Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders:
Gespeichert in:
| Format: | Elektronisch E-Book |
|---|---|
| Sprache: | English |
| Veröffentlicht: |
Stamford, Conn.
JAI Press
©1999
|
| Schriftenreihe: | Advances in cell aging and gerontology
3 |
| Schlagworte: | |
| Online-Zugang: | FAW01 URL des Erstveröffentlichers |
| Beschreibung: | Includes bibliographical references and index Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested |
| Beschreibung: | xiv, 428 pages |
| ISBN: | 0762304057 9780762304059 |
Internformat
MARC
| LEADER | 00000nmm a2200000zcb4500 | ||
|---|---|---|---|
| 001 | BV044380928 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 170630s1999 |||| o||u| ||||||eng d | ||
| 020 | |a 0762304057 |9 0-7623-0405-7 | ||
| 020 | |a 9780762304059 |9 978-0-7623-0405-9 | ||
| 035 | |a (ZDB-33-ESD)ocn646757007 | ||
| 035 | |a (OCoLC)646757007 | ||
| 035 | |a (DE-599)BVBBV044380928 | ||
| 040 | |a DE-604 |b ger |e aacr | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-1046 | ||
| 082 | 0 | |a 571.8/78 |2 23 | |
| 245 | 1 | 0 | |a Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders |c volume editor, Mark P. Mattson |
| 264 | 1 | |a Stamford, Conn. |b JAI Press |c ©1999 | |
| 300 | |a xiv, 428 pages | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Advances in cell aging and gerontology |v 3 | |
| 500 | |a Includes bibliographical references and index | ||
| 500 | |a Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested | ||
| 650 | 7 | |a Cells / Aging |2 fast | |
| 650 | 7 | |a Nervous system / Degeneration / Genetic aspects |2 fast | |
| 650 | 7 | |a Nervous system / Degeneration / Molecular aspects |2 fast | |
| 650 | 4 | |a Cells |x Aging | |
| 650 | 4 | |a Nervous system |x Degeneration |x Genetic aspects | |
| 650 | 4 | |a Nervous system |x Degeneration |x Molecular aspects | |
| 700 | 1 | |a Mattson, Mark Paul |e Sonstige |4 oth | |
| 856 | 4 | 0 | |u http://www.sciencedirect.com/science/bookseries/15663124/3 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-33-ESD | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-029783150 | ||
| 966 | e | |u http://www.sciencedirect.com/science/bookseries/15663124/3 |l FAW01 |p ZDB-33-ESD |q FAW_PDA_ESD |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804177643865636864 |
|---|---|
| any_adam_object | |
| building | Verbundindex |
| bvnumber | BV044380928 |
| collection | ZDB-33-ESD |
| ctrlnum | (ZDB-33-ESD)ocn646757007 (OCoLC)646757007 (DE-599)BVBBV044380928 |
| dewey-full | 571.8/78 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.8/78 |
| dewey-search | 571.8/78 |
| dewey-sort | 3571.8 278 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03615nmm a2200433zcb4500</leader><controlfield tag="001">BV044380928</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">170630s1999 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">0762304057</subfield><subfield code="9">0-7623-0405-7</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780762304059</subfield><subfield code="9">978-0-7623-0405-9</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-33-ESD)ocn646757007</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)646757007</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV044380928</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">aacr</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-1046</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">571.8/78</subfield><subfield code="2">23</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders</subfield><subfield code="c">volume editor, Mark P. Mattson</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Stamford, Conn.</subfield><subfield code="b">JAI Press</subfield><subfield code="c">©1999</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">xiv, 428 pages</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Advances in cell aging and gerontology</subfield><subfield code="v">3</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Includes bibliographical references and index</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Cells / Aging</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Nervous system / Degeneration / Genetic aspects</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Nervous system / Degeneration / Molecular aspects</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Cells</subfield><subfield code="x">Aging</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nervous system</subfield><subfield code="x">Degeneration</subfield><subfield code="x">Genetic aspects</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Nervous system</subfield><subfield code="x">Degeneration</subfield><subfield code="x">Molecular aspects</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Mattson, Mark Paul</subfield><subfield code="e">Sonstige</subfield><subfield code="4">oth</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">http://www.sciencedirect.com/science/bookseries/15663124/3</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-33-ESD</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-029783150</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">http://www.sciencedirect.com/science/bookseries/15663124/3</subfield><subfield code="l">FAW01</subfield><subfield code="p">ZDB-33-ESD</subfield><subfield code="q">FAW_PDA_ESD</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV044380928 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:51:21Z |
