DNA polymerases: discovery, characterization and functions in cellular DNA transactions
Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the p...
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| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
Singapore
World Scientific Pub. Co.
c2010
|
| Subjects: | |
| Online Access: | FHN01 Volltext |
| Summary: | Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes |
| Physical Description: | xv, 321 p. ill. (some col.) |
| ISBN: | 9789814299176 |
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| physical | xv, 321 p. ill. (some col.) |
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| spelling | DNA polymerases discovery, characterization and functions in cellular DNA transactions Ulrich Hubscher ... [et al.] Singapore World Scientific Pub. Co. c2010 xv, 321 p. ill. (some col.) txt rdacontent c rdamedia cr rdacarrier Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes DNA polymerases DNS-abhängige-DNS-Polymerasen (DE-588)4150345-4 gnd rswk-swf DNS-abhängige-DNS-Polymerasen (DE-588)4150345-4 s 1\p DE-604 Hubscher, Ulrich Sonstige oth Erscheint auch als Druck-Ausgabe 9789814299169 Erscheint auch als Druck-Ausgabe 9814299162 http://www.worldscientific.com/worldscibooks/10.1142/7667#t=toc Verlag URL des Erstveroeffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | DNA polymerases discovery, characterization and functions in cellular DNA transactions DNA polymerases DNS-abhängige-DNS-Polymerasen (DE-588)4150345-4 gnd |
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| title | DNA polymerases discovery, characterization and functions in cellular DNA transactions |
| title_auth | DNA polymerases discovery, characterization and functions in cellular DNA transactions |
| title_exact_search | DNA polymerases discovery, characterization and functions in cellular DNA transactions |
| title_full | DNA polymerases discovery, characterization and functions in cellular DNA transactions Ulrich Hubscher ... [et al.] |
| title_fullStr | DNA polymerases discovery, characterization and functions in cellular DNA transactions Ulrich Hubscher ... [et al.] |
| title_full_unstemmed | DNA polymerases discovery, characterization and functions in cellular DNA transactions Ulrich Hubscher ... [et al.] |
| title_short | DNA polymerases |
| title_sort | dna polymerases discovery characterization and functions in cellular dna transactions |
| title_sub | discovery, characterization and functions in cellular DNA transactions |
| topic | DNA polymerases DNS-abhängige-DNS-Polymerasen (DE-588)4150345-4 gnd |
| topic_facet | DNA polymerases DNS-abhängige-DNS-Polymerasen |
| url | http://www.worldscientific.com/worldscibooks/10.1142/7667#t=toc |
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