Nanoscience and nanotechnology for human health:
Saved in:
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Weinheim
Wiley-VCH
2017
|
| Series: | Nanotechnology innovation & applications
|
| Subjects: | |
| Online Access: | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-33860-3/ Inhaltsverzeichnis |
| Physical Description: | XXII, 393 Seiten Illustrationen |
| ISBN: | 9783527338603 3527338608 |
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MARC
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| 653 | |a Chemistry | ||
| 653 | |a Medical Science | ||
| 653 | |a Medizin | ||
| 653 | |a Medizinische Grundlagenfächer | ||
| 653 | |a Nanomedicine | ||
| 653 | |a Nanomedizin | ||
| 653 | |a Nanotechnologie | ||
| 653 | |a Nanotechnology | ||
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Record in the Search Index
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| adam_text | CONTENTS
NANOMEDICINE: PRESENT ACCOMPLISHMENTS AND FAR-REACHING
PROMISES
XXI
PART ONE INTRODUCTION TO NANOSCIENCE IN MEDICINE OF THE TWENTY-FIRST
CENTURY 1
1 CHALLENGES AND OPPORTUNITIES OF NANOTECHNOLOGY FOR HUMAN HEALTH
3
BERT MUELLER
REFERENCES 6
2 NANOSCIENCE AND NANOTECHNOLOGY AND THE ARMORY FOR THE TWENTY-FIRST
CENTURY HEALTH CARE 9
MARCEL VAN DE VOORDE AND PANKAJ VADGAMA
2.1 CONCEPTUAL DREAM 9
2.2 A REAL WORLD ENCOUNTER 9
2.3 MAPPING THE MICROCOSM OF DISEASE 10
2.4 DELIVERY AT THE CLINICAL COAL FACE* 10
2.5 A HIGH PRECISION AIM FOR DISEASE TARGETS 10
2.6 A MATERIALS REVOLUTION FOR CLINICAL CARE 11
2.7 ROBOTICS FOR MICROREPAIR AND HEALING 12
2.8 A DIALOG WITH CELLS 12
2.9 STEALTH MATERIALS FOR A MORE POTENT DELIVERY 13
2.10 IMPROVED BIOINTERROGATION FOR A BETTER UNDERSTANDING 13
2.11 CROSSING THE STRUCTURE-FUNCTION THRESHOLD 14
2.12 LIVING IMPLANTS FOR A LIVING MATRIX 15
2.13 TAMING THE NANOINTERFACE 15
2.14 WHERE ARE WE NOW? 16
2.15 WHERE WILL THE REVOLUTION TAKE US? 16
2.16 CONCLUSIONS 17
REFERENCES 18
3 NANOMEDICINE ACTIVITIES IN THE UNITED STATES AND WORLDWIDE
21
CARLOTTA BORSOI, JOY WOLFRAM, AND MAURO FERRARI
3.1 DRUG DELIVERY 22
3.1.1 STRATEGIES FOR LOCALIZED DELIVERY OF NANOPARTICLES 23
3.1.1.1 PHYSICAL TARGETING 24
3.1.1.2 BIOMATERIALS 25
3.1.1.3 MOLECULAR TARGETING 26
3.1.1.4 EXTERNAL ACTIVATION 26
3.1.2 NEXT-GENERATION DRUG DELIVERY VEHICLES 27
3.1.2.1 SEQUENTIAL DRUG DELIVERY 27
3.1.2.2 AMPLIFIED DRUG DELIVERY 29
3.1.2.3 BIOMIMICRY 29
3.1.3 IMPLANTABLE DEVICES 30
3.2 DIAGNOSTICS 31
3.3 SCAFFOLDS 33
3.3.1 BONE TISSUE REGENERATION 34
3.3.2 SKIN REGENERATION 35
3.3.3 NERVE REGENERATION 36
3.4 CLINICALLY APPROVED NANOPRODUCTS 37
REFERENCES 39
PART TWO LEADING CAUSE OF DEATH: CARDIOVASCULAR DISEASES 51
4 CHALLENGES IN CARDIOVASCULAR TREATMENTS USING NANOTECHNOLOGY-BASED
