Biomarkers of kidney disease:
Saved in:
| Other Authors: | |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Amsterdam
Elsevier, AP
[2017]
|
| Edition: | Second edition |
| Subjects: | |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | xvii, 613 Seiten Illustrationen |
| ISBN: | 9780128030141 |
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MARC
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Record in the Search Index
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| adam_text | CONTENTS
List of Contributors x/ii
Preface xv
1. Characteristics of an Ideal Biomarker of Kidney Diseases 1
M.R. Bennett and P. Devarajan
The Discovery of Biomarkers 1
Characteristics of an Ideal Biornarker 4
Biomarkers in AKi 7
Biomarkers in CKD 12
Conclusions and Future Directions 16
References 16
2. Statistical Considerations in Analysis and Interpretation
of Biomarker Studies 21
C.R. Parikh and H. Thiessen Philbrook
Introduction 21
Planning a Study 23
Metrics for Prediction Performance 24
Sample-Size Calculations 28
Evaluating Incremental Value 28
Summary 31
References 31
3. The Role of Metabolomics in the Study of Kidney Diseases
and in the Development of Diagnostic Tools 33
U. Christians, J. Klawitter, J. Klepacki and J. Kiawitter
introduction 34
Metabolic Mapping of the Kidney 40
Nontargeted and Targeted Metabolomics 42
The Sample 48
Analytical Technologies 50
Metabolic Molecular Marker Discovery and Development 68
Metabolomics in Rena) Research; Kidney Function, Disease, and Injury Markers 71
Metabolomics as a Clinical DiagnosticTool in Nephrology 94
References 100
vii
viii
Contents
4. The Role of Proteomics in the Study of Kidney Diseases
and in the Development of Diagnostic Tools 119
U. Christians, J. Klawitter, J. Klepacki and J. Klawitter
Introduction 120
Nontargeted and Targeted Proteomics 124
Proteins and the Kidney 127
The Proteomics Sample 131
Analytical Technologies 134
Proteomics in Renal Research and as a Marker for Kidney Function,
Disease, and injury 158
Proteomics as Clinical Diagnostic Tool in Nephrology 196
References 202
5. Cystatin C as a Multifaceted Biomarker in Kidney Disease
and Its Role in Defining Shrunken Pore Syndrome 225
A. Grubb
Factors Influencing the Diagnostic Performance of Cystatin C- or
Creatinine-Based GFR-Estimating Equations and Causing the Plethora
of Equations: The Concepts of Internal or Externa I Validation 226
Optimizing the Use of Cystatin C- and Creatinine-Based
GFR-Estimating Equations 228
Cystatin C and Creatinine (eGFRcysminc and eGFRcre3t;n,ne) as Markers
of End-Stage Renal Disease (ESRD), Hospitalization, Cardiovascular
Disease, and Death 230
identification of Shrunken Pore Syndrome : Its Influence on Mortality 231
Cystatin C as an Indictor of the Circadian Rhythm of GFR 234
Cystatin C as an Indicator of Rena! Reserve 237
References 237 6 * *
6. Biomarkers in Acute Kidney Injury 241
CL. Edelstein
Introduction 242
Definition and Classification of AKI 243
Serum Creatinine in AKI 245
Biology of Biomarkers 247
Biomarkers for the Differential Diagnosis of AKI 254
Biomarkers for the Early Diagnosis of AKI 259
Biomarkers That Predict Short-Term Outcomes 272
Contents
ix
Biomarkers for Risk Stratification of Patients With Existing AK! 278
Biomarkers of AKI and Long-Term Outcomes 280
Biomarkers of Subclînicai AKI 280
The Effect of Interventions on Biomarkers of AKI 283
Biomarkers of AKI in the ICU 285
Urinary Stability Studies for Biomarkers of AKI 295
Combinations of AKI Biomarkers 296
TIMP2 and IGFBP7 298
Conclusions 302
References 303
7. Biomarkers of Extra-Renal Complications of AKI 317
S. Faubel
