Lead generation: methods, strategies, and case studies
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Weinheim, Germany
Wiley-VCH
2016
|
| Schriftenreihe: | Methods and principles in medicinal chemistry
|
| Schlagworte: | |
| Online-Zugang: | FLA01 FRO01 TUM01 UBG01 Volltext |
| Beschreibung: | Introduction to Lead Generation. Introduction: Learnings from the Past : Characteristics of Successful Leads / Mike Hann -- Modern Lead Generation Strategies / Jörg Holenz, Dean G Brown -- The Importance of Target Identification for Generating Successful Leads. "Ligandability" of Drug Targets: Assessment of Chemical Tractability via Experimental and Approaches / Udo Bauer, Alexander L Breeze -- Chemistry-Driven Target Identification / Iván Cornella-Taracido, Ryan Hicks, Ola Engkvist, J Adam Hendricks, Ronald Tomlinson, M Paola Castaldi -- Hit Generation Methods. Lead Generation Based on Compound Collection Screening / Dirk Weigelt, Ismet Dorange -- Fragment-Based Lead Generation / Ivan V Efremov, Daniel A Erlanson -- Rational Hit Generation / Bernd Wellenzohn, Alexander Weber -- Competitive Intelligence-based Lead Generation and Fast Follower Approaches / Yu Jiang, Ziping Liu, Jörg Holenz, Hua Yang Selective Optimization of Side Activities: An Alternative and Promising Strategy for Lead Generation / Norbert Handler, Andrea Wolkerstorfer, Helmut Buschmann -- Lead Generation for Challenging Targets / Jinqiao Wan, Dengfeng Dou, Hongmei Song, Xian-Hui Wu Xuemin Cheng, Jin Li -- Collaborative Approaches to Lead Generation / Fabrizio Giordanetto, Anna Karawajczyk, Graham Showell -- Converting Hits to Successful Leads. A Medicinal Chemistry Perspective on the Hit-to-Lead Phase in the Current Era of Drug Discovery / Dean G Brown -- Molecular Recognition and Its Importance for Fragment-Based Lead Generation and Hit-to-Lead / Thorsten Nowak -- Affinity-Based Screening Methodologies and Their Application in the Hit-to-Lead Phase / Stefan Geschwindner -- Predictive Methods in Lead Generation / Matthew D Segall, Peter Hunt -- Lead Quality / J Willem M Nissink, Sebastien Degorce, Ken Page Hypothesis-driven Lead Optimization. The Strategies and Politics of Successful Design, Make, Test, and Analyze (DMTA) Cycles in Lead Generation / Steven S Wesolowski, Dean G Brown -- Recent Lead Generation Success Stories. Lead Generation Paved the Way for the Discovery of a Novel H Inverse Agonist Clinical Candidate / Christophe Genicot, Laurent Provins -- Vorapaxar: From Lead Identification to FDA Approval / Samuel Chackalamannil, Mariappan Chelliah -- Lead Generation Approaches Delivering Inhaled [beta]-Adrenoreceptor Agonist Drug Candidates / Michael Stocks, Lilian Alcaraz -- GPR81 HTS Case Study / Eric Wellner, Ola Fjellström -- Development of Influenza Virus Sialidase Inhibitors / Mauro Pascolutti, Robin J Thomson, Mark von Itzstein The Discovery of Cathepsin A Inhibitors: A Project-Adapted Fragment Approach Based on HTS Results / Sven Ruf, Christian Buning, Herman Schreuder, Wolfgang Linz, Dominik Linz, Hartmut Rütten, Georg Horstick, Markus Kohlmann, Katja Kroll, Klaus Wirth, Thorsten Sadowski -- Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery / Jeremy N Burrows, Takushi Kaneko -- A Fragmentation Enumeration Approach to Generating Novel Drug Leads / Pravin S Iyer, Manoranjan Panda. - Includes bibliographical references and index |
| Beschreibung: | 1 Online-Ressource |
| ISBN: | 3527333290 3527677046 3527677054 3527677062 3527677070 9783527333295 9783527677047 9783527677054 9783527677061 9783527677078 |
Internformat
MARC
| LEADER | 00000nmm a2200000zc 4500 | ||
|---|---|---|---|
| 001 | BV043769201 | ||