APPROACHES 53
TILL SAXER AND MARGARET N. HOLME
4.1 INTRODUCTION 53
4.2 UNMET NEEDS IN CARDIOLOGY 54
4.2.1 NANOMATERIALS FOR MEDICAL APPLICATIONS 55
4.2.2 NANOTECHNOLOGY APPLIED TO MEDICINE: A NEW MEDICAL DISCIPLINE
FOR CARDIOLOGY? 55
4.2.3 NANO APPROACHES FOR THERAPEUTIC PROBLEMS 56
4.2.4 AWARENESS OF RISKS INTRODUCING NANOTECHNOLOGY TO
PATIENT TREATMENT 57
4.2.5 DECISIONAL ANALYSIS IN NANOMEDICINE DEVELOPMENT 57
4.3 NANOPARTICLES FOR TREATMENT OF CVD 58
4.3.1 DELIVERY OF NITRIC OXIDE SMALL-MOLECULE DONORS 58
4.3.2 PLGA-BASED NANOPARTICLES FOR GENE DELIVERY 59
4.3.3 PERFLUOROCARBON NANOPARTICLES
60
4.3.4 TARGETING VESSEL GEOMETRY: A PHYSICS-BASED APPROACH 60
4.3.5 NANOPARTICLES ENDOGENOUS TO ATHEROSCLEROSIS PATHOLOGY 62
4.4 NANOTHERAPEUTICS IN SURGICAL INTERVENTIONS 62
4.4.1 NANOPARTICLES IN DRUG-ELUTING STENTS 63
4.4.2 NANOPATTERNING TO IMPROVE STENT INTEGRATION 64
4.4.3 NANOPARTICLE ALTERNATIVES TO STENTS 65
4.5 CONCLUSIONS 65
REFERENCES 66
5 SMART CONTAINER FOR TARGETED DRUG DELIVERY 71
ANDREAS ZUMBUEHL
5.1 INTRODUCTION 71
5.2 LIPOSOMES 72
5.2.1 GENERAL CHARACTERISTICS 72
5.2.2 RELEASE OF VESICLE-ENTRAPPED MOLECULES 74
5.2.2.1 TEMPERATURE AS TRIGGER 74
5.2.2.2 ULTRASOUND AS TRIGGER 75
5.2.2.Z ENZYMES AS TRIGGER 75
5.2.2.4 PH CHANGES AS TRIGGER 75
5.2.2.5 REDOX REACTIONS AS TRIGGER 75
5.2.2.6 PHOTOREACTIONS AS TRIGGER 75
5.2.2.7 SHEAR STRESS AS TRIGGER 76
5.3 SHEAR FORCES AND VESICLES 76
5.3.1 INFLUENCE OF SHEAR FORCES ON VESICLES 76
5.3.2 SHEAR FORCE-RESPONSIVE VESICLES 77
5.4 CONCLUSIONS 79
REFERENCES 79
6 HUMAN NANO-VESICLES IN PHYSIOLOGY AND PATHOLOGY 83
ARUN CUMPELIK AND JUERG A. SCHIFFERLI
6.1 INTRODUCTION 83
6.2 NOMENCLATURE AND DEFINITION 84
6.3 STIMULUS FOR VESICLE RELEASE 55
6.4 OVERVIEW OF EXTRACELLULAR VESICLE BIOLOGY 86
6.5 NVS OF POLYMORPHONUCLEAR LEUKOCYTES 88
6.6 ERYTHROCYTE NVS 89
6.7 PLATELET NVS 91
6.8 CONCLUSIONS 92
ACKNOWLEDGMENT 93
REFERENCES 93
7 CHALLENGES AND RISKS OF NANOTECHNOLOGY IN MEDICINE:
AN IMMUNOLOGIST S POINT OF VIEW 97
JANOS SZEBENI
7.1 INTRODUCTION 97
7.2 THE IMMUNE STIMULATORY VICIOUS CYCLE 98
7.3 THE CAUSE OF IMMUNE RECOGNITION OF NANOMEDICINES: SIMILARITY TO
VIRUSES 100
7.4 PROCESSES IN THE IMMUNE STIMULATORY VICIOUS CYCLE 101
7.4.1 COMPLEMENT ACTIVATION-RELATED PSEUDOALLERGY 101
7.4.1.1 DEFINITION AND BASICS 101
7.4.1.2 HISTORIE LEADS 101
7.4.1.3 FOUNDATION OF THE CONCEPT 104
7.4.1.4 PREVALENCE, SYMPTOMS, AND FEATURES 104
7.4.1.5 MECHANISM 105
7.4.2 IMMUNOGENICITY AND FORMATION OF ANTIDRUG ANTIBODIES 106
7.4.3 ACCELERATED BLOOD CLEARANCE (ABC PHENOMENON) 107
7.4.3.1 ESSENTIALS AND BACKGROUND 107
7.4.3.2 THE IMMUNOGENICITY OF PEG-CONJUGATED NANOMEDICINES 107
7.4.4 MECHANISM OF PEG IMMUNOGENICITY 108
