Neurotrophins:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cambridge, MA
Elsevier/Academic Press, an imprint of Elsevier
2017
|
| Ausgabe: | 1st edition |
| Schriftenreihe: | Vitamins and hormones
Volume 104 |
| Schlagworte: | |
| Beschreibung: | Literaturangaben ; Einzelaufnahme eines Ztschr.-heftes |
| Beschreibung: | xviii, 531 Seiten Illustrationen, Diagramme 24 cm |
| ISBN: | 9780128122631 |
Internformat
MARC
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| 020 | |a 9780128122631 |9 978-0-12-812263-1 | ||
| 035 | |a (OCoLC)1015873675 | ||
| 035 | |a (DE-599)GBV882687816 | ||
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| 041 | 0 | |a eng | |
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| 245 | 1 | 0 | |a Neurotrophins |c series editor, Gerald Litwack |
| 250 | |a 1st edition | ||
| 264 | 1 | |a Cambridge, MA |b Elsevier/Academic Press, an imprint of Elsevier |c 2017 | |
| 300 | |a xviii, 531 Seiten |b Illustrationen, Diagramme |c 24 cm | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 490 | 1 | |a Vitamins and hormones |v Volume 104 | |
| 500 | |a Literaturangaben ; Einzelaufnahme eines Ztschr.-heftes | ||
| 505 | 8 | |a Front Cover -- Neurotrophins -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Crystal Structures of Neurotrophin Receptors Kinase Domain -- 1. Introduction -- 1.1. Trk Receptors Global Structure -- 2. Crystal Structure of TrkA, TrkB, and TrkC Kinase Domain -- 2.1. Trk Kinase Domain apo Structures -- 2.2. Trk Kinase Domain Complexed Structures -- 3. Pharmacological Approach: The Selectivity Issue -- 4. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Two: BDNF Propeptide: A Novel Modulator of Synaptic Plasticity -- 1. Neurotrophins and Their Biological Actions -- 2. NT Receptors and Their Signaling -- 3. Synthesis, Intracellular Trafficking, and Secretion of BDNF Protein -- 4. Modulation of Synaptic Function by BDNF -- 5. BDNF Prodomain: New Roles Beyond a Molecular Chaperone -- 6. BDNF and Its Propeptide Are Localized in Presynaptic Dense Core Vesicles -- 7. The BDNF Propeptide Is a Novel Synaptic Modulator -- | |
| 505 | 8 | |a 8. Role of the Val66Met Polymorphism in BDNF Propeptide-Dependent LTD -- 9. Discussion -- References -- Chapter Three: Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments -- 1. Introduction -- 2. Brain-Derived Neurotrophic Factor -- 2.1. Peptides-Mimicking BDNF -- 3. Zinc in the Brain -- 3.1. Zinc Metallostasis in the Brain -- 4. Zinc(II) Interaction With BDNF and Related Peptides -- 4.1. Peptide Delivery -- 5. Zinc, BDNF, and Diet -- 6. Conclusion -- Acknowledgments -- References -- Chapter Four: Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily -- 1. TNFR Superfamily -- 1.1. The p75 Neurotrophin Receptor -- 2. Structural Characterization of p75NTR -- 2.1. The Extracellular Domain (ECD) -- 2.1.1. p75ECD Interaction With Neurotrophins -- 2.1.2. p75ECD Interaction With Pro-NGF -- 2.1.3. p75ECD Interaction With Sortilin -- 3. The Transmembrane Domain (TMD) -- 4. The Intracellular Domain (ICD) -- | |
| 505 | 8 | |a 4.1. p75NTR Juxtamembrane Domain (JTM) -- 4.2. The p75NTR Death Domain (DD) -- 4.2.1. p75DD-p75DD Symmetric Complex -- 4.2.2. p75-DD/p45-DD Interaction -- 4.2.3. p75DD-RhoGDI Complex -- 4.2.4. p75-DD/RIP2-CARD Complex -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Five: Releasing Mechanism of Neurotrophic Factors via Polysialic Acid -- 1. Introduction -- 2. Biochemical Features of BDNF -- 3. Regions and Cellular Distribution of BDNF -- 4. Extracellular Secretion of BDNF -- 4.1. BDNF Release via Exocytosis -- 4.2. BDNF Release via Polysialic Acid -- 5. Conclusion -- Acknowledgments -- References -- Chapter Six: Emergent Role of Coronin-1a in Neuronal Signaling -- 1. Introduction -- 2. The Coronin Family of Proteins -- 2.1. Type I Coronin Family -- 2.2. Type II Coronins -- 2.3. Type III Coronin -- 3. Type I Coronins as Actin Regulators -- 4. Coronin-1a as a Signaling Effector Protein -- 4.1. Coronin-1a in Pathogen-Host Signaling -- | |
| 505 | 8 | |a 4.2. Coronin-1a as a Regulator of Internalization Mechanisms -- 4.3. Coronin-1a Is Required for GPCR Activation in Excitatory Neurons -- 4.4. Coronin-1a in NGF-TrkA Signaling -- 4.5. Coronin-1a in Signaling Endosome Maturation -- 4.6. Coronin-1a in Signaling Endosome Trafficking -- 4.7. Coronin-1a in Axon Guidance and Target Innervation -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Seven: Neuronal Roles of the Bicaudal D Family of Motor Adaptors -- 1. Introduction -- 2. The BICD Family of Cargo Adaptors -- 3. Role of BicD in Drosophila Development -- 4. Mammalian BICDs and Their Role in Mitotic Cells -- 5. Role of BICD in Neurons -- 6. BICDs and NT Signaling -- 7. Conclusions -- Acknowledgments -- References -- Chapter Eight: BDNF and Hippocampal Synaptic Plasticity -- 1. Introduction -- 2. Basic Mechanisms of LTP -- 3. The Neurotrophin Family and Its Receptors -- 4. TrkB Localization and Signaling -- 4.1. Ras-MAPK Pathway -- 4.2. PI3K Pathway -- | |
| 505 | 8 | |a 4.3. PLCγ Pathway -- 5. Synthesis and Secretion of BDNF -- 6. BDNF and LTP in the Hippocampus -- 6.1. Pre- and Postsynaptic Secretion and Actions of BDNF During LTP -- 6.1.1. Secretion -- 6.1.2. Actions -- 6.2. Mechanisms Underlying Pre- and Postsynaptic Effects of BDNF -- 6.3. Modulatory Effects of BDNF on Synapse Structure -- 6.4. BDNF-Mediated Dendritic Protein Synthesis and LTP -- 6.5. BDNF-TrkB Signaling in Synaptic Tagging and Capture -- 6.6. BDNF Effects at Nonassociative MF LTP -- 6.7. BDNF as a Regulator of Neurogenesis -- 7. p75NTR and LTD -- 8. Interplay Between Glucocorticoids and BDNF to Determine Cellular Response to Stress -- 9. Concluding Remarks -- References -- Chapter Nine: Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development -- 1. Introduction -- 2. Neurotrophins and the Developing Brain -- 3. Alcohol as a Teratogenic Agent -- 3.1. Fetal Alcohol Spectrum Disorders -- 3.2. Modeling Developmental Alcohol Effects in Experimental Animals -- | |