| 003 | DE-604 | ||
| 005 | 20170407 | ||
| 007 | cr|uuu---uuuuu | ||
| 008 | 160916s2016 |||| o||u| ||||||eng d | ||
| 020 | |a 3527333290 |9 3-527-33329-0 | ||
| 020 | |a 3527677046 |9 3-527-67704-6 | ||
| 020 | |a 3527677054 |9 3-527-67705-4 | ||
| 020 | |a 3527677062 |9 3-527-67706-2 | ||
| 020 | |a 3527677070 |9 3-527-67707-0 | ||
| 020 | |a 9783527333295 |9 978-3-527-33329-5 | ||
| 020 | |a 9783527677047 |c Online |9 978-3-527-67704-7 | ||
| 020 | |a 9783527677054 |9 978-3-527-67705-4 | ||
| 020 | |a 9783527677061 |9 978-3-527-67706-1 | ||
| 020 | |a 9783527677078 |9 978-3-527-67707-8 | ||
| 024 | 7 | |a 10.1002/9783527677047 |2 doi | |
| 035 | |a (ZDB-35-WIC)ocn950467475 | ||
| 035 | |a (OCoLC)951152344 | ||
| 035 | |a (DE-599)BVBBV043769201 | ||
| 040 | |a DE-604 |b ger |e rda | ||
| 041 | 0 | |a eng | |
| 049 | |a DE-91 |a DE-860 |a DE-861 | ||
| 082 | 0 | |a 615.1/9 | |
| 084 | |a VS 5350 |0 (DE-625)147687:253 |2 rvk | ||
| 100 | 1 | |a Holenz, Jörg |d 1968- |0 (DE-588)118150243 |4 edt | |
| 245 | 1 | 0 | |a Lead generation |b methods, strategies, and case studies |c edited by Jörg Holenz |
| 264 | 1 | |a Weinheim, Germany |b Wiley-VCH |c 2016 | |
| 300 | |a 1 Online-Ressource | ||
| 336 | |b txt |2 rdacontent | ||
| 337 | |b c |2 rdamedia | ||
| 338 | |b cr |2 rdacarrier | ||
| 490 | 0 | |a Methods and principles in medicinal chemistry | |
| 500 | |a Introduction to Lead Generation. Introduction: Learnings from the Past : Characteristics of Successful Leads / Mike Hann -- Modern Lead Generation Strategies / Jörg Holenz, Dean G Brown -- The Importance of Target Identification for Generating Successful Leads. "Ligandability" of Drug Targets: Assessment of Chemical Tractability via Experimental and Approaches / Udo Bauer, Alexander L Breeze -- Chemistry-Driven Target Identification / Iván Cornella-Taracido, Ryan Hicks, Ola Engkvist, J Adam Hendricks, Ronald Tomlinson, M Paola Castaldi -- Hit Generation Methods. Lead Generation Based on Compound Collection Screening / Dirk Weigelt, Ismet Dorange -- Fragment-Based Lead Generation / Ivan V Efremov, Daniel A Erlanson -- Rational Hit Generation / Bernd Wellenzohn, Alexander Weber -- Competitive Intelligence-based Lead Generation and Fast Follower Approaches / Yu Jiang, Ziping Liu, Jörg Holenz, Hua Yang | ||
| 500 | |a Selective Optimization of Side Activities: An Alternative and Promising Strategy for Lead Generation / Norbert Handler, Andrea Wolkerstorfer, Helmut Buschmann -- Lead Generation for Challenging Targets / Jinqiao Wan, Dengfeng Dou, Hongmei Song, Xian-Hui Wu Xuemin Cheng, Jin Li -- Collaborative Approaches to Lead Generation / Fabrizio Giordanetto, Anna Karawajczyk, Graham Showell -- Converting Hits to Successful Leads. A Medicinal Chemistry Perspective on the Hit-to-Lead Phase in the Current Era of Drug Discovery / Dean G Brown -- Molecular Recognition and Its Importance for Fragment-Based Lead Generation and Hit-to-Lead / Thorsten Nowak -- Affinity-Based Screening Methodologies and Their Application in the Hit-to-Lead Phase / Stefan Geschwindner -- Predictive Methods in Lead Generation / Matthew D Segall, Peter Hunt -- Lead Quality / J Willem M Nissink, Sebastien Degorce, Ken Page | ||
| 500 | |a Hypothesis-driven Lead Optimization. The Strategies and Politics of Successful Design, Make, Test, and Analyze (DMTA) Cycles in Lead Generation / Steven S Wesolowski, Dean G Brown -- Recent Lead Generation Success Stories. Lead Generation Paved the Way for the Discovery of a Novel H Inverse Agonist Clinical Candidate / Christophe Genicot, Laurent Provins -- Vorapaxar: From Lead Identification to FDA Approval / Samuel Chackalamannil, Mariappan Chelliah -- Lead Generation Approaches Delivering Inhaled [beta]-Adrenoreceptor Agonist Drug Candidates / Michael Stocks, Lilian Alcaraz -- GPR81 HTS Case Study / Eric Wellner, Ola Fjellström -- Development of Influenza Virus Sialidase Inhibitors / Mauro Pascolutti, Robin J Thomson, Mark von Itzstein | ||
