Nanobiomaterials: classification, fabrication and biomedical applications
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| Sprache: | English |
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Weinheim, Germany
Wiley-VCH
[2018]
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| Online-Zugang: | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34067-5/ Inhaltsverzeichnis |
| Beschreibung: | xviii, 492 Seiten Illustrationen |
| ISBN: | 9783527340675 352734067X |
Internformat
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| 245 | 1 | 0 | |a Nanobiomaterials |b classification, fabrication and biomedical applications |c edited by XiuMei Wang, Murugan Ramalingam, Xiangdong Kong, and Lingyun Zhao |
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| 653 | |a Biomedizintechnik | ||
| 653 | |a Chemie | ||
| 653 | |a Chemistry | ||
| 653 | |a Nanomaterial | ||
| 653 | |a Nanomedicine | ||
| 653 | |a Nanomedizin | ||
| 653 | |a Nanotechnologie | ||
| 653 | |a Nanotechnology | ||
| 653 | |a Pharmaceutical & Medicinal Chemistry | ||
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Datensatz im Suchindex
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| adam_text | CONTENTS
PREFACE XVII
PART I INTRODUCTION 1
1 NANOBIOMATERIALS: STATE OF THE ART 3
LING WANG; HUIHUA LILINGLING TIAN, AND SEERAM RAMAKRISHNA
1.1 INTRODUCTION 3
1.1.1 PROPERTIES OF NANOBIOMATERIALS 4
1.1.2 INTERACTION BETWEEN NANOBIOMATERIALS AND BIOLOGICAL SYSTEM 4
1.1.3 BIOCOMPATIBILITY AND TOXICITY OF NANOBIOMATERIALS 5
1.2 NANOBIOMATERIALS FOR TISSUE ENGINEERING APPLICATIONS 6
1.2.1 VASCULAR TISSUE ENGINEERING 7
1.2.2 NEURAL TISSUE ENGINEERING 9
1.2.3 CARTILAGE TISSUE ENGINEERING 12
1.2.4 BONE TISSUE ENGINEERING 13
1.3 NANOBIOMATERIALS FOR DRUG DELIVERY APPLICATIONS 15
1.3.1 CARBON-BASED NANOBIOMATERIALS 15
1.3.2 SILICA NANOPARTICLES 17
1.3.3 POLYMER-BASED NANOMATERIALS 18
1.4 NANOBIOMATERIALS FOR IMAGING AND BIOSENSING APPLICATIONS 18
1.4.1 POLYMER-BASED NANOBIOMATERIALS 19
1.4.2 QUANTUM-DOT-BASED NANOBIOMATERIALS 19
1.4.3 MAGNETIC NANOPARTICLES 21
1.4.4 GOLD NANOBIOMATERIALS 22
1.4.5 ORGANIC-INORGANIC-BASED MATERIALS 23
1.4.6 CNT-BASED NANOBIOMATERIALS 23
1.5 CONCLUSIONS AND PERSPECTIVES 24
REFERENCES 25
PART II CLASSIFICATION OF NANOBIOMATERIALS 37
2 METALLIC NANOBIOMATERIALS 39
MAGESH SANKAR, VASONTH GOPAL, REVATHIALEXANDER, GEETHA MANIVASAGAM,
AND MURUGAN RAMALINGAM
2.1 INTRODUCTION 39
2.2 CONVENTIONAL TO ULTRAFINE-GRAINED MATERIALS - A NOVEL
TRANSFORMATION 40
2.2.1 BOTTOM-UP APPROACH 42
2.2.2 TOP-DOWN APPROACH 43
2.3 SEVERE PLASTIC DEFORMATION (SPD) 43
2.3.1 EQUAL CHANNEL ANGULAR PRESSING (ECAP) 43
2.3.2 HIGH-PRESSURE TORSION (HPT) 45
2.3.3 ACCUMULATIVE ROLL BONDING (ARB) 46
2.3.4 OTHER SPD PROCESSES 47
2.3.4.1 MULTIPASS CALIBER ROLLING (MPCR) 47
2.3.4.2 DISINTEGRATED MELT DEPOSITION (DMD) 47
2.4 MECHANICAL BEHAVIOR OF METALLIC NANOBIOMATERIALS 48
