Inorganic and organometallic transition metal complexes with biological molecules and living cells:
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| Other Authors: | |
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| Format: | Book |
| Language: | English |
| Published: |
London
Academic Press, an imprint of Elsevier
[2017]
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Item Description: | Includes bibliographical references and index |
| Physical Description: | xii, 393 Seiten Illustrationen, Diagramme 23 cm |
| ISBN: | 9780128038147 0128038144 |
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MARC
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| 245 | 1 | 0 | |a Inorganic and organometallic transition metal complexes with biological molecules and living cells |c edited by Kenneth Kam-Wing Lo, City University of Hong-Kong, Hong Kong |
| 264 | 1 | |a London |b Academic Press, an imprint of Elsevier |c [2017] | |
| 300 | |a xii, 393 Seiten |b Illustrationen, Diagramme |c 23 cm | ||
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| 500 | |a Includes bibliographical references and index | ||
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Record in the Search Index
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| adam_text | CONTENTS
List of Contributors ix
Preface xi
1 Luminescent Zinc Complexes as Bioprobes for Imaging
Molecular Events in Live Cells 1
J Tang, H -Y Yin and J -L Zhang
1 Introduction 2
2 General Considerations 3
3 Luminescent Zinc Complexes as Bioprobes 7
4 Conclusion and Outlook 42
Acknowledgment 45
References 45
2 Cellular Uptake and Sensing Capability of Transition Metal
Peptide Conjugates 55
C Dolan, C S Burke, A Byrne and T E Keyes
1 Introduction 55
2 Transition Metal Complexes for Cell Imaging and Sensing 57
3 Cell-Penetrating Peptides 58
4 Mechanism of CPP Uptake 60
5 CPP Modified Transition Metal Luminophores for Sensing
and Imaging 63
6 Signal Peptide-Modified Transition Metal Luminophores 71
7 Conclusions and Future Outlook 84
Acknowledgments 85
References 85
3 Luminescent Rhenium(l) and Iridium(lll) Complexes for
Intracellular Labeling, Sensing, and Photodynamic
Therapy Applications 91
K Y Zhang
1 Introduction 91
2 Intracellular Labels 92
3 Intracellular Sensors 101
v
vi
Contents
4 Ratiometric Sensors 109
5 PhotodynamicTherapy 113
6 Conclusion 115
Acknowledgments 115
References 115
4 Organoruthenium(ll)-Arene Complexes: Structural Building
Blocks for Anticancer Drug Discovery 119
MJ Chow and W H Ang
1 Introduction 119
2 Accessing the Ruthenium(ll)-Arene Scaffold 121
3 Ru(ll)-Arene Drug Candidates Under Investigation 123
4 Cytotoxic Ru(ll)-Arene Complexes via Classical Approaches 125
5 Nonclassical Ru(ll)-Arene Complexes by Rational Design 128
6 Nonclassical Ru(ll)-Arene Complexes From Classical Approaches 134
7 Conclusion 137
References 138
5 Medicinal Chemistry of Metal A/-Heterocyclic Carbene (NHC)
Complexes 147
I Ott
1 Introduction 147
2 Metal NHC Complexes With Classical N-C-N Carbene Ligands 149
3 Metal NHC Complexes With Nonclassical NHC Ligands and
Heterobimetallic Metal NHC Complexes 166
4 Metal NHC Complexes With Biologically Active, Biogenic,
or Targeting Ligands 169
5 Conclusions 172
References 173
6 Metal Complexes as Delivery Systems for CO, NO, and H2S to
Explore the Signaling Network of Small-Molecule Messengers 181
U Schatzschneider
1 Introduction 181
2 Enzymatic Generation of CO, NO, and H2S 182
3 Delivery Systems for CO, NO, and H2S 186
4 Molecular Probes for Small-Molecule Messengers 192
5 Cellular Target Structures of CO, NO, and H2S 196
6 Summary 199
References 199
Contents
vii
7 Antimicrobial Metallodrugs 205
D H Simpson and P Scott
1 Introduction 205
2 Redox-Active Metal Complexes 213
3 Complexes With Reactive Metal Centers 216
4 Complexes That Release Carbon Monoxide 218
5 Metal Centers as Structural Templates 219
6 Outlook 234
Acknowledgments 236
References 236
8 Carbon Nanotubes and Related Nanohybrids Incorporating
Inorganic Transition Metal Compounds and Radioactive
Species as Synthetic Scaffolds for Nanomedicine Design 245
F Cortezon-Tamarit, H Ge, V Mirabello, MBM Theobald,
D G Calatayud and S l Pascu
1 Introduction 246
2 Positron Emission Tomography-Single-Photon Emission Computed
Tomography Metal Complex Bioconjugates 259
