Cellular signal processing: an introduction to the molecular mechanisms of signal transduction
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York and London
Garland Science, Taylor & Francis Group
[2017]
|
| Ausgabe: | Second edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Klappentext |
| Beschreibung: | xv, 639 Seiten Illustrationen |
| ISBN: | 9780815345343 |
Internformat
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| 245 | 1 | 0 | |a Cellular signal processing |b an introduction to the molecular mechanisms of signal transduction |c Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker |
| 250 | |a Second edition | ||
| 264 | 1 | |a New York and London |b Garland Science, Taylor & Francis Group |c [2017] | |
| 264 | 4 | |c © 2017 | |
| 300 | |a xv, 639 Seiten |b Illustrationen | ||
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| 337 | |b n |2 rdamedia | ||
| 338 | |b nc |2 rdacarrier | ||
| 650 | 4 | |a Cellular signal transduction | |
| 650 | 4 | |a Intracellular Signaling Peptides and Proteins |x physiology | |
| 650 | 4 | |a Signal Transduction |x physiology | |
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Datensatz im Suchindex
| _version_ | 1804177481663512576 |
|---|---|
| adam_text | Detailed Contents
Chapter 1 The Brain of the Cell :
Data Processing by Protein Networks 1
1.1 Metaphors and reductionism: temptations
and limitations 1
1.2 Information and signals 3
1.3 Proteins are binary switches 7
1.4 Signal-transducing proteins are nanoneurons 9
1.5 Proteins form logical gates and neural networks 10
1.6 Privacy versus publicity 11
1.7 Cross talking and network formation 14
1.8 Interaction domains: how the network
is plugged together 17
1.9 Generation of signaling patterns 22
Chapter 2 Supplying the Network
with Energy: Basic Biochemistry
of Signal Transduction 27
2.1 No order without work 27
2.2 Redox and nitrosylation switches: a balance
on a narrow ridge 30
2.3 Switches operated by enzymes that hydrolyze
energy-rich compounds 34
2.4 GTPase or G-protein switch 36
2.5 ATPase switches 40
2.6 Protein phosphorylation 47
2.7 Protein acetylation and methylation: tools of
gene regulation and more 58
2.8 Protein ubiquitylation: more than a signal of
protein degradation 61
2.9 Mono- and poly(ADP-ribosylation) 69
2.10 Ion channel switches: howto make use of
electrical charge 71
2.11 Proteolysis switch: protein degradation
provides messenger molecules and energy 77
2.12 Receptors: how energy-supplying reactions
are combined with signal transduction 78
2.13 Brief summary of experimental standard
methods for investigation of signaling pathways 81
2.14 Model organisms for investigation of cellular
signal processing 83
Chapter 3 Evolution of Cellular
Data Processing 87
3.1 Evolution of biological signal processing 87
3.2 The RNA world 90
3.3 Signal-controlled membrane transport:
the ancient way to communicate 94
3.4 Sensor-dependent signal processing:
two-component systems 10!
3.5 From vagabonds to societies: bacterial
hormones 121
3.6 From bacteria to humans: evolution
of signaling mechanisms 126
Chapter 4 Basic Equipment:
G-Proteins, Second Messengers,
and Protein Kinases 141
4.1 Life is stress 141
4.2 Discovery of intracellular signal transduction 145
4.3 Trimeric G-proteins: coupling of receptors
with the protein network 147
4.4 Downstream of G-proteins: enzymes producing
second messengers 153
4.5 Guanylate cyclases are not controlled by
trimeric G-proteins 176
4.6 The next level: protein kinases as sensors
of second messengers 178
Chapter 5 Signal Transduction
by Receptors with Seven
Transmembrane Domains 191
5.1 An evolutionary model of success 191
5.2 G-protein-coupled receptors: structure and
mode of operation 193
5.3 Adrenergic receptors: sensors of stress and
sympathetic signals 202
5.4 Muscarinic acetylcholine receptors are sensors
of parasympathetic signals 209
5.5 Stress and the heart: the competition between
sympathetic and parasympathetic signals 210
5.6 Protease-activated receptors are major players
in blood clotting and inflammation 212
5.7 Adaptation of G-protein-controlled signaling:
a matter of feedback 214
5.8 Arrestins are multifunctional adaptors for
signaling cross talk 216
5.9 Heptahelical receptors in hedgehog and
Wnt signaling pathways 220
5.10 Other G-protein-independent heptahelical
receptors: lessons from slime molds
and Homer 225
xiv Detailed Table of Contents
Chapter 6 Signal Transduction by
Serine/Threonine Kinase-Coupled
Receptors 229
6.1 The principle of oligomerization-driven
signal transduction 229
6.2 Ser/Thr-kinases as receptors: transforming
growth factor p receptor family 231
6.3 Cytokine receptors: key players in defense
reactions 234
Chapter 7 Signal Transduction by
Tyrosine Kinase- and Protein
Phosphatase-Coupled Receptors 249
7.1 Receptor tyrosine kinases 249
7.2 Receptors associated with tyrosine kinases 268
7.3 Signal transduction by cell adhesion molecules 280
7.4 Protein tyrosine phosphatases and
phosphatase-coupled receptors 284
Chapter 8 Eukaryotic Gene
Transcription: The Ultimate Target
of Signal Transduction 291
8.1 Initiation of eukaryotic transcription 292
8.2 Histones, nucleosomes, and chromatin 296
8.3 Transcription factors as hormone receptors 306
8.4 Ligand-controlled transcription factors are
xenosensors of the toxic stress response 315
