How to overcome the antibiotic crisis: facts, challenges, technologies and future perspectives
This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on...
Gespeichert in:
| Weitere Verfasser: | , |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Cham, Switzerland
Springer
[2016]
|
| Schriftenreihe: | Current topics in microbiology and immunology
Volume 398 |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Zusammenfassung: | This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the "bad bugs" are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike |
| Beschreibung: | xii, 496 Seiten Illustrationen, Diagramme, Tabellen |
| ISBN: | 9783319492841 3319492845 |
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| 520 | 3 | |a This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the "bad bugs" are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike | |
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| 653 | 0 | |a Pharmaceutical microbiology | |
| 653 | 0 | |a Antibiotics | |
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| 653 | 0 | |a Medicine | |
| 653 | 0 | |a Medical microbiology | |
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Datensatz im Suchindex
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| adam_text | Contents
Part I Antibiotic Resistance: Problems and New Opportunities
Tackling Threats and Future Problems of Multidrug-Resistant
Bacteria 3
Eva Medina and Dietmar Helmut Pieper
Emergence and Spread of Antimicrobial Resistance:
Recent Insights from Bacterial Population Genomics 35
Ulrich Niibel
Epidemiology of Staphylococcus aureus Nasal Carriage
Patterns in the Community 55
Jaishri Mehraj, Wolfgang Witte, Manas K Akmatov,
Franziska Layer, Guido Werner and Gerard Krause
Diagnostics and Resistance Profiling of Bacterial Pathogens 89
Klaus Homischer and Susanne Häußler
Use of Antibiotics and Antimicrobial Resistance in Veterinary
Medicine as Exemplified by the Swine Pathogen Streptococcus suis 103
Maren Seitz, Peter Valentin-Weigand and Jörg Willenborg
Antibiotics and the Intestinal Microbiome: Individual Responses,
Resilience of the Ecosystem, and the Susceptibility to Infections 123
Sophie Thiemann, Nathiana Smit and Till Strowig
Anti-virulence Strategies to Target Bacterial Infections 147
Sabrina Mühlen and Petra Dersch
Strategies to Block Bacterial Pathogenesis by Interference
with Motility and Chemotaxis 185
Marc Erhardt
xi
Contents
xii
New Horizons in the Development of Novel Needle-Free
Immunization Strategies to Increase Vaccination Efficacy 207
Kai Schulze, Thomas Ebensen, Peggy Riese, Blair Prochnow,
Claus-Michael Lehr and Carlos A Guzman
Part II Natural Compound Research and Anti-infective
Development
History of Antibiotics Research 237
Kathrin I Mohr
Actinobacteria and Myxobacteria—Two of the Most Important
Bacterial Resources for Novel Antibiotics 273
Wiebke Landwehr, Corinna Wolf and Joachim Wink
Exploitation of Fungal Biodiversity for Discovery
of Novel Antibiotics 303
Sabrina Karwehl and Marc Stadler
Strategies for the Discovery and Development of New Antibiotics
from Natural Products: Three Case Studies 339
Jennifer Herrmann, Tadeja Lukezic, Angela Kling, Sascha Baumann,
Stephan Hüttel, Hrvoje Petkovic and Rolf Müller
New Structural Templates for Clinically Validated and Novel
Targets in Antimicrobial Drug Research and Development 365
Philipp Klahn and Mark Brönstrup
Synthesis of Antibiotics 419
Markus Kalesse, Andreas Böhm, Andi Kipper and Vanessa Wandelt
Antibiotics Clinical Development and Pipeline 447
Thomas Hesterkamp
Anti-infectives in Drug Delivery—Overcoming the Gram-Negative
Bacterial Cell Envelope 475
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| contents | Tackling threats and future problems of multidrug-resistant bacteria.-Emergence and spread of antimicrobial resistance: recent insights from bacterial population genomics -- Epidemiology of Staphylococcus aureus nasal carriage patterns in the community -- Diagnostics and resistance profiling of bacterial pathogens -- Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis.-Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem and the susceptibility to infections -- Anti-virulence strategies to target bacterial infections -- Strategies to block bacterial pathogenesis by interference with motility and chemotaxis -- New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy -- History of antibiotics research -- Actinobacteria and Myxobacteria -- Two of the most important bacterial resources for novel antibiotics -- Exploitation of fungal biodiversity for discovery of novel antibiotics -- Strategies for the discovery and development of new antibiotics from natural products: Three Case Studies -- New structural templates for clinically validated and novel targets in antimicrobial drug research and development -- Synthesis of antibiotics -- Antibiotics clinical development and pipeline -- Anti-infectives in drug delivery -- overcoming the Gram-negative bacterial cell envelope |
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| institution | BVB |
| isbn | 9783319492841 3319492845 |
| language | English |
