The innate immune response to noninfectious stressors: human and animal models
The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress respons...
Gespeichert in:
| Weitere Verfasser: | |
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| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
[2016]
London, UK Academic Press [2016] |
| Schlagworte: | |
| Online-Zugang: | TUM01 UBR01 URL des Erstveröffentlichers Inhaltsverzeichnis |
| Zusammenfassung: | The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation |
| Beschreibung: | 1 Online-Ressource (xxvii, 247 Seiten) Illustrationen, Diagramme |
| ISBN: | 0128019743 9780128019740 |
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Datensatz im Suchindex
| _version_ | 1804176779539120128 |
|---|---|
| adam_text | Titel: The innate immune response to noninfectious stressors
Autor: Amadori, Massimo
Jahr: 2016
Contents
Contributors xiii
Preface xv
1. An Overview of the Innate Immune Response
to Infectious and Noninfectious Stressors
Stefania Gallucci
Introduction 1
Recognition 2
PRRs and PAMPs 3
Toil-Like Receptors 5
C-Type Lectin Receptors 6
The RIG-I-Like Receptors 7
NLRs and the Inflammasome 8
AIM2-Like Receptors 9
C-CAS and Other DNA Sensors 10
RAGE 10
Soluble PRRs 11
PRR Localization 11
DAMPs 12
Nucleic Acids 12
ATP 13
Uric Acid 14
Heat-Shock Proteins 15
Mitochondrial Danger Signals 15
HMGB1 16
Degradation Products of the Extracellular Matrix 17
Secondary Endogenous Danger Signals 18
Emerging and Homeostatic Danger Signals 18
Conclusions 19
References 20
vii
viii Contents
2. Homeostatic Inflammation as Environmental-Adaptation
Strategy
Kensuke Miyake, Ryutaro Fukui
Introduction 25
Innate Immune Sensors Recognize Various Endogenous
Ligands Including Metabolites 25
Modulation of Metabolites Recognized by Extracellular Sensors 27
Modification of Nucleic Acid-Sensing Receptors 28
DNA and RNA are Modified to be Recognized or not by
Innate Immune Sensors 31
Priming Effect of Noninfectious Inflammation on
Immune Response 33
Correlation with Inflammatory and Autoimmune Diseases
in Adipose Tissue 35
Excessive Activation of Nucleic Acid-Sensing Sensors Induces
Autoimmune Diseases 37
Regulation of Homeostatic Inflammation and Innate Immune
Sensors for Controlling Immune System and Homeostasis 39
References 40
3. The Molecular Basis of the Immune Response
to Stressed Cells and Tissues
Segundo Gonzilez, Carlos Ldpez-Larrea, Alejandro Ldpez-Soto
Innate Immune Responses: Receptors and Ligands 54
Stress-Mediated Regulation of Immune Receptors and Ligands:
An Overview 54
Transcriptional Regulation of NK-Cell Activating Ligands
Modulated by Stress Responses 57
Posttranscriptional Regulation of Stress-Controlled NK-Cell
Activating Ligands 58
Translational and Posttranslational Regulation
of Stress-Modulated NK-Cell Activating Ligands 59
Different Forms of Stress Regulate Innate Immunity 61
Osmotic Stress 61
Thermal Stress 62
Genotoxic Stress 63
Oxidative Stress 65
Endoplasmic Reticulum Stress 66
Stress-Induced Senescence 67
Immunogenic Cell Death: Putting all the Things Together 68
References 70
Contents ix
4. Modulation of Innate Immunity by Hypoxia
Elena Riboidi, Antonio Sica
Hypoxia 81
Hypoxia Sensing 82
Hypoxia-Inducible Factors 83
Nuclear Factor kB 85
Hypoxia Effects on Leukocytes 86
Myeloid Cells 86
Lymphoid Cells 91
Hypoxia, Myeloid Cells, and Diseases 92
Pulmonary Hypertension (PH) 92
Rheumatoid Arthritis 92
Inflammatory Bowel Disease 93
Atherosclerosis 93
Ischemia 94
Preeclampsia 94
Allergy 94
Cancer 94
Therapeutic Targeting of Hypoxic Signaling 95
HIF Activators 95
HIF Inhibitors 96
References 97
5. Metabolic Stress, Heat Shock Proteins, and
Innate Immune Response
Nicola Lacetera
Introduction 107
Metabolic Stress Conditions 107
Metabolic Stress and Innate Immunity 110
Metabolic Stress, Oxidative Stress, and Heat Shock Proteins 113
Heat-Shock Proteins and Innate Immune Response 118
Conclusions 123
References 123
6. Innate Immune Responses and Cancer Metastasis
Yoshiro Maru
Clinical Information on Metastasis 133
Elements that Constitute Metastasis 134
Definition and Understanding 134
Triangle 136
Angiogenesis Promotes Coagulation and Induces Inflammation 136
Coagulation Promotes Angiogenesis and Inflammation 138
Inflammation Participates in Both Angiogenesis and Coagulation 143
x Contents
Lung Homeostasis 145
Interphase 145
Cell Mobilization 146
Mimicry 148
Premetastasis 148
An idea of Premetastasis 148
Isolated Lung Perfusion 149
Molecular Biology of Premetastatic Lungs 151
Defective Conservation of SAA3 152
Homeostatic Inflammation and Therapeutic Targeting 153
References 157
7. Innate Immune Response and Psychotic Disorders
Jaana Suvisaari, Outi Mantere
Introduction 165
Psychotic Disorders: Neurodevelopmental Disorders with
a Neuroprogressive Component 168
Pre- and Perinatal Exposures 169
Childhood and Adolescence Exposures 170
Genetic Evidence of the Contribution of Immunological
Factors to Psychotic Disorders 171
Innate Immunity Disturbances in People with
Psychotic Disorders 171