8.5 Chaperones and peptidyl-prolyl isomerases
prepare signaling proteins for work 318
8.6 Transcription factors as substrates of
protein kinases 321
8.7 The hypoxic stress response 323
Chapter 9 Signals Controlling
mRNA Translation 329
9.1 Eukaryotic mRNA translation: the essentials 329
9.2 Protein release by the endoplasmic reticulum
is controlled by G-proteins 331
9.3 Signaling cascades controlling translation 333
9.4 Network for adjustment of cell growth to the
supply situation 339
9.5 The signaling network of non-coding RNAs 355
Chapter 10 Signal Transduction
by Small G-Proteins: The Art
of Molecular Targeting 359
10.1 Ras proteins: generation of order in signal
transduction 359
10.2 Other G-proteins of the Ras subfamily: an
unfinished story 369
10.3 GTPases of the Rho family are master
regulators of the actin cytoskeleton and more 369
10.4 Arf and Rab proteins control vesicle
transport 383
10.5 Ran, nuclear transport, and mitosis 391
Chapter 11 Mitogen-activated
Protein Kinase and Nuclear Factor
kB Modules 395
11.1 MAP kinase modules are universal relay
stations of eukaryotic signal processing 395
11.2. MAP3 kinases are sensors of MAP kinase
modules 400
11.3 MAP4 kinases and G-proteins: lessons
learned from yeast 404
11.4 Organization of MAP kinase modules by
scaffold proteins 406
11.5 Downstream of MAP kinase modules: MAP
kinase-activated protein kinases 408
11.6 Downstream of MAP kinase modules:
transcription factors 410
11.7 NFkB signaling pathway 414
Chapter 12 Regulation of Cell
Division 423
12.1 The cell cycle 423
12.2 Cyclins: cell cycle regulators and beyond 425
12.3 Cyclin-dependent protein kinases: dual control
by phosphorylation and dephosphorylation 426
12.4 Cyclin-dependent kinase inhibitors: keeping
the cell cycle under control 428
12.5 GO cells, restriction points, and the effect of
mitogenic signals 429
12.6 Retinoblastoma proteins: master regulators of
the cell cycle 431
12.7 Regulation of G2 phase and G2-M transition:
precise like clockwork 433
12.8 Genotoxic stress response: a matter of life
and death 434
12.9 Phases of mitosis 439
12.10 Ubiquitin ligase APC/C: giving the beat
of mitosis 441
12.11 Mitotic protein kinases: formation
of the mitotic spindle 443
12.12 The spindle assembly checkpoint provides
a last chance to correct mistakes 445
12.13 Cytokinesis: how a new cell is born 447
12.14 Mitotic exit: characterization in yeast 448
Chapter 13 Signal Transduction
by Proteolysis, and Programmed
Cell Death 453
13.1 Secretase-coupled receptors: generation of
peptide second messengers 453
13.2 Signal-controlled suicide of cells 462
13.3 Cancer: a disease of signal processing 476
Detailed Table of Contents xv
Chapter 14 Signal Transduction
by Ions 485
14.1 Cation channels: prototypical structures and
gating mechanisms 486
14.2 Voltage-gated Na+ channels: masters of the
action potential 489
14.3 The multi-talented Epithelial Na+ channels 492
14.4 K+-selective ion channels are regulators of
hyperpolarization and osmotic pressure 494
14.5 Calcium ions: the most versatile
cellular signals 500
14.6 Downstream of Ca2+ signals 518
14.7 Anion channels 535
Chapter 15 Sensory Signal Processing 543
15.1 Taste 543
15.2 Mechanical stimuli: touch and sound 547
15.3 Temperature and pain 550
15.4 Smell 552
15.5 Vision 555
15.6 Sensory adaptation 559
Chapter 16 Signaling at Synapses:
Neurotransmitters and their
Receptors 563
16.1 Neurons and synapses 563
16.2 Acetylcholine receptors 572
16.3 y-Aminobutyric acid and glycine receptors
are the masters of inhibitory
neurotransmission 576
16.4 Glutamate receptors are favorites of
molecular brain research 580
16.5 Nitric oxide: a Janus-faced signal molecule 589
16.6 Receptors of purine and pyrimidine
nucleotides: the ATP signal 593
16.7 Cannabinoid and vanilloid receptors 595
16.8 Opioid receptors 596
16.9 Narcotics and drug addiction 597
Chapter 17 Putting Together the
Pieces: The Approach of Systems
Biology 607
17.1 The whole is greater than the sum of its parts 607
17.2 Systems biology: origin and focus 607
17.3 System structure: basic network topologies
and properties 608
17.4 The iterative cycle: laboratory experiments and
mathematical model development 612
17.5 Problems of quantitative data generation and
mathematical model development 613
17.6 Mathematical modeling of a signaling pathway 614
17.7 Synthetic and predictive biology:
the improvement of biological systems 619
Index 623
The second edition of Cellular Signal Pro expands
coverage of prokaryotes and features new developments in
systems biology, epigenetics, redox signaling, and small,
non-coding RNA signaling. Intended for use in signal
transduction courses for advanced students working in
biology, biochemistry, bioinformatics, medicine, and
pharmacology, this textbook offers a unifying view of cell
signaling based on the concept that protein interactions act
as sophisticated data processing networks that govern
intracellular and extracellular communication.The book is
organized by three key topics central to signal transduction:
the protein network, its energy supply, and its evolution. It
covers all important aspects of cell signaling—including
new coverage of intrinsically disordered proteins,
inflammasomes, regulated necrosis, autophagy, and
optogenetics—and also highlights the clinical aspects of
cell signaling in health and disease.
