Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome: = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | German |
| Published: |
Würzburg
Juni 2016
|
| Subjects: | |
| Online Access: | Volltext Inhaltsverzeichnis Inhaltsverzeichnis |
| Physical Description: | 123 Seiten Illustrationen, Diagramme 21 cm |
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| 246 | 1 | 1 | |a Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas |
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Record in the Search Index
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|---|---|
| adam_text | AUS DEM INSTITUT FUER PATHOLOGIE
DER UNIVERSITAET WUERZBURG
VORSTAND: PROFESSOR DR. MED. ANDREAS ROSENWALD
UNTERSUCHUNGEN ZU SEKRETORISCH DIFFERENZIERTEN MARGINALZONEN-
LYMPHOMEN UNTER BESONDERER BERUECKSICHTIGUNG PRIMAER KUTANER
MARGINALZONEN-LYMPHOME
INAUGURAL - DISSERTATION
ZUR ERLANGUNG DER DOKTORWUERDE DER
MEDIZINISCHEN FAKULTAET
DER
JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG
VORGELEGT VON
ISABEL KATHARINA BRENNER
AUS GROENINGEN
WUERZBURG, JUNI 2016
INHALTSVERZEICHNIS
1
EINLEITUNG....................................................................................................................1
1.1
IMMUNOLOGIE........................................................................................................
1
1.1.1 DAS
IMMUNSYSTEM......................................................................................1
1.1.2 B-ZELLEN UND DIE B-ZELL-ENTWICKLUNG
......................................................
4
1.1.2.1 ANTIGENUNABHAENGIGE ENTWICKLUNG IM KNOCHENMARK
...................
4
1.1.2.2 ANTIGENABHAENGIGE ENTWICKLUNG IN PERIPHEREN LYMPHATISCHEN
ORGANEN
................................................................................................................
6
1.1.2.3 CLUSTER OF
DIFFERENTIATION......................................................................9
1.1.3
IMMUNGLOBULINE..........................................................................................
9
1.1.3.1 SOMATISCHE
REKOMBINATION.......................................................
.....
17
1.1.3.2
KLASSENWECHSEL..................................................................................20
1.1.4
T-ZELLEN......................................................................................................21
1.1.4.1 CD4+
T-ZELLEN.....................................................................................21
1.1.4.2 C D
8+T-ZELLEN.....................................................................................22
1.1.4.3 REGULATORISCHE
T-ZELLEN....................................................................23
1.1.4.4 FOLLIKULAERE HELFER-T-ZELLEN
................................................................
23
1.2 MALIGNE
LYMPHOME..........................................................................................
24
1.3
NON-HODGKIN-LYMPHOME...............................................................................24
1.4 MYELOID DIFFERENTIATION PRIMARY RESPONSE GENE 88 (M YD 88)
...................
28
1.5
MARGINALZONEN-LYMPHOME..............................................................................30
1.5.1 EXTRANODALES MARGINALZONEN-LYMPHOM VOM MALT-TYP
..................
31
1.6 LGG
4
-ASSOZIIERTE ERKRANKUNG
...........................................................................
37
1.7 FRAGESTELLUNG UND ZIELE
...................................................
40
2 MATERIAL UND METHODEN. 42
2.1 AUSWAHL DER FAELLE.
42
2.2 ETHIKVOTUM UND
DATENSCHUTZ.........................................................................43
2.3
IMMUNHISTOCHEMIE..........................................................................................
43
2.3.1
FAERBEMETHODE..........................................................................................
43
2.3.2 GERAETE UND
MATERIALIEN...........................................................................
44
2.3.3
CHEMIKALIEN...............................................................................................45
2.3.4
PRIMAERANTIKOERPER.......................................................................................46
2.3.5 IMMUNHISTOCHEMISCHE
EINFACHFAERBUNGEN...........................................47
2.3.6
FLUORESZENZFAERBUNG.................................................................................49
2.3.6.1 AUSWAHLKRITERIEN FUER DIE FAERBUNG
...................................................
49
2.3.6.2
FAERBEMETHODE....................................................................................49
2.3.6.3 MATERIALIEN UND
CHEMIKALIEN...........................................................49
2.3.6.4 PRIMAERANTIKOERPER UND FLUORESZENZGEKOPPELTE
SEKUNDAERANTIKOERPER..........................................................................................
