Building brains: an introduction to neural development
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| Main Authors: | , , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Hoboken, NJ
Wiley
2018
|
| Edition: | Second edition |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | xxi, 360 Seiten Illustrationen |
| ISBN: | 9781119293880 |
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MARC
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| 245 | 1 | 0 | |a Building brains |b an introduction to neural development |c David J. Price, Andrew P. Jarman, John O. Mason and Peter C. Kind |
| 250 | |a Second edition | ||
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Record in the Search Index
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| adam_text | Contents
Preface to Second Edition xi
Preface to First Edition xiii
Conventions and Commonly used
Abbreviations xv
Introduction xix
About the Companion Website xxiii
1 Models and Methods for Studying Neural
Development 1
1.1 What is neural development? 1
1.2 Why research neural development? 2
The uncertainty of current understanding 2
Implications for human health 3
Implications forfuture technologies 4
1.3 Major breakthroughs that have
contributed to understanding
developmental mechanisms 4
1.4 Invertebrate model organisms 5
Fly 5
Worm 7
Other invertebrates 11
1.5 Vertebrate model organisms 11
Frog 11
Chick 12
Zebrafish 12
Mouse 12
Humans 19
Other vertebrates 20
1.6 Observation and experiment: methods
for studying neural development 23
1.7 Summary 24
2 The Anatomy of Developing Nervous
Systems 25
2.1 The nervous system develops from
the embryonic neuroectoderm 25
2.2 Anatomical terms used to describe
locations in embryos 26
2.3 Development of the neuroectoderm
of invertebrates 27
C. elegans 27
Drosophila 27
2.4 Development of the neuroectoderm
of vertebrates and the process of
neurulation 30
Frog 31
Chick 33
Zebrafish 35
Mouse 36
Human 43
2.5 Secondary neurulation
in vertebrates 47
2.6 Formation of invertebrate
and vertebrate peripheral nervous
systems 47
Invertebrates 49
Vertebrates: the neural crest
and the placodes 49
Vertebrates: development of sense
organs 50
2.7 Summary 52
3 Neural Induction: An Example of How
Intercellular Signalling Determines
Cell Fates 53
3.1 What is neural induction? 53
3.2 Specification and commitment 54
3.3 The discovery of neural induction 54
3.4 A more recent breakthrough:
identifying molecules that mediate
neural induction 56
3.5 Conservation of neural induction
mechanisms in Drosophila 58
3.6 Beyond the default model - other
signalling pathways involved in neural
induction 59
3.7 Signal transduction: how cells respond
to intercellular signals 64
3.8 Intercellular signalling regulates gene
expression 65
Vl * CONTENTS
General mechanisms of transcriptional
regulation 65
Transcription factors involved in neural
induction 67
What genes do transcription factors
control? 69
Gene function can also be controlled by
other mechanisms 71
3.9 The essence of development:
a complex interplay of intercellular
and intracellular signalling 75
3.10 Summary 75
4 Patterning the Neuroectoderm 77
4.1 Regional patterning of the nervous
system 77
Patterns of gene expression are set
up by morphogens 78
Patterning happens progressively 80
4.2 Patterning the anteroposterior (AP) axis
of the Drosophila CNS 81
From gradients of signals to domains
of transcription factor expression 81
Dividing the ectoderm into segmental units 83
Assigning segmental identity - the Hox code 83
4.3 Patterning the AP axis of the vertebrate
CNS 86
Hox genes are highly conserved 87
Initial AP information is imparted by
the mesoderm 88
Genes that pattern the anterior brain 90
4.4 Local patterning in Drosophila:
refining neural patterning within
segments 91
In Drosophila a signalling boundary within
each segment provides local AP positional
information 92
Patterning in the Drosophila dorsoventral
(DV) axis 94
Unique neuroblast identities
from the integration of AP and DV
patterning information 96
4.5 Local patterning in the vertebrate
nervous system 97
In the vertebrate brain, AP boundaries
organize local patterning 97
Patterning in the DV axis of the vertebrate
CNS 99
Signal gradients that drive DVpatterning 100
SHH and BMP are morphogens for DV
progenitor domains in the neural tube 101
Integration ofAP and DV patterning
information 103
4.6 Summary 103
5 Neurogenesis: Generating Neural