2.5 CORROSION 49
2.5.1 CORROSION MECHANISM 50
2.5.2 PASSIVATION OF METALLIC BIOMATERIALS 50
2.5.3 BIOLOGICAL ENVIRONMENT AND ITS INFLUENCE ON CORROSION OF METALLIC
BIOMATERIALS 51
2.5.4 CORROSION BEHAVIOR OF METALLIC NANOBIOMATERIALS 52
2.6 WEAR 53
2.6.1 WEAR ASSESSMENT 54
2.6.2 WEAR ASPECTS OF METALLIC NANOBIOMATERIALS 55
2.7 BIOCOMPATIBILITY OF METALLIC NANOBIOMATERIALS 56
2.8 BIOMEDICAL APPLICATION OF METALLIC NANOBIOMATERIALS 59
2.9 FUTURE ASPECTS 59
REFERENCES 60
3 POLYMERIC NANOBIOMATERIALS 65
DEEPTI RANA, KEERTHANA RAMASAMY, SAMAD AHADIAN, GEETHA MANIVASAGAM,
XIUMEI WANG, AND MURUGAN RAMALINGAM
3.1 INTRODUCTION 65
3.2 TYPES OF POLYMERIC NANOBIOMATERIALS 66
3.3 POLYMERIC NANOFIBERS 67
3.4 POLYMERIC NANOFIBERS TO PROVIDE MICROENVIRONMENTAL CUES 69
3.5 BIOLOGICAL RELEVANCE OF POLYMERIC NANOFIBERS 71
3.6 RECENT TRENDS IN POLYMERIC NANOFIBERS 72
3.6.1 HYBRID NANOFIBERS 72
3.6.2 GRADIENT NANOFIBERS 74
3.7 APPLICATIONS OF NANOFIBERS IN REGENERATIVE MEDICINE 75
3.7.1 BONE TISSUE ENGINEERING 75
3.7.2 NERVE TISSUE ENGINEERING 77
3.7.3 VASCULAR TISSUE ENGINEERING 78
3.8 CONCLUDING REMARKS 79
ACKNOWLEDGMENT 80
REFERENCES 80
4 CARBON-BASED NANOBIOMATERIALS 85
SAMAD AHADIAN, FORHOD BATMANGHELICH, RAQUEL OBREGON, DEEPTI RANA, JAVIER
RAMON-AZCON, RAMIN BANAN SADEGHIAN, AND MURUGAN RAMA UNGARN
4.1 INTRODUCTION 85
4.2 TISSUE ENGINEERING 87
4.2.1 NEURAL TISSUE ENGINEERING 87
4.2.1.1 CNTS IN NEURAL TISSUE ENGINEERING 88
4.2.1.2 GRAPHENE IN NEURAL TISSUE ENGINEERING 89
4.2.2 BONE TISSUE ENGINEERING 89
4.2.2.1 CNTS IN BONE TISSUE ENGINEERING 89
4.2.2.2 GRAPHENE IN BONE TISSUE ENGINEERING 92
4.3 GENE AND DRUG DELIVERY 92
4.3.1 CNTS IN DELIVERY SYSTEMS 92
4.3.2 GRAPHENE IN DELIVERY SYSTEMS 93
4.4 BIOSENSING 93
4.4.1 CNTS IN BIOSENSING 93
4.4.2 GRAPHENE IN BIOSENSING 94
4.5 BIOMEDICAL IMAGING 95
4.5.1 CNTS IN BIOMEDICAL IMAGING 95
4.5.2 GRAPHENE IN BIOMEDICAL IMAGING 95
4.6 CONCLUSIONS 97
REFERENCES 97
PART III NANOTECHNOLOGY-BASED APPROACHES IN BIOMATERIALS
FABRICATIONS 105
5 MOLECULAR SELF-ASSEMBLY FOR NANOBIOMATERIAL
FABRICATION 107
LING ZHU, YANIIAN YANG; AND CHEN WANG
5.1 INTRODUCTION 107
5.1.1 MOLECULAR SELF-ASSEMBLY 107
5.1.2 NANOSCALE INTERACTIONS AND THEIR ROLES IN SELF-ASSEMBLY 107
5.1.3 TECHNOLOGIES FOR THE CHARACTERIZATION OF SELF-ASSEMBLIES 108
5.1.3.1 MICROSCOPIES 108
5.1.3.2 DYNAMIC LIGHT SCATTERING 110
5.1.3.3 SPECTROSCOPIES 110
5.2 SELF-ASSEMBLING PEPTIDES 111
5.2.1 PEPTIDE SELF-ASSEMBLY AND ITS APPLICATIONS 111
5.2.2 DRIVING FORCE FOR PEPTIDE SELF-ASSEMBLY 112
5.2.3 SECONDARY STRUCTURES OF PEPTIDE SELF-ASSEMBLIES 112
5.2.3.1 SS-SHEET-FORMING PEPTIDES 112
5.23.2 COILED-COIL PEPTIDES 114
5.2.3.3 COLLAGEN-LIKE TRIPLE-HELICAL PEPTIDES 114
5.2.3.4 SECONDARY STRUCTURE TRANSITION PEPTIDES 115
5.2.4 PEPTIDE NANOSTRUCTURES 115
5.2.4.1 NANOFIBERS AND HYDROGEL 115
5.2.4.2 PEPTIDE NANOTUBES 116
5.2.4.3 VESICLE/SPHERICAL STRUCTURES FROM SURFACTANT PEPTIDES 118