7.5 PARTICLE FEATURES INFLUENCING THE IMMUNE SIDE EFFECTS OF
NANOMEDICINES 109
7.6 EXPERIMENTAL ANALYSIS OF THE ADVERSE IMMUNE EFFECTS OF
NANOMEDICINES 110
7.6.1 MEASUREMENT OF C ACTIVATION 110
7.6.2 PREDICTION OF IMMUNOGENICITY 110
7.6.3 PREDICTION OF CARP A 111
7.7 DECISION TREE TO GUIDE THE EVALUATION OF THE CARPAGENIC POTENTIAL OF
NANOMEDICINES 113
7.8 OUTLOOK 114
REFERENCES 114
PART THREE SECOND MOST COMMON CAUSE OF DEATH: CANCER 125
8 CHALLENGES OF APPLYING TARGETED NANOSTRUCTURES WITH MULTIFUNCTIONAL
PROPERTIES IN CANCER TREATMENTS 127
JEAN-LUC COLL AND JUNGYOON CHOI
8.1 INTRODUCTION 127
8.2 ENHANCED PERMEABILITY AND RETENTION EFFECT 128
8.2.1 BIOLOGICAL POINT OF VIEW 128
8.2.2 BIOPHYSICAL PERSPECTIVE 129
8.3 PHYSICOCHEMICAL FACTORS THAT INFLUENCE NP PASSIVE PROPERTIES 129
8.3.1 INFLUENCE OF THE SIZE OF THE NP 130
8.3.2 SURFACE MODIFICATION AND OPSONIZATION 131
8.3.3 ELECTRIC CHARGE 133
8.3.4 DENSITY OF LIGANDS 134
8.4 TARGETED NPS 134
8.4.1 CHOICE OF TARGET RECEPTOR 135
8.4.2 TARGETING FOLATE RECEPTOR USING FOLIC ACID AS AN EXAMPLE OF A
SMALL LIGAND 135
8.4.2.1 FOLIC ACID RECEPTOR-TARGETED NPS FOR DRUG DELIVERY 136
5.4.2.2 FOLIC ACID RECEPTOR-TARGETED NPS AS CONTRAST AGENTS 137
8.4.3 TARGETING INTEGRIN WITH PEPTIDES 138
8.4.3.1 RGD-TARGETED GOLD NPS 139
8.4.4 PROTEIN-TARGETED NPS 141
8.4.4.1 TARGETING TRANSFERRIN RECEPTOR 141
5.4.4.2 TARGETING THE EPITHELIAL GROWTH FACTOR RECEPTOR 143
8.5 CONCLUSIONS 143
ACKNOWLEDGMENTS 144
REFERENCES 145
9 HIGHLY CONFORMAL RADIOTHERAPY USING PROTONS 157
ANTONY JOHN LOMAX
9.1 INTRODUCTION 157
9.1.1 PRINCIPLES OF RADIOTHERAPY 157
9.1.2 RADIOTHERAPY WITH X-RAYS 157
9.1.3 RADIOTHERAPY USING PROTONS 159
9.2 PROTON PHYSICS 161
9.2.1 ENERGY LOSS 161
9.2.2 MULTIPLE COULOMB SCATTERING 161
9.2.3 NUCLEAR INTERACTIONS AND SECONDARY PARTICLES 162
9.2.4 LINEAR ENERGY TRANSFER AND RELATIVE BIOLOGICAL EFFECTIVENESS 163
9.2.5 DENSITY HETEROGENEITIES 163
9.2.6 GENERATING HIGH-ENERGY PROTON BEAMS I64
9.2.6.1 CYCLOTRON 164
9.2.6.2 SYNCHROTRONS 165
9.3 DELIVERING PROTON THERAPY I65
9.3.1 IMAGING AND TREATMENT PLANNING 165
9.3.2 PASSIVE SCATTERING 166
9.3.2.1 SPREAD-OUT BRAGG PEAK 166
9.3.2.2 SINGLE AND DOUBLE SCATTERING 167
9.3.2.3 COLLIMATORS AND COMPENSATORS 168
9.3.2.4 PASSIVE SCATTERING IN PRACTICE 168
9.3.3 PENCIL BEAM SCANNING 169
9.3.3.1 PRINCIPLE OF PBS 169
9.3.3.2 PBS VERSUS PASSIVE SCATTERING 170
9.3.4 TREATMENT GANTRIES 171
9.4 CLINICAL APPLICATIONS 172
9.4.1 SELECTED CLINICAL INDICATIONS 172
9.4.1.1 UVEAL MELANOMA 172
9.4.1.2 SKULL-BASE CHORDOMAS 174
9.4.1.3 EPENDYMOMA 176
9.5 THE FUTURE OF PROTON THERAPY 177
9.5.1 FUTURE IS PBS 177
9.5.2 CURRENT AND FUTURE TECHNOLOGICAL DEVELOPMENTS 178
9.5.2.1 TREATMENT DELIVERY 178