Cells 105
5.1 Generating neural cells 105
5.2 Neurogenesis in Drosophila 106
Proneural genes promote neural
commitment 106
Lateral inhibition: Notch signalling inhibits
commitment 106
5.3 Neurogenesis in vertebrates 107
Proneural genes are conserved 107
In the vertebrate CNS, neurogenesis involves
radial glial cells 111
Proneural factors and Notch signalling
in the vertebrate CNS 111
5.4 The regulation of neuronal subtype
identity 114
Different proneural genes - different
programmes of neurogenesis 114
Combinatorial control by transcription
factors creates neuronal diversity 114
5.5 The regulation of cell proliferation
during neurogenesis 117
Signals that promote proliferation 117
Cell division patterns during
neurogenesis 118
Asymmetric cell division in Drosophila
requires Numb 118
Control of asymmetric cell division
in vertebrate neurogenesis 121
In vertebrates, division patterns are
regulated to generate vast numbers
of neurons 122
5.6 Temporal regulation of neural
identity 124
A neural cells time of birth is important
for neural identity 124
Time of birth can generate spatial patterns
of neurons 126
How does birth date influence a neuron’s
fate? 128
Intrinsic mechanism of temporal control
in Drosophila neuroblasts 128
Birth date, lamination and competence
in the mammalian cortex 129
5.7 Why do we need to know about
neurogenesis? 133
5.8 Summary 133
6 How Neurons Develop Their Shapes 135
6.1 Neurons form two specialized types
of outgrowth 135
Axons and dendrites 135
The cytoskeleton in mature axons
and dendrites 137
CONTENTS • Vll
6.2 The growing neurite 138
A neurite extends by growth at its tip 138
Mechanisms of growth cone
dynamics 139
6.3 Stages of neurite outgrowth 141
Neurite outgrowth in cultured hippocampal
neurons 141
Neurite outgrowth in vivo 142
6.4 Neurite outgrowth is influenced
by a neuron s surroundings 143
The importance of extracellular cues 143
Extracellular signals that promote or inhibit
neurite outgrowth 143
6.5 Molecular responses in the growth
cone 145
Key intracellular signal transduction
events 145
Small G proteins are critical regulators
of neurite growth 145
Effector molecules directly influence actin
filament dynamics 147
Regulation of other processes in the extending
neurite 148
6.6 Active transport along the axon is
important for outgrowth 149
6.7 The developmental regulation
of neuronal polarity 149
Signalling during axon specification 149
Ensuring there is just one axon 151
Which neurite becomes the axon? 152
6.8 Dendrites 153
Regulation of dendrite branching 153
Dendrite branches undergo
self-avoidance 154
Dendritic fields exhibit tiling 155
6.9 Summary 156
7 Neuronal Migration 157
7.1 Many neurons migrate long distances
during formation of the nervous
system 157
7.2 How can neuronal migration
be observed? 157
Watching neurons move in living
embryos 158
Observing migrating neurons in cultured
tissues 158
Tracking cell migration by indirect
methods 158
7.3 Major modes of migration 164
Some migrating neurons are guided by
a scaffold 164
Some neurons migrate in groups 165
Some neurons migrate individually 168
7.4 Initiation of migration 169
Initiation of neural crest cell
migration 170
Initiation of neuronal migration 170
7.5 How are migrating cells guided to their
destinations? 170
Directional migration of neurons in
C. elegans 171
Guidance of neural crest cell
migration 173
Guidance of neural precursors
in the developing lateral line
of zebrafish 174
Guidance by radial glial fibres 174
7.6 Locomotion 176
7.7 Journeys end - termination
of migration 179
7.8 Embryonic cerebral cortex contains
both radially and tangentially migrating
cells 182
7.9 Summary 184
8 Axon Guidance 185
8.1 Many axons navigate long and complex
routes 185
How might axons be guided to their
targets? 185
The growth cone 187
Breaking the journey - intermediate
targets 188
8.2 Contact guidance 190
Contact guidance in action: pioneers
and followers, fasciculation
and defasciculation 191
Ephs and ephrins: versatile cell surface
molecules with roles in contact
guidance 191
8.3 Guidance of axons by diffusible
cues - chemotropism 194
Netrin - a chemotropic cue expressed
at the ventral midline 195
Slits 195
Semaphorins 198
Other axon guidance molecules 198
8.4 How do axons change their behaviour
at choice points? 199
Commissural axons lose their attraction
to netrin once they have crossed the
floor plate 199
Putting it all together - guidance cues