5.3 NANO-DRUG CARRIERS 118
5.3.1 LIPOSOMES 119
5.3.2 POLYMERIC DRUG CARRIERS 121
5.3.2.1 POLY LACTIC-CO-GLYCOLIC ACID (PLGA) NANOPARTICLES 121
53.2.2 PEGYLATION 121
53.23 POLYMERIC MICELLES 122
5.3.3 DRUG DELIVERY STRATEGIES: PASSIVE TARGETING VERSUS ACTIVE
TARGETING 123
5.3.4 TRIGGERED DRUG RELEASE 123
5.3.5 OTHER APPLICATIONS OF NANO-DRUG CARRIERS 124
5.4 INORGANIC NANOBIOMATERIALS 124
5.4.1 GRAPHENE 124
5.4.2 CARBON NANOTUBES 125
5.4.3 SURFACE FUNCTIONALIZATION OF CARBON NANOMATERIALS FOR BIOMEDICAL
APPLICATION 126
5.4.3.1 SURFACE FUNCTIONALIZATION OF GRAPHENE 126
5.4.3.2 GRAPHENE-PEPTIDE HYBRIDS 126
5A.3.3 LAYER-BY-LAYER ASSEMBLY OF GRAPHENE FILMS 127
5.4.3.4 APPLICATION OF FUNCTIONALIZED GRAPHENE 127
5.4.3.5 SURFACE FUNCTIONALIZATION OF CARBON NANOTUBES 128
5.4.3.6 APPLICATION OF FUNCTIONALIZED CARBON NANOTUBES 128
5.5 PERSPECTIVES 129
ACKNOWLEDGMENTS 129
REFERENCES 229
6 ELECTROSPRAYING AND ELECTROSPINNING FOR NANOBIOMATERIAL
FABRICATION 143
LIUMIN HE, YUYUAN ZHAO, LINGLING TIAN, AND SEERAM RAMAKRISHNA
6.1 INTRODUCTION 143
6.2 WHAT IS ELECTROSPINNING? 143
6.2.1 THE ELECTROSPINNING PROCESS 144
6.2.2 THE ELECTROSPINNING DEVICE 144
6.2.3 ADVANCES IN ELECTROSPINNING DEVICES 146
6.2.3.1 ADVANCES IN THE COLLECTOR 146
6.23.2 ADVANCES IN THE SPINNERET 146
6.3 KEY CONSIDERATIONS IN ELECTROSPINNING 146
6.3.1 THE SPINNABLE MATERIALS 146
6.3.1.1 BIOPOLYMERS 147
6.3.1.2 WATER-SOLUBLE POLYMERS 147
6.3.1.3 ORGANOSOLUBLE POLYMERS 147
6.3.1.4 BIODEGRADABLE POLYMERS 147
6.3.1.5 COPOLYMERS 148
6.3.1.6 MELT-ELECTROSPINNABLE POLYMERS 148
6.3.2 PARAMETERS IN ELECTROSPINNING 148
6.3.2.1 SOLUTION PROPERTIES 148
6.3.2.2 PROCESS PARAMETERS ISO
6 3 2 3 AMBIENT PARAMETERS 151
6.3.2.4 CONCLUSION 151
6.4 THE APPLICATION OF ELECTROSPUN MATERIALS IN BIOMEDICINE 151
6.4.1 TISSUE ENGINEERING APPLICATIONS 151
6.4.1.1 VASCULAR TISSUE ENGINEERING 152
6.4.1.2 BONE TISSUE ENGINEERING 152
6.4.1.3 NERVE TISSUE ENGINEERING 153
6.4.1.4 SKIN TISSUE ENGINEERING 154
6.4.1.5 TENDON AND LIGAMENT TISSUE ENGINEERING 155
6.4.2 TRANSPORT AND RELEASE OF DRUGS 156
6.4.3 WOUND DRESSING 157
6.5 FUTURE DIRECTIONS 159
REFERENCES 159
7 LAYER-BY-LAYER TECHNIQUE: FROM CAPSULE ASSEMBLY TO
APPLICATION IN BIOLOGICAL DOMAINS 165
XICHEN
7.1 DEFINITION OF LAYER-BY-LAYER (LBL) ASSEMBLY 165
12 STABILIZING INTERACTIONS BETWEEN LBL FILMS 166
7.2.1 LBL ASSEMBLY VIA ELECTROSTATIC BONDING 167
7 2 2 LBL ASSEMBLY VIA HYDROGEN BONDING 168
7 2 3 LBL ASSEMBLY VIA COVALENT BONDING 168
7.2.4 SUMMARY 169
7.3 EMERGED TECHNOLOGIES EMPLOYED FOR LBL ASSEMBLY 169
7.3.1 IMMERSIVE LBL ASSEMBLY 169
7.3.2 SPIN LBL ASSEMBLY 169
7.3.3 SPRAY LBL ASSEMBLY 171
7.3.4 ELECTRIC AND MAGNETIC LBL ASSEMBLY 171
7.3.5 FLUIDIC LBL ASSEMBLY 172
7.3.6 SUMMARY 172
7.4 TYPICAL METHODS FOR THE ASSEMBLY OF LBL PARTICLES/CAPSULES 172
7.4.1 CENTRIFUGATION 172
7.4.2 MICROFLUIDICS 174
7.4.3 ELECTROPHORESIS 174