| 500 | |a The Discovery of Cathepsin A Inhibitors: A Project-Adapted Fragment Approach Based on HTS Results / Sven Ruf, Christian Buning, Herman Schreuder, Wolfgang Linz, Dominik Linz, Hartmut Rütten, Georg Horstick, Markus Kohlmann, Katja Kroll, Klaus Wirth, Thorsten Sadowski -- Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery / Jeremy N Burrows, Takushi Kaneko -- A Fragmentation Enumeration Approach to Generating Novel Drug Leads / Pravin S Iyer, Manoranjan Panda. - Includes bibliographical references and index | ||
| 650 | 7 | |a Drug development |2 fast | |
| 650 | 7 | |a Drugs / Structure-activity relationships |2 fast | |
| 650 | 7 | |a Pharmaceutical chemistry |2 fast | |
| 650 | 4 | |a Drugs / Structure-activity relationships | |
| 650 | 4 | |a Drug development | |
| 650 | 4 | |a Pharmaceutical chemistry | |
| 650 | 0 | 7 | |a Arzneimittelforschung |0 (DE-588)4003120-2 |2 gnd |9 rswk-swf |
| 689 | 0 | 0 | |a Arzneimittelforschung |0 (DE-588)4003120-2 |D s |
| 689 | 0 | |5 DE-604 | |
| 776 | 0 | 8 | |i Erscheint auch als |n Druckausgabe |z 978-3-527-33329-5 |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047 |x Verlag |z URL des Erstveröffentlichers |3 Volltext |
| 912 | |a ZDB-35-WIC | ||
| 940 | 1 | |q UBG_PDA_WIC | |
| 999 | |a oai:aleph.bib-bvb.de:BVB01-029180374 | ||
| 966 | e | |u https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047 |l FLA01 |p ZDB-35-WIC |q FLA_PDA_WIC_Kauf |x Verlag |3 Volltext | |
| 966 | e | |u https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047 |l FRO01 |p ZDB-35-WIC |q FRO_PDA_WIC |x Verlag |3 Volltext | |
| 966 | e | |u https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047 |l TUM01 |p ZDB-35-WIC |q TUM_PDA_WIC_Kauf |x Verlag |3 Volltext | |
| 966 | e | |u https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047 |l UBG01 |p ZDB-35-WIC |q UBG_PDA_WIC |x Verlag |3 Volltext | |
Datensatz im Suchindex
| _version_ | 1804176590386495488 |
|---|---|
| any_adam_object | |
| author2 | Holenz, Jörg 1968- |
| author2_role | edt |
| author2_variant | j h jh |
| author_GND | (DE-588)118150243 |
| author_facet | Holenz, Jörg 1968- |
| building | Verbundindex |
| bvnumber | BV043769201 |
| classification_rvk | VS 5350 |
| collection | ZDB-35-WIC |
| ctrlnum | (ZDB-35-WIC)ocn950467475 (OCoLC)951152344 (DE-599)BVBBV043769201 |
| dewey-full | 615.1/9 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
| dewey-raw | 615.1/9 |
| dewey-search | 615.1/9 |
| dewey-sort | 3615.1 19 |
| dewey-tens | 610 - Medicine and health |
| discipline | Chemie / Pharmazie Medizin |
| format | Electronic eBook |
| fullrecord | <?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>05810nmm a2200673zc 4500</leader><controlfield tag="001">BV043769201</controlfield><controlfield tag="003">DE-604</controlfield><controlfield tag="005">20170407 </controlfield><controlfield tag="007">cr|uuu---uuuuu</controlfield><controlfield tag="008">160916s2016 |||| o||u| ||||||eng d</controlfield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3527333290</subfield><subfield code="9">3-527-33329-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3527677046</subfield><subfield code="9">3-527-67704-6</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3527677054</subfield><subfield