Microglia in Psychotic Disorders 175
Neuronal Autoantibodies and Psychosis 176
Microbiome and Inflammation in Psychotic Disorders 176
An Immune-Mediated Two-Hit Model for Psychosis 177
Confounders 178
Psychosis as Compared to Autoimmune Disorders 179
Anti-Inflammatory Drugs as Adjunctive Medication in
Psychotic Disorders 179
Future Directions 180
References 182
8. Modulation of the Interferon Response
by Environmental, Noninfectious Stressors
Elisahetta Razzuoli, Cinzia Zanotti, Massimo Amadori
Introduction 191
Biological Functions 192
Constitutive Expression 194
Stress, Tissue Damage, and IFN Responses 196
Human Models 197
Contents xi
Animal Models 199
Weaning Stress 199
Transportation Stress 199
Exposure to Mycotoxins 200
Pregnancy 201
Conclusions 202
References 202
9. Disease-Predicting and Prognostic Potential of Innate
Immune Responses to Noninfectious Stressors:
Human and Animal Models
Erminio Trevisi, Livia Moscati, Massimo Amadori
Introduction 209
Health and Disease 209
Innate Immunity and Inflammation 210
Mediators of Inflammation: Local and Systemic Effects 210
Possible Causes of Dysregulated Inflammatory Response 213
Inflammation and Disease 214
Human Models 214
Animal Models: The Periparturient Dairy Cow 217
Disease Occurrence in Periparturient Dairy Cows 217
Causes of the Inflammatory Response in Periparturient
Dairy Cows 217
Blood Indexes to Assess the Inflammatory Response in
Dairy Cows 218
Aggregate Indices of the Inflammatory Response After
Calving Allow Early Diagnosis and/or Prognosis of
Disease Conditions 219
Blood Indices in Late Pregnancy Allow to Predict
Disease Occurrence After Calving 223
Animal Models: The Farmed Pig 225
Disease Occurrence in Farmed Pigs 225
Lean Type Pig: Borderline Animal 226
Case 1: Innate Immunity Parameters as Prognostic
and Diagnostic Tools 227
Case 2: Human-Animal Relationship in Pig Production:
Influence on Innate Immunity 227
Case 3: Innate Immune Response to Thermal Stress 228
References 229
Subject Index 237
|
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| spelling | The innate immune response to noninfectious stressors human and animal models edited by Massimo Amadori Amsterdam Elsevier [2016] London, UK Academic Press [2016] 1 Online-Ressource (xxvii, 247 Seiten) Illustrationen, Diagramme txt rdacontent c rdamedia cr rdacarrier The Innate Immune Response to Non-infectious Stressors: Human and Animal Models highlights fundamental mechanisms of stress response and important findings on how the immune system is affected, and in turn affects such a response. In addition, this book covers the crucial link between stress response and energy metabolism, prompts a re-appraisal of some crucial issues, and helps to define research priorities in this fascinating, somehow elusive field of investigation Chronic diseases Immune response Mensch (DE-588)4038639-9 gnd rswk-swf Tiermodell (DE-588)4140660-6 gnd rswk-swf Nichtinfektiöse Entzündung (DE-588)4171739-9 gnd rswk-swf Immunreaktion (DE-588)4133841-8 gnd rswk-swf Immunreaktion (DE-588)4133841-8 s Mensch (DE-588)4038639-9 s Tiermodell (DE-588)4140660-6 s Nichtinfektiöse Entzündung (DE-588)4171739-9 s DE-604 Amadori, Massimo edt Erscheint auch als Druck-Ausgabe 978-0-12-801968-9 http://www.sciencedirect.com/science/book/9780128019689 Verlag URL des Erstveröffentlichers Volltext HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029292465&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The innate immune response to noninfectious stressors human and animal models Chronic diseases Immune response Mensch (DE-588)4038639-9 gnd Tiermodell (DE-588)4140660-6 gnd Nichtinfektiöse Entzündung (DE-588)4171739-9 gnd Immunreaktion (DE-588)4133841-8 gnd |
| subject_GND | (DE-588)4038639-9 (DE-588)4140660-6 (DE-588)4171739-9 (DE-588)4133841-8 |
| title | The innate immune response to noninfectious stressors human and animal models |
| title_auth | The innate immune response to noninfectious stressors human and animal models |
| title_exact_search | The innate immune response to noninfectious stressors human and animal models |
| title_full | The innate immune response to noninfectious stressors human and animal models edited by Massimo Amadori |
| title_fullStr | The innate immune response to noninfectious stressors human and animal models edited by Massimo Amadori |
| title_full_unstemmed | The innate immune response to noninfectious stressors human and animal models edited by Massimo Amadori |
| title_short | The innate immune response to noninfectious stressors |
| title_sort | the innate immune response to noninfectious stressors human and animal models |
| title_sub | human and animal models |
| topic | Chronic diseases Immune response Mensch (DE-588)4038639-9 gnd Tiermodell (DE-588)4140660-6 gnd Nichtinfektiöse Entzündung (DE-588)4171739-9 gnd Immunreaktion (DE-588)4133841-8 gnd |
| topic_facet | Chronic diseases Immune response Mensch Tiermodell Nichtinfektiöse Entzündung Immunreaktion |
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