7.5 APPLICATION OF LBL CAPSULES IN BIOLOGICAL ENVIRONMENT 174
7.5.1 THERAPEUTIC DELIVERY 174
7.5.2 BIOSENSORS AND BIOREACTORS 175
7.6 LBL CAPSULES AS A THERAPEUTIC DELIVERY PLATFORM: CARGO LOADING AND
RELEASE 176
7.6.1 CARGO LOADING 176
7.6.1.1 PRE-LOADING 176
7.6.1.2 POST-LOADING 176
7.6.1.3 LOADING CARGO ON CAPSULE SHELLS 176
7.6.2 BIOLOGICAL STIMULI-RESPONSIVE CARGO RELEASE 177
7.6.2.1 ENZYME 177
7.6.2.2 PH 178
7.6.23 REDOX 178
7.6.3 SUMMARY 179
7.7 THE EFFECT OF PHYSICOCHEMICAL PROPERTIES OF LBL CAPSULES ON
CELLULAR INTERACTIONS 179
7.7.1 MORPHOLOGY EFFECTS 179
7.7.2 SURFACE PROPERTY EFFECTS 180
7.7.3 MECHANICAL EFFECTS 181
7.7 A SUMMARY 182
7.8 CONCLUSION AND OUTLOOK 182
REFERENCES 182
8 NANOPATTERNING TECHNIQUES 189
LAKSHMI PRIYA MANICKAM, AKSHAY BHATT, DEEPTI RANA, SERGE OSTROVIDOV,
RENU PASRICHA, XIUMEI WANG, AND MURUGAN RAMALINGAM
8.1 INTRODUCTION 189
8.2 TYPES OF NANOPATTERNING TECHNIQUES 190
8.3 NANO-BIOPATTERNING 190
8.4 CHEMICAL PATTERNING 192
8.5 TOPOGRAPHICAL PATTERNING 196
8.6 COMBINATORIAL PATTERNING 200
8.7 3D PATTERNING 201
8.8 FACTORS INFLUENCING NANOPATTERNING 202
8.9 CONCLUDING REMARKS 204
REFERENCES 204
9 SURFACE MODIFICATION OF METALLIC IMPLANTS WITH NANOTUBULAR
ARRAYS VIA ELECTROCHEMICAL ANODIZATION 211
MING JIN, SHENGLIAN YAO, AND LUNING WANG
9.1 INTRODUCTION 211
9.2 FABRICATION OF NANOTUBULAR ARRAYS ON METALS VIA ELECTROCHEMICAL
ANODIZATION 213
9.2.1 THE INFLUENCE OF FLUORIDE CONCENTRATION ON T I02 NANOTUBES 216
9.2.2 THE EFFECT OF PH VALUE ON THE FORMATION OF TI02 NANOTUBES 218
9.2.3 THE EFFECT OF APPLIED POTENTIAL ON THE FORMATION OF TI02
NANOTUBES 219
9.2.4 THE EFFECT OF ANODIZATION DURATION ON THE FORMATION OF TI02
NANOTUBES 219
9.2.5 NANOTUBE OXIDE LAYER ON TITANIUM ALLOYS AND OTHER METALS 220
9.3 BIOCOMPATIBILITY OF METALS WITH NANOTUBULAR SURFACES 223
9.3.1 HYDROXYAPATITE FORMATION ON NANO TUBULAR ARRAYS 223
9.3.2 IN VITRO BIOCOMPATIBILITY STUDIES 225
9.3.3 IN VIVO BIOCOMPATIBILITY STUDIES 227
9.3.4 NANOTUBULAR ARRAYS FOR DRUG DELIVERY AND OTHER PRELOAD
APPLICATIONS 228
9.4 CONCLUSION 230
REFERENCES 230
PART IV NANOBIOMATERIALS IN BIOMEDICAL APPLICATIONS:
DIAGNOSIS, IMAGING, AND THERAPY 239
10 NONCONVENTIONAL BIOSENSORS BASED ON NANOMEMBRANE
MATERIALS 241
LARI YIN AND XING SHENG
10.1 INTRODUCTION 241
10.2 SOFT ELECTRONICS 242
10.3 INJECTABLE ELECTRONICS 246
10.4 BIODEGRADABLE ELECTRONICS 248
10.5 CONCLUSIONS 252
REFERENCES 253
11 NANOBIOMATERIALS FOR MOLECULAR IMAGING 259
PRASHANT CHANDRASEKHARAN AND CHANG-TONG YANG
11.1 INTRODUCTION 259
11.1.1 REPORTER NANOBIOMATERIAL SYSTEM FOR MOLECULAR IMAGING 260
11.1.2 BIOMATERIAL PACKING FOR MOLECULAR IMAGING 264
11.1.3 TARGETING LIGANDS AND MOLECULAR IMAGING 268
11.2 CONCLUSION 272
REFERENCES 272
12 ENGINEERING NANOBIOMATERIALS FOR IMPROVED TISSUE
REGENERATION 281
LIPING XIE, WEI QIAN, JIANJUN SUN, AND BO ZOU
12.1 INTRODUCTION 281
12.2 EXTRACELLULAR MICROENVIRONMENT: ROLE OF NANOTOPOGRAPHY 282
