Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity:
Gespeichert in:
| 1. Verfasser: | |
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| Format: | Abschlussarbeit Buch |
| Sprache: | English |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online-Zugang: | Inhaltsverzeichnis |
| Beschreibung: | XV, 213 Bl. Ill., graph. Darst. 30 cm |
Internformat
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| 245 | 1 | 0 | |a Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity |c von Raphael Hilgenstock |
| 264 | 1 | |c 2012 | |
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| adam_text | IMAGE 1
II
TABLE OF CONTENTS
ACKNOWLEDGEMENTS I
TABLE OF CONTENTS I I
L I S T OF ABBREVIATIONS V I
FIGURE DIRECTORY X
TABLE DIRECTORY X I
ZUSAMMENFASSUNG X I I
ABSTRACT X I V
1 INTRODUCTION 1
1.1 TOPIC AND RELEVANCE 1
1.2 OBJECTIVES AND SCIENTIFIC APPROACH 3
1.3 STRUCTURE AND CHAPTER OUTLINE 3
2 LITERATURE R E V I E W 4
2.1 PERCEPTUAL LEARNING 4
2.1.1 WHAT IS PERCEPTUAL LEARNING? 5
2.1.2 WHY IS PERCEPTUAL LEARNING INTERESTING TO STUDY? 6
2.1.3 DIMENSIONS O F PERCEPTUAL LEARNING 6
2.1.4 THE LEVEL O F PERCEPTUAL LEARNING 9
2.1.5 CELLULAR MECHANISMS O F PERCEPTUAL LEARNING 12
2.1.6 SLEEP AND PERCEPTUAL LEARNING 15
2.1.7 SUMMARY O F PERCEPTUAL LEARNING 16
2.2 TRANSCRANIAL DIRECT CURRENT STIMULATION (TDCS) 16
2.2.1 WHAT IS TDCS? 17
2.2.2 SAFETY CONSIDERATIONS 18
2.2.3 MODERATING FACTORS 19
2.2.4 MECHANISMS O F ACTION O F TDCS 20
2.2.5 SUMMARY O F TDCS 29
3 AIMS AND HYPOTHESES 30
3.1 OBJECTIVES AND HYPOTHESES 30
3.2 HYPOTHESIS 1: SHORT-TERM BEHAVIORAL EFFECTS O F ANODAL TDCS 30
3.3 HYPOTHESIS 2: THE BENEFIT O F NEURONAVIGATION 31
3.4 HYPOTHESIS 3: THE GOT WITHIN THE FMRI FRAMEWORK 32
3.5 HYPOTHESIS 4: CONFOUNDERS O F TDCS EFFECTS 32
3.6 HYPOTHESIS 5: SIDE EFFECTS O F LONGITUDINAL TDCS 33
HTTP://D-NB.INFO/1026440122
IMAGE 2
I L L
3.7 HYPOTHESIS 6: LONG-TERM BEHAVIORAL EFFECTS O F SHAM AND ANODAL TDCS
..34
3.8 HYPOTHESIS 7: EFFECTS OF LONGITUDINAL TDCS ON THE BRAIN S GRAY
MATTER 37
3.9 HYPOTHESIS 8: EFFECTS O F LONGITUDINAL TDCS ON THE BRAIN S WHITE
MATTER 39
3.10 HYPOTHESIS 9: EFFECTS O F LONGITUDINAL TDCS ON FUNCTIONAL BRAIN
ACTIVATION 40
4 OVERALL STUDY DESIGN 4 3
5 PRESTUDY 1 4 4
5.1 INTRODUCTION 44
5.2 METHOD 44
5.2.1 PARTICIPANTS 44
5.2.2 STUDY DESIGN 44
5.2.3 DATA ANALYSIS 48
5.3 RESULTS 48
5.4 DISCUSSION 50
5.5 CONCLUSION 51
6 PRESTUDY I I 5 2
6.1 INTRODUCTION 52
6.2 METHOD 52
6.2.1 PARTICIPANTS 52
6.2.2 STUDY DESIGN 52
6.2.3 DATA ANALYSIS 54
6.3 RESULTS 54
6.4 DISCUSSION 55
6.5 CONCLUSION 56
7 PRESTUDY I I I 5 7
7.1 INTRODUCTION 57
7.2 METHOD 57
7.2.1 PARTICIPANTS 57
7.2.2 STUDY DESIGN 58
7.2.3 DATA ANALYSIS 59
7.3 RESULTS 60
7.3.1 NEURONAVIGATION 60
IMAGE 3
IV
7.3.2 GOT PERFORMANCE 60
7.4 DISCUSSION 61
7.5 CONCLUSION 62
8 PRESTUDY I V 6 3
8.1 INTRODUCTION 63
8.2 METHOD 63
8.2.1 PARTICIPANTS 63
8.2.2 STUDY DESIGN 64
8.2.3 DATA ANALYSIS 68
8.3 RESULTS 72
8.3.1 BEHAVIORAL DATA 72
8.3.2 FMRI DATA 72
8.4 DISCUSSION 73
8.4.1 TASK-RELATED ACTIVATION 74
8.4.2 TASK-RELATED DEACTIVATION 75
8.5 CONCLUSION 76
9 M A I N STUDY 7 7
9.1 INTRODUCTION 77
9.2 METHOD 77
9.2.1 PARTICIPANTS 78
9.2.2 STUDY DESIGN 79
9.2.3 DATA ACQUISITION 84
9.2.4 VOXEL-BASED MORPHOMETRY ANALYSIS 85
9.2.5 DIFFUSION TENSOR IMAGING (DTI) ANALYSIS 87
9.2.6 FMRI - MEASUREMENT AND ANALYSIS 92
9.2.7 DATA ANALYSIS 95
