Nanocrystals & lipid nanoparticles for optimized delivery of actives: = Nanocrystals and lipid nanoparticles for optimized delivery of actives
Saved in:
| Main Author: | |
|---|---|
| Format: | Thesis Book |
| Language: | English |
| Published: |
Berlin
2016
|
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | V, 184 Seiten Illustrationen, Diagramme |
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| 245 | 1 | 0 | |a Nanocrystals & lipid nanoparticles for optimized delivery of actives |b = Nanocrystals and lipid nanoparticles for optimized delivery of actives |c by Sung Min Pyo |
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Record in the Search Index
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| adam_text | CONTENTS
1.
INTRODUCTION...................................................................................................................................1
1.1.
NANOCRYSTALS...........................................................................................................................................................
2
1.1.1. DEFINITION OF
NANOCRYSTALS............................................................................................................................
2
1.1.2. SPECIAL PROPERTIES OF NANOCRYSTALS FOR DERMAL
USE.....................................................................................
2
1.1.2.1. SATURATION SOLUBILITY
............................................................................................................................................4
1.1.2.2. DISSOLUTION VELOCITY
.............................................................................................................................................4
1.1.2.3. ADHESIVENESS
.......................................................................................................................................................4
1.1.3. PRODUCTION METHOD OF
NANOSUSPENSIONS.......................................................................................................5
1.1.3.1. WET BEAD MILLING
.................................................................................................................................................6
1.1.3.2. HIGH PRESSURE HOMOGENIZATION
............................................................................................................................
6 .
1.1.3.3. SMARTCRYSTALS TECHNOLOGY
...................................................................................................................................
6
1.1.4. INCORPORATION INTO DERMAL
FORMULATIONS.......................................................................................................7
1.2. LIPID
NANOPARTICLES...............................................................................................................................................
7
1.2.1. DEFINITION O F LIPID
NANOPARTICLES..................................................................................................................
7
1.2.2. DIFFERENT GENERATIONS OF LIPID
NANOPARTICLES................................................................................................
8
1.2.2.1. SOLID LIPID NANOPARTICLES (SLN)
..........................................................................................................................
8
1.2.2.2. NANOSTRUCTURED LIPID CARRIERS (NLC)
..................................................................................................................
9
1.2.2.3. SMARTLIPIDS
.........................................................................................................................................................9
1.2.3. SPECIAL PROPERTIES O F LIPID NANOPARTICLES FOR DERMAL U SE
........................................................................
10
1.2.3.1. OCCLUSIVE FILM FO R PENETRATION ENHANCEMENT AND REPAIR O F
NATURAL SKIN BARRIER
.............................................10
1.2.3.2. INCREASED CHEMICAL STABILITY O F LABILE ACTIVES
...................................................................................................
11
1.2.4. INCORPORATION INTO DERMAL
FORMULATIONS.....................................................................................................11
1.3. NOVEL CONCEPT OF COMBINING NANOCRYSTALS AND LIPID
NANOPARTICLES...........................................................11
1.4.
NANOTOXICITY.........................................................................................................................................................
12
1.5.
REFERENCES............................................................................................................................................................
13
2. AIM OF THE
THESIS.........................................................................................................................15
3. THEORETICAL
BACKGROUND..................................................................................................
18
3.1. LIPID
NANOPARTICLES.........................................................................................................................................19
3.1.1. ENCAPSULATION BY NANOSTRUCTURED LIPID
CARRIERS.....................................................................................19
3.1.1.1. INTRODUCTION
......................................................................................................................................................
21
3.1.1.2. THE LOGIC BEHIND THE DEVELOPMENT O F SOLID LIPID NANOPARTICLES
........................................................................
22
3.1.1.3. FIRST TWO GENERATIONS O F LIPID NANOPARTICLES: SLN VS. N L C
.............................................................................
24
3.1.1.4. THE THIRD GENERATION: SMARTLIPIDS
..................................................................................................................
26
3.1.1.5. SELECTION O F INGREDIENTS FO R SLN/NLC PRODUCTION - SCREENING
.......................................................................
28
3.1.1.6. INDUSTRIAL RELEVANT PRODUCTION PROCESSES: HIGH PRESSURE
HOMOGENIZATION ON LAB SCALE
..................................
30
3.1.1.
7.
MEDIUM AND LARGE SCALE INDUSTRIAL PRODUCTION
.................................................................................................