9.5.2.2 TREATMENT EFFICIENCY 179
9.5.23 IN-ROOM/ONBOARD 3D IMAGING AND ADAPTIVE THERAPY 180
9.5.3 CLINICAL FUTURE OF PROTON THERAPY 182
9.6 IS THERE A ROLE FOR NANOTECHNOLOGY IN PROTON THERAPY? 183
9.6.1 TUMOR IMAGING 184
9.6.2 DOSE ENHANCEMENT 184
9.6.3 NANODOSIMETRY 185
9.6.4 SUMMARY 186
REFERENCES 186
10 SELF-ORGANIZATION ON A CHIP: FROM NANOSCALE ACT IN ASSEMBLIES TO
TUMOR SPHEROIDS 191
CORA-ANN SCHOENENBERGER AND THOMAS PFOHL
10.1 INTRODUCTION 192
10.2 MICROFLUIDIC CELL CULTURE 197
10.3 SELF-REGULATED LOADING OF CELLS INTO MICROCHAMBERS 197
10.4 2D CELL CULTURE IN MICROFLUIDICS 200
10.5 EXPANDING MICROFLUIDIC CELL CULTURE TO THE THIRD DIMENSION 200
10.6 MICROFLUIDIC BIOMIMETIC MODELS OF CANCER 204
10.7 FUTURE PERSPECTIVES 204
ACKNOWLEDGMENTS 205
REFERENCES 205
11 THE NANOMECHANICAL SIGNATURE OF TISSUES IN HEALTH AND
DISEASE 209
DAPHNE O. ASGEIRSSON, PHILIPP OERTLE, MARKO LOPARIC, AND
MARIJA PLODINEC
11.1 SUMMARY 209
11.2 TISSUE MECHANICS ACROSS LENGTH SCALES 210
11.3 ATOMIC FORCE MICROSCOPY (AFM) IN CELL AND TISSUE BIOLOGY 211
11.3.1 BASIC OPERATING PRINCIPLES OF AFM 211
11.3.2 SCALE DEPENDENCY AND RESOLUTION 212
11.3.3 AFM IN CELL BIOLOGY 215
11.4 THE NANOMECHANICAL SIGNATURE OF ARTICULAR CARTILAGE 218
11.4.1 ARTICULAR CARTILAGE COMPOSITION AND FUNCTION 218
11.4.2 THE NANOMECHANICS OF ARTICULAR CARTILAGE 219
11.4.3 THE NANOMECHANICAL SIGNATURE OF OSTEOARTHRITIS 221
11.5 THE NANOMECHANICAL SIGNATURE OF MAMMARY TISSUES 224
11.5.1 MAMMARY GLAND COMPOSITION AND MECHANICS 224
11.5.2 THE NANOMECHANICAL SIGNATURE OF BREAST CANCER 225
11.6 AFM - THE DIAGNOSTIC AND PROGNOSTIC TOOL OF THE
FUTURE 229
ACKNOWLEDGMENTS 232
COMPETING FINANCIAL INTERESTS 232
REFERENCES 232
PART FOUR MOST COMMON DISEASES: CARIES, MUSCULOSKELETAL DISEASES,
INCONTINENCE, ALLERGIES 241
12 REVEALING THE NANO-ARCHITECTURE OF HUMAN HARD AND SOFT TISSUES BY
SPATIALLY RESOLVED HARD X-RAY SCATTERING 243
HANS DEYHLE AND BERT MUELLER
12.1 INTRODUCTION 243
12.2 SPATIALLY RESOLVED HARD X-RAY SCATTERING 244
12.2.1 INTRODUCTORY REMARKS ON X-RAY SCATTERING 244
12.2.2 EXPERIMENTAL SETUP FOR X-RAY SCATTERING 246
12.2.3 TWO-DIMENSIONAL SCANNING SMALL-ANGLE X-RAY SCATTERING 248
12.2.4 SCATTERING PATTERN ANALYSIS 249
12.2.5 TISSUE PREPARATION 250
12.3 NANOANATOMY OF HUMAN HARD AND SOFT TISSUES 251
12.3.1 HUMAN TOOTH 251
12.3.2 FEMORAL HEAD 254
12.3.3 BREAST TUMOR 256
12.3.4 BRAIN TISSUE 256
12.4 CONCLUSIONS AND OUTLOOK 259
REFERENCES 259
13 REGENERATIVE DENTISTRY USING STEM CELLS AND NANOTECHNOLOGY 263
THIMIOS A. MITSIADIS AND GIOVANNA ORSINI
13.1 INTRODUCTION 263
13.2 REPAIR OF DENTAL TISSUES 264
13.3 DENTAL STEM CELLS AND THEIR REGENERATIVE POTENTIAL 265
13.4 REGENERATIVE DENTISTRY 267
13.5 NANOTECHNOLOGY IN DENTISTRY 269