12.3 TYPE OF NANOBIOMATERIALS FOR TISSUE ENGINEERING 284
12.3.1 NANOPARTICLES AND NANOCLUSTERS 284
12.3.2 NANOFIBROUS SCAFFOLDS 286
12.3.3 NANOCOMPOSITES 288
12.3.3.1 NANOCOMPOSITE HYDROGELS 289
12.3.3.2 NANOCOMPOSITE SPONGE 290
12.4 APPLICATIONS OF NANOBIOMATERIALS TO TISSUE REGENERATION 290
12.4.1 NANOBIOMATERIALS FOR NEURAL TISSUE ENGINEERING 291
12.4.2 NANOBIOMATERIALS FOR BONE REGENERATION 294
12.4.3 NANOBIOMATERIALS FOR HEART REGENERATION 295
12.5 CONCLUSIONS AND FUTURE PERSPECTIVES 296
REFERENCES 298
13 NANOBIOMATERIALS FOR CANCER THERAPY 305
WEI TAO AND LIN MEI
13.1 INTRODUCTION 305
13.2 CANCER PATHOPHYSIOLOGY 306
13.2.1 ANGIOGENESIS AND *ANGIOGENIC SWITCH* 307
13.2.2 ENHANCED PERMEABILITY AND RETENTION EFFECT 309
13.3 TYPES OF CANCER TREATMENT AND RELATED NBMS 310
13.3.1 SURGERY 310
13.3.2 CHEMOTHERAPY AND NBMS 311
13.3.3 RADIOTHERAPY AND NBMS 312
13.3.4 PHOTOTHERAPY THERAPY AND NBMS 313
13.3.5 GENE THERAPY AND NBMS 313
13.3.6 IMMUNE THERAPY AND NBMS 314
13.4 CURRENT NBMS IN CANCER THERAPY 315
13.4.1 POLYMERIC NPS 315
13.4.2 LIPOSOMES 316
13.4.3 QDS 317
13.4.4 INORGANIC NPS 318
13.4.5 CARBON NANOTUBES 319
13.5 CONCLUSIONS 319
REFERENCES 320
14 CHEMICAL SYNTHESIS AND BIOMEDICAL APPLICATIONS OF IRON OXIDE
NANOPARTICLES 329
LING YU, YANMIN JU, FAN CHEN, SHENGLEI CHE, LINGYUN ZHAO, FUGENG SHENG,
AND
YANGIONG HOU
14.1 INTRODUCTION 329
14.2 CHEMICAL SYNTHESIS OF IONP (FE30 4) NPS 330
14.2.1 CO-PRECIPITATION 330
14.2.2 THERMAL DECOMPOSITION 331
14.2.3 HYDROTHERMAL SYNTHESIS 333
14.2.4 MICROEMULSION 334
14.2.5 SOL-GEL METHOD 334
14.2.6 POLYOL METHOD 335
14.3 BIOMEDICAL APPLICATIONS OF IONPS 335
14.3.1 MR IMAGING (TJ/D,) 337
14.3.2 MAGNETIC HYPERTHERMIA 340
14.3.3 MAGNETIC TARGETING (DRUG DELIVERY, GENE DELIVERY) 342
14.3.3.1 MAGNETICALLY CONTROLLED DRUG DELIVERY 343
14.3.3.2 MAGNETICALLY CONTROLLED GENE DELIVERY 344
14.3.4 TISSUE ENGINEERING 345
14.3.5 CELL TRACKING 346
14.4 CONCLUSION AND PERSPECTIVE 348
REFERENCES 348
15 GOLD NANOPARTICLES AND THEIR BIOAPPLICATIONS 359
HEYUN SHEN, LI CHENG; LINLIN LI, AND HUIYU LIU
15.1 INTRODUCTION 359
15.2 THE PREPARATION OF VARIOUS AUNPS 360
15.2.1 GOLD NANOSHELLS 360
15.2.2 GOLD NANORODS 361
15.2.3 GOLD NANOCAGES 362
15.2.4 GOLD NANOCLUSTERS 362
15.3 OPTICAL BIOIMAGING BASED ON AUNPS 363
15.3.1 AUNPS FOR OCT IMAGING 364
15.3.2 AUNPS FOR PHOTOACOUSTIC IMAGING 364
15.3.3 AUNPS FOR SERS DETECTION AND IMAGING 365
15.3.4 AUNPS FOR MULTIMODE IMAGING 367
15.3.4.1 DARK-FIELD IMAGING COMBINED WITH SERS IMAGING 367
15.3.4.2 FLUORESCENCE IMAGING COMBINED WITH SERS IMAGING 368
15.4 AUNPS FOR THERANOSTIC INTEGRATION PLATFORMS 368
15.4.1 GOLD NANOSHELLS FOR THERANOSTIC INTEGRATION PLATFORMS 368
15.4.2 GOLD NANO RODS FOR THERANOSTIC INTEGRATION PLATFORMS 371
15.4.3 GOLD NANOCAGES FOR THERANOSTIC INTEGRATION PLATFORMS 372
15.5 CONCLUSIONS AND PERSPECTIVES 374
REFERENCES 375