| 505 | 8 | |a 4. Neurotrophins as Targets of Alcohol Exposure -- 4.1. BDNF -- 4.2. Other Neurotrophic Factors: NGF, NT-3, VEGF -- 5. Interactions Between Developmental Alcohol Exposure and Neurotrophins in the Brain: Molecular and Intracellular Effects -- 5.1. Glutamatergic NMDA Receptors and GABA Receptors -- 5.2. Oxidative Stress -- 5.3. Neuroinflammation -- 6. Interactions Between Developmental Alcohol Exposure and Neurotrophins: Neuroanatomical and Behavioral Effects -- 6.1. Neuroanatomical Effects -- 6.1.1. Brain Region Volume and Alcohol-Induced Apoptosis -- 6.1.2. Adult Neurogenesis: Proliferation, Differentiation, Migration, and Cell Survival -- 6.1.3. Dendritic Morphology and Spine Density -- 6.1.4. Microvasculature -- 6.2. Behavioral Effects -- 7. Neurotrophins as Compensatory/Neuroprotective Molecules Following Developmental Alcohol Exposure -- 8. Conclusions -- Acknowledgments -- References -- Chapter Ten: Neurotrophins: Role in Placental Growth and Development -- 1. Introduction -- | |
| 505 | 8 | |a 2. Role of Neurotrophins in Placental Growth and Development -- 3. Neurotrophins in Different Regions of the Placenta -- 4. Cross Talk of Neurotrophins With Other Growth Factors and Proteases Involved in Placental Development -- 5. Role of Neurotrophins in Pregnancy -- 5.1. Neurotrophins and Preeclampsia -- 5.2. Neurotrophins and Preterm Birth -- 5.3. Neurotrophins and Other Pregnancy Complications -- 6. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Eleven: Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases -- 1. Introduction -- 2. Mammalian Neurotrophin Ligand-Receptor System -- 2.1. Neurotrophin Ligands -- 2.2. Neurotrophin Receptors -- 3. Neurotrophin Ligand-Receptor Biological Functionality -- 3.1. Neurotrophin Processing and Cell Survival -- 3.2. Regulation of Synaptic Plasticity by Neurotrophins -- 3.3. Neurotrophins and Age-Related Neurodegeneration -- | |
| 505 | 8 | |a 3.3.1. NGF/TrkA Functionality in AD-Related CNS Neurodegeneration -- 3.3.2. BDNF/TrkB Functionality in AD-Related CNS Neurodegeneration -- 4. Proneurotrophin-Based Therapy for Age-Related Neurodegeneration -- 4.1. Effective Drug Design-Related Considerations for Refining Neurotrophic Activity -- 4.1.1. Multiple Dimensions of Neurotrophic Signal Transduction Efficacy -- 4.1.2. GPCR-Based Manipulation of Neurotrophin Signaling Paradigms -- 4.2. Small-Molecule Neurotrophic Groups and Lead Compounds -- 4.2.1. Small-Molecule Modulators of Trk Receptor Activity -- 4.2.2. Potentiation and Modulation of Endogenous Neurotrophin/Neurotrophic Functionality -- 4.2.3. Parallel Modulation of Synergistic Growth Factor Pathways -- 4.3. Clinical Activity of Small-Molecule Neurotrophic Therapeutics -- 5. Future Developments in Small-Molecule Neurotrophic Agents -- References -- Chapter Twelve: The Role of Neurotrophins in Inflammation and Allergy -- 1. Introduction -- 1.1. The Neurotrophin Family -- | |
| 505 | 8 | |a 1.2. The NT Receptors -- 2. NTs and Allergic Disease -- 3. NTs and Inflammatory Responses -- 3.1. Eosinophils -- 3.2. Macrophages -- 3.3. Mast Cells -- 3.4. Lymphocytes -- 3.5. Nerves and Structural Cells -- 4. Conclusions -- References -- Chapter Thirteen: Neurotrophic Factors and Maternal Nutrition During Pregnancy -- 1. Introduction -- 2. Neurotrophic Factors -- 2.1. Nerve Growth Factor (NGF) -- 2.2. Brain-Derived Neurotrophic Factor (BDNF) -- 2.3. Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5) -- 3. Maternal Nutrition -- 3.1. Macronutrients -- 3.1.1. Proteins -- 3.1.2. Carbohydrates -- 3.1.3. Fats -- 3.2. Micronutrients -- 3.2.1. Antioxidants -- 3.2.2. Folate -- 3.2.3. Vitamin B12 -- 3.2.4. Trace Minerals -- 3.2.5. Long-Chain Polyunsaturated Fatty Acids (LCPUFA) -- 4. Association Between Maternal Nutrition and Neurotrophic Factors Through One Carbon Cycle -- 4.1. One Carbon Cycle and Neurotrophic Factors -- 4.2. One Carbon Cycle and Epigenetics -- | |
| 505 | 8 | |a 5. Consequences of Altered Maternal Nutrition in Pregnancy -- References -- Chapter Fourteen: The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/C ... -- 1. General Overview -- 2. Malignant Glioma: A Major Clinical Challenge -- 3. Glioma Disease Reservoirs -- 3.1. The Brain Tumor Stem Cell Disease Reservoir | |
| 655 | 7 | |0 (DE-588)4143413-4 |a Aufsatzsammlung |2 gnd-content | |
| 700 | 1 | |a Litwack, Gerald |4 edt | |
| 830 | 0 | |a Vitamins and hormones |v Volume 104 |w (DE-604)BV002530597 |9 104 | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-030076449 | ||
Datensatz im Suchindex
| _version_ | 1804178133118615552 |
|---|---|
| any_adam_object | |
| author2 | Litwack, Gerald |
| author2_role | edt |
| author2_variant | g l gl |
| author_facet | Litwack, Gerald |
| building | Verbundindex |
| bvnumber | BV044679249 |
| contents | Front Cover -- Neurotrophins -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Crystal Structures of Neurotrophin Receptors Kinase Domain -- 1. Introduction -- 1.1. Trk Receptors Global Structure -- 2. Crystal Structure of TrkA, TrkB, and TrkC Kinase Domain -- 2.1. Trk Kinase Domain apo Structures -- 2.2. Trk Kinase Domain Complexed Structures -- 3. Pharmacological Approach: The Selectivity Issue -- 4. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Two: BDNF Propeptide: A Novel Modulator of Synaptic Plasticity -- 1. Neurotrophins and Their Biological Actions -- 2. NT Receptors and Their Signaling -- 3. Synthesis, Intracellular Trafficking, and Secretion of BDNF Protein -- 4. Modulation of Synaptic Function by BDNF -- 5. BDNF Prodomain: New Roles Beyond a Molecular Chaperone -- 6. BDNF and Its Propeptide Are Localized in Presynaptic Dense Core Vesicles -- 7. The BDNF Propeptide Is a Novel Synaptic Modulator -- 8. Role of the Val66Met Polymorphism in BDNF Propeptide-Dependent LTD -- 9. Discussion -- References -- Chapter Three: Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments -- 1. Introduction -- 2. Brain-Derived Neurotrophic Factor -- 2.1. Peptides-Mimicking BDNF -- 3. Zinc in the Brain -- 3.1. Zinc Metallostasis in the Brain -- 4. Zinc(II) Interaction With BDNF and Related Peptides -- 4.1. Peptide Delivery -- 5. Zinc, BDNF, and Diet -- 6. Conclusion -- Acknowledgments -- References -- Chapter Four: Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily -- 1. TNFR Superfamily -- 1.1. The p75 Neurotrophin Receptor -- 2. Structural Characterization of p75NTR -- 2.1. The Extracellular Domain (ECD) -- 2.1.1. p75ECD Interaction With Neurotrophins -- 2.1.2. p75ECD Interaction With Pro-NGF -- 2.1.3. p75ECD Interaction With Sortilin -- 3. The Transmembrane Domain (TMD) -- 4. The Intracellular Domain (ICD) -- 4.1. p75NTR Juxtamembrane Domain (JTM) -- 4.2. The p75NTR Death Domain (DD) -- 4.2.1. p75DD-p75DD Symmetric Complex -- 4.2.2. p75-DD/p45-DD Interaction -- 4.2.3. p75DD-RhoGDI Complex -- 4.2.4. p75-DD/RIP2-CARD Complex -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Five: Releasing Mechanism of Neurotrophic Factors via Polysialic Acid -- 1. Introduction -- 2. Biochemical Features of BDNF -- 3. Regions and Cellular Distribution of BDNF -- 4. Extracellular Secretion of BDNF -- 4.1. BDNF Release via Exocytosis -- 4.2. BDNF Release via Polysialic Acid -- 5. Conclusion -- Acknowledgments -- References -- Chapter Six: Emergent Role of Coronin-1a in Neuronal Signaling -- 1. Introduction -- 2. The Coronin Family of Proteins -- 2.1. Type I Coronin Family -- 2.2. Type II Coronins -- 2.3. Type III Coronin -- 3. Type I Coronins as Actin Regulators -- 4. Coronin-1a as a Signaling Effector Protein -- 4.1. Coronin-1a in Pathogen-Host Signaling -- 4.2. Coronin-1a as a Regulator of Internalization Mechanisms -- 4.3. Coronin-1a Is Required for GPCR Activation in Excitatory Neurons -- 4.4. Coronin-1a in NGF-TrkA Signaling -- 4.5. Coronin-1a in Signaling Endosome Maturation -- 4.6. Coronin-1a in Signaling Endosome Trafficking -- 4.7. Coronin-1a in Axon Guidance and Target Innervation -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Seven: Neuronal Roles of the Bicaudal D Family of Motor Adaptors -- 1. Introduction -- 2. The BICD Family of Cargo Adaptors -- 3. Role of BicD in Drosophila Development -- 4. Mammalian BICDs and Their Role in Mitotic Cells -- 5. Role of BICD in Neurons -- 6. BICDs and NT Signaling -- 7. Conclusions -- Acknowledgments -- References -- Chapter Eight: BDNF and Hippocampal Synaptic Plasticity -- 1. Introduction -- 2. Basic Mechanisms of LTP -- 3. The Neurotrophin Family and Its Receptors -- 4. TrkB Localization and Signaling -- 4.1. Ras-MAPK Pathway -- 4.2. PI3K Pathway -- 4.3. PLCγ Pathway -- 5. Synthesis and Secretion of BDNF -- 6. BDNF and LTP in the Hippocampus -- 6.1. Pre- and Postsynaptic Secretion and Actions of BDNF During LTP -- 6.1.1. Secretion -- 6.1.2. Actions -- 6.2. Mechanisms Underlying Pre- and Postsynaptic Effects of BDNF -- 6.3. Modulatory Effects of BDNF on Synapse Structure -- 6.4. BDNF-Mediated Dendritic Protein Synthesis and LTP -- 6.5. BDNF-TrkB Signaling in Synaptic Tagging and Capture -- 6.6. BDNF Effects at Nonassociative MF LTP -- 6.7. BDNF as a Regulator of Neurogenesis -- 7. p75NTR and LTD -- 8. Interplay Between Glucocorticoids and BDNF to Determine Cellular Response to Stress -- 9. Concluding Remarks -- References -- Chapter Nine: Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development -- 1. Introduction -- 2. Neurotrophins and the Developing Brain -- 3. Alcohol as a Teratogenic Agent -- 3.1. Fetal Alcohol Spectrum Disorders -- 3.2. Modeling Developmental Alcohol Effects in Experimental Animals -- 4. Neurotrophins as Targets of Alcohol Exposure -- 4.1. BDNF -- 4.2. Other Neurotrophic Factors: NGF, NT-3, VEGF -- 5. Interactions Between Developmental Alcohol Exposure and Neurotrophins in the Brain: Molecular and Intracellular Effects -- 5.1. Glutamatergic NMDA Receptors and GABA Receptors -- 5.2. Oxidative Stress -- 5.3. Neuroinflammation -- 6. Interactions Between Developmental Alcohol Exposure and Neurotrophins: Neuroanatomical and Behavioral Effects -- 6.1. Neuroanatomical Effects -- 6.1.1. Brain Region Volume and Alcohol-Induced Apoptosis -- 6.1.2. Adult Neurogenesis: Proliferation, Differentiation, Migration, and Cell Survival -- 6.1.3. Dendritic Morphology and Spine Density -- 6.1.4. Microvasculature -- 6.2. Behavioral Effects -- 7. Neurotrophins as Compensatory/Neuroprotective Molecules Following Developmental Alcohol Exposure -- 8. Conclusions -- Acknowledgments -- References -- Chapter Ten: Neurotrophins: Role in Placental Growth and Development -- 1. Introduction -- 2. Role of Neurotrophins in Placental Growth and Development -- 3. Neurotrophins in Different Regions of the Placenta -- 4. Cross Talk of Neurotrophins With Other Growth Factors and Proteases Involved in Placental Development -- 5. Role of Neurotrophins in Pregnancy -- 5.1. Neurotrophins and Preeclampsia -- 5.2. Neurotrophins and Preterm Birth -- 5.3. Neurotrophins and Other Pregnancy Complications -- 6. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Eleven: Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases -- 1. Introduction -- 2. Mammalian Neurotrophin Ligand-Receptor System -- 2.1. Neurotrophin Ligands -- 2.2. Neurotrophin Receptors -- 3. Neurotrophin Ligand-Receptor Biological Functionality -- 3.1. Neurotrophin Processing and Cell Survival -- 3.2. Regulation of Synaptic Plasticity by Neurotrophins -- 3.3. Neurotrophins and Age-Related Neurodegeneration -- 3.3.1. NGF/TrkA Functionality in AD-Related CNS Neurodegeneration -- 3.3.2. BDNF/TrkB Functionality in AD-Related CNS Neurodegeneration -- 4. Proneurotrophin-Based Therapy for Age-Related Neurodegeneration -- 4.1. Effective Drug Design-Related Considerations for Refining Neurotrophic Activity -- 4.1.1. Multiple Dimensions of Neurotrophic Signal Transduction Efficacy -- 4.1.2. GPCR-Based Manipulation of Neurotrophin Signaling Paradigms -- 4.2. Small-Molecule Neurotrophic Groups and Lead Compounds -- 4.2.1. Small-Molecule Modulators of Trk Receptor Activity -- 4.2.2. Potentiation and Modulation of Endogenous Neurotrophin/Neurotrophic Functionality -- 4.2.3. Parallel Modulation of Synergistic Growth Factor Pathways -- 4.3. Clinical Activity of Small-Molecule Neurotrophic Therapeutics -- 5. Future Developments in Small-Molecule Neurotrophic Agents -- References -- Chapter Twelve: The Role of Neurotrophins in Inflammation and Allergy -- 1. Introduction -- 1.1. The Neurotrophin Family -- 1.2. The NT Receptors -- 2. NTs and Allergic Disease -- 3. NTs and Inflammatory Responses -- 3.1. Eosinophils -- 3.2. Macrophages -- 3.3. Mast Cells -- 3.4. Lymphocytes -- 3.5. Nerves and Structural Cells -- 4. Conclusions -- References -- Chapter Thirteen: Neurotrophic Factors and Maternal Nutrition During Pregnancy -- 1. Introduction -- 2. Neurotrophic Factors -- 2.1. Nerve Growth Factor (NGF) -- 2.2. Brain-Derived Neurotrophic Factor (BDNF) -- 2.3. Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5) -- 3. Maternal Nutrition -- 3.1. Macronutrients -- 3.1.1. Proteins -- 3.1.2. Carbohydrates -- 3.1.3. Fats -- 3.2. Micronutrients -- 3.2.1. Antioxidants -- 3.2.2. Folate -- 3.2.3. Vitamin B12 -- 3.2.4. Trace Minerals -- 3.2.5. Long-Chain Polyunsaturated Fatty Acids (LCPUFA) -- 4. Association Between Maternal Nutrition and Neurotrophic Factors Through One Carbon Cycle -- 4.1. One Carbon Cycle and Neurotrophic Factors -- 4.2. One Carbon Cycle and Epigenetics -- 5. Consequences of Altered Maternal Nutrition in Pregnancy -- References -- Chapter Fourteen: The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/C ... -- 1. General Overview -- 2. Malignant Glioma: A Major Clinical Challenge -- 3. Glioma Disease Reservoirs -- 3.1. The Brain Tumor Stem Cell Disease Reservoir |
| ctrlnum | (OCoLC)1015873675 (DE-599)GBV882687816 |
| edition | 1st edition |
| format | Book |
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Introduction -- 1.1. Trk Receptors Global Structure -- 2. Crystal Structure of TrkA, TrkB, and TrkC Kinase Domain -- 2.1. Trk Kinase Domain apo Structures -- 2.2. Trk Kinase Domain Complexed Structures -- 3. Pharmacological Approach: The Selectivity Issue -- 4. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Two: BDNF Propeptide: A Novel Modulator of Synaptic Plasticity -- 1. Neurotrophins and Their Biological Actions -- 2. NT Receptors and Their Signaling -- 3. Synthesis, Intracellular Trafficking, and Secretion of BDNF Protein -- 4. Modulation of Synaptic Function by BDNF -- 5. BDNF Prodomain: New Roles Beyond a Molecular Chaperone -- 6. BDNF and Its Propeptide Are Localized in Presynaptic Dense Core Vesicles -- 7. The BDNF Propeptide Is a Novel Synaptic Modulator -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">8. Role of the Val66Met Polymorphism in BDNF Propeptide-Dependent LTD -- 9. Discussion -- References -- Chapter Three: Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments -- 1. Introduction -- 2. Brain-Derived Neurotrophic Factor -- 2.1. Peptides-Mimicking BDNF -- 3. Zinc in the Brain -- 3.1. Zinc Metallostasis in the Brain -- 4. Zinc(II) Interaction With BDNF and Related Peptides -- 4.1. Peptide Delivery -- 5. Zinc, BDNF, and Diet -- 6. Conclusion -- Acknowledgments -- References -- Chapter Four: Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily -- 1. TNFR Superfamily -- 1.1. The p75 Neurotrophin Receptor -- 2. Structural Characterization of p75NTR -- 2.1. The Extracellular Domain (ECD) -- 2.1.1. p75ECD Interaction With Neurotrophins -- 2.1.2. p75ECD Interaction With Pro-NGF -- 2.1.3. p75ECD Interaction With Sortilin -- 3. The Transmembrane Domain (TMD) -- 4. The Intracellular Domain (ICD) -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">4.1. p75NTR Juxtamembrane Domain (JTM) -- 4.2. The p75NTR Death Domain (DD) -- 4.2.1. p75DD-p75DD Symmetric Complex -- 4.2.2. p75-DD/p45-DD Interaction -- 4.2.3. p75DD-RhoGDI Complex -- 4.2.4. p75-DD/RIP2-CARD Complex -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Five: Releasing Mechanism of Neurotrophic Factors via Polysialic Acid -- 1. Introduction -- 2. Biochemical Features of BDNF -- 3. Regions and Cellular Distribution of BDNF -- 4. Extracellular Secretion of BDNF -- 4.1. BDNF Release via Exocytosis -- 4.2. BDNF Release via Polysialic Acid -- 5. Conclusion -- Acknowledgments -- References -- Chapter Six: Emergent Role of Coronin-1a in Neuronal Signaling -- 1. Introduction -- 2. The Coronin Family of Proteins -- 2.1. Type I Coronin Family -- 2.2. Type II Coronins -- 2.3. Type III Coronin -- 3. Type I Coronins as Actin Regulators -- 4. Coronin-1a as a Signaling Effector Protein -- 4.1. Coronin-1a in Pathogen-Host Signaling -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">4.2. Coronin-1a as a Regulator of Internalization Mechanisms -- 4.3. Coronin-1a Is Required for GPCR Activation in Excitatory Neurons -- 4.4. Coronin-1a in NGF-TrkA Signaling -- 4.5. Coronin-1a in Signaling Endosome Maturation -- 4.6. Coronin-1a in Signaling Endosome Trafficking -- 4.7. Coronin-1a in Axon Guidance and Target Innervation -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Seven: Neuronal Roles of the Bicaudal D Family of Motor Adaptors -- 1. Introduction -- 2. The BICD Family of Cargo Adaptors -- 3. Role of BicD in Drosophila Development -- 4. Mammalian BICDs and Their Role in Mitotic Cells -- 5. Role of BICD in Neurons -- 6. BICDs and NT Signaling -- 7. Conclusions -- Acknowledgments -- References -- Chapter Eight: BDNF and Hippocampal Synaptic Plasticity -- 1. Introduction -- 2. Basic Mechanisms of LTP -- 3. The Neurotrophin Family and Its Receptors -- 4. TrkB Localization and Signaling -- 4.1. Ras-MAPK Pathway -- 4.2. PI3K Pathway -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">4.3. PLCγ Pathway -- 5. Synthesis and Secretion of BDNF -- 6. BDNF and LTP in the Hippocampus -- 6.1. Pre- and Postsynaptic Secretion and Actions of BDNF During LTP -- 6.1.1. Secretion -- 6.1.2. Actions -- 6.2. Mechanisms Underlying Pre- and Postsynaptic Effects of BDNF -- 6.3. Modulatory Effects of BDNF on Synapse Structure -- 6.4. BDNF-Mediated Dendritic Protein Synthesis and LTP -- 6.5. BDNF-TrkB Signaling in Synaptic Tagging and Capture -- 6.6. BDNF Effects at Nonassociative MF LTP -- 6.7. BDNF as a Regulator of Neurogenesis -- 7. p75NTR and LTD -- 8. Interplay Between Glucocorticoids and BDNF to Determine Cellular Response to Stress -- 9. Concluding Remarks -- References -- Chapter Nine: Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development -- 1. Introduction -- 2. Neurotrophins and the Developing Brain -- 3. Alcohol as a Teratogenic Agent -- 3.1. Fetal Alcohol Spectrum Disorders -- 3.2. Modeling Developmental Alcohol Effects in Experimental Animals -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">4. Neurotrophins as Targets of Alcohol Exposure -- 4.1. BDNF -- 4.2. Other Neurotrophic Factors: NGF, NT-3, VEGF -- 5. Interactions Between Developmental Alcohol Exposure and Neurotrophins in the Brain: Molecular and Intracellular Effects -- 5.1. Glutamatergic NMDA Receptors and GABA Receptors -- 5.2. Oxidative Stress -- 5.3. Neuroinflammation -- 6. Interactions Between Developmental Alcohol Exposure and Neurotrophins: Neuroanatomical and Behavioral Effects -- 6.1. Neuroanatomical Effects -- 6.1.1. Brain Region Volume and Alcohol-Induced Apoptosis -- 6.1.2. Adult Neurogenesis: Proliferation, Differentiation, Migration, and Cell Survival -- 6.1.3. Dendritic Morphology and Spine Density -- 6.1.4. Microvasculature -- 6.2. Behavioral Effects -- 7. Neurotrophins as Compensatory/Neuroprotective Molecules Following Developmental Alcohol Exposure -- 8. Conclusions -- Acknowledgments -- References -- Chapter Ten: Neurotrophins: Role in Placental Growth and Development -- 1. Introduction -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">2. Role of Neurotrophins in Placental Growth and Development -- 3. Neurotrophins in Different Regions of the Placenta -- 4. Cross Talk of Neurotrophins With Other Growth Factors and Proteases Involved in Placental Development -- 5. Role of Neurotrophins in Pregnancy -- 5.1. Neurotrophins and Preeclampsia -- 5.2. Neurotrophins and Preterm Birth -- 5.3. Neurotrophins and Other Pregnancy Complications -- 6. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Eleven: Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases -- 1. Introduction -- 2. Mammalian Neurotrophin Ligand-Receptor System -- 2.1. Neurotrophin Ligands -- 2.2. Neurotrophin Receptors -- 3. Neurotrophin Ligand-Receptor Biological Functionality -- 3.1. Neurotrophin Processing and Cell Survival -- 3.2. Regulation of Synaptic Plasticity by Neurotrophins -- 3.3. Neurotrophins and Age-Related Neurodegeneration -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">3.3.1. NGF/TrkA Functionality in AD-Related CNS Neurodegeneration -- 3.3.2. BDNF/TrkB Functionality in AD-Related CNS Neurodegeneration -- 4. Proneurotrophin-Based Therapy for Age-Related Neurodegeneration -- 4.1. Effective Drug Design-Related Considerations for Refining Neurotrophic Activity -- 4.1.1. Multiple Dimensions of Neurotrophic Signal Transduction Efficacy -- 4.1.2. GPCR-Based Manipulation of Neurotrophin Signaling Paradigms -- 4.2. Small-Molecule Neurotrophic Groups and Lead Compounds -- 4.2.1. Small-Molecule Modulators of Trk Receptor Activity -- 4.2.2. Potentiation and Modulation of Endogenous Neurotrophin/Neurotrophic Functionality -- 4.2.3. Parallel Modulation of Synergistic Growth Factor Pathways -- 4.3. Clinical Activity of Small-Molecule Neurotrophic Therapeutics -- 5. Future Developments in Small-Molecule Neurotrophic Agents -- References -- Chapter Twelve: The Role of Neurotrophins in Inflammation and Allergy -- 1. Introduction -- 1.1. The Neurotrophin Family -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">1.2. The NT Receptors -- 2. NTs and Allergic Disease -- 3. NTs and Inflammatory Responses -- 3.1. Eosinophils -- 3.2. Macrophages -- 3.3. Mast Cells -- 3.4. Lymphocytes -- 3.5. Nerves and Structural Cells -- 4. Conclusions -- References -- Chapter Thirteen: Neurotrophic Factors and Maternal Nutrition During Pregnancy -- 1. Introduction -- 2. Neurotrophic Factors -- 2.1. Nerve Growth Factor (NGF) -- 2.2. Brain-Derived Neurotrophic Factor (BDNF) -- 2.3. Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5) -- 3. Maternal Nutrition -- 3.1. Macronutrients -- 3.1.1. Proteins -- 3.1.2. Carbohydrates -- 3.1.3. Fats -- 3.2. Micronutrients -- 3.2.1. Antioxidants -- 3.2.2. Folate -- 3.2.3. Vitamin B12 -- 3.2.4. Trace Minerals -- 3.2.5. Long-Chain Polyunsaturated Fatty Acids (LCPUFA) -- 4. Association Between Maternal Nutrition and Neurotrophic Factors Through One Carbon Cycle -- 4.1. One Carbon Cycle and Neurotrophic Factors -- 4.2. One Carbon Cycle and Epigenetics -- </subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">5. Consequences of Altered Maternal Nutrition in Pregnancy -- References -- Chapter Fourteen: The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/C ... -- 1. General Overview -- 2. Malignant Glioma: A Major Clinical Challenge -- 3. Glioma Disease Reservoirs -- 3.1. 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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV044679249 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:59:07Z |
| institution | BVB |
| isbn | 9780128122631 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030076449 |
| oclc_num | 1015873675 |
| open_access_boolean | |
| owner | DE-11 |
| owner_facet | DE-11 |
| physical | xviii, 531 Seiten Illustrationen, Diagramme 24 cm |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Elsevier/Academic Press, an imprint of Elsevier |
| record_format | marc |
| series | Vitamins and hormones |
| series2 | Vitamins and hormones |
