The molecular basis of drug addiction:
Gespeichert in:
| Weitere Verfasser: | |
|---|---|
| Format: | Buch |
| Sprache: | English |
| Veröffentlicht: |
Amsterdam
Elsevier
2016
|
| Ausgabe: | First edition |
| Schriftenreihe: | Progress in molecular biology and translational science
137 |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XIII, 264 Seiten Illustrationen |
| ISBN: | 9780128037867 |
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Datensatz im Suchindex
| _version_ | 1804176377758351360 |
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| adam_text | Titel: The molecular basis of drug addiction
Autor: Rahman, Shafiqur
Jahr: 2016
CONTENTS
Contributors jx
Preface x/
1. Molecular Mechanism: ERK Signaling, Drug Addiction,
and Behavioral Effects 1
Wei-Lun Sun, Pamela M. Quizon, Jun Zhu
1. Introduction 3
2. ERK Signaling Pathway 4
3. ERK Signaling and Drug Addiction 5
4. Conclusions and Future Directions 23
Acknowledgment 25
References 25
2. Ethanol-Associated Changes in Glutamate Reward Neurocircuitry:
A Minireview of Clinical and Preclinical Genetic Findings 41
Richard L. Bell, Sheketha R. Hauser, Jeanette McClintick, Shafiqur Rahman,
Howard J. Edenberg, Karen K. Szumlinski, William J. McBride
1. Alcoholism and Genetics 42
2. Central Glutamatergic Activity 44
3. Central Glutamate Activity and Alcohol Dependence 50
4. Glutamate-Associated Genetic Variations and Alcoholism 57
5. Alcohol and Glutamate Gene Expression 59
6. Alcohol-Associated Changes in Gene/Protein Expression of P Rats 60
7. Conclusions 72
Acknowledgments 73
References 73
3. S-Glutathionylation and Redox Protein Signaling
in Drug Addiction 87
Jacqueline S. Womersley, Joachim D. Uys
1. Introduction 88
2. Oxidative Stress 88
vi Contents
3. S-Glutathionylation of Proteins Occurs in Response to Oxidative Stress 89
4. S-Glutathionylation of Proteins is a Redox-Sensitive Signaling
Mechanism in Cells 90
5. S-Glutathionylation in Addiction-Related Protein Signaling 92
6. S-Glutathionylation of PKA, PKC, Cdk5 and Actin May Influence
Drug Behavior 99
7. S-Glutathionylation in Alchohol Addiction 101
8. S-Glutathionylation in Cocaine Addiction 104
9. S-Glutathionylation in Heroin Addiction 107
10. Future Research 110
11. Conclusions 111
Acknowledgment 112
References 112
4. Molecular Mechanisms of Cannabis Signaling in the Brain 123
Patrick J. Ronan, Narin Wongngamnit, Thomas P. Beresford
1. Introduction 124
2. Chemical Components of Cannabis 124
3. Endocannabinoid System 125
4. Signal Transduction 126
5. CB, Distribution 128
6. CB2 Receptors 129
7. Cannabis and Addiction 130
8. Animal Models 130
9. Molecular Adaptations to Chronic Use 133
10. Synaptic Plasticity 133
11. Cannabis Withdrawal 134
12. Monoaminergic Systems 135
13. Cannabidiol 137
14. The Case of Charlotte s Web 138
15. Conclusions 139
References 139
5. The Nociceptin Receptor as an Emerging Molecular Target
for Cocaine Addiction 149
Kabirullah Lutfy, Nurulain T. Zaveri
150
151
158
168
169
2. Introduction
3. Orphanin FQ/Nociceptin/NOPr System
4. Molecular Mechanisms of Cocaine Addiction
5. Conclusions
References
Contents vii
6. Recent Advances in Nicotinic Receptor Signaling in Alcohol
Abuse and Alcoholism 183
Shafiqur Rahman, Eric A. Engleman, Richard L. Bell
2. Introduction 184
3. Mesolimbic-Dopamine System and nAChRs 185
4. Knockout and Transgenic Models and nAChRs 186
5. Alcohol, Nicotine Coabuse, and nAChRs 188
6. Genetic Polymorphisms, Alcohol Dependence and nAChRs 189
7. Alcohol Dependence, Comorbid Psychiatric Condition and nAChRs 190
8. Alcohol, Transcription Factors, and nAChRs 191
9. Conclusions 192
Acknowledgments 193
References 193
7. Molecular Changes in Opioid Addiction: The Role of Adenylyl
Cyclase and cAMP/PKA System 203
Patrick Chan, Kabirullah Lutfy
2. Introduction 204
3. The Adenylyl Cyclase Pathway 205
4. Opioid Effect on cAMP- Responsive Element-Binding Protein 209
5. Molecular Changes in Brain Regions That May Underlie Opiate Dependence 211
6. Molecular Changes in the Ventral Tegmental Area 217
7. Molecular Changes in Other CNS Regions 218
8. Conclusions 219
References 219
8. Caenorhabditis elegans as a Model to Study the Molecular
and Genetic Mechanisms of Drug Addiction 229
Eric A. Engleman, Simon N. Katner, Bethany S. Neal-Beliveau
2. Introduction 230
3. Models of Addiction 231
4. Invertebrate Models 232
5. C. elegans as a Model System to Study Addiction 233
6. Drugs of Abuse 233
7. Convergent Mechanisms of Drugs of Abuse in C. elegans 238
8. Leveraging C. elegans for Model Development and Drug Discovery 245
9. Conclusions 246
Acknowledgment 247
References 247
Index
253
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| indexdate | 2024-07-10T07:31:13Z |
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| isbn | 9780128037867 |
| language | English |
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| physical | XIII, 264 Seiten Illustrationen |
| publishDate | 2016 |
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| series | Progress in molecular biology and translational science |
| series2 | Progress in molecular biology and translational science |
| spelling | The molecular basis of drug addiction edited by Shafiqur Rahman First edition Amsterdam Elsevier 2016 XIII, 264 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier Progress in molecular biology and translational science 137 Rahman, Shafiqur (DE-588)170863840 edt Progress in molecular biology and translational science 137 (DE-604)BV035256576 137 HBZ Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029052613&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | The molecular basis of drug addiction Progress in molecular biology and translational science |
| title | The molecular basis of drug addiction |
| title_auth | The molecular basis of drug addiction |
| title_exact_search | The molecular basis of drug addiction |
| title_full | The molecular basis of drug addiction edited by Shafiqur Rahman |
| title_fullStr | The molecular basis of drug addiction edited by Shafiqur Rahman |
| title_full_unstemmed | The molecular basis of drug addiction edited by Shafiqur Rahman |
| title_short | The molecular basis of drug addiction |
| title_sort | the molecular basis of drug addiction |
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