3 Potential Application of Carbon Nanomaterial Nanohybrids Incorporating
Inorganic Transition Metal Complexes in Biomedical Applications 278
4 Conclusions and Future Prospects 306
Acknowledgments 309
References 309
9 Immobilized Metal Affinity Chromatography (IMAC) for
Metalloproteomics and Phosphoproteomics 329
Y -Y Chang, H Li and H Sun
1 Introduction 329
2 Principles and Design of Immobilized Metal Affinity Chromatography
Columns 331
3 Immobilized Metal Affinity Chromatography for Metalloproteomic
Study 333
4 Immobilized Metal Affinity Chromatography for the Analysis of Protein
Phosphorylation 341
5 Novel Polymer-Based Metal Ion Affinity Capture: Alternative to
Immobilized Metal Affinity Chromatography 347
6 Conclusion 348
Acknowledgments 348
References 349
viii
Contents
10 The Analysis of Therapeutic Metal Complexes and Their
Biomolecular Interactions 355
M P Sullivan, H U Holtkamp, S M Meier and C G Hartinger
1 Introduction 355
2 Metallodrug Binding to Blood Serum Proteins 357
3 Tissue Distribution and Cellular Accumulation 365
4 Cellular Targets 369
5 Conclusions 379
Acknowledgments 380
References 380
|
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| id | DE-604.BV044560546 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:55:55Z |
| institution | BVB |
| isbn | 9780128038147 0128038144 |
| language | English |
| lccn | 017288609 |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029959168 |
| oclc_num | 1013591620 |
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| owner | DE-19 DE-BY-UBM DE-20 |
| owner_facet | DE-19 DE-BY-UBM DE-20 |
| physical | xii, 393 Seiten Illustrationen, Diagramme 23 cm |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Academic Press, an imprint of Elsevier |
| record_format | marc |
| spelling | Inorganic and organometallic transition metal complexes with biological molecules and living cells edited by Kenneth Kam-Wing Lo, City University of Hong-Kong, Hong Kong London Academic Press, an imprint of Elsevier [2017] xii, 393 Seiten Illustrationen, Diagramme 23 cm txt rdacontent n rdamedia nc rdacarrier Includes bibliographical references and index Transition metal complexes / fast / (OCoLC)fst01154759 Transition metal complexes Übergangsmetallkomplexe (DE-588)4131837-7 gnd rswk-swf Übergangsmetallkomplexe (DE-588)4131837-7 s DE-604 Lo, Kenneth Kam-Wing (DE-588)1074371550 edt HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029959168&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Inorganic and organometallic transition metal complexes with biological molecules and living cells Transition metal complexes / fast / (OCoLC)fst01154759 Transition metal complexes Übergangsmetallkomplexe (DE-588)4131837-7 gnd |
| subject_GND | (DE-588)4131837-7 |
| title | Inorganic and organometallic transition metal complexes with biological molecules and living cells |
| title_auth | Inorganic and organometallic transition metal complexes with biological molecules and living cells |
| title_exact_search | Inorganic and organometallic transition metal complexes with biological molecules and living cells |
| title_full | Inorganic and organometallic transition metal complexes with biological molecules and living cells edited by Kenneth Kam-Wing Lo, City University of Hong-Kong, Hong Kong |
| title_fullStr | Inorganic and organometallic transition metal complexes with biological molecules and living cells edited by Kenneth Kam-Wing Lo, City University of Hong-Kong, Hong Kong |
| title_full_unstemmed | Inorganic and organometallic transition metal complexes with biological molecules and living cells edited by Kenneth Kam-Wing Lo, City University of Hong-Kong, Hong Kong |
| title_short | Inorganic and organometallic transition metal complexes with biological molecules and living cells |
| title_sort | inorganic and organometallic transition metal complexes with biological molecules and living cells |
| topic | Transition metal complexes / fast / (OCoLC)fst01154759 Transition metal complexes Übergangsmetallkomplexe (DE-588)4131837-7 gnd |
| topic_facet | Transition metal complexes / fast / (OCoLC)fst01154759 Transition metal complexes Übergangsmetallkomplexe |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029959168&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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