code="9">3-527-67705-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3527677062</subfield><subfield code="9">3-527-67706-2</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">3527677070</subfield><subfield code="9">3-527-67707-0</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783527333295</subfield><subfield code="9">978-3-527-33329-5</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783527677047</subfield><subfield code="c">Online</subfield><subfield code="9">978-3-527-67704-7</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783527677054</subfield><subfield code="9">978-3-527-67705-4</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783527677061</subfield><subfield code="9">978-3-527-67706-1</subfield></datafield><datafield tag="020" ind1=" " ind2=" "><subfield code="a">9783527677078</subfield><subfield code="9">978-3-527-67707-8</subfield></datafield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/9783527677047</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(ZDB-35-WIC)ocn950467475</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)951152344</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BVBBV043769201</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-604</subfield><subfield code="b">ger</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1="0" ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="049" ind1=" " ind2=" "><subfield code="a">DE-91</subfield><subfield code="a">DE-860</subfield><subfield code="a">DE-861</subfield></datafield><datafield tag="082" ind1="0" ind2=" "><subfield code="a">615.1/9</subfield></datafield><datafield tag="084" ind1=" " ind2=" "><subfield code="a">VS 5350</subfield><subfield code="0">(DE-625)147687:253</subfield><subfield code="2">rvk</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Holenz, Jörg</subfield><subfield code="d">1968-</subfield><subfield code="0">(DE-588)118150243</subfield><subfield code="4">edt</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Lead generation</subfield><subfield code="b">methods, strategies, and case studies</subfield><subfield code="c">edited by Jörg Holenz</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Weinheim, Germany</subfield><subfield code="b">Wiley-VCH</subfield><subfield code="c">2016</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="490" ind1="0" ind2=" "><subfield code="a">Methods and principles in medicinal chemistry</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Introduction to Lead Generation. Introduction: Learnings from the Past : Characteristics of Successful Leads / Mike Hann -- Modern Lead Generation Strategies / Jörg Holenz, Dean G Brown -- The Importance of Target Identification for Generating Successful Leads. "Ligandability" of Drug Targets: Assessment of Chemical Tractability via Experimental and Approaches / Udo Bauer, Alexander L Breeze -- Chemistry-Driven Target Identification / Iván Cornella-Taracido, Ryan Hicks, Ola Engkvist, J Adam Hendricks, Ronald Tomlinson, M Paola Castaldi -- Hit Generation Methods. Lead Generation Based on Compound Collection Screening / Dirk Weigelt, Ismet Dorange -- Fragment-Based Lead Generation / Ivan V Efremov, Daniel A Erlanson -- Rational Hit Generation / Bernd Wellenzohn, Alexander Weber -- Competitive Intelligence-based Lead Generation and Fast Follower Approaches / Yu Jiang, Ziping Liu, Jörg Holenz, Hua Yang</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Selective Optimization of Side Activities: An Alternative and Promising Strategy for Lead Generation / Norbert Handler, Andrea Wolkerstorfer, Helmut Buschmann -- Lead Generation for Challenging Targets / Jinqiao Wan, Dengfeng Dou, Hongmei