DNA repair, genetic instability, and cancer:
This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in...
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Singapore
World Scientific Pub. Co.
c2007
|
| Schlagworte: | |
| Online-Zugang: | FHN01 URL des Erstveroeffentlichers |
| Zusammenfassung: | This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention |
| Beschreibung: | xx, 353 p. ill. (some col.) |
| ISBN: | 9789812706782 |
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| 520 | |a This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention | ||
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| 650 | 4 | |a Cancer / Genetic aspects | |
| 700 | 1 | |a Wei, Qingyi |e Sonstige |4 oth | |
| 700 | 1 | |a Li, Lei |e Sonstige |4 oth | |
| 700 | 1 | |a Chen, David |e Sonstige |4 oth | |
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| dewey-ones | 616 - Diseases |
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| dewey-search | 616.99/4042 |
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| discipline | Medizin |
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| id | DE-604.BV044634488 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:57:44Z |
| institution | BVB |
| isbn | 9789812706782 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030032460 |
| oclc_num | 1012623102 |
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| physical | xx, 353 p. ill. (some col.) |
| psigel | ZDB-124-WOP ZDB-124-WOP FHN_PDA_WOP |
| publishDate | 2007 |
| publishDateSearch | 2007 |
| publishDateSort | 2007 |
| publisher | World Scientific Pub. Co. |
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| spelling | DNA repair, genetic instability, and cancer editors, Qingyi Wei, Lei Li, David J. Chen Singapore World Scientific Pub. Co. c2007 xx, 353 p. ill. (some col.) txt rdacontent c rdamedia cr rdacarrier This volume describes the elaborate surveillance systems and various DNA repair mechanisms that ensure accurate passage of genetic information onto daughter cells. In particular, it narrates how the cell cycle checkpoint and DNA repair machineries detect and restore DNA damages that are embedded in millions to billions of normal base pairs. The scope of the book ranges from biochemical analyses and structural details of DNA repair proteins, to integrative genomics and population-based studies. It provides a snapshot of current understanding about some of the major DNA repair pathways, including base-excision repair, nucleotide excision repair, mismatch repair, homologous recombination, and non-homologous end-joining as well as cell cycle checkpoints and translesion DNA synthesis. One of the particular emphases of the book is the link between inherited DNA repair deficiencies and susceptibility to cancer in the general population. For the first time, the book brings together a collection of review articles written by a group of active and laboratory-based investigators who have a clear understanding of the recent advances in the fields of DNA damage repair and genomic stability and their implications in carcinogenesis, new approaches in cancer therapy, and cancer prevention Tumors / Etiology Tumors / Genetics DNA damage / Genetics DNA repair / Genetics Cancer / Genetic aspects Wei, Qingyi Sonstige oth Li, Lei Sonstige oth Chen, David Sonstige oth Erscheint auch als Druck-Ausgabe 9789812700148 Erscheint auch als Druck-Ausgabe 9812700145 http://www.worldscientific.com/worldscibooks/10.1142/6228#t=toc Verlag URL des Erstveroeffentlichers Volltext |
| spellingShingle | DNA repair, genetic instability, and cancer Tumors / Etiology Tumors / Genetics DNA damage / Genetics DNA repair / Genetics Cancer / Genetic aspects |
| title | DNA repair, genetic instability, and cancer |
| title_auth | DNA repair, genetic instability, and cancer |
| title_exact_search | DNA repair, genetic instability, and cancer |
| title_full | DNA repair, genetic instability, and cancer editors, Qingyi Wei, Lei Li, David J. Chen |
| title_fullStr | DNA repair, genetic instability, and cancer editors, Qingyi Wei, Lei Li, David J. Chen |
| title_full_unstemmed | DNA repair, genetic instability, and cancer editors, Qingyi Wei, Lei Li, David J. Chen |
| title_short | DNA repair, genetic instability, and cancer |
| title_sort | dna repair genetic instability and cancer |
| topic | Tumors / Etiology Tumors / Genetics DNA damage / Genetics DNA repair / Genetics Cancer / Genetic aspects |
| topic_facet | Tumors / Etiology Tumors / Genetics DNA damage / Genetics DNA repair / Genetics Cancer / Genetic aspects |
| url | http://www.worldscientific.com/worldscibooks/10.1142/6228#t=toc |
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