and their receptors choreograph commissural
axon pathfinding at the ventral midline 202
After crossing the midline, commissural
axons project towards the brain 205
viii • CONTENTS
8.5 How can such a small number of cues
guide such a large number of axons? 207
The same guidance cues are deployed
in multiple axon pathways 208
Interactions between guidance cues and their
receptors can be altered by co-factors 208
8.6 Some axons form specific connections
over very short distances, probably
using different mechanisms 209
8.7 The growth cone has autonomy in its
ability to respond to guidance cues 209
Growth cones can still navigate when severed
from their cell bodies 209
Local translation in growth cones 210
8.8 Transcription factors regulate axon
guidance decisions 211
8.9 Summary 212
9 Life and Death in the Developing
Nervous System 215
9.1 The frequency and function of cell
death during normal development 215
9.2 Cells die in one of two main ways:
apoptosis or necrosis 217
9.3 Studies in invertebrates have taught us
much about how cells kill
themselves 219
The specification phase 221
The killing phase 221
The engulfment phase 222
9.4 Most of the genes that regulate
programmed cell death in C. elegans are
conserved in vertebrates 222
9.5 Examples of neurodevelopmental
processes in which programmed cell
death plays a prominent role 224
Programmed cell death in early progenitor
cell populations 224
Programmed cell death contributes to sexual
differences in the nervous system 225
Programmed cell death removes cells
with transient functions once their task is
done 227
Programmed cell death matches the numbers
of cells in interacting neural tissues 230
9.6 Neurotrophic factors are important
regulators of cell survival
and death 232
Growth factors 232
Cytokines 235
9.7 A role for electrical activity in regulating
programmed cell death 235
9.8 Summary 237
10 Map Formation 239
10.1 What are maps? 239
10.2 Types of maps 239
Coarse maps 241
Fine maps 242
10.3 Principles of map formation 243
Axon order during development 244
Theories of map formation 245
10.4 Development of coarse maps:
cortical areas 246
Protomap versus protocortex 246
Spatial position of cortical areas 247
10.5 Development of fine maps:
topographic 248
Retinotectal pathways 248
Sperry and the chemoaffinity
hypothesis 250
Ephrins act as molecular postcodes
in the chick tectum 252
10.6 Inputs from multiple structures:
when maps collide 253
From retina to cortex in mammals 254
Activity-dependent eye-specific segregation:
a role for retinal waves 254
Formation of ocular dominance
bands 257
Ocular dominance bands form by directed
ingrowth of thalamocortical axons 257
Activity and the formation of ocular
dominance bands 259
Integration of sensory maps 260
10.7 Development of feature maps 261
Feature maps in the visual system 261
Role of experience in orientation
and direction map formation 263
10.8 Summary 264
11 Maturation of Functional
Properties 265
11.1 Neurons are excitable cells 266
What makes a cell excitable? 266
Electrical properties of neurons 267
Regulation of intrinsic neuronal
physiology 269
11.2 Neuronal excitability during
development 271
Neuronal excitability changes dramatically
during development 271
Early action potentials are driven
by Ca2+, notNa+ 271
Neurotransmitter receptors regulate
excitability prior to synapse formation 273
GABAergic receptor activation switches
from being excitatory to inhibitory 273
CONTENTS • IX
11.3 Developmental processes regulated by
neuronal excitability 275
Electrical excitability regulates neuronal
proliferation and migration 275
Neuronal activity and axon guidance 277
11.4 Synaptogenesis 277
The synapse 278
Electrical properties of dendrites 278
Stages of synaptogenesis 280
Synaptic specification and induction 281
Synapse formation 285
Synapse selection: stabilization
and withdrawal 286
11.5 Spinogenesis 286
Spine shape and dynamics 287
Theories of spinogenesis 289
Mouse models of spinogenesis: the weaver
mutant 290
Molecular regulators of spine
development 291
11.6 Summary 293
12 Experience-Dependent Development 295
12.1 Effects of experience on visual system
development 296
Seeing one world with two eyes: ocular
dominance of cortical cells 296
Visual experience regulates ocular
dominance 297
Competition regulates experience-
dependent plasticity: the effects of dark-
rearing and strabismus 299
Physiological changes in ocular dominance