13.6 NANOSCALE SURFACE MODIFICATIONS OF DENTAL BIOMATERIALS 270
13.6.1 APPROACHES FOR NANOSCALE SURFACE MODIFICATION IN
DENTAL IMPLANTS 270
13.6.2 BIOLOGICAL SURFACES PRINCIPLES 271
13.6.3 CELLULAR RESPONSES TO NANOSTRUCTURED SURFACES 272
13.6.4 CLINICAL APPLICATIONS OF NANOSTRUCTURED DENTAL IMPLANTS 273
13.6.5 NANOMODIFICATIONS OF BONE REPLACEMENTS MATERIALS 275
13.6.6 NANOFILLERS IN DENTAL RESTORATIVE MATERIALS 276
13.6.7 NANOSCALE MODIFICATION IN THE TREATMENT OF DENTIN
HYPERSENSITIVITY
AND ENAMEL REMINERALIZATION 278
13.7 CONCLUDING REMARKS 279
ACKNOWLEDGMENTS 280
REFERENCES 280
14 NANOSTRUCTURED POLYMERS FOR MEDICAL APPLICATIONS 293
PRABITHA URWYLER AND HELMUT SCHIFT
14.1 INTRODUCTION 293
14.1.1 NANOSTRUCTURED POLYMERS - A PROMISING APPROACH IN BIOMEDICAL
APPLICATIONS 293
14.1.2 STRATEGIES FOR CREATION OF SURFACE NANOTOPOGRAPHIES 294
14.2 APPLICATIONS OF NANOSTRUCTURES 295
14.2.1 WHICH NANOEFFECTS WILL BE EXPLOITED FOR BIOMEDICAL
APPLICATIONS? 296
14.2.1.1 COMBINED EFFECTS 298
14.2.1.2 CELL PROLIFERATION AND DIFFERENTIATION 298
14.2.1.3 PROTEIN NANOPATTERN 300
14.2.2 MIMICKING NATURE 300
14.2.3 GECKO-INSPIRED BANDAGE AS AN EXAMPLE 301
14.3 PROCESSES FOR GENERATION OF NANOTOPOGRAPHIES 301
14.3.1 TOP-DOWN MANUFACTURING BY ORIGINATION, TOOLING, REPLICATION 302
14.3.2 BOTTOM-UP MANUFACTURING BY SELF-ORGANIZATION AND SURFACE
POSTPROCESSING 303
14.4 SURFACE PATTERNING OF MICROCANTILEVERS USING MOLD INLAYS 303
14.5 SURFACE PATTERNING USING PLASMA ETCHING 306
14.6 CELL RESPONSE TO SURFACE PATTERNING 308
14.7 CONCLUSION 309
REFERENCES 310
15 NANOTECHNOLOGY IN THE TREATMENT OF INCONTINENCE 315
VANESSA LEUNG AND CHRISTIAN GINGERT
15.1 URINARY INCONTINENCE 316
15.1.1 URINARY INCONTINENCE ETIOLOGY 316
15.1.2 URINARY IN-/CONTINENCE ASSESSMENT 316
15.1.3 PHYSICS OF URINARY CONTINENCE 318
15.1.4 TISSUE ENGINEERING AND SLING MATERIAL FOR SPHINCTER REGENERATION
319
15.2 FECAL INCONTINENCE 321
15.2.1 FECAL INCONTINENCE ETIOLOGY 321
15.2.2 PHYSICS OF FECAL CONTINENCE 321
15.2.3 FECAL IN-/CONTINENCE ASSESSMENT 322
15.2.4 TISSUE ENGINEERING FOR SPHINCTER REGENERATION 323
15.2.5 DIELECTRIC ELASTOMER ACTUATORS FOR SPHINCTER REPLACEMENT 324
REFERENCES 327
16 NANOMEDICINE IN DERMATOLOGY: NANOTECHNOLOGY IN PREVENTION,
DIAGNOSIS, AND THERAPY 329
KATHRIN SCHERER HOFMEIER AND CHRISTIAN SURBER
16.1 INTRODUCTION 329
16.2 NATURE OF NANOPARTICLES 330
16.2.1 SOFT PARTICLES 330
16.2.2 RIGID PARTICLES 331
16.2.3 SURFACE FUNCTIONALIZATION 332
16.2.4 FORMULATIONS WITH NANOPARTICLES 333
16.3 ABSORPTION OF NANOPARTICLES THROUGH SKIN 333
16.3.1 ABSORPTION PATHWAYS 333
16.3.2 RISK AND SAFETY CONSIDERATIONS 335
16.4 NANOPARTICLES IN PREVENTION, DIAGNOSIS, AND THERAPY 336
16.4.1 PREVENTION 336