Song, Xian-Hui Wu Xuemin Cheng, Jin Li -- Collaborative Approaches to Lead Generation / Fabrizio Giordanetto, Anna Karawajczyk, Graham Showell -- Converting Hits to Successful Leads. A Medicinal Chemistry Perspective on the Hit-to-Lead Phase in the Current Era of Drug Discovery / Dean G Brown -- Molecular Recognition and Its Importance for Fragment-Based Lead Generation and Hit-to-Lead / Thorsten Nowak -- Affinity-Based Screening Methodologies and Their Application in the Hit-to-Lead Phase / Stefan Geschwindner -- Predictive Methods in Lead Generation / Matthew D Segall, Peter Hunt -- Lead Quality / J Willem M Nissink, Sebastien Degorce, Ken Page</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Hypothesis-driven Lead Optimization. The Strategies and Politics of Successful Design, Make, Test, and Analyze (DMTA) Cycles in Lead Generation / Steven S Wesolowski, Dean G Brown -- Recent Lead Generation Success Stories. Lead Generation Paved the Way for the Discovery of a Novel H Inverse Agonist Clinical Candidate / Christophe Genicot, Laurent Provins -- Vorapaxar: From Lead Identification to FDA Approval / Samuel Chackalamannil, Mariappan Chelliah -- Lead Generation Approaches Delivering Inhaled [beta]-Adrenoreceptor Agonist Drug Candidates / Michael Stocks, Lilian Alcaraz -- GPR81 HTS Case Study / Eric Wellner, Ola Fjellström -- Development of Influenza Virus Sialidase Inhibitors / Mauro Pascolutti, Robin J Thomson, Mark von Itzstein</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">The Discovery of Cathepsin A Inhibitors: A Project-Adapted Fragment Approach Based on HTS Results / Sven Ruf, Christian Buning, Herman Schreuder, Wolfgang Linz, Dominik Linz, Hartmut Rütten, Georg Horstick, Markus Kohlmann, Katja Kroll, Klaus Wirth, Thorsten Sadowski -- Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery / Jeremy N Burrows, Takushi Kaneko -- A Fragmentation Enumeration Approach to Generating Novel Drug Leads / Pravin S Iyer, Manoranjan Panda. - Includes bibliographical references and index</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Drug development</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Drugs / Structure-activity relationships</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="7"><subfield code="a">Pharmaceutical chemistry</subfield><subfield code="2">fast</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drugs / Structure-activity relationships</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Drug development</subfield></datafield><datafield tag="650" ind1=" " ind2="4"><subfield code="a">Pharmaceutical chemistry</subfield></datafield><datafield tag="650" ind1="0" ind2="7"><subfield code="a">Arzneimittelforschung</subfield><subfield code="0">(DE-588)4003120-2</subfield><subfield code="2">gnd</subfield><subfield code="9">rswk-swf</subfield></datafield><datafield tag="689" ind1="0" ind2="0"><subfield code="a">Arzneimittelforschung</subfield><subfield code="0">(DE-588)4003120-2</subfield><subfield code="D">s</subfield></datafield><datafield tag="689" ind1="0" ind2=" "><subfield code="5">DE-604</subfield></datafield><datafield tag="776" ind1="0" ind2="8"><subfield code="i">Erscheint auch als</subfield><subfield code="n">Druckausgabe</subfield><subfield code="z">978-3-527-33329-5</subfield></datafield><datafield tag="856" ind1="4" ind2="0"><subfield code="u">https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047</subfield><subfield code="x">Verlag</subfield><subfield code="z">URL des Erstveröffentlichers</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ZDB-35-WIC</subfield></datafield><datafield tag="940" ind1="1" ind2=" "><subfield