Apoptosis in health and disease: clinical and therapeutic aspects
The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions...
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| Other Authors: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cambridge
Cambridge University Press
2005
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| Subjects: | |
| Online Access: | BSB01 FHN01 Volltext |
| Summary: | The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states |
| Item Description: | Title from publisher's bibliographic system (viewed on 05 Oct 2015) |
| Physical Description: | 1 online resource (ix, 249 pages) |
| ISBN: | 9780511663543 |
| DOI: | 10.1017/CBO9780511663543 |
Staff View
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| 520 | |a The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states | ||
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| contents | Apoptosis in health, disease and therapy: overview and methodology -- Developmental apoptosis in health and disease -- Apoptosis and cancer -- Neuronal cell death in human neurodegenerative diseases and their animal/cell models -- Apoptosis in the cardiovascular system: incidence, regulation, and therapeutic options -- Cytotoxic lymphocytes, apoptosis, and autoimmunity -- Pro- and anti-apoptotic strategies of viruses |
| ctrlnum | (ZDB-20-CBO)CR9780511663543 (OCoLC)992853235 (DE-599)BVBBV043944451 |
| dewey-full | 571.9/36 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.9/36 |
| dewey-search | 571.9/36 |
| dewey-sort | 3571.9 236 |
| dewey-tens | 570 - Biology |
| discipline | Biologie |
| doi_str_mv | 10.1017/CBO9780511663543 |
| format | Electronic eBook |
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| id | DE-604.BV043944451 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:39:21Z |
| institution | BVB |
| isbn | 9780511663543 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029353421 |
| oclc_num | 992853235 |
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| owner_facet | DE-12 DE-92 |
| physical | 1 online resource (ix, 249 pages) |
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| publisher | Cambridge University Press |
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| spelling | Apoptosis in health and disease clinical and therapeutic aspects edited by Martin Holcik [and others] Apoptosis in Health & Disease Cambridge Cambridge University Press 2005 1 online resource (ix, 249 pages) txt rdacontent c rdamedia cr rdacarrier Title from publisher's bibliographic system (viewed on 05 Oct 2015) Apoptosis in health, disease and therapy: overview and methodology -- Developmental apoptosis in health and disease -- Apoptosis and cancer -- Neuronal cell death in human neurodegenerative diseases and their animal/cell models -- Apoptosis in the cardiovascular system: incidence, regulation, and therapeutic options -- Cytotoxic lymphocytes, apoptosis, and autoimmunity -- Pro- and anti-apoptotic strategies of viruses The process of programmed cell death or apoptosis has, in the decade preceding the publication of this 2005 book, been shown to be centrally involved in the pathogenesis of the significant majority of human illnesses and injury states. The cellular attrition observed in most degenerative conditions is apoptotic in nature; conversely a failure of apoptosis has been proposed to underlie many forms of cancer. The central role of apoptosis in human disease clearly brings with it clinical promise; for example, the strong possibility exists that attenuation of apoptotic death will significantly modulate the severity of degenerative disorders. Similarly, conditions, such as cancer, autoimmune disease, psoriasis and endometriosis, in which aberrant cellular proliferation is observed, may benefit from enhanced rates of apoptosis. This book surveys the underlying molecular mechanisms of apoptosis, investigates its role in degenerative and other diseases, and evaluates potential therapies that will permit appropriate activation or inhibition of apoptosis in disease and injury states Apoptosis Pathology, Cellular Apoptosis (DE-588)4291096-1 gnd rswk-swf Apoptosis (DE-588)4291096-1 s 1\p DE-604 Holcik, Martin 1967- edt Erscheint auch als Druckausgabe 978-0-521-15944-9 Erscheint auch als Druckausgabe 978-0-521-52956-3 https://doi.org/10.1017/CBO9780511663543 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Apoptosis in health and disease clinical and therapeutic aspects Apoptosis in health, disease and therapy: overview and methodology -- Developmental apoptosis in health and disease -- Apoptosis and cancer -- Neuronal cell death in human neurodegenerative diseases and their animal/cell models -- Apoptosis in the cardiovascular system: incidence, regulation, and therapeutic options -- Cytotoxic lymphocytes, apoptosis, and autoimmunity -- Pro- and anti-apoptotic strategies of viruses Apoptosis Pathology, Cellular Apoptosis (DE-588)4291096-1 gnd |
| subject_GND | (DE-588)4291096-1 |
| title | Apoptosis in health and disease clinical and therapeutic aspects |
| title_alt | Apoptosis in Health & Disease |
| title_auth | Apoptosis in health and disease clinical and therapeutic aspects |
| title_exact_search | Apoptosis in health and disease clinical and therapeutic aspects |
| title_full | Apoptosis in health and disease clinical and therapeutic aspects edited by Martin Holcik [and others] |
| title_fullStr | Apoptosis in health and disease clinical and therapeutic aspects edited by Martin Holcik [and others] |
| title_full_unstemmed | Apoptosis in health and disease clinical and therapeutic aspects edited by Martin Holcik [and others] |
| title_short | Apoptosis in health and disease |
| title_sort | apoptosis in health and disease clinical and therapeutic aspects |
| title_sub | clinical and therapeutic aspects |
| topic | Apoptosis Pathology, Cellular Apoptosis (DE-588)4291096-1 gnd |
| topic_facet | Apoptosis Pathology, Cellular |
| url | https://doi.org/10.1017/CBO9780511663543 |
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