Friedrich Marks is Professor Emeritus of Biochemistry at
the University of Heidelberg and Emeritus Department
Head, German Cancer Research Center.
Ursula Klingmüller is Professor of Systems Biology of
Signal Transduction at the University of Heidelberg and
Head of the Systems Biology of Signal Transduction
Division, German Cancer Research Center.
Karin Müller-Decker is a Lecturer at the University of
Heidelberg and Head of the Tumor Models Unit, German
Cancer Research Center.
|
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| isbn | 9780815345343 |
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| publisher | Garland Science, Taylor & Francis Group |
| record_format | marc |
| spelling | Marks, Friedrich 1936- Verfasser (DE-588)132367084 aut Cellular signal processing an introduction to the molecular mechanisms of signal transduction Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker Second edition New York and London Garland Science, Taylor & Francis Group [2017] © 2017 xv, 639 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Cellular signal transduction Intracellular Signaling Peptides and Proteins physiology Signal Transduction physiology Cytologie (DE-588)4070177-3 gnd rswk-swf Signaltransduktion (DE-588)4318717-1 gnd rswk-swf Zelle (DE-588)4067537-3 gnd rswk-swf Molekularbiologie (DE-588)4039983-7 gnd rswk-swf (DE-588)4123623-3 Lehrbuch gnd-content Signaltransduktion (DE-588)4318717-1 s Cytologie (DE-588)4070177-3 s DE-604 Molekularbiologie (DE-588)4039983-7 s Zelle (DE-588)4067537-3 s DE-188 Klingmüller, Ursula 1964- Verfasser (DE-588)1098573455 aut Müller-Decker, Karin Verfasser (DE-588)1084651351 aut Erscheint auch als Online-Ausgabe, eBook 978-1-315-16547-9 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029691209&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029691209&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Klappentext |
| spellingShingle | Marks, Friedrich 1936- Klingmüller, Ursula 1964- Müller-Decker, Karin Cellular signal processing an introduction to the molecular mechanisms of signal transduction Cellular signal transduction Intracellular Signaling Peptides and Proteins physiology Signal Transduction physiology Cytologie (DE-588)4070177-3 gnd Signaltransduktion (DE-588)4318717-1 gnd Zelle (DE-588)4067537-3 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| subject_GND | (DE-588)4070177-3 (DE-588)4318717-1 (DE-588)4067537-3 (DE-588)4039983-7 (DE-588)4123623-3 |
| title | Cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_auth | Cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_exact_search | Cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_full | Cellular signal processing an introduction to the molecular mechanisms of signal transduction Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker |
| title_fullStr | Cellular signal processing an introduction to the molecular mechanisms of signal transduction Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker |
| title_full_unstemmed | Cellular signal processing an introduction to the molecular mechanisms of signal transduction Friedrich Marks, Ursula Klingmüller, Karin Müller-Decker |
| title_short | Cellular signal processing |
| title_sort | cellular signal processing an introduction to the molecular mechanisms of signal transduction |
| title_sub | an introduction to the molecular mechanisms of signal transduction |
| topic | Cellular signal transduction Intracellular Signaling Peptides and Proteins physiology Signal Transduction physiology Cytologie (DE-588)4070177-3 gnd Signaltransduktion (DE-588)4318717-1 gnd Zelle (DE-588)4067537-3 gnd Molekularbiologie (DE-588)4039983-7 gnd |
| topic_facet | Cellular signal transduction Intracellular Signaling Peptides and Proteins physiology Signal Transduction physiology Cytologie Signaltransduktion Zelle Molekularbiologie Lehrbuch |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029691209&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029691209&sequence=000002&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT marksfriedrich cellularsignalprocessinganintroductiontothemolecularmechanismsofsignaltransduction AT klingmullerursula cellularsignalprocessinganintroductiontothemolecularmechanismsofsignaltransduction AT mullerdeckerkarin cellularsignalprocessinganintroductiontothemolecularmechanismsofsignaltransduction |