prior to anatomical changes 301
Cooperative binocular interactions
and visual cortex plasticity 304
The timing of developmental plasticity:
sensitive or critical periods 305
Multiple sensitive periods in the developing
visual system 306
12.2 How does experience change
functional connectivity? 307
Cellular basis of plasticity: synaptic
strengthening and weakening 309
The time-course of changes in synaptic
weight in response to monocular
deprivation 310
Cellular and molecular mechanisms
ofLTP/LTD induction 312
Synaptic changes that mediate the
expression of LTP/LTD and experience-
dependent plasticity 314
Metaplasticity 318
Spike-timing dependent plasticity 320
12.3 Cellular basis of plasticity:
development of inhibitory
networks 322
Inhibition contributes to the expression
of the effects of monocular
deprivation 322
Development of inhibitory circuits regulates
the time-course of the sensitive period
for monocular deprivation 323
12.4 Homeostatic plasticity 324
Mechanisms of homeostatic
plasticity 325
12.5 Structural plasticity and the role of the
extracellular matrix 327
12.6 Summary 328
Glossary 329
Index 349
|
| any_adam_object | 1 |
| author | Price, David J. 1957- Jarman, Andrew P. Mason, John O. Kind, Peter C. |
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| dewey-full | 612.82 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 612 - Human physiology |
| dewey-raw | 612.82 |
| dewey-search | 612.82 |
| dewey-sort | 3612.82 |
| dewey-tens | 610 - Medicine and health |
| discipline | Biologie Psychologie Medizin |
| edition | Second edition |
| format | Book |
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| id | DE-604.BV044620488 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:57:21Z |
| institution | BVB |
| isbn | 9781119293880 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-030018774 |
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| spelling | Price, David J. 1957- Verfasser (DE-588)1011622378 aut Building brains an introduction to neural development David J. Price, Andrew P. Jarman, John O. Mason and Peter C. Kind Second edition Hoboken, NJ Wiley 2018 xxi, 360 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Gehirn (DE-588)4019752-9 gnd rswk-swf Neurogenese (DE-588)4331352-8 gnd rswk-swf Entwicklung (DE-588)4113450-3 gnd rswk-swf Brain--Growth. Developmental neurobiology. Neurogenese (DE-588)4331352-8 s DE-188 Gehirn (DE-588)4019752-9 s Entwicklung (DE-588)4113450-3 s 1\p DE-604 Jarman, Andrew P. Verfasser aut Mason, John O. Verfasser aut Kind, Peter C. Verfasser aut Erscheint auch als Online-Ausgabe, PDF 978-1-119-29391-0 Erscheint auch als Online-Ausgabe, EPUB 978-1-119-29371-2 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030018774&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Price, David J. 1957- Jarman, Andrew P. Mason, John O. Kind, Peter C. Building brains an introduction to neural development Gehirn (DE-588)4019752-9 gnd Neurogenese (DE-588)4331352-8 gnd Entwicklung (DE-588)4113450-3 gnd |
| subject_GND | (DE-588)4019752-9 (DE-588)4331352-8 (DE-588)4113450-3 |
| title | Building brains an introduction to neural development |
| title_auth | Building brains an introduction to neural development |
| title_exact_search | Building brains an introduction to neural development |
| title_full | Building brains an introduction to neural development David J. Price, Andrew P. Jarman, John O. Mason and Peter C. Kind |
| title_fullStr | Building brains an introduction to neural development David J. Price, Andrew P. Jarman, John O. Mason and Peter C. Kind |
| title_full_unstemmed | Building brains an introduction to neural development David J. Price, Andrew P. Jarman, John O. Mason and Peter C. Kind |
| title_short | Building brains |
| title_sort | building brains an introduction to neural development |
| title_sub | an introduction to neural development |
| topic | Gehirn (DE-588)4019752-9 gnd Neurogenese (DE-588)4331352-8 gnd Entwicklung (DE-588)4113450-3 gnd |
| topic_facet | Gehirn Neurogenese Entwicklung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=030018774&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT pricedavidj buildingbrainsanintroductiontoneuraldevelopment AT jarmanandrewp buildingbrainsanintroductiontoneuraldevelopment AT masonjohno buildingbrainsanintroductiontoneuraldevelopment AT kindpeterc buildingbrainsanintroductiontoneuraldevelopment |