Science is not a quiet life: unravelling the atomic mechanism of haemoglobin
Linus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphou...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Pub. Co.
c1997
|
| Schlagworte: | |
| Online-Zugang: | FHN01 URL des Erstveroeffentlichers |
| Zusammenfassung: | Linus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphous replacement with heavy atoms which led to the first protein structures, haemoglobin and its simpler relative myoglobin. Later papers deal with the stereochemistry of the cooperative effects of haemoglobin, with the relationships between the structures and impaired functions of abnormal haemoglobin, with species adaptation of haemoglobin, and with its action as a drug receptor and as an oxygen sensor. The final papers deal with amino acid repeats which act as polar zippers and their role in certain inherited neurodegenerative diseases |
| Beschreibung: | xxi, 636 p. ill |
| ISBN: | 9789812813039 9810230575 |
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| 520 | |a Linus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphous replacement with heavy atoms which led to the first protein structures, haemoglobin and its simpler relative myoglobin. Later papers deal with the stereochemistry of the cooperative effects of haemoglobin, with the relationships between the structures and impaired functions of abnormal haemoglobin, with species adaptation of haemoglobin, and with its action as a drug receptor and as an oxygen sensor. The final papers deal with amino acid repeats which act as polar zippers and their role in certain inherited neurodegenerative diseases | ||
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| language | English |
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| spelling | Science is not a quiet life unravelling the atomic mechanism of haemoglobin [edited by] Max Perutz Singapore World Scientific Pub. Co. c1997 xxi, 636 p. ill txt rdacontent c rdamedia cr rdacarrier Linus Pauling called haemoglobin the most interesting and important of molecules. This important volume shows how X-ray crystallography was used to determine its bewilderingly complex atomic structure and to unravel the stereochemical mechanisms of its respiratory functions. It introduces isomorphous replacement with heavy atoms which led to the first protein structures, haemoglobin and its simpler relative myoglobin. Later papers deal with the stereochemistry of the cooperative effects of haemoglobin, with the relationships between the structures and impaired functions of abnormal haemoglobin, with species adaptation of haemoglobin, and with its action as a drug receptor and as an oxygen sensor. The final papers deal with amino acid repeats which act as polar zippers and their role in certain inherited neurodegenerative diseases Hemoglobin / Structure X-ray crystallography Hemoglobinopathy Molekularpathologie (DE-588)4170396-0 gnd rswk-swf Molekülstruktur (DE-588)4170383-2 gnd rswk-swf Hämoglobinopathie (DE-588)4022815-0 gnd rswk-swf Hämoglobin (DE-588)4022814-9 gnd rswk-swf 1\p (DE-588)4143413-4 Aufsatzsammlung gnd-content Hämoglobinopathie (DE-588)4022815-0 s Molekularpathologie (DE-588)4170396-0 s 2\p DE-604 Hämoglobin (DE-588)4022814-9 s Molekülstruktur (DE-588)4170383-2 s 3\p DE-604 Perutz, Max F. Sonstige oth Erscheint auch als Druck-Ausgabe 9789810227746 Erscheint auch als Druck-Ausgabe 9810230575 http://www.worldscientific.com/worldscibooks/10.1142/3204#t=toc Verlag URL des Erstveroeffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 2\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk 3\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Science is not a quiet life unravelling the atomic mechanism of haemoglobin Hemoglobin / Structure X-ray crystallography Hemoglobinopathy Molekularpathologie (DE-588)4170396-0 gnd Molekülstruktur (DE-588)4170383-2 gnd Hämoglobinopathie (DE-588)4022815-0 gnd Hämoglobin (DE-588)4022814-9 gnd |
| subject_GND | (DE-588)4170396-0 (DE-588)4170383-2 (DE-588)4022815-0 (DE-588)4022814-9 (DE-588)4143413-4 |
| title | Science is not a quiet life unravelling the atomic mechanism of haemoglobin |
| title_auth | Science is not a quiet life unravelling the atomic mechanism of haemoglobin |
| title_exact_search | Science is not a quiet life unravelling the atomic mechanism of haemoglobin |
| title_full | Science is not a quiet life unravelling the atomic mechanism of haemoglobin [edited by] Max Perutz |
| title_fullStr | Science is not a quiet life unravelling the atomic mechanism of haemoglobin [edited by] Max Perutz |
| title_full_unstemmed | Science is not a quiet life unravelling the atomic mechanism of haemoglobin [edited by] Max Perutz |
| title_short | Science is not a quiet life |
| title_sort | science is not a quiet life unravelling the atomic mechanism of haemoglobin |
| title_sub | unravelling the atomic mechanism of haemoglobin |
| topic | Hemoglobin / Structure X-ray crystallography Hemoglobinopathy Molekularpathologie (DE-588)4170396-0 gnd Molekülstruktur (DE-588)4170383-2 gnd Hämoglobinopathie (DE-588)4022815-0 gnd Hämoglobin (DE-588)4022814-9 gnd |
| topic_facet | Hemoglobin / Structure X-ray crystallography Hemoglobinopathy Molekularpathologie Molekülstruktur Hämoglobinopathie Hämoglobin Aufsatzsammlung |
| url | http://www.worldscientific.com/worldscibooks/10.1142/3204#t=toc |
| work_keys_str_mv | AT perutzmaxf scienceisnotaquietlifeunravellingtheatomicmechanismofhaemoglobin |