Optimal high-throughput screening: practical experimental design and data analysis for genome-scale RNAi research
This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental de...
Gespeichert in:
| 1. Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cambridge
Cambridge University Press
2011
|
| Schlagworte: | |
| Online-Zugang: | BSB01 FHN01 Volltext |
| Zusammenfassung: | This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments |
| Beschreibung: | Title from publisher's bibliographic system (viewed on 05 Oct 2015) |
| Beschreibung: | 1 online resource (xviii, 203 pages) |
| ISBN: | 9780511973888 |
| DOI: | 10.1017/CBO9780511973888 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV043943977 | ||
| 003 | DE-604 | ||
| 005 | 00000000000000.0 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 161206s2011 |||| o||u| ||||||eng d | ||
| 020 | |a 9780511973888 |c Online |9 978-0-511-97388-8 | ||
| 024 | 7 | |a 10.1017/CBO9780511973888 |2 doi | |
| 035 | |a (ZDB-20-CBO)CR9780511973888 | ||
| 035 | |a (OCoLC)967698800 | ||
| 035 | |a (DE-599)BVBBV043943977 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-12 |a DE-92 | ||
| 082 | 0 | |a 615/.19 |2 22 | |
| 100 | 1 | |a Zhang, Xiaohua Douglas |d 1966- |e Verfasser |4 aut | |
| 245 | 1 | 0 | |a Optimal high-throughput screening |b practical experimental design and data analysis for genome-scale RNAi research |c Xiaohua Douglas Zhang, Merck Research Laboratories |
| 264 | 1 | |a Cambridge |b Cambridge University Press |c 2011 | |
| 300 | |a 1 online resource (xviii, 203 pages) | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 500 | |a Title from publisher's bibliographic system (viewed on 05 Oct 2015) | ||
| 505 | 8 | |a Machine generated contents note: Part I. RNAi HTS and Data Analysis: 1. Introduction to genome-scale RNAi research; 2. Experimental designs; 3. Data display and normalization; 4. Quality control in genome-scale RNAi screens; 5. Hit selection in genome-scale RNAi screens without replicates; 6. Hit selection in genome-scale RNAi screens with replicates; Part II. Methodological Development for Analyzing RNAi HTS Screens: 7. Statistical methods for group comparison; 8. Statistical methods for assessing the size of siRNA effects | |
| 520 | |a This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments | ||
| 650 | 4 | |a High throughput screening (Drug development) | |
| 650 | 4 | |a Small interfering RNA. | |
| 650 | 4 | |a Experimental design | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druckausgabe |z 978-0-521-51771-3 |
| 776 | 0 | 8 | |i Erscheint auch als |n Druckausgabe |z 978-0-521-73444-8 |
| 856 | 4 | 0 | |u https://doi.org/10.1017/CBO9780511973888 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-20-CBO | ||
| 999 | |a oai:aleph.bib-bvb.de:BVB01-029352948 | ||
| 966 | e | |u https://doi.org/10.1017/CBO9780511973888 |l BSB01 |p ZDB-20-CBO |q BSB_PDA_CBO |x Verlag |3 Volltext | |
| 966 | e | |u https://doi.org/10.1017/CBO9780511973888 |l FHN01 |p ZDB-20-CBO |q FHN_PDA_CBO |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804176888394940416 |
|---|---|
| any_adam_object | |
| author | Zhang, Xiaohua Douglas 1966- |
| author_facet | Zhang, Xiaohua Douglas 1966- |
| author_role | aut |
| author_sort | Zhang, Xiaohua Douglas 1966- |
| author_variant | x d z xd xdz |
| building | Verbundindex |
| bvnumber | BV043943977 |
| collection | ZDB-20-CBO |
| contents | Machine generated contents note: Part I. RNAi HTS and Data Analysis: 1. Introduction to genome-scale RNAi research; 2. Experimental designs; 3. Data display and normalization; 4. Quality control in genome-scale RNAi screens; 5. Hit selection in genome-scale RNAi screens without replicates; 6. Hit selection in genome-scale RNAi screens with replicates; Part II. Methodological Development for Analyzing RNAi HTS Screens: 7. Statistical methods for group comparison; 8. Statistical methods for assessing the size of siRNA effects |
| ctrlnum | (ZDB-20-CBO)CR9780511973888 (OCoLC)967698800 (DE-599)BVBBV043943977 |
| dewey-full | 615/.19 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615/.19 |
| dewey-search | 615/.19 |
| dewey-sort | 3615 219 |
| dewey-tens | 610 - Medicine and health |
| discipline | Medizin |
| doi_str_mv | 10.1017/CBO9780511973888 |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>03135nmm a2200433zc 4500</leader><controlfield tag="001">BV043943977</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">00000000000000.0</controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">161206s2011 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9780511973888</subfield><subfield code="c">Online</subfield><subfield code="9">978-0-511-97388-8</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1017/CBO9780511973888</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-20-CBO)CR9780511973888</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)967698800</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043943977</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-12</subfield><subfield code="a">DE-92</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615/.19</subfield><subfield code="2">22</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Zhang, Xiaohua Douglas</subfield><subfield code="d">1966-</subfield><subfield code="e">Verfasser</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Optimal high-throughput screening</subfield><subfield code="b">practical experimental design and data analysis for genome-scale RNAi research</subfield><subfield code="c">Xiaohua Douglas Zhang, Merck Research Laboratories</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Cambridge</subfield><subfield code="b">Cambridge University Press</subfield><subfield code="c">2011</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 online resource (xviii, 203 pages)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Title from publisher's bibliographic system (viewed on 05 Oct 2015)</subfield></datafield><datafield tag="505" ind1="8" ind2=" "><subfield code="a">Machine generated contents note: Part I. RNAi HTS and Data Analysis: 1. Introduction to genome-scale RNAi research; 2. Experimental designs; 3. Data display and normalization; 4. Quality control in genome-scale RNAi screens; 5. Hit selection in genome-scale RNAi screens without replicates; 6. Hit selection in genome-scale RNAi screens with replicates; Part II. Methodological Development for Analyzing RNAi HTS Screens: 7. Statistical methods for group comparison; 8. Statistical methods for assessing the size of siRNA effects</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">High throughput screening (Drug development)</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Small interfering RNA.