code="q">UBG_PDA_WIC</subfield></datafield><datafield tag="999" ind1=" " ind2=" "><subfield code="a">oai:aleph.bib-bvb.de:BVB01-029180374</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047</subfield><subfield code="l">FLA01</subfield><subfield code="p">ZDB-35-WIC</subfield><subfield code="q">FLA_PDA_WIC_Kauf</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047</subfield><subfield code="l">FRO01</subfield><subfield code="p">ZDB-35-WIC</subfield><subfield code="q">FRO_PDA_WIC</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047</subfield><subfield code="l">TUM01</subfield><subfield code="p">ZDB-35-WIC</subfield><subfield code="q">TUM_PDA_WIC_Kauf</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield><datafield tag="966" ind1="e" ind2=" "><subfield code="u">https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047</subfield><subfield code="l">UBG01</subfield><subfield code="p">ZDB-35-WIC</subfield><subfield code="q">UBG_PDA_WIC</subfield><subfield code="x">Verlag</subfield><subfield code="3">Volltext</subfield></datafield></record></collection> |
| id | DE-604.BV043769201 |
| illustrated | Not Illustrated |
| indexdate | 2024-07-10T07:34:36Z |
| institution | BVB |
| isbn | 3527333290 3527677046 3527677054 3527677062 3527677070 9783527333295 9783527677047 9783527677054 9783527677061 9783527677078 |
| language | English |
| oai_aleph_id | oai:aleph.bib-bvb.de:BVB01-029180374 |
| oclc_num | 950467475 951152344 |
| open_access_boolean | |
| owner | DE-91 DE-BY-TUM DE-860 DE-861 |
| owner_facet | DE-91 DE-BY-TUM DE-860 DE-861 |
| physical | 1 Online-Ressource |
| psigel | ZDB-35-WIC UBG_PDA_WIC ZDB-35-WIC FLA_PDA_WIC_Kauf ZDB-35-WIC FRO_PDA_WIC ZDB-35-WIC TUM_PDA_WIC_Kauf ZDB-35-WIC UBG_PDA_WIC |
| publishDate | 2016 |
| publishDateSearch | 2016 |
| publishDateSort | 2016 |
| publisher | Wiley-VCH |
| record_format | marc |
| series2 | Methods and principles in medicinal chemistry |
| spelling | Holenz, Jörg 1968- (DE-588)118150243 edt Lead generation methods, strategies, and case studies edited by Jörg Holenz Weinheim, Germany Wiley-VCH 2016 1 Online-Ressource txt rdacontent c rdamedia cr rdacarrier Methods and principles in medicinal chemistry Introduction to Lead Generation. Introduction: Learnings from the Past : Characteristics of Successful Leads / Mike Hann -- Modern Lead Generation Strategies / Jörg Holenz, Dean G Brown -- The Importance of Target Identification for Generating Successful Leads. "Ligandability" of Drug Targets: Assessment of Chemical Tractability via Experimental and Approaches / Udo Bauer, Alexander L Breeze -- Chemistry-Driven Target Identification / Iván Cornella-Taracido, Ryan Hicks, Ola Engkvist, J Adam Hendricks, Ronald Tomlinson, M Paola Castaldi -- Hit Generation Methods. Lead Generation Based on Compound Collection Screening / Dirk Weigelt, Ismet Dorange -- Fragment-Based Lead Generation / Ivan V Efremov, Daniel A Erlanson -- Rational Hit Generation / Bernd Wellenzohn, Alexander Weber -- Competitive Intelligence-based Lead Generation and Fast Follower Approaches / Yu Jiang, Ziping Liu, Jörg Holenz, Hua Yang Selective Optimization of Side Activities: An Alternative and Promising Strategy for Lead Generation / Norbert Handler, Andrea Wolkerstorfer, Helmut Buschmann -- Lead Generation for Challenging Targets / Jinqiao Wan, Dengfeng Dou, Hongmei Song, Xian-Hui Wu Xuemin Cheng, Jin Li -- Collaborative Approaches to Lead Generation / Fabrizio Giordanetto, Anna Karawajczyk, Graham Showell -- Converting Hits to Successful Leads. A Medicinal Chemistry Perspective on the Hit-to-Lead Phase in the Current Era of Drug Discovery / Dean