Biochemical evolution: the pursuit of perfection
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
New York ; London
Garland Science, Taylor & Francis Group, LLC
[2016]
|
| Ausgabe: | Second edition |
| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis Inhaltsverzeichnis |
| Beschreibung: | Revised edition of: The pursuit of perfection : aspects of biochemical evolution / Athel Cornish-Bowden. 2004 |
| Beschreibung: | xviii, 274 Seiten Illustrationen |
| ISBN: | 9780815345527 |
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Datensatz im Suchindex
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|---|---|
| adam_text | BIOCHEMICAL EVOLUTION
/ CORNISH-BOWDEN, ATHELYYEAUTHOR
: 2016
TABLE OF CONTENTS / INHALTSVERZEICHNIS
SOME BASIC BIOCHEMISTRY
THE NUTS AND BOLTS OF EVOLUTION
ADAPTATION AND ACCIDENTS
METABOLISM AND CELLS
THE GAMES CELLS PLAY
THE PERFECT MOLECULE
FEAR OF PHANTOMS
LIVING ON A KNIFE EDGE
BROWN EYES AND BLUE
AN ECONOMY THAT WORKS
FAILURES OF NATURAL SELECTION
A SMALL CORNER OF THE UNIVERSE
ASPECTS OF CANCER
THE MEANING OF LIFE
THE AGE OF ENDARKENMENT
DIESES SCHRIFTSTCK WURDE MASCHINELL ERZEUGT.
Biochemical
Evolution Second Edition
The Pursuit of Perfection
Athel Cornish-Bowden
O? Garland Science
V—AJ Taylor amp; Francis Group
NEW YORK AND LONDON
Contents
Foreword xi
Preface xv
1 Some Basic Biochemistry 1
Unity of biochemistry 2
Water 4
Enzymes 5
Proteins 10
DNA and RNA 12
The central dogma 16
Carbohydrates and lipids 17
Adenosine phosphates 18
Thermodynamics 18
ATP and ADP 19
Real metabolites 20
2 The Nuts and Bolts of Evolution 23
Base pairing 24
Quality control 26
Fixation 28
Mitochondrial Eve 31
Y-chromosome Adam 32
Point mutations 33
Constructing a phylogenetic tree 35
Neutral evolution 38
Gross replication errors 40
Chromosomal abnormalities 42
What is a species? 44
3 Adaptation and Accidents 47
Sperm whale myoglobin 48
Horse liver alcohol dehydrogenase 49
Polar bear liver 50
Non-coding DNA 50
Genetic load 51
Insulin in pigs, dogs, and humans 52
Left and right brains 53
Arginine codons 53
Likelihood of surviving a change in the genetic code 55
Bias in probability calculations 60
viii Biochemical Evolution
Mitochondrial genetic codes 61
4 Metabolism and Cells 63
Metabolism 63
Metabolic pathways 66
The pentose phosphate cycle 67
Functions of the cycle 67
Two worlds of sugars 69
5 The Games Cells Play 71
Fox, goose, and oats 71
Sending goods or information securely 72
Machine intelligence 75
Bacterial chemotaxis 76
Moving prisoners 77
The pentose phosphate cycle 81
The Calvin cycle 87
Simpler is better? 88
6 The Perfect Molecule 93
NAD: A degraded fragment of RNA? 93
Glycogen 95
Hydrostatic pressure 95
Osmotic pressure 95
Mobilization of glycogen 99
Structure 99
Optimizing the structure 102
7 Fear of Phantoms 107
Physics and biochemistry 107
Too good to be true? 108
Entropy and enthalpy 110
The Arrhenius equation 114
Extrapolation 115
FishATPases 115
Entropy-enthalpy compensation 117
What is being optimized? 118
8 Living on a Knife Edge 123
Enzyme regulation 124
50% just as good as 100%? 125
Enzymes in isolation 126
Biochemical Evolution ix
Is the steady state an illusion? 127
Saturation 129
Rate-limiting enzymes 130
Increasing the activity of one enzyme by 5% 131
Increasing all activities by 5% 132
Shared flux control 134
Saving excess production of enzymes 136
Unregulated flow in rivers 138
Regulated flow in metabolism 139
Switching enzyme activity on and off 141
Responding to signals 142
AMP as an enzyme regulator 143
9 Brown Eyes and Blue 145
Particulate inheritance 147
Eye color 148
Phenylketonuria and alkaptonuria 149
Breeding pea plants under Mendelian rules 151
and in a paint-mixing world 153
Shared flux control 155
Inheritance in Chlamydomonas reinhardtii 157
Humans: a unique species? 159