16 SILICON-BASED NANOPARTICLES FOR DRUG DELIVERY 379
YIXUAN YU AND XI LIU
16.1 INTRODUCTION 379
16.2 POROUS SILICON NANOPARTICLES 380
16.2.1 SYNTHESIS OF POROUS SILICON NANOPARTICLES 380
16.2.2 PROPERTIES OF POROUS SILICON NANOPARTICLES 381
16.2.3 APPLICATION OF POROUS SILICON NANOPARTICLES IN DRUG DELIVERY 383
16.3 SILICON NANOCRYSTALS (SILICON QUANTUM DOTS) 386
16.3.1 SYNTHESIS OF SILICON NANOCRYSTALS 386
16.3.2 SURFACE CHEMISTRY OF SILICON NANOCRYSTALS 387
16.3.3 PROPERTIES OF SILICON NANOCRYSTALS 389
16.3.4 APPLICATION OF SILICON NANOCRYSTALS IN DRUG DELIVERY 391
16.4 POROUS SILICA NANOPARTICLES 392
16.4.1 SYNTHESIS OF POROUS SILICA NANOPARTICLES 392
16.4.2 TUNING THE POROUS STRUCTURE OF SILICA NANOPARTICLES 394
16.4.3 POROUS SILICA NANOPARTICLES AS DRUG DELIVERY VEHICLES 395
16.5 CONCLUSIONS 396
REFERENCES 397
17 DENDRITIC-POLYMER-BASED NANOMATERIALS FOR CANCER DIAGNOSIS
AND THERAPY 403
NA ZHU, QIYONG GONG, ZHONGWEI GU, AND KUI LUO
INTRODUCTION 403
17.1
17.2 DENDRITIC-POLYMER-BASED NANOMATERIALS FOR CANCER DIAGNOSIS 404
17.2.1 DENDRIMERS FOR MRI 404
17.2.2 DENDRIMER-ENTRAPPED GOLD NANOPARTICLES FOR CT IMAGING 408
17.2.3 DENDRIMERS AS OPTICAL NANOPROBES 409
17.3 DENDRIMERS AS DRUG CARRIERS FOR CANCER THERAPY 410
17.3.1 FUNCTIONAL DENDRITIC POLYMERS FOR ENCAPSULATION OF ANTICANCER
DRUGS 410
17.3.2 CHEMICAL DENDRITIC-POLYMER-DRUG CONJUGATES VIA PERIPHERAL
MODIFICATION AS ANTICANCER DRUG DELIVERY SYSTEMS 411
17.3.3 DENDRITIC-POLYMER-DRUG CONJUGATES OF PRECISE MOLECULAR STRUCTURES
AS ANTICANCER DRUG NANOCARRIERS 413
17.4 DENDRITIC POLYMERS FOR THERANOSTICS 414
17.4.1 THERANOSTIC DENDRIMERS FOR MRI 415
17.4.2 THERONOSTIC DENDRIMERS FOR CT IMAGING 417
17.4.3 THERANOSTIC DENDRITIC-POLYMER-BASED VEHICLES FOR PHOTOTHERAPY AND
FLUORESCENCE IMAGING 418
17.5 CONCLUSION AND PROSPECTS 420
REFERENCES 420
PART V BIOSAFETY AND CLINICAL TRANSLATION OF
NANOBIOMATERIALS 429
18 BIOSAFETY OF CARBON-BASED NANOPARTICLES AND
NANOCOMPOSITES 431
YONG CHEOL SHIN, JONG HO LEE, IN-SEOP LEE, AND DONG-WOOK HAN
18.1 INTRODUCTION 431
18.2 EVALUATION OF BIOSAFETY OF CARBON-BASED NMS 432
18.3 CARBON NANOTUBES 434
18.3.1 TYPES AND STRUCTURES 434
18.3.2 IN VITRO BIOSAFETY OF CNTS 435
18.3.3 IN VIVO BIOSAFETY OF CNTS 437
18.4 GRAPHENE AND ITS DERIVATIVES 439
18.4.1 THE TYPES AND CHARACTERISTICS OF GRAPHENE 439
18.4.2 IN VITRO BIOSAFETY OF GRAPHENE AND ITS DERIVATIVES 440
18.4.3 IN VIVO BIOSAFETY OF GRAPHENE AND ITS DERIVATIVES 443
18.5 CARBON-BASED NCS 447
18.5.1 CNT-BASED NCS 447
18.5.2 GRAPHENE-BASED NCS 448
18.6 SUMMARY AND OUTLOOK 449
ACKNOWLEDGMENT 450
REFERENCES 450
19 CLINICAL TRANSLATION AND SAFETY REGULATION OF
NANOBIOMATERIALS 459
RUIBOZHAO, LAWRENCE KEEN, ANDXIANGDONG KONG
19.1 INTRODUCTION 459
19.2 KEY EXAMPLES OF NANOBIOMATERIALS IN CLINICAL APPLICATIONS 460
19.2.1 LIPOSOMAL NANOBIOMATERIALS 460
19.2.2 PEG-COATED NANOBIOMATERIALS 462
19.2.3 POLYMER NANOBIOMATERIALS 463
