Fragment-based drug design: tools, practical approaches, and examples
Saved in:
| Format: | Electronic eBook |
|---|---|
| Language: | English |
| Published: |
Amsterdam
Academic Press
c2011
|
| Edition: | 1st ed |
| Series: | Methods in enzymology
v. 493 |
| Subjects: | |
| Online Access: | UER01 FAW01 Volltext |
| Item Description: | Includes bibliographical references and indexes There are numerous excellent reviews on Fragment Based Drug Discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. |
| Physical Description: | li, 591 p., [16] p. of plates |
| ISBN: | 9780123812759 0123812755 9780123812742 0123812747 |
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| indexdate | 2024-07-10T07:37:28Z |
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| isbn | 9780123812759 0123812755 9780123812742 0123812747 |
| language | English |
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| physical | li, 591 p., [16] p. of plates |
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| publishDate | 2011 |
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| series2 | Methods in enzymology |
| spelling | Fragment-based drug design tools, practical approaches, and examples edited by Lawrence C. Kuo 1st ed Amsterdam Academic Press c2011 li, 591 p., [16] p. of plates txt rdacontent c rdamedia cr rdacarrier Methods in enzymology v. 493 Includes bibliographical references and indexes There are numerous excellent reviews on Fragment Based Drug Discovery (FBDD), but there are to date no hand-holding guides or protocols with which one can embark on this orthogonal approach to complement traditional high throughput screening methodologies. This Methods in Enzymology volume offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. Also elaborated by experienced researchers in FBDD are sample preparations of fragments, proteins, and GPCR as well as examples of how to generate leads from hits. Offers the tools, practical approaches, and hit-to-lead examples on how to conduct FBDD screens. The chapters in this volume cover methods that have proven to be successful in generating leads from fragments, including chapters on how to apply computational techniques, nuclear magnetic resonance, surface plasma resonance, thermal shift and binding assays, protein crystallography, and medicinal chemistry in FBDD. MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Drug development fast Drugs / Design fast Drugs / Research fast Drug Design Evaluation Studies as Topic Medizin Drugs Design Drug development Drugs Research Ligand Biochemie (DE-588)4606532-5 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 gnd rswk-swf Arzneimittelentwicklung (DE-588)4143176-5 s Ligand Biochemie (DE-588)4606532-5 s 1\p DE-604 Kuo, Lawrence C. Sonstige oth http://www.sciencedirect.com/science/book/9780123812742 Verlag URL des Erstveröffentlichers Volltext 1\p cgwrk 20201028 DE-101 https://d-nb.info/provenance/plan#cgwrk |
| spellingShingle | Fragment-based drug design tools, practical approaches, and examples MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Drug development fast Drugs / Design fast Drugs / Research fast Drug Design Evaluation Studies as Topic Medizin Drugs Design Drug development Drugs Research Ligand Biochemie (DE-588)4606532-5 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| subject_GND | (DE-588)4606532-5 (DE-588)4143176-5 |
| title | Fragment-based drug design tools, practical approaches, and examples |
| title_auth | Fragment-based drug design tools, practical approaches, and examples |
| title_exact_search | Fragment-based drug design tools, practical approaches, and examples |
| title_full | Fragment-based drug design tools, practical approaches, and examples edited by Lawrence C. Kuo |
| title_fullStr | Fragment-based drug design tools, practical approaches, and examples edited by Lawrence C. Kuo |
| title_full_unstemmed | Fragment-based drug design tools, practical approaches, and examples edited by Lawrence C. Kuo |
| title_short | Fragment-based drug design |
| title_sort | fragment based drug design tools practical approaches and examples |
| title_sub | tools, practical approaches, and examples |
| topic | MEDICAL / Drug Guides bisacsh MEDICAL / Pharmacology bisacsh MEDICAL / Pharmacy bisacsh MEDICAL / Nursing / Pharmacology bisacsh Drug development fast Drugs / Design fast Drugs / Research fast Drug Design Evaluation Studies as Topic Medizin Drugs Design Drug development Drugs Research Ligand Biochemie (DE-588)4606532-5 gnd Arzneimittelentwicklung (DE-588)4143176-5 gnd |
| topic_facet | MEDICAL / Drug Guides MEDICAL / Pharmacology MEDICAL / Pharmacy MEDICAL / Nursing / Pharmacology Drug development Drugs / Design Drugs / Research Drug Design Evaluation Studies as Topic Medizin Drugs Design Drugs Research Ligand Biochemie Arzneimittelentwicklung |
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