16.4.1.1 ANTISEPSIS 336
16.4.1.2 PHOTOPROTECTION, COLOR, AND LIGHT REFLECTANCE CONTROL 337
16.4.1.3 PREVENTIVE CARE 338
16.4.1.4 ODOR NEUTRALIZERS 338
16.4.1.5 VACCINES 338
16.4.2 DIAGNOSIS AND MONITORING 338
16.4.3 THERAPY 340
16.4.3.1 SEBACEOUS GLAND DISORDERS 340
16.4.3.2 HAIR DISORDERS 340
16.4.3.3 INFLAMMATORY DISORDERS 341
16.4.3.4 CANCER 341
16.4.3.5 SURGERY 343
16.5 REGULATORY ISSUES 344
16.6 PUBLIC PERCEPTION OF NANOPARTICLES IN TOPICALS 344
16.7 CONCLUSIONS AND FUTURE PERSPECTIVES 345
REFERENCES 347
PART FIVE BENEFITING PATIENTS 357
17 THERAPEUTIC DEVELOPMENT AND THE EVOLUTION OF PRECISION MEDICINE 359
GARETH D. HEALEY AND R. STEVEN CONLAN
17.1 ORIGINS OF NANOMEDICINE 359
17.2 GLOBAL NANOMEDICINE MARKET 360
17.3 NANOMEDICINE CABINET 361
17.4 APPLICATION OF NANOMEDICINE - A PARADIGM SHIFT 365
17.5 TARGETED DRUG DISCOVERY AND THE HUMAN KINOME 367
17.6 TRANSLATION FROM DISCOVERY TO THE CLINIC 369
17.7 EVOLUTION OF KINASE INHIBITORS 370
17.8 NANOPARTICLE DELIVERY 372
17.9 CONCLUSIONS 374
REFERENCES 374
18 BENEFIT FROM NANOSCIENCE AND NANOTECHNOLOGY: BENEFITTING
PATIENTS 379
BERT MUELLER AND MARCEL H. VAN DE VOORDE
INDEX 383
|
| any_adam_object | 1 |
| author2 | Müller, Bert 1962- Voorde, Marcel H. van de 1936- |
| author2_role | edt edt |
| author2_variant | b m bm m h v d v mhvd mhvdv |
| author_GND | (DE-588)1129794326 (DE-588)121729028 |
| author_facet | Müller, Bert 1962- Voorde, Marcel H. van de 1936- |
| building | Verbundindex |
| bvnumber | BV044183122 |
| classification_rvk | VE 9850 ZN 3700 |
| ctrlnum | (OCoLC)979535829 (DE-599)DNB1107790689 |
| dewey-full | 610 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 610 - Medicine and health |
| dewey-raw | 610 |
| dewey-search | 610 |
| dewey-sort | 3610 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Elektrotechnik / Elektronik / Nachrichtentechnik Medizin |
| format | Book |
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| genre | (DE-588)4143413-4 Aufsatzsammlung gnd-content |
| genre_facet | Aufsatzsammlung |
| id | DE-604.BV044183122 |
| illustrated | Illustrated |
| indexdate | 2024-07-10T07:46:01Z |
| institution | BVB |
| institution_GND | (DE-588)16179388-5 |
| isbn | 9783527338603 3527338608 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029589954 |
| oclc_num | 979535829 |
| open_access_boolean | |
| owner | DE-12 DE-29T DE-20 |
| owner_facet | DE-12 DE-29T DE-20 |
| physical | XXII, 393 Seiten Illustrationen |
| publishDate | 2017 |
| publishDateSearch | 2017 |
| publishDateSort | 2017 |
| publisher | Wiley-VCH |
| record_format | marc |
| series2 | Nanotechnology innovation & applications |
