Influence of chemotherapeutic drugs on human granulosa cells:
Cancer is one of the leading causes of death in persons aged 1 to 14 years and leukemias are the most common malignancies in childhood and are the primary cause of cancer-related mortality in the world. Chemotherapy is quite effective in treating cancers, but after successful treatment, young female...
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
Jena
2017
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| Schlagworte: | |
| Zusammenfassung: | Cancer is one of the leading causes of death in persons aged 1 to 14 years and leukemias are the most common malignancies in childhood and are the primary cause of cancer-related mortality in the world. Chemotherapy is quite effective in treating cancers, but after successful treatment, young female cancer survivors face a potential threat of premature ovarian failure (POF) and infertility from gonadotoxicity of chemotherapeutic agent. Cytostatic drugs can target the oocyte directly, or can induce oocyte death indirectly via damage to surrounding granulosa cells, which play a key role in folliculogenesis and oocyte maturation. A more thorough understanding of the mechanism behind chemotherapy-induced infertility is necessary to develop new methods to preserve fertility in these patients. MicroRNAs (miRNAs) have recently begun to be explored in ovarian cells as small molecules with critical regulatory role. Importantly, the miRNAs profile in granulosa cells may possess high potential as a new marker for successful folliculogenesis and oocyte development. They can control steroidogenesis in cultured granulosa cells and are involved in control of proliferation, apoptosis and carcinogenesis. MicroRNA-21 (miR-21) and microRNA-132 (miR-132) are of the most abundant and highly expressed miRNAs in human oocytes and granulosa cells. miR-21 is an oncogenic miRNA and plays a critical role in maintaining the survival of granulosa cells in periovulatory follicles and acts as an antiapoptotic factor in granulosa cells. miR-132 has a key role in promotion of estradiol (E2) synthesis in murine ovarian granulosa cells. .. |
| Beschreibung: | V, 79 Blätter Illustrationen, Diagramme 29,5 cm |
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| 520 | 3 | |a Cancer is one of the leading causes of death in persons aged 1 to 14 years and leukemias are the most common malignancies in childhood and are the primary cause of cancer-related mortality in the world. Chemotherapy is quite effective in treating cancers, but after successful treatment, young female cancer survivors face a potential threat of premature ovarian failure (POF) and infertility from gonadotoxicity of chemotherapeutic agent. Cytostatic drugs can target the oocyte directly, or can induce oocyte death indirectly via damage to surrounding granulosa cells, which play a key role in folliculogenesis and oocyte maturation. A more thorough understanding of the mechanism behind chemotherapy-induced infertility is necessary to develop new methods to preserve fertility in these patients. MicroRNAs (miRNAs) have recently begun to be explored in ovarian cells as small molecules with critical regulatory role. Importantly, the miRNAs profile in granulosa cells may possess high potential as a new marker for successful folliculogenesis and oocyte development. They can control steroidogenesis in cultured granulosa cells and are involved in control of proliferation, apoptosis and carcinogenesis. MicroRNA-21 (miR-21) and microRNA-132 (miR-132) are of the most abundant and highly expressed miRNAs in human oocytes and granulosa cells. miR-21 is an oncogenic miRNA and plays a critical role in maintaining the survival of granulosa cells in periovulatory follicles and acts as an antiapoptotic factor in granulosa cells. miR-132 has a key role in promotion of estradiol (E2) synthesis in murine ovarian granulosa cells. .. | |
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Datensatz im Suchindex
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| author | Al-Kawlani, Boodor 1981- |