AKI and Inflammation 319
Serum Cytokines are Increased in Patients With AKI 321
Pulmonary Complications of AKI 324
Summary 329
References 329
8. Biomarkers in Kidney Transplantation 335
S. Jain and A. Jani
Biomarkers: An Overview 336
Biomarkers of AKI Posttransplantation 336
Biomarkers of Acute Rejection 348
Biomarkers of Chronic Allograft Nephropathy 378
Biomarkers of Polyoma Virus Infection 388
Summary 393
References 410 9 * * *
9. Biomarkers of Renal Cancer 421
N.S. Vasudev and R.E. Banks
Renal Cancer 421
Cancer Biomarkers—General Concepts 429
Renal Cancer Biomarkers 430
Conclusions 455
Acknowledgments 456
References . 456
X
Contents
10. Proteomics and Advancements in Urinary Biomarkers
of Diabetics Kidney Disease 469
M.L. Merchant and J.B. Klein
Introduction 469
Urinary Peptides as Biomarkers of Diabetic Kidney Disease 475
Future Developments and Applications of Proteomics for Biomarker Discovery 481
References 482
11. Biomarkers of Cardiovascular Risk in Chronic Kidney Disease 485
Z.H. Endre and RJ. Walker
introduction 485
The Definition of CKD and the Risk of Cardiovascular Diseases:
GFR, Albuminuria, and Proteinuria 486
Cardiac Biomarkers in CKD 497
Summary 507
References 508
12. Diagnostic and Prognostic Biomarkers in Autosomal
Dominant Polycystic Kidney Disease 513
G. Fick-Brosnahan and B.Y. Reed
Genetic Testing for Diagnosis and Prognosis 513
Total Kidney Volume 515
Renal Blood Flow 518
Serum and Urine Biomarkers 519
References 526 13
13. Biomarkers in Glomerular Disease 531
J.M. Arthur, E. Elnagar and N. Karakala
Biomarkers in Glomerular Diseases 532
Predictors of Outcome in Glomerular Diseases 532
Biomarkers in Lupus Nephritis 533
Predictors of Lupus Nephritis Class 533
Biomarkers that Predict Renal Lupus Flares 534
Membranous Nephropathy 536
Focal Segmental Glomerulosclerosis 540
Minimal Change Disease 542
CD80/B7 1 in Minimal Change and FSGS 543
Contents xi
IgA Nephropathy 544
Discovery of New Biomarkers Using Proteomics 547
References 550
14. Biomarkers in Preeclampsia 555
S.A. Karumanchi
Definition and Prevalence of the Disease 555
Pathophysiology and Mechanisms 557
Clinical Manifestations 558
Diagnosis 563
Biomarkers 565
Novel Biomarkers and Future Perspectives 579
Conclusions 583
References 585
Index 595
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| spelling | Biomarkers of kidney disease edited by Charles L. Edelstein, MD, PhD Second edition Amsterdam Elsevier, AP [2017] xvii, 613 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Biomarker (DE-588)4425928-1 gnd rswk-swf Nierenkrankheit (DE-588)4075399-2 gnd rswk-swf (DE-588)4143413-4 Aufsatzsammlung gnd-content Nierenkrankheit (DE-588)4075399-2 s Biomarker (DE-588)4425928-1 s b DE-604 Edelstein, Charles L. edt Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029152448&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
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| title | Biomarkers of kidney disease |
| title_auth | Biomarkers of kidney disease |
| title_exact_search | Biomarkers of kidney disease |
| title_full | Biomarkers of kidney disease edited by Charles L. Edelstein, MD, PhD |
| title_fullStr | Biomarkers of kidney disease edited by Charles L. Edelstein, MD, PhD |
| title_full_unstemmed | Biomarkers of kidney disease edited by Charles L. Edelstein, MD, PhD |
| title_short | Biomarkers of kidney disease |
| title_sort | biomarkers of kidney disease |
| topic | Biomarker (DE-588)4425928-1 gnd Nierenkrankheit (DE-588)4075399-2 gnd |
| topic_facet | Biomarker Nierenkrankheit Aufsatzsammlung |
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