32
3.1.1.8. REGULATORY ASPECTS - NANOTECHNOLOGY
............................................................................................................
33
3.1.1.9. CHEMICAL STABILIZATION O F ACTIVES
.....................................................................................................................
34
3.1.1.10. CONTROLLED RELEASE
-
STRUCTURES O F PARTICLE MATRIX
.........................................................................................
35
3.1.1.11. ORAL DELIVERY IN MOUTH CAVITY
-
MECHANISMS
.................................................................................................
38
3.1.1.12. PERORAL BIOAVAILABILITY ENHANCEMENT - MECHANISM & EFFICIENCY
..................................................................
38
3.1.1.13. EXAMPLES O F SLN & NLC FORMULATIONS FROM FO O D INDUSTRY
...........................................................................
41
3.1.1.14. EXAMPLES O F ORAL BIOAVAILABILITY ENHANCEMENT
.............................................................................................
43
3.1.1.15. LIPID NANOPARTICLE PRODUCTS ON THE MARKET
...................................................................................................
45
3.1.1.16. COMMERCIAL SUPPLIERS O F LIPID NANOPARTICLE CONCENTRATES
.............................................................................
47
3.1.1.17. PERSPECTIVES FO R FO O D & NUTRACEUTICAL PRODUCTS
............................................................................................
47
4. RESULTS AND
DISCUSSIONS....................................................................................................52
4.1.
NANOCRYSTALS....................................................................................................................................................
53
4.1.1. RUTIN - INCREASED ANTIOXIDANT ACTIVITY AND SKIN PENETRATION BY
NANOCIYSTAL TECHNOLOGY
(SMARTCRYSTALS).......................................................................................................................................................
53
4.1.1.1. INTRODUCTION
......................................................................................................................................................
55
4.1.1.2. EXPERIMENTAL SECTION
.......................................................................................................................................
57
4.1.1.3. RESULTS AND DISCUSSION
....................................................................................................................................
61
4.1.1.4. CONCLUSIONS
......................................................................................................................................................
68
4.1.2. LIDOCAINE NANOCRYSTALS FOR IMPROVED TOPICAL
ANAESTHESIA.....................................................................
70
4.1.2.1. INTRODUCTION
......................................................................................................................................................
72
4.1.2.2. MATERIALS AND METHODS
.....................................................................................................................................
74
4.1.2.3. RESULTS AND DISCUSSION
.....................................................................................................................................
79
4.1.2A.
CONCLUSIONS.....................................................................................................................................................
92
4.1.3. DERMAL MICONAZOLE NITRATE NANOCRYSTALS - FORMULATION DEVELOPMENT,
INCREASED ANTIFUNGAL EFFICACY &
SKIN
PENETRATION......................................................................................................................................................
95
4.1.3.1. INTRODUCTION
......................................................................................................................................................
97
4.1.3.2. MATERIALS AND METHODS
....................................................................................................................................
98
4.1.3.3. RESULTS AND DISCUSSION
..................................................................................................................................
102
4.1.3.4. CONCLUSIONS
....................................................................................................................................................
115
4.2. LIPID
NANOPARTICLES.....................................................................................................................................
118
4.2.1. SMARTLIPIDS/NANOSTRUCTURED LIPID CARRIERS (NLC) FOR CHEMICAL
STABILIZATION OF DERMAL RETINOL
....
118
4.2.1.1. INTRODUCTION
....................................................................................................................................................
120
4.2.1.2. MATERIALS AND METHODS
..................................................................................................................................
122
4.2.1.3. RESULTS AND DISCUSSION
..................................................................................................................................
124
4.2.1.4. CONCLUSIONS
....................................................................................................................................................
138
4.3. NOVEL CONCEPT OF COMBINING NANOCRYSTALS AND LIPID
NANOPARTICLES....................................................141
4.3.1. A NOVEL CONCEPT FOR THE TREATMENT OF COUPEROSIS BASED ON
NANOCRYSTALS IN COMBINATION WITH SOLID
LIPID NANOPARTICLES
(SLN)...................................................................................................................................141
4.3.1.1. INTRODUCTION
..................................................................................................................................................
143
4.3.1.2. MATERIALS AND METHODS
...................................................................................................................................
146
4.3.1.3. RESULTS AND DISCUSSION
...................................................................................................................................