9.3 RESULTS 101
9.3.1 ANALYSIS O F CONFOUNDERS 101
9.3.2 SAFETY CONSIDERATIONS 102
9.3.3 ACCURACY O F STIMULATION 103
9.3.4 BEHAVIORAL DATA 104
9.3.5 MRI DATA ANALYSIS 113
9.4 DISCUSSION 138
9.4.1 THE EFFECTIVENESS O F SHAM STIMULATION (HYPOTHESES H4A AND H 4B )
139
9.4.2 ATTENTION, FATIGUE AND DISCOMFORT (HYPOTHESIS H4C) 139
IMAGE 4
V
9.4.3 SAFETY O F TDCS DELIVERY (HYPOTHESIS H$ ) 140
9.4.4 ONLINE LEARNING (HYPOTHESES H 6A A N D HG B ) 140
9.4.5 OFFLINE EFFECTS (HYPOTHESIS H ^ B ) 142
9.4.6 TOTAL LEARNING (HYPOTHESES H^C AND 143
9.4.7 FOLLOW-UP (HYPOTHESIS H ^ D ) 144
9.4.8 TRANSFER LEARNING (HYPOTHESIS H S E ) 145
9.4.9 STRUCTURAL MRI - VBM (HYPOTHESES H 7 A 1 , H 7 A 2 , H 7 B I , AND
H 7 B 2 ) 147
9.4.10 STRUCTURAL MRI - DTI (HYPOTHESES H 8 A - I HC, AND QUESTIONS QI
AND QJ) 150
9.4.11 FUNCTIONAL MRI (HYPOTHESES HG AI , H9A2, H 9 B I , AND QJ) 155
1 0 IMPLICATIONS AND FUTURE RESEARCH 1 6 1
10.1 SKILL LEARNING AND TDCS 161
10.1.1 LEARNING O F INDEX FINGER O F THE (RIGHT) DOMINANT HAND 161
10.1.2 LEARNING O F THE INDEX FINGER O F THE NON-DOMINANT (LEFT) HAND
162
10.1.3 TRANSFER LEARNING 162
10.2 MRI DATA AND TDCS 163
10.2.1 STRUCTURAL MRI DATA - VBM 163
10.2.2 STRUCTURAL MRI DATA - DTI 163
10.2.3 FMRI DATA 164
1 1 OVERALL CONCLUSION 1 6 6
REFERENCES..... 1 6 8
APPENDIX 2 0 0
EHRENWORTLICHE ERKLARUNG 2 1 2
LEBENSLAUF 2 1 3
|
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| author_sort | Hilgenstock, Raphael 1981- |
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| bvnumber | BV043634843 |
| ctrlnum | (DE-599)DNB1026440122 |
| discipline | Medizin |
| format | Thesis Book |
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| language | English |
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| spelling | Hilgenstock, Raphael 1981- Verfasser (DE-588)1026439671 aut Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity von Raphael Hilgenstock 2012 XV, 213 Bl. Ill., graph. Darst. 30 cm txt rdacontent n rdamedia nc rdacarrier Jena, Univ., Diss., 2012 (DE-588)4113937-9 Hochschulschrift gnd-content DNB Datenaustausch application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029048798&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Hilgenstock, Raphael 1981- Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity |
| subject_GND | (DE-588)4113937-9 |
| title | Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity |
| title_auth | Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity |
| title_exact_search | Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity |
| title_full | Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity von Raphael Hilgenstock |
| title_fullStr | Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity von Raphael Hilgenstock |
| title_full_unstemmed | Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity von Raphael Hilgenstock |
| title_short | Longitudinal anordal transcranial direct current stimulation (tDCS) and its behavioral and neural effects on spatial tactile acuity |
| title_sort | longitudinal anordal transcranial direct current stimulation tdcs and its behavioral and neural effects on spatial tactile acuity |
| topic_facet | Hochschulschrift |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=029048798&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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