Holdings: Dynamic insight into naïve lymphocyte extravasation in vivo

Dynamic insight into naïve lymphocyte extravasation in vivo:

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Bibliographic Details
Main Author:	Yan, Li-Sue Serena 1982- (Author)
Format:	Thesis Book
Language:	English
Published:	Münster 2016
Subjects:	Hochschulschrift
Online Access:	Inhaltsverzeichnis Inhaltsverzeichnis
Physical Description:	125 Seiten Illustrationen 30 cm

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adam_text	CONTENTS INTRODUCTION.................................................................................................................................- 9 - 1.1 BACKGROUND........................................................................................................................- 9 - 1.2 SPECIALIZED LYMPHOID TISSUE STRUCTURES ....................................................................... -11 - 1.2.1 THE HIGH ENDOTHELIAL VENULES (HEVS) ...................................................................... -13 - 1.2.2 THE STROMAL NETWORKS...............................................................................................-1 6 - 1.2.3 THE LYMPHATICS..........................................................................................................- 1 6 * 1.3 ENTRY OF IMMUNE CELLS THROUGH HEVS ........................................................................... -17 - 1.3.1 HEV CHARACTERISTICS...................................................................................................-1 8 - 1.3.2 HEVS * PATHOPHYSIOLOGICAL CONDITIONS ................................................................... -19 - 1.3.3 ENTRYOFTANDBCELLS.................................................................................................-2 1 - 1.3.4 ENTRY OF OTHER MMUNE CELL TYPES ........................................................................... - 23 - 1.4 DCS REGULATE IMMUNE CELL ENTRY THROUGH HEVS ........................................................... - 24- 1.4.1 DENDRITIC CELL TRAFFICKING............................................................................................-2 4 - 1.4.2 MAINTENANCE OF HEV PHENOTYPE............................................................................ - 26 - 1.4.3 CONTROLLING LYMPHOCYTE HOMING TO LNS.................................................................. - 27 - 1.5 INTRANODAL MIGRATION OF LYMPHOCYTES............................................................................-28 - 1.5.1 T CELLS TRAFFICKING.......................................................................................................-2 9 - 1.5.2 B CELL TRAFFICKING........................................................................................................- 31- 1.5.3 DENDRITIC CELL TRAFFICKING............................................................................................-32 - 1.6 EGRESS THROUGH EFFERENT LYMPHATICS....................................................... **********-33- 1.7 LYMPHOCYTE TRANSENDOTHELIAL MIGRATION ....................................................................... - 35 - 1.8 DYNAMIC IMMUNO-LMAGING..............................................................................................- * - 1.9 AIM OFTHESIS...................................................................................................................-40 - MATERIALS AND METHODS.............................................................................................................- 41 - 2.1 INTRODUCTION.....................................................................................................................-4 2 - 2.2 DEVELOPMENT AND OVERVIEW OF THE MAGE SYSTEM ........................................................ - 43 - 2.3 CONFOCAL INTRAVITAL MICROSCOPY (IVM) OF MURINE INGUINAL LYMPH NODE... - 44- 2.4 APPLICATIONS OF THE METHOD.............................................................................................-4 5 - 2.5 COMPARISON WITH OTHER METHODS......................................................................................- 45 - 2.6 LIMITATIONS OF THE APPROACH..............................................................................................- 46 - 2.7 EXPERIMENTAL DESIGN........................................................................................................-4 7 - 2.7.1 LABELING WITH FLUORESCENT INTRAVITAL MARKERS .......................................................... - 48 - 2.7.2 CHOICE OF FLUOROPHORES.............................................................................................-4 9 - 2.7.3 PREPARATION AND INJECTION OF LEUKOCYTES ................................................................... - 49 - 2.7.4 CHEMOKINE INDUCTION OF IN VIVO TRANSMIGRATION ........................................................ - 50 - 2.7.5 VISUALIZING LYMPH NODE VASCULATURE (HEVS & BASEMENT MEMBRANE) .....