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| spelling | Stadler, Marc 1962- (DE-588)172665221 edt How to overcome the antibiotic crisis facts, challenges, technologies and future perspectives Marc Stadler, Petra Dersch, editors ; responsible series editor: Klaus Aktories Cham, Switzerland Springer [2016] © 2016 xii, 496 Seiten Illustrationen, Diagramme, Tabellen txt rdacontent n rdamedia nc rdacarrier Current topics in microbiology and immunology Volume 398 Tackling threats and future problems of multidrug-resistant bacteria.-Emergence and spread of antimicrobial resistance: recent insights from bacterial population genomics -- Epidemiology of Staphylococcus aureus nasal carriage patterns in the community -- Diagnostics and resistance profiling of bacterial pathogens -- Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis.-Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem and the susceptibility to infections -- Anti-virulence strategies to target bacterial infections -- Strategies to block bacterial pathogenesis by interference with motility and chemotaxis -- New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy -- History of antibiotics research -- Actinobacteria and Myxobacteria -- Two of the most important bacterial resources for novel antibiotics -- Exploitation of fungal biodiversity for discovery of novel antibiotics -- Strategies for the discovery and development of new antibiotics from natural products: Three Case Studies -- New structural templates for clinically validated and novel targets in antimicrobial drug research and development -- Synthesis of antibiotics -- Antibiotics clinical development and pipeline -- Anti-infectives in drug delivery -- overcoming the Gram-negative bacterial cell envelope This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the "bad bugs" are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike Medizin Pharmaceutical microbiology Antibiotics Drug resistance in microorganisms Medicine Medical microbiology Pharmacology Pharmaceutical chemistry Infectious diseases Bacteriology MEDICAL / Pharmacology Dersch, Petra 1965- (DE-588)1016389515 edt Aktories, Klaus 1948- Sonstige (DE-588)121590712 oth Erscheint auch als Online-Ausgabe 3319492845 Current topics in microbiology and immunology Volume 398 (DE-604)BV002527248 398 HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029610010&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | How to overcome the antibiotic crisis facts, challenges, technologies and future perspectives Current topics in microbiology and immunology Tackling threats and future problems of multidrug-resistant bacteria.-Emergence and spread of antimicrobial resistance: recent insights from bacterial population genomics -- Epidemiology of Staphylococcus aureus nasal carriage patterns in the community -- Diagnostics and resistance profiling of bacterial pathogens -- Use of antibiotics and antimicrobial resistance in veterinary medicine as exemplified by the swine pathogen Streptococcus suis.-Antibiotics and the intestinal microbiome: individual responses, resilience of the ecosystem and the susceptibility to infections -- Anti-virulence strategies to target bacterial infections -- Strategies to block bacterial pathogenesis by interference with motility and chemotaxis -- New horizons in the development of novel needle-free immunization strategies to increase vaccination efficacy -- History of antibiotics research -- Actinobacteria and Myxobacteria -- Two of the most important bacterial resources for novel antibiotics -- Exploitation of fungal biodiversity for discovery of novel antibiotics -- Strategies for the discovery and development of new antibiotics from natural products: Three Case Studies -- New structural templates for clinically validated and novel targets in antimicrobial drug research and development -- Synthesis of antibiotics -- Antibiotics clinical development and pipeline -- Anti-infectives in drug delivery -- overcoming the Gram-negative bacterial cell envelope Medizin |
| title | How to overcome the antibiotic crisis facts, challenges, technologies and future perspectives |
| title_auth | How to overcome the antibiotic crisis facts, challenges, technologies and future perspectives |
| title_exact_search | How to overcome the antibiotic crisis facts, challenges, technologies and future perspectives |
| title_full | How to overcome the antibiotic crisis facts, challenges, technologies and future perspectives Marc Stadler, Petra Dersch, editors ; responsible series editor: Klaus Aktories |
| title_fullStr | How to overcome the antibiotic crisis facts, challenges, technologies and future perspectives Marc Stadler, Petra Dersch, editors ; responsible series editor: Klaus Aktories |
| title_full_unstemmed | How to overcome the antibiotic crisis facts, challenges, technologies and future perspectives Marc Stadler, Petra Dersch, editors ; responsible series editor: Klaus Aktories |
| title_short | How to overcome the antibiotic crisis |
| title_sort | how to overcome the antibiotic crisis facts challenges technologies and future perspectives |
| title_sub | facts, challenges, technologies and future perspectives |
| topic | Medizin |
| topic_facet | Medizin |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029610010&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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