Protein therapeutics: Volume 1
Saved in:
| Other Authors: | , , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Weinheim, Germany
Wiley-VCH
[2017]
|
| Series: | Methods and principles in medicinal chemistry
Volume 71a Methods and principles in medicinal chemistry volume 71 |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | XXI, 309 Seiten Illustrationen, Diagramme |
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| 245 | 1 | 0 | |a Protein therapeutics |n Volume 1 |c edited by Tristan Vaughan, Jane Osbourn, and Bahija Jallal |
| 264 | 1 | |a Weinheim, Germany |b Wiley-VCH |c [2017] | |
| 300 | |a XXI, 309 Seiten |b Illustrationen, Diagramme | ||
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| 490 | 1 | |a Methods and principles in medicinal chemistry |v Volume 71a | |
| 490 | 1 | |a Methods and principles in medicinal chemistry |v volume 71 | |
| 700 | 1 | |a Vaughan, Tristan |4 edt | |
| 700 | 1 | |a Osbourn, Jane |4 edt | |
| 700 | 1 | |a Jallal, Bahija |4 edt | |
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Record in the Search Index
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| adam_text | CONTENTS TO VOLUME 1
I
1.1
1.2
1.3
1.3.1
1.3.2
1.3.3
1.4
1.5
1.6
1.7
1.8
1.9
2
2.1
2.2
2.3
2.3.1
2.3.2
2.4
PREFACE X V
A PERSONAL FOREWORD XIX
ACKNOWLEDGMENTS XXI
PART I INTRODUCTION TO PROTEIN THERAPEUTICS: PAST AND PRESENT 1
EARLY RECOMBINANT PROTEIN THERAPEUTICS 3
PIERRE DE MEYTS
INTRODUCTION 3
THE BIRTH OF GENETIC ENGINEERING 4
RECOMBINANT HUMAN INSULIN 6
THE RACE TO CLONE THE HUMAN INSULIN GENE AND TO PRODUCE HUMAN
RECOMBINANT INSULIN 6
NOVO*S COUNTER STRATEGY: SEMISYNTHETIC HUMAN INSULIN 9
YEAST RECOMBINANT INSULIN 11
RECOMBINANT HUMAN GROWTH HORMONE 12
RECOMBINANT HUMAN INTERFERONS 14
RECOMBINANT HUMAN ERYTHROPOIETIN 16
RECOMBINANT TISSUE - TYPE PLASMINOGEN ACTIVATOR 17
RECOMBINANT HEPATITIS B VIRUS (HBV) VACCINE 18
POSTSCRIPT 18
ACKNOWLEDGMENTS 19
REFERENCES 19
EVOLUTION OF ANTIBODY THERAPEUTICS 25
HERVE WATIER AND JANICE M. REICHERT
OVERVIEW OF ANTIBODY THERAPEUTICS DEVELOPMENT 25
POLYCLONAL ANTIBODIES - LAYING THE FOUNDATION FOR MAH
THERAPY 33
EVOLUTION OF MONOCLONAL ANTIBODY THERAPEUTICS 33
CHIMERIC AND HUMANIZED MABS 34
FULLY HUMAN ANTIBODIES 34
FC FUSION PROTEINS 36
2.5
EVOLUTION OF CONCEPTS IN ANTIBODY PHARMACOLOGY 42
2.5.1
NEUTRALIZATION 42
2.5.2
FROM KILLING BACTERIA TO KILLING HUMAN CELLS 43
2.5.3
TARGETING MEMBRANE RECEPTORS 44
2.6
FUTURE DIRECTIONS FOR ANTIBODY THERAPEUTICS DEVELOPMENT
ACKNOWLEDGMENTS 46
REFERENCES 47
PART II ANTIBODIES: THE ULTIMATE SCAFFOLD FOR PROTEIN
THERAPEUTICS 51
3
HUMAN ANTIBODY STRUCTURE AND FUNCTION 53
PONRAJ PRABAKARAN AND DIMITERS. DIMITROV
3.1
INTRODUCTION 53
3.2
GENERAL SEQUENCE AND STRUCTURAL FEATURES OF ANTIBODIES 54
3.2.1
ANTIBODY NUMBERING SCHEMES 54
3.2.2
ANTIBODY ISOTYPES 56
3.2.3
ANTIBODY FRAGMENTS 58
3.2.3.1
V AND C DOMAINS 59
3.2.3.2
FAB AND FV 61
3.2.3.3
FC STRUCTURE AND ITS FRAGMENTS 62
3.3 ANTIBODY DIVERSITY 63
3.3.1
VDJ/VJ RECOMBINATION 65
3.3.2
JUNCTIONAL DIVERSITY 65
3.3.3
CDR H3 DIVERSITY 65
3.3.4
GERMLINE VH - VL PAIRING 66
3.4
CANONICAL STRUCTURES OF CDR LOOPS 68
3.4.1
CDR LOOP CONFORMATIONS 68
3.4.1.1 CDR LI 68
3.4.1.2