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| spelling | Al-Kawlani, Boodor 1981- Verfasser (DE-588)1150264799 aut Influence of chemotherapeutic drugs on human granulosa cells by M.Sc. Boodor M. S. Al-Kawlani Jena 2017 V, 79 Blätter Illustrationen, Diagramme 29,5 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Friedrich-Schiller-Universität Jena 2017 Cancer is one of the leading causes of death in persons aged 1 to 14 years and leukemias are the most common malignancies in childhood and are the primary cause of cancer-related mortality in the world. Chemotherapy is quite effective in treating cancers, but after successful treatment, young female cancer survivors face a potential threat of premature ovarian failure (POF) and infertility from gonadotoxicity of chemotherapeutic agent. Cytostatic drugs can target the oocyte directly, or can induce oocyte death indirectly via damage to surrounding granulosa cells, which play a key role in folliculogenesis and oocyte maturation. A more thorough understanding of the mechanism behind chemotherapy-induced infertility is necessary to develop new methods to preserve fertility in these patients. MicroRNAs (miRNAs) have recently begun to be explored in ovarian cells as small molecules with critical regulatory role. Importantly, the miRNAs profile in granulosa cells may possess high potential as a new marker for successful folliculogenesis and oocyte development. They can control steroidogenesis in cultured granulosa cells and are involved in control of proliferation, apoptosis and carcinogenesis. MicroRNA-21 (miR-21) and microRNA-132 (miR-132) are of the most abundant and highly expressed miRNAs in human oocytes and granulosa cells. miR-21 is an oncogenic miRNA and plays a critical role in maintaining the survival of granulosa cells in periovulatory follicles and acts as an antiapoptotic factor in granulosa cells. miR-132 has a key role in promotion of estradiol (E2) synthesis in murine ovarian granulosa cells. .. Zusammenfassungen in deutscher und englischer Sprache Chemotherapeutikum (DE-588)4009895-3 gnd rswk-swf Kind (DE-588)4030550-8 gnd rswk-swf Granulosazelle (DE-588)4302325-3 gnd rswk-swf Chemotherapie (DE-588)4127083-6 gnd rswk-swf Fertilitätsstörung (DE-588)4154157-1 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Chemotherapie (DE-588)4127083-6 s Chemotherapeutikum (DE-588)4009895-3 s Kind (DE-588)4030550-8 s Fertilitätsstörung (DE-588)4154157-1 s Granulosazelle (DE-588)4302325-3 s DE-604 Friedrich-Schiller-Universität Jena Medizinische Fakultät (DE-588)2024286-4 dgg Erscheint auch als Online-Ausgabe Influence of chemotherapeutic drugs on human granulosa cells |
| spellingShingle | Al-Kawlani, Boodor 1981- Influence of chemotherapeutic drugs on human granulosa cells Chemotherapeutikum (DE-588)4009895-3 gnd Kind (DE-588)4030550-8 gnd Granulosazelle (DE-588)4302325-3 gnd Chemotherapie (DE-588)4127083-6 gnd Fertilitätsstörung (DE-588)4154157-1 gnd |
| subject_GND | (DE-588)4009895-3 (DE-588)4030550-8 (DE-588)4302325-3 (DE-588)4127083-6 (DE-588)4154157-1 (DE-588)4113937-9 |
| title | Influence of chemotherapeutic drugs on human granulosa cells |
| title_auth | Influence of chemotherapeutic drugs on human granulosa cells |
| title_exact_search | Influence of chemotherapeutic drugs on human granulosa cells |
| title_full | Influence of chemotherapeutic drugs on human granulosa cells by M.Sc. Boodor M. S. Al-Kawlani |
| title_fullStr | Influence of chemotherapeutic drugs on human granulosa cells by M.Sc. Boodor M. S. Al-Kawlani |
| title_full_unstemmed | Influence of chemotherapeutic drugs on human granulosa cells by M.Sc. Boodor M. S. Al-Kawlani |
| title_short | Influence of chemotherapeutic drugs on human granulosa cells |
| title_sort | influence of chemotherapeutic drugs on human granulosa cells |
| topic | Chemotherapeutikum (DE-588)4009895-3 gnd Kind (DE-588)4030550-8 gnd Granulosazelle (DE-588)4302325-3 gnd Chemotherapie (DE-588)4127083-6 gnd Fertilitätsstörung (DE-588)4154157-1 gnd |
| topic_facet | Chemotherapeutikum Kind Granulosazelle Chemotherapie Fertilitätsstörung Hochschulschrift |
| work_keys_str_mv | AT alkawlaniboodor influenceofchemotherapeuticdrugsonhumangranulosacells AT friedrichschilleruniversitatjenamedizinischefakultat influenceofchemotherapeuticdrugsonhumangranulosacells |