| institution | BVB |
| isbn | 0762304057 9780762304059 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029783150 |
| oclc_num | 646757007 |
| open_access_boolean | |
| owner | DE-1046 |
| owner_facet | DE-1046 |
| physical | xiv, 428 pages |
| psigel | ZDB-33-ESD ZDB-33-ESD FAW_PDA_ESD |
| publishDate | 1999 |
| publishDateSearch | 1999 |
| publishDateSort | 1999 |
| publisher | JAI Press |
| record_format | marc |
| series2 | Advances in cell aging and gerontology |
| spelling | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders volume editor, Mark P. Mattson Stamford, Conn. JAI Press ©1999 xiv, 428 pages txt rdacontent c rdamedia cr rdacarrier Advances in cell aging and gerontology 3 Includes bibliographical references and index Genetic Aberrancies and Neurodegenerative Disorders presents critical reviews and emerging findings concerning the roles of genetic mutations and polymorphisms in the pathogenesis of a range of neurological disorders including Alzheimer's and Parkinson's diseases, trinucleotide repeat disorders, stroke, epilepsy and others. This volume, written by leading experts, brings together fundamental information concerning the roles of inherited traits in the pathogenesis of different neurodegenerative disorders. In addition to providing a catalogue of the known genetic alterations that are linked to specific neurodegenerative disorders, the chapters detail the current state of understanding of the cellular and biochemical mechanisms whereby the genetic aberrancies lead to neuronal dysfunction and degeneration. The emerging picture of each disorder, painted by pathological, biochemical and molecular brushes, suggests that they share key mechanisms including increased levels of oxidative stress, perturbed ion homeostasis, mitochondrial dysfunction and apoptotic proteolytic cascades. The existence of specific molecular defects provides the opportunity to design experiments that can establish the precise pathogenic mechanism of a specific mutation or genetic risk factor. The value of this approach is exemplified by recent studies of how mutations in Cu/Zn-superoxide dismutase cause amyotrophic lateral sclerosis and how presenilin mutations result in early-onset Alzheimer's disease. A theme developed among the different chapters is that events that occur during aging predispose neurons to genetic aberrancies that promote degenerative cascades, and that specific genetic defects exert their influence on particular populations of neurons in a disorder-specific manner. The chapters in this volume will stimulate readers to generate new hypotheses concerning the pathogenic mechanisms of genetic aberrancies that can be experimentally tested Cells / Aging fast Nervous system / Degeneration / Genetic aspects fast Nervous system / Degeneration / Molecular aspects fast Cells Aging Nervous system Degeneration Genetic aspects Nervous system Degeneration Molecular aspects Mattson, Mark Paul Sonstige oth http://www.sciencedirect.com/science/bookseries/15663124/3 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders Cells / Aging fast Nervous system / Degeneration / Genetic aspects fast Nervous system / Degeneration / Molecular aspects fast Cells Aging Nervous system Degeneration Genetic aspects Nervous system Degeneration Molecular aspects |
| title | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders |
| title_auth | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders |
| title_exact_search | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders |
| title_full | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders volume editor, Mark P. Mattson |
| title_fullStr | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders volume editor, Mark P. Mattson |
| title_full_unstemmed | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders volume editor, Mark P. Mattson |
| title_short | Advances in cell aging and gerontology, Volume 3, Genetic aberrancies and neurodegenerative disorders |
| title_sort | advances in cell aging and gerontology volume 3 genetic aberrancies and neurodegenerative disorders |
| topic | Cells / Aging fast Nervous system / Degeneration / Genetic aspects fast Nervous system / Degeneration / Molecular aspects fast Cells Aging Nervous system Degeneration Genetic aspects Nervous system Degeneration Molecular aspects |
| topic_facet | Cells / Aging Nervous system / Degeneration / Genetic aspects Nervous system / Degeneration / Molecular aspects Cells Aging Nervous system Degeneration Genetic aspects Nervous system Degeneration Molecular aspects |
| url | http://www.sciencedirect.com/science/bookseries/15663124/3 |
| work_keys_str_mv | AT mattsonmarkpaul advancesincellagingandgerontologyvolume3geneticaberranciesandneurodegenerativedisorders |