CDR L2 70
3.4.1.3 CDR L3 70
3.4.1.4
CDR HI 71
3.4.1.5 CDR H2
71
3.4.1.6 CDR-H3
71
3.5 CRYSTAL STRUCTURES OF ANTIBODY-ANTIGEN INTERACTIONS 72
3.5.1
HUMAN ANTIBODY COMPLEXES WITH VIRAL ENVELOP
GLYCOPROTEINS 72
3.6 GLYCOSYLATION 74
3.7
ROLE OF THE FC AND FC RECEPTORS 76
3.7.1 IGG - FCYR INTERACTION 77
3.7.2 IGE - FCERI INTERACTION 78
3.7.3
IGA 1 - FCARI INTERACTION 78
3.8 CONCLUSIONS AND OUTLOOK 79
ACKNOWLEDGMENTS 81
REFERENCES 81
4
ANTIBODIES FROM OTHER SPECIES 85
MELISSA L VADNAIS, MICHAEL F. CRISCITIELLO, AND VAUGHN V. SMIDER
4.1
INTRODUCTION 85
4.2
MAMMALS 86
4.2.1
RAT AND MOUSE 86
4.2.1.1 PASSIVE TRANSFER 86
4.2.1.2
LYMPHOID SYSTEM 89
4.2.1.3 ANTIBODY ORGANIZATION 89
4.2.1.4 ANTIBODY ISOTYPES 89
4.2.2
CAT/DOG 90
4.2.2.1 ANTIBODY ORGANIZATION 90
4.2.2.2 ANTIBODY ISOTYPES 90
4.2.3
PIG 91
4.2.3.1 ANTIBODY ORGANIZATION 91
4.2.3.2
ANTIBODY ISOTYPES 91
4.2.4
COW 91
4.2.4.1 ANTIBODY ORGANIZATION 92
4.2.4.2 ANTIBODY ISOTYPES 93
4.2.4.3 THERAPEUTIC APPLICATIONS 93
4.2.5
CAMEL 94
4.2.5.1 ANTIBODY ORGANIZATION 94
4.2.S.2
THERAPEUTIC APPLICATIONS 94
4.3 REPTILES 95
4.3.1 CHICKEN 95
4.3.1.1 LYMPHOID SYSTEM 95
4.3.1.2 ANTIBODY ORGANIZATION 95
4.3.1.3 ANTIBODY ISOTYPES 96
4.3.1.4 THERAPEUTIC APPLICATIONS 96
4.3.2
SAUROPSIDA 97
4.3.2.1
ANTIBODY ISOTYPES 97
4.4
AMPHIBIANS 97
4.4.1
XENOPUS 97
4.4.1.1 LYMPHOID SYSTEM, ANTIBODY ORGANIZATION, AND ANTIBODY
ISOTYPES 97
4.5 FISH
98
4.5.1 TELEOST
98
4.5.1.1
LYMPHOID SYSTEM 98
4.5.1.2
ANTIBODY ISOTYPES 99
4.5.2
SHARK 99
4.5.2.1
LYMPHOID SYSTEM 99
4.5.2.2 ANTIBODY ORGANIZATION 100
4.5.2.3 ANTIBODY ISOTYPES 101
4.S.2.4 THERAPEUTIC APPLICATION 101
4.6
CONCLUSIONS 101
REFERENCES 102
|
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| indexdate | 2024-07-10T07:50:29Z |
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| language | English |
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| spelling | Protein therapeutics Volume 1 edited by Tristan Vaughan, Jane Osbourn, and Bahija Jallal Weinheim, Germany Wiley-VCH [2017] XXI, 309 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Methods and principles in medicinal chemistry Volume 71a Methods and principles in medicinal chemistry volume 71 Vaughan, Tristan edt Osbourn, Jane edt Jallal, Bahija edt (DE-604)BV044349964 1 Methods and principles in medicinal chemistry Volume 71a (DE-604)BV035418617 71,1 Methods and principles in medicinal chemistry volume 71 (DE-604)BV035418617 71 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029752848&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Protein therapeutics Methods and principles in medicinal chemistry |
| title | Protein therapeutics |
| title_auth | Protein therapeutics |
| title_exact_search | Protein therapeutics |
| title_full | Protein therapeutics Volume 1 edited by Tristan Vaughan, Jane Osbourn, and Bahija Jallal |
| title_fullStr | Protein therapeutics Volume 1 edited by Tristan Vaughan, Jane Osbourn, and Bahija Jallal |
| title_full_unstemmed | Protein therapeutics Volume 1 edited by Tristan Vaughan, Jane Osbourn, and Bahija Jallal |
| title_short | Protein therapeutics |
| title_sort | protein therapeutics |
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