</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Experimental design</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druckausgabe</subfield><subfield code="z">978-0-521-51771-3</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druckausgabe</subfield><subfield code="z">978-0-521-73444-8</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://doi.org/10.1017/CBO9780511973888</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-20-CBO</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-029352948</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1017/CBO9780511973888</subfield><subfield code="l">BSB01</subfield><subfield code="p">ZDB-20-CBO</subfield><subfield code="q">BSB_PDA_CBO</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://doi.org/10.1017/CBO9780511973888</subfield><subfield code="l">FHN01</subfield><subfield code="p">ZDB-20-CBO</subfield><subfield code="q">FHN_PDA_CBO</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV043943977 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:39:20Z |
| institution | BVB |
| isbn | 9780511973888 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029352948 |
| oclc_num | 967698800 |
| open_access_boolean | |
| owner | DE-12 DE-92 |
| owner_facet | DE-12 DE-92 |
| physical | 1 online resource (xviii, 203 pages) |
| psigel | ZDB-20-CBO ZDB-20-CBO BSB_PDA_CBO ZDB-20-CBO FHN_PDA_CBO |
| publishDate | 2011 |
| publishDateSearch | 2011 |
| publishDateSort | 2011 |
| publisher | Cambridge University Press |
| record_format | marc |
| spelling | Zhang, Xiaohua Douglas 1966- Verfasser aut Optimal high-throughput screening practical experimental design and data analysis for genome-scale RNAi research Xiaohua Douglas Zhang, Merck Research Laboratories Cambridge Cambridge University Press 2011 1 online resource (xviii, 203 pages) txt rdacontent c rdamedia cr rdacarrier Title from publisher's bibliographic system (viewed on 05 Oct 2015) Machine generated contents note: Part I. RNAi HTS and Data Analysis: 1. Introduction to genome-scale RNAi research; 2. Experimental designs; 3. Data display and normalization; 4. Quality control in genome-scale RNAi screens; 5. Hit selection in genome-scale RNAi screens without replicates; 6. Hit selection in genome-scale RNAi screens with replicates; Part II. Methodological Development for Analyzing RNAi HTS Screens: 7. Statistical methods for group comparison; 8. Statistical methods for assessing the size of siRNA effects This concise, self-contained and cohesive book focuses on commonly used and recently developed methods for designing and analyzing high-throughput screening (HTS) experiments from a statistically sound basis. Combining ideas from biology, computing and statistics, the author explains experimental designs and analytic methods that are amenable to rigorous analysis and interpretation of RNAi HTS experiments. The opening chapters are carefully presented to be accessible both to biologists with training only in basic statistics and to computational scientists and statisticians with basic biological knowledge. Biologists will see how new experiment designs and rudimentary data-handling strategies for RNAi HTS experiments can improve their results, whereas analysts will learn how to apply recently developed statistical methods to interpret HTS experiments High throughput screening (Drug development) Small interfering RNA. Experimental design Erscheint auch als Druckausgabe 978-0-521-51771-3 Erscheint auch als Druckausgabe 978-0-521-73444-8 https://doi.org/10.1017/CBO9780511973888 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Zhang, Xiaohua Douglas 1966- Optimal high-throughput screening practical experimental design and data analysis for genome-scale RNAi research Machine generated contents note: Part I. RNAi HTS and Data Analysis: 1. Introduction to genome-scale RNAi research; 2. Experimental designs; 3. Data display and normalization; 4. Quality control in genome-scale RNAi screens; 5. Hit selection in genome-scale RNAi screens without replicates; 6. Hit selection in genome-scale RNAi screens with replicates; Part II. Methodological Development for Analyzing RNAi HTS Screens: 7. Statistical methods for group comparison; 8. Statistical methods for assessing the size of siRNA effects High throughput screening (Drug development) Small interfering RNA. Experimental design |
| title | Optimal high-throughput screening practical experimental design and data analysis for genome-scale RNAi research |
| title_auth | Optimal high-throughput screening practical experimental design and data analysis for genome-scale RNAi research |
| title_exact_search | Optimal high-throughput screening practical experimental design and data analysis for genome-scale RNAi research |
| title_full | Optimal high-throughput screening practical experimental design and data analysis for genome-scale RNAi research Xiaohua Douglas Zhang, Merck Research Laboratories |
| title_fullStr | Optimal high-throughput screening practical experimental design and data analysis for genome-scale RNAi research Xiaohua Douglas Zhang, Merck Research Laboratories |
| title_full_unstemmed | Optimal high-throughput screening practical experimental design and data analysis for genome-scale RNAi research Xiaohua Douglas Zhang, Merck Research Laboratories |
| title_short | Optimal high-throughput screening |
| title_sort | optimal high throughput screening practical experimental design and data analysis for genome scale rnai research |
| title_sub | practical experimental design and data analysis for genome-scale RNAi research |
| topic | High throughput screening (Drug development) Small interfering RNA. Experimental design |
| topic_facet | High throughput screening (Drug development) Small interfering RNA. Experimental design |
| url | https://doi.org/10.1017/CBO9780511973888 |
| work_keys_str_mv | AT zhangxiaohuadouglas optimalhighthroughputscreeningpracticalexperimentaldesignanddataanalysisforgenomescalernairesearch |