| spelling | Neurotrophins series editor, Gerald Litwack 1st edition Cambridge, MA Elsevier/Academic Press, an imprint of Elsevier 2017 xviii, 531 Seiten Illustrationen, Diagramme 24 cm txt rdacontent n rdamedia nc rdacarrier Vitamins and hormones Volume 104 Literaturangaben ; Einzelaufnahme eines Ztschr.-heftes Front Cover -- Neurotrophins -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Crystal Structures of Neurotrophin Receptors Kinase Domain -- 1. Introduction -- 1.1. Trk Receptors Global Structure -- 2. Crystal Structure of TrkA, TrkB, and TrkC Kinase Domain -- 2.1. Trk Kinase Domain apo Structures -- 2.2. Trk Kinase Domain Complexed Structures -- 3. Pharmacological Approach: The Selectivity Issue -- 4. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Two: BDNF Propeptide: A Novel Modulator of Synaptic Plasticity -- 1. Neurotrophins and Their Biological Actions -- 2. NT Receptors and Their Signaling -- 3. Synthesis, Intracellular Trafficking, and Secretion of BDNF Protein -- 4. Modulation of Synaptic Function by BDNF -- 5. BDNF Prodomain: New Roles Beyond a Molecular Chaperone -- 6. BDNF and Its Propeptide Are Localized in Presynaptic Dense Core Vesicles -- 7. The BDNF Propeptide Is a Novel Synaptic Modulator -- 8. Role of the Val66Met Polymorphism in BDNF Propeptide-Dependent LTD -- 9. Discussion -- References -- Chapter Three: Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments -- 1. Introduction -- 2. Brain-Derived Neurotrophic Factor -- 2.1. Peptides-Mimicking BDNF -- 3. Zinc in the Brain -- 3.1. Zinc Metallostasis in the Brain -- 4. Zinc(II) Interaction With BDNF and Related Peptides -- 4.1. Peptide Delivery -- 5. Zinc, BDNF, and Diet -- 6. Conclusion -- Acknowledgments -- References -- Chapter Four: Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily -- 1. TNFR Superfamily -- 1.1. The p75 Neurotrophin Receptor -- 2. Structural Characterization of p75NTR -- 2.1. The Extracellular Domain (ECD) -- 2.1.1. p75ECD Interaction With Neurotrophins -- 2.1.2. p75ECD Interaction With Pro-NGF -- 2.1.3. p75ECD Interaction With Sortilin -- 3. The Transmembrane Domain (TMD) -- 4. The Intracellular Domain (ICD) -- 4.1. p75NTR Juxtamembrane Domain (JTM) -- 4.2. The p75NTR Death Domain (DD) -- 4.2.1. p75DD-p75DD Symmetric Complex -- 4.2.2. p75-DD/p45-DD Interaction -- 4.2.3. p75DD-RhoGDI Complex -- 4.2.4. p75-DD/RIP2-CARD Complex -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Five: Releasing Mechanism of Neurotrophic Factors via Polysialic Acid -- 1. Introduction -- 2. Biochemical Features of BDNF -- 3. Regions and Cellular Distribution of BDNF -- 4. Extracellular Secretion of BDNF -- 4.1. BDNF Release via Exocytosis -- 4.2. BDNF Release via Polysialic Acid -- 5. Conclusion -- Acknowledgments -- References -- Chapter Six: Emergent Role of Coronin-1a in Neuronal Signaling -- 1. Introduction -- 2. The Coronin Family of Proteins -- 2.1. Type I Coronin Family -- 2.2. Type II Coronins -- 2.3. Type III Coronin -- 3. Type I Coronins as Actin Regulators -- 4. Coronin-1a as a Signaling Effector Protein -- 4.1. Coronin-1a in Pathogen-Host Signaling -- 4.2. Coronin-1a as a Regulator of Internalization Mechanisms -- 4.3. Coronin-1a Is Required for GPCR Activation in Excitatory Neurons -- 4.4. Coronin-1a in NGF-TrkA Signaling -- 4.5. Coronin-1a in Signaling Endosome Maturation -- 4.6. Coronin-1a in Signaling Endosome Trafficking -- 4.7. Coronin-1a in Axon Guidance and Target Innervation -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Seven: Neuronal Roles of the Bicaudal D Family of Motor Adaptors -- 1. Introduction -- 2. The BICD Family of Cargo Adaptors -- 3. Role of BicD in Drosophila Development -- 4. Mammalian BICDs and Their Role in Mitotic Cells -- 5. Role of BICD in Neurons -- 6. BICDs and NT Signaling -- 7. Conclusions -- Acknowledgments -- References -- Chapter Eight: BDNF and Hippocampal Synaptic Plasticity -- 1. Introduction -- 2. Basic Mechanisms of LTP -- 3. The Neurotrophin Family and Its Receptors -- 4. TrkB Localization and Signaling -- 4.1. Ras-MAPK Pathway -- 4.2. PI3K Pathway -- 4.3. PLCγ Pathway -- 5. Synthesis and Secretion of BDNF -- 6. BDNF and LTP in the Hippocampus -- 6.1. Pre- and Postsynaptic Secretion and Actions of BDNF During LTP -- 6.1.1. Secretion -- 6.1.2. Actions -- 6.2. Mechanisms Underlying Pre- and Postsynaptic Effects of BDNF -- 6.3. Modulatory Effects of BDNF on Synapse Structure -- 6.4. BDNF-Mediated Dendritic Protein Synthesis and LTP -- 6.5. BDNF-TrkB Signaling in Synaptic Tagging and Capture -- 6.6. BDNF Effects at Nonassociative MF LTP -- 6.7. BDNF as a Regulator of Neurogenesis -- 7. p75NTR and LTD -- 8. Interplay Between Glucocorticoids and BDNF to Determine Cellular Response to Stress -- 9. Concluding Remarks -- References -- Chapter Nine: Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development -- 1. Introduction -- 2. Neurotrophins and the Developing Brain -- 3. Alcohol as a Teratogenic Agent -- 3.1. Fetal Alcohol Spectrum Disorders -- 3.2. Modeling Developmental Alcohol Effects in Experimental Animals -- 4. Neurotrophins as Targets of Alcohol Exposure -- 4.1. BDNF -- 4.2. Other Neurotrophic Factors: NGF, NT-3, VEGF -- 5. Interactions Between Developmental Alcohol Exposure and Neurotrophins in the Brain: Molecular and Intracellular Effects -- 5.1. Glutamatergic NMDA Receptors and GABA Receptors -- 5.2. Oxidative Stress -- 5.3. Neuroinflammation -- 6. Interactions Between Developmental Alcohol Exposure and Neurotrophins: Neuroanatomical and Behavioral Effects -- 6.1. Neuroanatomical Effects -- 6.1.1. Brain Region Volume and Alcohol-Induced Apoptosis -- 6.1.2. Adult Neurogenesis: Proliferation, Differentiation, Migration, and Cell Survival -- 6.1.3. Dendritic Morphology and Spine Density -- 6.1.4. Microvasculature -- 6.2. Behavioral Effects -- 7. Neurotrophins as Compensatory/Neuroprotective Molecules Following Developmental Alcohol Exposure -- 8. Conclusions -- Acknowledgments -- References -- Chapter Ten: Neurotrophins: Role in Placental Growth and Development -- 1. Introduction -- 2. Role of Neurotrophins in Placental Growth and Development -- 3. Neurotrophins in Different Regions of the Placenta -- 4. Cross Talk of Neurotrophins With Other Growth Factors and Proteases Involved in Placental Development -- 5. Role of Neurotrophins in Pregnancy -- 5.1. Neurotrophins and Preeclampsia -- 5.2. Neurotrophins and Preterm Birth -- 5.3. Neurotrophins and Other Pregnancy Complications -- 6. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Eleven: Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases -- 1. Introduction -- 2. Mammalian Neurotrophin Ligand-Receptor System -- 2.1. Neurotrophin Ligands -- 2.2. Neurotrophin Receptors -- 3. Neurotrophin Ligand-Receptor Biological Functionality -- 3.1. Neurotrophin Processing and Cell Survival -- 3.2. Regulation of Synaptic Plasticity by Neurotrophins -- 3.3. Neurotrophins and Age-Related Neurodegeneration -- 3.3.1. NGF/TrkA Functionality in AD-Related CNS Neurodegeneration -- 3.3.2. BDNF/TrkB Functionality in AD-Related CNS Neurodegeneration -- 4. Proneurotrophin-Based Therapy for Age-Related Neurodegeneration -- 4.1. Effective Drug Design-Related Considerations for Refining Neurotrophic Activity -- 4.1.1. Multiple Dimensions of Neurotrophic Signal Transduction Efficacy -- 4.1.2. GPCR-Based Manipulation of Neurotrophin Signaling Paradigms -- 4.2. Small-Molecule Neurotrophic Groups and Lead Compounds -- 4.2.1. Small-Molecule Modulators of Trk Receptor Activity -- 4.2.2. Potentiation and Modulation of Endogenous Neurotrophin/Neurotrophic Functionality -- 4.2.3. Parallel Modulation of Synergistic Growth Factor Pathways -- 4.3. Clinical Activity of Small-Molecule Neurotrophic Therapeutics -- 5. Future Developments in Small-Molecule Neurotrophic Agents -- References -- Chapter Twelve: The Role of Neurotrophins in Inflammation and Allergy -- 1. Introduction -- 1.1. The Neurotrophin Family -- 1.2. The NT Receptors -- 2. NTs and Allergic Disease -- 3. NTs and Inflammatory Responses -- 3.1. Eosinophils -- 3.2. Macrophages -- 3.3. Mast Cells -- 3.4. Lymphocytes -- 3.5. Nerves and Structural Cells -- 4. Conclusions -- References -- Chapter Thirteen: Neurotrophic Factors and Maternal Nutrition During Pregnancy -- 1. Introduction -- 2. Neurotrophic Factors -- 2.1. Nerve Growth Factor (NGF) -- 2.2. Brain-Derived Neurotrophic Factor (BDNF) -- 2.3. Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5) -- 3. Maternal Nutrition -- 3.1. Macronutrients -- 3.1.1. Proteins -- 3.1.2. Carbohydrates -- 3.1.3. Fats -- 3.2. Micronutrients -- 3.2.1. Antioxidants -- 3.2.2. Folate -- 3.2.3. Vitamin B12 -- 3.2.4. Trace Minerals -- 3.2.5. Long-Chain Polyunsaturated Fatty Acids (LCPUFA) -- 4. Association Between Maternal Nutrition and Neurotrophic Factors Through One Carbon Cycle -- 4.1. One Carbon Cycle and Neurotrophic Factors -- 4.2. One Carbon Cycle and Epigenetics -- 5. Consequences of Altered Maternal Nutrition in Pregnancy -- References -- Chapter Fourteen: The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/C ... -- 1. General Overview -- 2. Malignant Glioma: A Major Clinical Challenge -- 3. Glioma Disease Reservoirs -- 3.1. The Brain Tumor Stem Cell Disease Reservoir (DE-588)4143413-4 Aufsatzsammlung gnd-content Litwack, Gerald edt Vitamins and hormones Volume 104 (DE-604)BV002530597 104 |
| spellingShingle | Neurotrophins Vitamins and hormones Front Cover -- Neurotrophins -- Copyright -- Contents -- Contributors -- Preface -- Chapter One: Crystal Structures of Neurotrophin Receptors Kinase Domain -- 1. Introduction -- 1.1. Trk Receptors Global Structure -- 2. Crystal Structure of TrkA, TrkB, and TrkC Kinase Domain -- 2.1. Trk Kinase Domain apo Structures -- 2.2. Trk Kinase Domain Complexed Structures -- 3. Pharmacological Approach: The Selectivity Issue -- 4. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Two: BDNF Propeptide: A Novel Modulator of Synaptic Plasticity -- 1. Neurotrophins and Their Biological Actions -- 2. NT Receptors and Their Signaling -- 3. Synthesis, Intracellular Trafficking, and Secretion of BDNF Protein -- 4. Modulation of Synaptic Function by BDNF -- 5. BDNF Prodomain: New Roles Beyond a Molecular Chaperone -- 6. BDNF and Its Propeptide Are Localized in Presynaptic Dense Core Vesicles -- 7. The BDNF Propeptide Is a Novel Synaptic Modulator -- 8. Role of the Val66Met Polymorphism in BDNF Propeptide-Dependent LTD -- 9. Discussion -- References -- Chapter Three: Zinc Interactions With Brain-Derived Neurotrophic Factor and Related Peptide Fragments -- 1. Introduction -- 2. Brain-Derived Neurotrophic Factor -- 2.1. Peptides-Mimicking BDNF -- 3. Zinc in the Brain -- 3.1. Zinc Metallostasis in the Brain -- 4. Zinc(II) Interaction With BDNF and Related Peptides -- 4.1. Peptide Delivery -- 5. Zinc, BDNF, and Diet -- 6. Conclusion -- Acknowledgments -- References -- Chapter Four: Structural Characterization of the p75 Neurotrophin Receptor: A Stranger in the TNFR Superfamily -- 1. TNFR Superfamily -- 1.1. The p75 Neurotrophin Receptor -- 2. Structural Characterization of p75NTR -- 2.1. The Extracellular Domain (ECD) -- 2.1.1. p75ECD Interaction With Neurotrophins -- 2.1.2. p75ECD Interaction With Pro-NGF -- 2.1.3. p75ECD Interaction With Sortilin -- 3. The Transmembrane Domain (TMD) -- 4. The Intracellular Domain (ICD) -- 4.1. p75NTR Juxtamembrane Domain (JTM) -- 4.2. The p75NTR Death Domain (DD) -- 4.2.1. p75DD-p75DD Symmetric Complex -- 4.2.2. p75-DD/p45-DD Interaction -- 4.2.3. p75DD-RhoGDI Complex -- 4.2.4. p75-DD/RIP2-CARD Complex -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Five: Releasing Mechanism of Neurotrophic Factors via Polysialic Acid -- 1. Introduction -- 2. Biochemical Features of BDNF -- 3. Regions and Cellular Distribution of BDNF -- 4. Extracellular Secretion of BDNF -- 4.1. BDNF Release via Exocytosis -- 4.2. BDNF Release via Polysialic Acid -- 5. Conclusion -- Acknowledgments -- References -- Chapter Six: Emergent Role of Coronin-1a in Neuronal Signaling -- 1. Introduction -- 2. The Coronin Family of Proteins -- 2.1. Type I Coronin Family -- 2.2. Type II Coronins -- 2.3. Type III Coronin -- 3. Type I Coronins as Actin Regulators -- 4. Coronin-1a as a Signaling Effector Protein -- 4.1. Coronin-1a in Pathogen-Host Signaling -- 4.2. Coronin-1a as a Regulator of Internalization Mechanisms -- 4.3. Coronin-1a Is Required for GPCR Activation in Excitatory Neurons -- 4.4. Coronin-1a in NGF-TrkA Signaling -- 4.5. Coronin-1a in Signaling Endosome Maturation -- 4.6. Coronin-1a in Signaling Endosome Trafficking -- 4.7. Coronin-1a in Axon Guidance and Target Innervation -- 5. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Seven: Neuronal Roles of the Bicaudal D Family of Motor Adaptors -- 1. Introduction -- 2. The BICD Family of Cargo Adaptors -- 3. Role of BicD in Drosophila Development -- 4. Mammalian BICDs and Their Role in Mitotic Cells -- 5. Role of BICD in Neurons -- 6. BICDs and NT Signaling -- 7. Conclusions -- Acknowledgments -- References -- Chapter Eight: BDNF and Hippocampal Synaptic Plasticity -- 1. Introduction -- 2. Basic Mechanisms of LTP -- 3. The Neurotrophin Family and Its Receptors -- 4. TrkB Localization and Signaling -- 4.1. Ras-MAPK Pathway -- 4.2. PI3K Pathway -- 4.3. PLCγ Pathway -- 5. Synthesis and Secretion of BDNF -- 6. BDNF and LTP in the Hippocampus -- 6.1. Pre- and Postsynaptic Secretion and Actions of BDNF During LTP -- 6.1.1. Secretion -- 6.1.2. Actions -- 6.2. Mechanisms Underlying Pre- and Postsynaptic Effects of BDNF -- 6.3. Modulatory Effects of BDNF on Synapse Structure -- 6.4. BDNF-Mediated Dendritic Protein Synthesis and LTP -- 6.5. BDNF-TrkB Signaling in Synaptic Tagging and Capture -- 6.6. BDNF Effects at Nonassociative MF LTP -- 6.7. BDNF as a Regulator of Neurogenesis -- 7. p75NTR and LTD -- 8. Interplay Between Glucocorticoids and BDNF to Determine Cellular Response to Stress -- 9. Concluding Remarks -- References -- Chapter Nine: Neurotrophins in the Brain: Interaction With Alcohol Exposure During Development -- 1. Introduction -- 2. Neurotrophins and the Developing Brain -- 3. Alcohol as a Teratogenic Agent -- 3.1. Fetal Alcohol Spectrum Disorders -- 3.2. Modeling Developmental Alcohol Effects in Experimental Animals -- 4. Neurotrophins as Targets of Alcohol Exposure -- 4.1. BDNF -- 4.2. Other Neurotrophic Factors: NGF, NT-3, VEGF -- 5. Interactions Between Developmental Alcohol Exposure and Neurotrophins in the Brain: Molecular and Intracellular Effects -- 5.1. Glutamatergic NMDA Receptors and GABA Receptors -- 5.2. Oxidative Stress -- 5.3. Neuroinflammation -- 6. Interactions Between Developmental Alcohol Exposure and Neurotrophins: Neuroanatomical and Behavioral Effects -- 6.1. Neuroanatomical Effects -- 6.1.1. Brain Region Volume and Alcohol-Induced Apoptosis -- 6.1.2. Adult Neurogenesis: Proliferation, Differentiation, Migration, and Cell Survival -- 6.1.3. Dendritic Morphology and Spine Density -- 6.1.4. Microvasculature -- 6.2. Behavioral Effects -- 7. Neurotrophins as Compensatory/Neuroprotective Molecules Following Developmental Alcohol Exposure -- 8. Conclusions -- Acknowledgments -- References -- Chapter Ten: Neurotrophins: Role in Placental Growth and Development -- 1. Introduction -- 2. Role of Neurotrophins in Placental Growth and Development -- 3. Neurotrophins in Different Regions of the Placenta -- 4. Cross Talk of Neurotrophins With Other Growth Factors and Proteases Involved in Placental Development -- 5. Role of Neurotrophins in Pregnancy -- 5.1. Neurotrophins and Preeclampsia -- 5.2. Neurotrophins and Preterm Birth -- 5.3. Neurotrophins and Other Pregnancy Complications -- 6. Conclusion and Future Directions -- Acknowledgments -- References -- Chapter Eleven: Development of Precision Small-Molecule Proneurotrophic Therapies for Neurodegenerative Diseases -- 1. Introduction -- 2. Mammalian Neurotrophin Ligand-Receptor System -- 2.1. Neurotrophin Ligands -- 2.2. Neurotrophin Receptors -- 3. Neurotrophin Ligand-Receptor Biological Functionality -- 3.1. Neurotrophin Processing and Cell Survival -- 3.2. Regulation of Synaptic Plasticity by Neurotrophins -- 3.3. Neurotrophins and Age-Related Neurodegeneration -- 3.3.1. NGF/TrkA Functionality in AD-Related CNS Neurodegeneration -- 3.3.2. BDNF/TrkB Functionality in AD-Related CNS Neurodegeneration -- 4. Proneurotrophin-Based Therapy for Age-Related Neurodegeneration -- 4.1. Effective Drug Design-Related Considerations for Refining Neurotrophic Activity -- 4.1.1. Multiple Dimensions of Neurotrophic Signal Transduction Efficacy -- 4.1.2. GPCR-Based Manipulation of Neurotrophin Signaling Paradigms -- 4.2. Small-Molecule Neurotrophic Groups and Lead Compounds -- 4.2.1. Small-Molecule Modulators of Trk Receptor Activity -- 4.2.2. Potentiation and Modulation of Endogenous Neurotrophin/Neurotrophic Functionality -- 4.2.3. Parallel Modulation of Synergistic Growth Factor Pathways -- 4.3. Clinical Activity of Small-Molecule Neurotrophic Therapeutics -- 5. Future Developments in Small-Molecule Neurotrophic Agents -- References -- Chapter Twelve: The Role of Neurotrophins in Inflammation and Allergy -- 1. Introduction -- 1.1. The Neurotrophin Family -- 1.2. The NT Receptors -- 2. NTs and Allergic Disease -- 3. NTs and Inflammatory Responses -- 3.1. Eosinophils -- 3.2. Macrophages -- 3.3. Mast Cells -- 3.4. Lymphocytes -- 3.5. Nerves and Structural Cells -- 4. Conclusions -- References -- Chapter Thirteen: Neurotrophic Factors and Maternal Nutrition During Pregnancy -- 1. Introduction -- 2. Neurotrophic Factors -- 2.1. Nerve Growth Factor (NGF) -- 2.2. Brain-Derived Neurotrophic Factor (BDNF) -- 2.3. Neurotrophin-3 (NT-3) and Neurotrophin-4/5 (NT-4/5) -- 3. Maternal Nutrition -- 3.1. Macronutrients -- 3.1.1. Proteins -- 3.1.2. Carbohydrates -- 3.1.3. Fats -- 3.2. Micronutrients -- 3.2.1. Antioxidants -- 3.2.2. Folate -- 3.2.3. Vitamin B12 -- 3.2.4. Trace Minerals -- 3.2.5. Long-Chain Polyunsaturated Fatty Acids (LCPUFA) -- 4. Association Between Maternal Nutrition and Neurotrophic Factors Through One Carbon Cycle -- 4.1. One Carbon Cycle and Neurotrophic Factors -- 4.2. One Carbon Cycle and Epigenetics -- 5. Consequences of Altered Maternal Nutrition in Pregnancy -- References -- Chapter Fourteen: The Role of Neurotrophin Signaling in Gliomagenesis: A Focus on the p75 Neurotrophin Receptor (p75NTR/C ... -- 1. General Overview -- 2. Malignant Glioma: A Major Clinical Challenge -- 3. Glioma Disease Reservoirs -- 3.1. The Brain Tumor Stem Cell Disease Reservoir |
| subject_GND | (DE-588)4143413-4 |
| title | Neurotrophins |
| title_auth | Neurotrophins |
| title_exact_search | Neurotrophins |
| title_full | Neurotrophins series editor, Gerald Litwack |
| title_fullStr | Neurotrophins series editor, Gerald Litwack |
| title_full_unstemmed | Neurotrophins series editor, Gerald Litwack |
| title_short | Neurotrophins |
| title_sort | neurotrophins |
| topic_facet | Aufsatzsammlung |
| volume_link | (DE-604)BV002530597 |
| work_keys_str_mv | AT litwackgerald neurotrophins |