Biomedical applications of acridines: derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Cham, Switzerland
Springer
[2017]
|
| Series: | Progress in drug research
volume 72 |
| Subjects: | |
| Online Access: | DE-523 Inhaltsverzeichnis |
| Physical Description: | xiii,, 237 Seiten Illustrationen, Diagramme |
| ISBN: | 9783319639529 |
Staff View
MARC
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| 100 | 1 | |a Ježek, Jan |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Biomedical applications of acridines |b derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases |c Jan Ježek, Jan Hlaváček, Jaroslav Šebestík |
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| 650 | 4 | |a Neurochemistry | |
| 650 | 4 | |a Pharmacology | |
| 650 | 4 | |a Bioorganic chemistry | |
| 650 | 4 | |a Medicinal chemistry | |
| 650 | 4 | |a Nucleic acids | |
| 650 | 4 | |a Proteins | |
| 650 | 4 | |a Chemistry | |
| 650 | 4 | |a Medicinal Chemistry | |
| 650 | 4 | |a Neurochemistry | |
| 650 | 4 | |a Pharmacology/Toxicology | |
| 650 | 4 | |a Protein-Ligand Interactions | |
| 650 | 4 | |a Bioorganic Chemistry | |
| 650 | 4 | |a Nucleic Acid Chemistry | |
| 650 | 4 | |a Chemie | |
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| 650 | 0 | 7 | |a Nervendegeneration |0 (DE-588)4300182-8 |2 gnd |9 rswk-swf |
| 650 | 0 | 7 | |a Acridin |0 (DE-588)4347531-0 |2 gnd |9 rswk-swf |
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Record in the Search Index
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Contents
1 Introduction. 1
References. 3
2 Nomenclature. 5
References. 6
3 Syntheses. 9
3.1 Syntheses of Acridine Ring and Its Precursors. 9
3.2 Acridine-Peptide Conjugates. . 26
3.3 Acridines as Catalysts. 31
References. 33
4 Interactions of Acridines with Nucleic Acids. 47
4.1 DNA. 47
4.2 DNA Quadruplexes. 51
4.3 RNA. 54
4.4 PNA. 56
4.5 Acridine Metal Complexes. 57
4.6 Structural Aspects of Nucleic Acid Binding. 59
References. 64
5 Interactions with Proteins. 73
5.1 Interactions with Nucleic Acids Processing Proteins. 73
5.1.1 Topoisomerases. 74
5.1.2 Transcription Factors. 76
5.1.3 RecA Protein. 76
5.1.4 Telomerase. 76
5.2 Interactions with Other Proteins. 77
5.3 Structural Aspects of Acridine Interactions with Proteins. 83
References. 90
ix
x Contents
6 Applications for Treatment of Neurodegenerative Diseases. 99
6.1 Alzheimer’s Disease. 104
6.1.1 Multitargeted Strategy in AD. 108
6.2 Parkinson’s Disease. 112
6.3 Prion Diseases. 114
6.4 Other Neurodegenerative Diseases. 118
References. 121
7 Some Application of Selective Toxicities of Acridines. 135
7.1 Antiparasitic Drug. 135
7.2 Cancer Treatment. 146
7.3 Antibacterial Drugs. 153
7.4 Antiviral Drugs. 154
References. . 155
8 Pharmacokinetics and Metabolism of Acridine Drugs. 165
References. . 1^1
9 Acridine on Dendrimeric Carriers. . 187
9.1 Application for Drug and Gene Delivery. 188
References. 190
10 Acridines Used for Staining. 193
References. 201
11 Miscellaneous. 207
References. 209
12 Conclusions and Outlook. 211
Index. 213 |
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| author_facet | Ježek, Jan Hlaváček, Jan Šebestík, Jaroslav |
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| dewey-ones | 615 - Pharmacology and therapeutics |
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| id | DE-604.BV044484831 |
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| indexdate | 2024-12-06T19:01:15Z |
| institution | BVB |
| isbn | 9783319639529 |
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| physical | xiii,, 237 Seiten Illustrationen, Diagramme |
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| spelling | Ježek, Jan Verfasser aut Biomedical applications of acridines derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases Jan Ježek, Jan Hlaváček, Jaroslav Šebestík Cham, Switzerland Springer [2017] xiii,, 237 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Progress in drug research volume 72 Chemistry Neurochemistry Pharmacology Bioorganic chemistry Medicinal chemistry Nucleic acids Proteins Medicinal Chemistry Pharmacology/Toxicology Protein-Ligand Interactions Bioorganic Chemistry Nucleic Acid Chemistry Chemie Biologische Aktivität (DE-588)4291566-1 gnd rswk-swf Nervendegeneration (DE-588)4300182-8 gnd rswk-swf Acridin (DE-588)4347531-0 gnd rswk-swf Aufsatzsammlung gnd rswk-swf Acridin (DE-588)4347531-0 s Biologische Aktivität (DE-588)4291566-1 s Nervendegeneration (DE-588)4300182-8 s Aufsatzsammlung f DE-604 Hlaváček, Jan Verfasser aut Šebestík, Jaroslav Verfasser aut Erscheint auch als Online-Ausgabe 978-3-319-63953-6 Progress in drug research volume 72 (DE-604)BV002528909 72 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029884934&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Ježek, Jan Hlaváček, Jan Šebestík, Jaroslav Biomedical applications of acridines derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases Progress in drug research Chemistry Neurochemistry Pharmacology Bioorganic chemistry Medicinal chemistry Nucleic acids Proteins Medicinal Chemistry Pharmacology/Toxicology Protein-Ligand Interactions Bioorganic Chemistry Nucleic Acid Chemistry Chemie Biologische Aktivität (DE-588)4291566-1 gnd Nervendegeneration (DE-588)4300182-8 gnd Acridin (DE-588)4347531-0 gnd |
| subject_GND | (DE-588)4291566-1 (DE-588)4300182-8 (DE-588)4347531-0 |
| title | Biomedical applications of acridines derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases |
| title_auth | Biomedical applications of acridines derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases |
| title_exact_search | Biomedical applications of acridines derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases |
| title_full | Biomedical applications of acridines derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases Jan Ježek, Jan Hlaváček, Jaroslav Šebestík |
| title_fullStr | Biomedical applications of acridines derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases Jan Ježek, Jan Hlaváček, Jaroslav Šebestík |
| title_full_unstemmed | Biomedical applications of acridines derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases Jan Ježek, Jan Hlaváček, Jaroslav Šebestík |
| title_short | Biomedical applications of acridines |
| title_sort | biomedical applications of acridines derivatives syntheses properties and biological activities with a focus on neurodegenerative diseases |
| title_sub | derivatives, syntheses, properties and biological activities with a focus on neurodegenerative diseases |
| topic | Chemistry Neurochemistry Pharmacology Bioorganic chemistry Medicinal chemistry Nucleic acids Proteins Medicinal Chemistry Pharmacology/Toxicology Protein-Ligand Interactions Bioorganic Chemistry Nucleic Acid Chemistry Chemie Biologische Aktivität (DE-588)4291566-1 gnd Nervendegeneration (DE-588)4300182-8 gnd Acridin (DE-588)4347531-0 gnd |
| topic_facet | Chemistry Neurochemistry Pharmacology Bioorganic chemistry Medicinal chemistry Nucleic acids Proteins Medicinal Chemistry Pharmacology/Toxicology Protein-Ligand Interactions Bioorganic Chemistry Nucleic Acid Chemistry Chemie Biologische Aktivität Nervendegeneration Acridin Aufsatzsammlung |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029884934&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| volume_link | (DE-604)BV002528909 |
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