Modulating the fear network: preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex
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| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English German |
| Published: |
Würzburg
2015
|
| Subjects: | |
| Online Access: | Volltext Inhaltsverzeichnis Inhaltsverzeichnis |
| Item Description: | Veröffentlicht 2017 |
| Physical Description: | 121 Seiten Illustrationen 30 cm |
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MARC
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| 245 | 1 | 0 | |a Modulating the fear network |b preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex |c submitted by Anne Guhn from Potsdam |
| 246 | 1 | 1 | |a Modulation des Furchtnetzwerkes |
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Record in the Search Index
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| adam_text | MODULATING THE FEAR NETWORK:
PRECLINICAL STUDIES ON PREFRONTAL CORTEX STIMULATION
MODULATION DES FURCHTNETZWERKES:
VORKLINISCHE STUDIEN ZUR STIMULATION DES PRAEFRONTALKORTEX
DOCTORAL THESIS FOR A DOCTORAL DEGREE
AT THE GRADUATE SCHOOL OF LIFE SCIENCES,
JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG,
SECTION NEUROSCIENCE
SUBMITTED BY
ANNE GUHN
FROM
POTSDAM
WUERZBURG, 2015
TABLE OF CONTENTS
LIST OF
ABBREVIATIONS....................................................................................................................7
SUMMARY......................................................................................................................................
9
ZUSAMMENFASSUNG......................................................................................................................
10
1. FEAR AND
EXTINCTION...................................................................................................................12
1.1 FEAR CONDITIONING - AN HISTORICAL ABSTRACT
.....................................................................
12
1.2 THE NEURAL MECHANISMS OF FEAR CONDITIONING AND
EXTINCTION.......................................13
1.3 HUMAN
FINDINGS................................................................................................................17
1.3.1 EXCURSUS: SKIN CONDUCTANCE RESPONSE
(SCR)............................................................ 19
1.3.2 EXCURSUS: FUNCTIONAL NEAR-INFRARED SPECTROSCOPY
(MRS)........................................20
1.4 STUDY 1: INVESTIGATING FEAR EXTINCTION BY USING M R S
.....................................................22
2. THE NEURAL MECHANISMS INVOLVED IN THE FAILURE OF FEAR EXTINCTION
....................................
34
2.1 PATHOLOGICAL
ANXIETY.........................................................................................................35
2.2 FROM RODENTS TO HUMANS: PREFRONTAL CORTEX
STIMULATION.............................................38
2.2.1 EXCURSUS: TRANSCRANIAL MAGNETIC STIMULATION
(TMS)................................................39
2.2.2 EXCURSUS: FEAR-POTENTIATED STARTLE RESPONSE
(FPS)..................................................41
2.3 STUDY 2: TMS EFFECTS ON CONDITIONED
FEAR......................................................................42
3. THE PROBLEM OF FEAR
GENERALIZATION......................................................................................59
3.1 OVERGENERALIZATION IN PATHOLOGICAL
ANXIETY.....................................................................
59
3.2 RODENT FINDINGS ON THE GENERALIZATION OF
EXTINCTION......................................................61
3.3 HOW TO INVESTIGATE THE GENERALIZATION OF EXTINCTION IN HUMANS?
...................
62
3.4 STUDY 3: TMS EFFECTS ON THE GENERALIZATION OF
EXTINCTION..............................................63
4. GENERAL
DISCUSSION.......................................................................................................................82
4.1 HOW DID THE STORY OF LITTLE ALBERT
CONTINUE?..................................................................
82
4.2 EXCURSUS: THE CONCEPT OF INTERMEDIATE PHENOTYPES OF ANXIETY
....................................
83
4.2.1 STUDY 4: MULTI-LEVEL EFFECTS OF GENOTYPE AND ANXIETY ON PFC
ACTIVITY
...................
85
4.2.2 INTEGRATION OF STUDY 4 INTO THE FINDINGS ON PATHOLOGICAL A NXIETY
.........................
94
4.3 WHAT DID WE LEARN FROM FEAR EXTINCTION AND ITS ENHANCEMENT VIA RTMS?
..................
94
4.3.1 STRENGTHS OF THE
STUDIES............................................................................................
95
4.3.2 WEAKNESSES OF THE
STUDIES.......................................................................................
98
4.4 CONCLUSIONS: FROM THE PRECLINICAL TO THE CLINICAL MODEL
..............................................100
REFERENCES.......................................................................................................................................
104
DANKSAGUNG (ACKNOWLEDGMENT)
.............................................................................................
117
CURRICULUM
VITAE.......................................................................................................................118
LIST OF
PUBLICATIONS....................................................................................................................120
|
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| author | Guhn, Anne 1985- |
| author_GND | (DE-588)1134989482 |
| author_facet | Guhn, Anne 1985- |
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| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Psychologie Medizin |
| format | Thesis Book |
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| spelling | Guhn, Anne 1985- Verfasser (DE-588)1134989482 aut Modulating the fear network preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex submitted by Anne Guhn from Potsdam Modulation des Furchtnetzwerkes Würzburg 2015 121 Seiten Illustrationen 30 cm txt rdacontent n rdamedia nc rdacarrier Veröffentlicht 2017 Dissertation Julius-Maximilians-Universität Würzburg 2016 Zusammenfassung in deutscher und englischer Sprache Konditionierung (DE-588)4032036-4 gnd rswk-swf Angststörung (DE-588)4295459-9 gnd rswk-swf Präfrontaler Cortex (DE-588)4837794-6 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Angststörung (DE-588)4295459-9 s Konditionierung (DE-588)4032036-4 s Präfrontaler Cortex (DE-588)4837794-6 s DE-604 Erscheint auch als Online-Ausgabe, PDF urn:nbn:de:bvb:20-opus-133403 https://nbn-resolving.org/urn:nbn:de:bvb:20-opus-133403 Resolving-System kostenfrei Volltext B:DE-101 application/pdf http://d-nb.info/1132589991/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029747823&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Guhn, Anne 1985- Modulating the fear network preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex Konditionierung (DE-588)4032036-4 gnd Angststörung (DE-588)4295459-9 gnd Präfrontaler Cortex (DE-588)4837794-6 gnd |
| subject_GND | (DE-588)4032036-4 (DE-588)4295459-9 (DE-588)4837794-6 (DE-588)4113937-9 |
| title | Modulating the fear network preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex |
| title_alt | Modulation des Furchtnetzwerkes |
| title_auth | Modulating the fear network preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex |
| title_exact_search | Modulating the fear network preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex |
| title_full | Modulating the fear network preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex submitted by Anne Guhn from Potsdam |
| title_fullStr | Modulating the fear network preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex submitted by Anne Guhn from Potsdam |
| title_full_unstemmed | Modulating the fear network preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex submitted by Anne Guhn from Potsdam |
| title_short | Modulating the fear network |
| title_sort | modulating the fear network preclinical studies on prefrontal cortex stimulation modulation des furchtnetzwerkes vorklinische studien zur stimulation des prafrontalkortex |
| title_sub | preclinical studies on prefrontal cortex stimulation = Modulation des Furchtnetzwerkes : Vorklinische Studien zur Stimulation des Präfrontalkortex |
| topic | Konditionierung (DE-588)4032036-4 gnd Angststörung (DE-588)4295459-9 gnd Präfrontaler Cortex (DE-588)4837794-6 gnd |
| topic_facet | Konditionierung Angststörung Präfrontaler Cortex Hochschulschrift |
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