 ECM Related Disorders 74
2.6 Conclusion 79
2.6.1 Classification 79
2.6.2 Inter Intramolecular ECM Interactions 80
2.6.3 Implications 81
ECM Mimicking for 3D Cell Culture 103
3.1 3D Cell Culture (Introduction) 103
3.1.1 Significance of ECM Mimicking 104
3.1.2 ECM Mimicking/Reconstitution 107
3.1.2.1 Physical mimicking 108
3.1.2.2 Biochemical mimicking 110
3.1.2.3 Mechanical mimicking 110
3.1.2.4 ECM mimicking through organ/tissue
decellularization 113
3.1.3 Need for Compatible Cell-Types 114
3.2 Models for 3D Cell Culture 115
3.2.1 Spheroids 115
3.2.2 Hydrogels 116
3.2.3 Scaffolds and Matrices 118
3.3 Materials for 3D Cell Culture 119
3.3.1 Natural 120
3.3.2 Synthetic 121
3.3.3 Hybrid 122
3.3.3.1 Physical blends 123
3.3.3.2 Chemical blends 125
3.4 Methods of Creating Scaffold/Matrices for
3D Culture 125
3.4.1 Conventional Techniques 126
3.4.1.1 Solvent casting/melt molding 126
3.4.1.2 Extrusion 126
3.4.1.3 Molding with particle leaching 127
3.4.1.4 Gel casting and freeze drying 127
3.4.1.5 Thermally induced phase
transition/gas foaming 128
3.4.1.6 Fiber bonding 128
Contents
vii
3.4.1.7 Microsphere sintering 128
3.4.1.8 Micro-contact printing 128
3.4.2 Advanced Techniques 128
3.4.2.1 Electrospinning 129
3.4.2.2 Rapid prototyping or solid free form
fabrication 130
3.4.2.3 Emulsion templating 132
3.4.2.4 Micromolding 133
3.4.2.5 Photoplating/photolithography 133
3.4.2.6 Designed self-assembly 134
3.5 Applications of 3D Scaffolds/Matrices 138
3.5.1 In Research and Development 138
3.5.2 Diagnostics 139
3.5.3 Cell-Based Sensors 140
3.5.4 High Throughput Screening 141
3.5.5 Biotech Industry 141
3.5.6 Drug Delivery 142
3.5.7 Biochemical Replacement 142
3.5.8 In Tissue Engineering (TE) 142
3.5.8.1 Ex vivo organ model 143
3.5.8.2 Tissue explants 144
3.5.8.3 In vivo tissue regeneration 144
3.5.9 Human-Organoid Models for Physiology 145
Scaffolds/Matrices for 3D Cell/Tissue Culture 159
4.1 Introduction 159
4.2 Non-specific in vitro 3D Culture 165
4.3 Tissue Engineering 165
4.4 Regenerative Medicine 167
4.4.1 In situ 167
4.4.2 Ex situ 167
4.5 Available Technologies 168
4.5.1 Matrigel 170
4.5.2 Alvetex® 171
4.5.3 3D-Biotek® 172
4.5.4 AlgiMatrix® 3D Cell Culture System 172
4.5.5 PuraMatrix® 173
4.5.6 Integra® 174
viii Contents
4.5.7 PriMatrix 176
4.5.8 Hyalubrix® /Hyalgan 176
4.5.9 Extracel™ 177
4.5.10 Mebiol 178
4.5.11 Up Cell™ 179
4.5.12 BioVaSc-TERM® 180
4.5.13 Corgel® 180
4.5.14 Opsite, Biobrane and Oasis® Wound Matrix 181
4.5.15 Cyto-Matrix 182
4.5.16 AmnioGraft® 182
4.5.17 Artiss/Tisseel 183
4.5.18 ECM Analog® 185
4.6 Future Trends/Challenges Ahead 187
Recommended Reading
Glossary
Index
197
199
203
|
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| illustrated | Illustrated |
| indexdate | 2024-07-10T08:01:36Z |
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| isbn | 9789814774536 |
| language | English |
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| spelling | Dutta, Ranjna C. Verfasser aut 3D cell culture fundamentals and applications in tissue engineering and regenerative medicine Ranjna C. Dutta, Aroop K. Dutta Singapore Pan Standford Publishing [2018] xiv, 211 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Organkultur (DE-588)4274421-0 gnd rswk-swf Zellkultur (DE-588)4067547-6 gnd rswk-swf Tissue Engineering (DE-588)4646061-5 gnd rswk-swf Organkultur (DE-588)4274421-0 s Zellkultur (DE-588)4067547-6 s Tissue Engineering (DE-588)4646061-5 s DE-604 Dutta, Aroop K. Verfasser aut Erscheint auch als Online-Ausgabe 978-1-315-14682-9 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030160710&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030160710&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Dutta, Ranjna C. Dutta, Aroop K. 3D cell culture fundamentals and applications in tissue engineering and regenerative medicine Organkultur (DE-588)4274421-0 gnd Zellkultur (DE-588)4067547-6 gnd Tissue Engineering (DE-588)4646061-5 gnd |
| subject_GND | (DE-588)4274421-0 (DE-588)4067547-6 (DE-588)4646061-5 |
| title | 3D cell culture fundamentals and applications in tissue engineering and regenerative medicine |
| title_auth | 3D cell culture fundamentals and applications in tissue engineering and regenerative medicine |
| title_exact_search | 3D cell culture fundamentals and applications in tissue engineering and regenerative medicine |
| title_full | 3D cell culture fundamentals and applications in tissue engineering and regenerative medicine Ranjna C. Dutta, Aroop K. Dutta |
| title_fullStr | 3D cell culture fundamentals and applications in tissue engineering and regenerative medicine Ranjna C. Dutta, Aroop K. Dutta |
| title_full_unstemmed | 3D cell culture fundamentals and applications in tissue engineering and regenerative medicine Ranjna C. Dutta, Aroop K. Dutta |
| title_short | 3D cell culture |
| title_sort | 3d cell culture fundamentals and applications in tissue engineering and regenerative medicine |
| title_sub | fundamentals and applications in tissue engineering and regenerative medicine |
| topic | Organkultur (DE-588)4274421-0 gnd Zellkultur (DE-588)4067547-6 gnd Tissue Engineering (DE-588)4646061-5 gnd |
| topic_facet | Organkultur Zellkultur Tissue Engineering |
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