- 50 - 2.7.6 CONFOCAL INTRAVITAL MICROSCOPY OF MURINE INGUINAL LYMPH NODE .....- 51 - 2.7.7 DURATION OF CONTINUOUS IMAGING.................................................................................- 52 - 2.7.8 STATISTICAL ANALYSIS.....................................................................................................-5 2 - 2.8 MATERIALS.........................................................................................................................- 53 - 2.8.1 REAGENTS...................................................................................................................- 53 - 2.8.2 EQUIPMENT................................................................................................................-5 4 - 2.8.3 MICROSCOPE...............................................................................................................-5 4 - 2.8.4 REAGENT SET-UP.........................................................................................................-5 5 - 2.9 PROCEDURE........................................................................................................... ***-5 6 - 2.10 ANTICIPATED RESULTS........................................................................................................-6 2 - RESULTS..........................................................................................................................................- 69 - 3.1 REAL-TIME IMAGING AND ANALYSIS OF HEV ULTRASTRUCTURE IN VIVO.......................................- 69 - 3.2 FOUR-DIMENSIONAL IMAGING FOR ANALYSIS OF HEVS N VIVO ................................................. - 74 - 3.3 CCL19INDUCED MIGRATION OF ADOPTIVE TRANSFERRED LYMPHOCYTES TOWARDS SUPERFICIAL HEVS.- * * - 3.4 HEVS ARE SITES OF HIGH CELLULAR FLU X ................................................................................... - 81 - 3.5 HEV POCKETS ARE FORMED BY ACCUMULATED LYMPHOCYTES .................................................. - 83 - 3.6 FOUR-DIMENSIONAL IMAGING FOR ANALYSIS OF LEUKOCYTE * N VIVO ................................. - 85 - 3.7 NAIVE LYMPHOCYTE MAINLY USE PARACEHULAR * IN VIVO ................................................ - 88 - 3.8 LYMPHOCYTES UNDERGO SHAPE CHANGE DURING *** ........................................................... - 93 - 3.9 REALTIME FORMATION OF HEV POCKETS.................................................................................- 95 - 3.10 HEV POCKET LOCATION........................................................................................................- 99 - DISCUSSION................................................................................................................................* 102 * TRAFFICKING OF MMUNE CELLS N NFLAMED LYMPH NODES ........................................................ -104 - REFERENCES...............................................................................................................................-109- LIST OF TABLES AND FIGURES........................................................................................................-120 - ABBREVIATION............................................................................................................................-122-
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author	Yan, Li-Sue Serena 1982-
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spelling	Yan, Li-Sue Serena 1982- Verfasser (DE-588)1102925349 aut Dynamic insight into naïve lymphocyte extravasation in vivo Li-Sue Serena Yan Münster 2016 125 Seiten Illustrationen 30 cm txt rdacontent n rdamedia nc rdacarrier Dissertation Westfälische Wilhelms-Universität Münster 2016 (DE-588)4113937-9 Hochschulschrift gnd-content B:DE-101 application/pdf http://d-nb.info/1104174227/04 Inhaltsverzeichnis DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029110090&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis
spellingShingle	Yan, Li-Sue Serena 1982- Dynamic insight into naïve lymphocyte extravasation in vivo
subject_GND	(DE-588)4113937-9
title	Dynamic insight into naïve lymphocyte extravasation in vivo
title_auth	Dynamic insight into naïve lymphocyte extravasation in vivo
title_exact_search	Dynamic insight into naïve lymphocyte extravasation in vivo
title_full	Dynamic insight into naïve lymphocyte extravasation in vivo Li-Sue Serena Yan
title_fullStr	Dynamic insight into naïve lymphocyte extravasation in vivo Li-Sue Serena Yan
title_full_unstemmed	Dynamic insight into naïve lymphocyte extravasation in vivo Li-Sue Serena Yan
title_short	Dynamic insight into naïve lymphocyte extravasation in vivo
title_sort	dynamic insight into naive lymphocyte extravasation in vivo
topic_facet	Hochschulschrift
url	http://d-nb.info/1104174227/04 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029110090&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA
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