G Brown -- Molecular Recognition and Its Importance for Fragment-Based Lead Generation and Hit-to-Lead / Thorsten Nowak -- Affinity-Based Screening Methodologies and Their Application in the Hit-to-Lead Phase / Stefan Geschwindner -- Predictive Methods in Lead Generation / Matthew D Segall, Peter Hunt -- Lead Quality / J Willem M Nissink, Sebastien Degorce, Ken Page Hypothesis-driven Lead Optimization. The Strategies and Politics of Successful Design, Make, Test, and Analyze (DMTA) Cycles in Lead Generation / Steven S Wesolowski, Dean G Brown -- Recent Lead Generation Success Stories. Lead Generation Paved the Way for the Discovery of a Novel H Inverse Agonist Clinical Candidate / Christophe Genicot, Laurent Provins -- Vorapaxar: From Lead Identification to FDA Approval / Samuel Chackalamannil, Mariappan Chelliah -- Lead Generation Approaches Delivering Inhaled [beta]-Adrenoreceptor Agonist Drug Candidates / Michael Stocks, Lilian Alcaraz -- GPR81 HTS Case Study / Eric Wellner, Ola Fjellström -- Development of Influenza Virus Sialidase Inhibitors / Mauro Pascolutti, Robin J Thomson, Mark von Itzstein The Discovery of Cathepsin A Inhibitors: A Project-Adapted Fragment Approach Based on HTS Results / Sven Ruf, Christian Buning, Herman Schreuder, Wolfgang Linz, Dominik Linz, Hartmut Rütten, Georg Horstick, Markus Kohlmann, Katja Kroll, Klaus Wirth, Thorsten Sadowski -- Lead Structure Discovery for Neglected Diseases: Product Development Partnerships Driving Drug Discovery / Jeremy N Burrows, Takushi Kaneko -- A Fragmentation Enumeration Approach to Generating Novel Drug Leads / Pravin S Iyer, Manoranjan Panda. - Includes bibliographical references and index Drug development fast Drugs / Structure-activity relationships fast Pharmaceutical chemistry fast Drugs / Structure-activity relationships Drug development Pharmaceutical chemistry Arzneimittelforschung (DE-588)4003120-2 gnd rswk-swf Arzneimittelforschung (DE-588)4003120-2 s DE-604 Erscheint auch als Druckausgabe 978-3-527-33329-5 https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047 Verlag URL des Erstveröffentlichers Volltext |
| spellingShingle | Lead generation methods, strategies, and case studies Drug development fast Drugs / Structure-activity relationships fast Pharmaceutical chemistry fast Drugs / Structure-activity relationships Drug development Pharmaceutical chemistry Arzneimittelforschung (DE-588)4003120-2 gnd |
| subject_GND | (DE-588)4003120-2 |
| title | Lead generation methods, strategies, and case studies |
| title_auth | Lead generation methods, strategies, and case studies |
| title_exact_search | Lead generation methods, strategies, and case studies |
| title_full | Lead generation methods, strategies, and case studies edited by Jörg Holenz |
| title_fullStr | Lead generation methods, strategies, and case studies edited by Jörg Holenz |
| title_full_unstemmed | Lead generation methods, strategies, and case studies edited by Jörg Holenz |
| title_short | Lead generation |
| title_sort | lead generation methods strategies and case studies |
| title_sub | methods, strategies, and case studies |
| topic | Drug development fast Drugs / Structure-activity relationships fast Pharmaceutical chemistry fast Drugs / Structure-activity relationships Drug development Pharmaceutical chemistry Arzneimittelforschung (DE-588)4003120-2 gnd |
| topic_facet | Drug development Drugs / Structure-activity relationships Pharmaceutical chemistry Arzneimittelforschung |
| url | https://onlinelibrary.wiley.com/doi/book/10.1002/9783527677047 |
| work_keys_str_mv | AT holenzjorg leadgenerationmethodsstrategiesandcasestudies |