| spelling | Nanoscience and nanotechnology for human health edited by Bert Müller and Marcel Van de Voorde Weinheim Wiley-VCH 2017 XXII, 393 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Nanotechnology innovation & applications Medizin (DE-588)4038243-6 gnd rswk-swf Nanomedizin (DE-588)1067838503 gnd rswk-swf Nanotechnologie (DE-588)4327470-5 gnd rswk-swf Basic Medical Sciences Chemie Chemistry Medical Science Medizin Medizinische Grundlagenfächer Nanomedicine Nanomedizin Nanotechnologie Nanotechnology Pharmaceutical & Medicinal Chemistry Pharmazeutische u. Medizinische Chemie (DE-588)4143413-4 Aufsatzsammlung gnd-content Nanomedizin (DE-588)1067838503 s DE-604 Nanotechnologie (DE-588)4327470-5 s Medizin (DE-588)4038243-6 s Müller, Bert 1962- (DE-588)1129794326 edt Voorde, Marcel H. van de 1936- (DE-588)121729028 edt Wiley-VCH (DE-588)16179388-5 pbl Erscheint auch als Online-Ausgabe, ePDF 978-3-527-69204-0 Erscheint auch als Online-Ausgabe, ePub 978-3-527-6906-4 Erscheint auch alsi Online-Ausgabe, Mobi 978-3-527-69207-1 Erscheint auch als Online-Ausgabe, oBook 978-3-527-69205-7 http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-33860-3/ Verlag DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029589954&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Nanoscience and nanotechnology for human health Medizin (DE-588)4038243-6 gnd Nanomedizin (DE-588)1067838503 gnd Nanotechnologie (DE-588)4327470-5 gnd |
| subject_GND | (DE-588)4038243-6 (DE-588)1067838503 (DE-588)4327470-5 (DE-588)4143413-4 |
| title | Nanoscience and nanotechnology for human health |
| title_auth | Nanoscience and nanotechnology for human health |
| title_exact_search | Nanoscience and nanotechnology for human health |
| title_full | Nanoscience and nanotechnology for human health edited by Bert Müller and Marcel Van de Voorde |
| title_fullStr | Nanoscience and nanotechnology for human health edited by Bert Müller and Marcel Van de Voorde |
| title_full_unstemmed | Nanoscience and nanotechnology for human health edited by Bert Müller and Marcel Van de Voorde |
| title_short | Nanoscience and nanotechnology for human health |
| title_sort | nanoscience and nanotechnology for human health |
| topic | Medizin (DE-588)4038243-6 gnd Nanomedizin (DE-588)1067838503 gnd Nanotechnologie (DE-588)4327470-5 gnd |
| topic_facet | Medizin Nanomedizin Nanotechnologie Aufsatzsammlung |
| url | http://www.wiley-vch.de/publish/dt/books/ISBN978-3-527-33860-3/ http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029589954&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
| work_keys_str_mv | AT mullerbert nanoscienceandnanotechnologyforhumanhealth AT voordemarcelhvande nanoscienceandnanotechnologyforhumanhealth AT wileyvch nanoscienceandnanotechnologyforhumanhealth |