151
4.3.1.4. CONCULUSION
....................................................................................................................................................
161
5.
CONCLUSION....................................................................................................................................164
6.
SUMMARY..........................................................................................................................................
166
ZUSAMMENFASSUNG..........................................................................................................................................170
7. OVERALL SUMMARY OF THE
THESIS..................................................................................
173
GESAMTZUSAMMENFASSUNG........................................................................................................................
175
8.
PUBLICATIONS................................................................................................................................
176
8.1. FULL
PAPERS..........................................................................................................................................................
177
8.2. NON-REFEREED
PAPERS.........................................................................................................................................177
8 3 . BOOK
CHAPTER......................................................................................................................................................177
8.4. CONFERENCE
CONTRIBUTIONS............................................................................................................................
178
8.4.1.
PROCEEDINGS................................................................................................................................................
178
8.4.2.
ABSTRACTS.....................................................................................................................................................179
9.
ACKNOWLEDGEMENT................................................................................................................
183
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| spelling | Pyo, Sung Min Verfasser aut Nanocrystals & lipid nanoparticles for optimized delivery of actives = Nanocrystals and lipid nanoparticles for optimized delivery of actives by Sung Min Pyo Nanocrystals and lipid nanoparticles for optimized delivery of actives Berlin 2016 V, 184 Seiten Illustrationen, Diagramme txt rdacontent n rdamedia nc rdacarrier Dissertation Freie Universität Berlin 2017 Rosazea (DE-588)4300506-8 gnd rswk-swf Dermatikum (DE-588)4011488-0 gnd rswk-swf Lipide (DE-588)4035873-2 gnd rswk-swf Nanopartikel (DE-588)4333369-2 gnd rswk-swf Nanokristall (DE-588)7574326-7 gnd rswk-swf (DE-588)4113937-9 Hochschulschrift gnd-content Nanokristall (DE-588)7574326-7 s Lipide (DE-588)4035873-2 s Nanopartikel (DE-588)4333369-2 s Dermatikum (DE-588)4011488-0 s Rosazea (DE-588)4300506-8 s DE-188 DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029653446&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Pyo, Sung Min Nanocrystals & lipid nanoparticles for optimized delivery of actives = Nanocrystals and lipid nanoparticles for optimized delivery of actives Rosazea (DE-588)4300506-8 gnd Dermatikum (DE-588)4011488-0 gnd Lipide (DE-588)4035873-2 gnd Nanopartikel (DE-588)4333369-2 gnd Nanokristall (DE-588)7574326-7 gnd |
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| title | Nanocrystals & lipid nanoparticles for optimized delivery of actives = Nanocrystals and lipid nanoparticles for optimized delivery of actives |
| title_alt | Nanocrystals and lipid nanoparticles for optimized delivery of actives |
| title_auth | Nanocrystals & lipid nanoparticles for optimized delivery of actives = Nanocrystals and lipid nanoparticles for optimized delivery of actives |
| title_exact_search | Nanocrystals & lipid nanoparticles for optimized delivery of actives = Nanocrystals and lipid nanoparticles for optimized delivery of actives |
| title_full | Nanocrystals & lipid nanoparticles for optimized delivery of actives = Nanocrystals and lipid nanoparticles for optimized delivery of actives by Sung Min Pyo |
| title_fullStr | Nanocrystals & lipid nanoparticles for optimized delivery of actives = Nanocrystals and lipid nanoparticles for optimized delivery of actives by Sung Min Pyo |
| title_full_unstemmed | Nanocrystals & lipid nanoparticles for optimized delivery of actives = Nanocrystals and lipid nanoparticles for optimized delivery of actives by Sung Min Pyo |
| title_short | Nanocrystals & lipid nanoparticles for optimized delivery of actives |
| title_sort | nanocrystals lipid nanoparticles for optimized delivery of actives nanocrystals and lipid nanoparticles for optimized delivery of actives |
| title_sub | = Nanocrystals and lipid nanoparticles for optimized delivery of actives |
| topic | Rosazea (DE-588)4300506-8 gnd Dermatikum (DE-588)4011488-0 gnd Lipide (DE-588)4035873-2 gnd Nanopartikel (DE-588)4333369-2 gnd Nanokristall (DE-588)7574326-7 gnd |
| topic_facet | Rosazea Dermatikum Lipide Nanopartikel Nanokristall Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029653446&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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