50
2.3.6.5
IMMUNFLUORESZENZFAERBUNG...............................................................51
2.3.6.6 AUSWERTUNG MIT HILFE DER KONFOKALEN MIKROSKOPIE
.....................
53
2.4 EVALUATIONSKRITERIEN DER IMMUNGLOBULINLEICHT- UND -
SCHWERKETTENEXPRESSION..........................................................................................
53
2.5 PRIMAER KUTANE
MARGINALZONEN-LYMPHOME..................................................54
2.5.1 ANALYSE DES
B-ZELL-INFILTRATES.................................................................54
2.5.2 ANALYSE DES
T-ZE11-1NFIITRATES.................................................................55
2.6 MOLEKULARBIOLOGISCHE
METHODEN................................................................-..
56
2.6.1 MATERIALIEN UND
CHEMIKALIEN.................................................................57
2.6.2 DNA-EXTRAKTION AUS PARAFFINMATERIAL
...................................................
58
2.6.3 PCR UND
SEQUENZIERUNG........................................................................58
2.7 KLINISCHE DATEN
62
2.8 STATISTISCHE
AUSWERTUNG..................................................................................63
3
ERGEBNISSE...............................................................................................................
64
3.1
IMMUNHISTOCHEMIE..........................................................................................
64
3.1.1
LEICHTKETTENEXPRESSION...........................................................................
64
3.1.2
SCHWERKETTENEXPRESSION.........................................................................65
3.2 MORPHOLOGISCHE UND IMMUNPHAENOTYPISCHE CHARAKTERISIERUNG DER
PCMZL.........................................................................................................................
68
3.2.1
B-ZELL-INFILTRAT.............................................................................................71
3.2.2 T
-ZELL-INFILTRAT..............................................................................................71
3.2.3 KLINISCHE CHARAKTERISTIKA DER PRIMAER KUTANEN M
ZL:..........................75
3.3 ANALYSE DER MYD88 (L265P)-MUTATION IN DEN PCMZL
.............................
79
4
DISKUSSION................................................................................................................
81
5
ZUSAMMENFASSUNG.................................................................................................
95
6
LITERATURVERZEICHNIS..............................................................................................100
7 T
ABELLENVERZEICHNIS.............................................................................................114
6
ABBILDUNGSVERZEICHNIS..........................................................................................
116
9
ABKUERZUNGSVERZEICHNIS.......................................................................................119
10
DANKSAGUNG...............................................................................................!
...........
11
LEBENSLAUF...............................................................................................................
|
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| physical | 123 Seiten Illustrationen, Diagramme 21 cm |
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| spelling | Brenner, Isabel Katharina 1984- Verfasser (DE-588)1133301010 aut Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas vorgelegt von Isabel Katharina Brenner aus Gröningen Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas Würzburg Juni 2016 123 Seiten Illustrationen, Diagramme 21 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Julius-Maximilians-Universität Würzburg 2017 (DE-588)4113937-9 Hochschulschrift gnd-content Erscheint auch als Online-Ausgabe, PDF urn:nbn:de:bvb:20-opus-147237 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-147237 Resolving-System kostenfrei Volltext B:DE-101 application/pdf http://d-nb.info/1132592291/04 Resolving-System Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029756009&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Brenner, Isabel Katharina 1984- Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas |
| subject_GND | (DE-588)4113937-9 |
| title | Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas |
| title_alt | Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas |
| title_auth | Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas |
| title_exact_search | Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas |
| title_full | Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas vorgelegt von Isabel Katharina Brenner aus Gröningen |
| title_fullStr | Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas vorgelegt von Isabel Katharina Brenner aus Gröningen |
| title_full_unstemmed | Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas vorgelegt von Isabel Katharina Brenner aus Gröningen |
| title_short | Untersuchungen zu sekretorisch differenzierten Marginalzonen-Lymphomen unter besonderer Berücksichtigung primär kutaner Marginalzonen-Lymphome |
| title_sort | untersuchungen zu sekretorisch differenzierten marginalzonen lymphomen unter besonderer berucksichtigung primar kutaner marginalzonen lymphome marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas |
| title_sub | = Marginal zone lymphomas with plasmacytic differentiation with special focus on primary cutaneous marginal zone lymphomas |
| topic_facet | Hochschulschrift |
| url | https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-147237 http://d-nb.info/1132592291/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029756009&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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