10 An Economy that Works 161
How well do economic laws work? 161
Biosynthetic pathways 162
Feedback regulation 163
Classical inhibition 168
Allosteric inhibition 169
Cooperativity 169
Hemoglobin and myoglobin 170
Detoxification 172
Digesting food 173
Overexpressing the rate-limiting enzyme 175
Engineering a leak 177
Complexity 179
11 Failures of Natural Selection 181
What is an animal? 181
Collagen 182
Glycine 183
Allometric scaling 186
How much glycine is available? 188
X Biochemical Evolution
Obesity 189
Dietary carbohydrate 190
Regulation of the tricarboxylate cycle 193
Why has natural selection failed? 195
12 A Small Corner of the Universe 197
Emergence of life 198
Size of the Universe 198
The origin of life: a vastly improbable event? 199
Age of the Universe 201
Only one possible sequence for each function? 202
Frequency of improbable events 207
The solar eclipse of 1999 209
13 Aspects of Cancer 213
Aneuploidy 214
All cancer cells are aneuploid 217
Does aneuploidy necessarily lead to cancer? 218
The pursuit of perfection? 222
Cancer and the pentose phosphate pathway 222
14 The Meaning of Life 227
Living and nonliving 228
LUCA 230
What does it mean to say that a creature is alive? 232
Creating life 233
Cell-free fermentation 234
Schrodinger s analysis 237
(M, R) systems 238
Autopoiesis 241
The chemoton 243
Autocatalytic sets 244
15 The Age of Endarkenment 247
Teaching biology in the USA, Europe, and Turkey 248
Intelligent design 250
Irreducible complexity 254
Microevolution and macroevolution 256
The Wedge Document 256
How real science is done 259
Index 263
|
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| language | English |
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| physical | xviii, 274 Seiten Illustrationen |
| publishDate | 2016 |
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| spelling | Cornish-Bowden, Athel 1943- (DE-588)1047958619 aut (DE-588)1113900962 The pursuit of perfection Biochemical evolution the pursuit of perfection Athel Cornish-Bowden Second edition New York ; London Garland Science, Taylor & Francis Group, LLC [2016] xviii, 274 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Revised edition of: The pursuit of perfection : aspects of biochemical evolution / Athel Cornish-Bowden. 2004 Evolution, Molecular Biochemical Phenomena Molekulare Evolution (DE-588)4812902-1 gnd rswk-swf Molekulare Evolution (DE-588)4812902-1 s DE-604 LoC Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029134869&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis HEBIS Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029134869&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Cornish-Bowden, Athel 1943- Biochemical evolution the pursuit of perfection Evolution, Molecular Biochemical Phenomena Molekulare Evolution (DE-588)4812902-1 gnd |
| subject_GND | (DE-588)4812902-1 |
| title | Biochemical evolution the pursuit of perfection |
| title_GND | (DE-588)1113900962 |
| title_alt | The pursuit of perfection |
| title_auth | Biochemical evolution the pursuit of perfection |
| title_exact_search | Biochemical evolution the pursuit of perfection |
| title_full | Biochemical evolution the pursuit of perfection Athel Cornish-Bowden |
| title_fullStr | Biochemical evolution the pursuit of perfection Athel Cornish-Bowden |
| title_full_unstemmed | Biochemical evolution the pursuit of perfection Athel Cornish-Bowden |
| title_short | Biochemical evolution |
| title_sort | biochemical evolution the pursuit of perfection |
| title_sub | the pursuit of perfection |
| topic | Evolution, Molecular Biochemical Phenomena Molekulare Evolution (DE-588)4812902-1 gnd |
| topic_facet | Evolution, Molecular Biochemical Phenomena Molekulare Evolution |
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