19.2.4 IRON OXIDE NANOBIOMATERIALS 464
19.2.5 GOLD NANOPARTICLE NANOBIOMATERIALS 464
19.2.6 SILVER NANOBIOMATERIALS 465
19.2.7 QUANTUM DOT (QD) NANOBIOMATERIALS 466
19.2.8 TISSUE ENGINEERING SCAFFOLD WITH NANOSTRUCTURE 467
19.3 SAFETY OF NANOBIOMATERIALS 467
19.3.1 INFLUENCE FACTOR FOR NANOSAFETY 467
19.3.2 ANALYSIS OF NANOMATERIAL TOXICITY 469
19.4 PROSPECTIVE FUTURE OF NANOBIOMATERIALS 470
REFERENCES 471
INDEX 481
|
| any_adam_object | 1 |
| author2 | Wang, Xiumei Ramalingam, Murugan Kong, Xiangdong Zhao, Lingyun |
| author2_role | edt edt edt edt |
| author2_variant | x w xw m r mr x k xk l z lz |
| author_GND | (DE-588)1153369397 (DE-588)1153363054 (DE-588)1153369958 (DE-588)1153364115 |
| author_facet | Wang, Xiumei Ramalingam, Murugan Kong, Xiangdong Zhao, Lingyun |
| building | Verbundindex |
| bvnumber | BV044668217 |
| classification_rvk | VE 9850 YI 3200 ZM 7070 ZN 3700 |
| ctrlnum | (OCoLC)1022090851 (DE-599)DNB1126451878 |
| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Werkstoffwissenschaften / Fertigungstechnik Elektrotechnik / Elektronik / Nachrichtentechnik Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV044668217 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:58:47Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 9783527340675 352734067X |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030065610 |
| oclc_num | 1022090851 |
| open_access_boolean | |
| owner | DE-703 DE-20 |
| owner_facet | DE-703 DE-20 |
| physical | xviii, 492 Seiten Illustrationen |
| publishDate | 2018 |
| publishDateSearch | 2018 |
| publishDateSort | 2018 |
| publisher | Wiley-VCH |
| record_format | marc |
| spelling | Nanobiomaterials classification, fabrication and biomedical applications edited by XiuMei Wang, Murugan Ramalingam, Xiangdong Kong, and Lingyun Zhao Weinheim, Germany Wiley-VCH [2018] xviii, 492 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Medizintechnik (DE-588)4074676-8 gnd rswk-swf Biotechnologie (DE-588)4069491-4 gnd rswk-swf Nanotechnologie (DE-588)4327470-5 gnd rswk-swf Biomedizinische Technik (DE-588)4006882-1 gnd rswk-swf Biomaterial (DE-588)4267769-5 gnd rswk-swf Werkstoff (DE-588)4065579-9 gnd rswk-swf Nanokomposit (DE-588)4768127-5 gnd rswk-swf Nanostrukturiertes Material (DE-588)4342626-8 gnd rswk-swf Biomaterial Biomaterialien Biomaterials Biomedical Engineering Biomedizinische Technik Biomedizintechnik Chemie Chemistry Nanomaterial Nanomedicine Nanomedizin Nanotechnologie Nanotechnology Pharmaceutical & Medicinal Chemistry Pharmazeutische u. Medizinische Chemie (DE-588)4143413-4 Aufsatzsammlung gnd-content Biomaterial (DE-588)4267769-5 s Nanokomposit (DE-588)4768127-5 s DE-604 Biotechnologie (DE-588)4069491-4 s Nanostrukturiertes Material (DE-588)4342626-8 s Werkstoff (DE-588)4065579-9 s Medizintechnik (DE-588)4074676-8 s Biomedizinische Technik (DE-588)4006882-1 s Nanotechnologie (DE-588)4327470-5 s Wang, Xiumei (DE-588)1153369397 edt Ramalingam, Murugan (DE-588)1153363054 edt Kong, Xiangdong (DE-588)1153369958 edt Zhao, Lingyun (DE-588)1153364115 edt Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, PDF 978-3-527-69863-9 Erscheint auch als Online-Ausgabe, EPUB 978-3-527-69865-3 Erscheint auch als Online-Ausgabe, MOBI 978-3-527-69866-0 Erscheint auch als Online-Ausgabe, oBook 978-3-527-69864-6 X:MVB http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34067-5/ DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030065610&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nanobiomaterials classification, fabrication and biomedical applications Medizintechnik (DE-588)4074676-8 gnd Biotechnologie (DE-588)4069491-4 gnd Nanotechnologie (DE-588)4327470-5 gnd Biomedizinische Technik (DE-588)4006882-1 gnd Biomaterial (DE-588)4267769-5 gnd Werkstoff (DE-588)4065579-9 gnd Nanokomposit (DE-588)4768127-5 gnd Nanostrukturiertes Material (DE-588)4342626-8 gnd |
| subject_GND | (DE-588)4074676-8 (DE-588)4069491-4 (DE-588)4327470-5 (DE-588)4006882-1 (DE-588)4267769-5 (DE-588)4065579-9 (DE-588)4768127-5 (DE-588)4342626-8 (DE-588)4143413-4 |
| title | Nanobiomaterials classification, fabrication and biomedical applications |
| title_auth | Nanobiomaterials classification, fabrication and biomedical applications |
| title_exact_search | Nanobiomaterials classification, fabrication and biomedical applications |
| title_full | Nanobiomaterials classification, fabrication and biomedical applications edited by XiuMei Wang, Murugan Ramalingam, Xiangdong Kong, and Lingyun Zhao |
| title_fullStr | Nanobiomaterials classification, fabrication and biomedical applications edited by XiuMei Wang, Murugan Ramalingam, Xiangdong Kong, and Lingyun Zhao |
| title_full_unstemmed | Nanobiomaterials classification, fabrication and biomedical applications edited by XiuMei Wang, Murugan Ramalingam, Xiangdong Kong, and Lingyun Zhao |
| title_short | Nanobiomaterials |
| title_sort | nanobiomaterials classification fabrication and biomedical applications |
| title_sub | classification, fabrication and biomedical applications |
| topic | Medizintechnik (DE-588)4074676-8 gnd Biotechnologie (DE-588)4069491-4 gnd Nanotechnologie (DE-588)4327470-5 gnd Biomedizinische Technik (DE-588)4006882-1 gnd Biomaterial (DE-588)4267769-5 gnd Werkstoff (DE-588)4065579-9 gnd Nanokomposit (DE-588)4768127-5 gnd Nanostrukturiertes Material (DE-588)4342626-8 gnd |
| topic_facet | Medizintechnik Biotechnologie Nanotechnologie Biomedizinische Technik Biomaterial Werkstoff Nanokomposit Nanostrukturiertes Material Aufsatzsammlung |
| url | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-34067-5/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030065610&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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