Controversies in diabetic neuropathy:
Saved in:
| Other Authors: | , |
|---|---|
| Format: | Book |
| Language: | English |
| Published: |
Amsterdam ; Heidelberg
Elsevier
2016
|
| Edition: | First edition |
| Series: | International review of neurobiology
Volume 127 |
| Online Access: | Inhaltsverzeichnis |
| Physical Description: | xvi, 375 Seiten Illustrationen |
| ISBN: | 9780128039151 |
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| 245 | 1 | 0 | |a Controversies in diabetic neuropathy |c edited by Nigel A. Calcutt, Paul Fernyhough |
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| 264 | 1 | |a Amsterdam ; Heidelberg |b Elsevier |c 2016 | |
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| adam_text | CONTENTS
Contributors */
Preface xiii
Section I
Clinical Context
1. A Brief introduction to the History and Controversies
of Clinical Trials in Diabetic Neuropathy 3
N.A. Calcutt and P. Fernyhough
2. Neuropathy in the DCCT/EDIC—What Was Done
Then and What We Would Do Better Now 9
R. Pop-Busui and C. Martin
1. introduction 10
2. Neuropathy Outcomes Assessments 1}
3. Complementary Assessments in EDiC 16
4. DCCT/EDIC Findings 17
5. Discussion 19
References 23
3. The Perfect Clinical Trial 27
V. Bril
t. introduction 27
2. Study Aims: Prevent DSP, Prevent Progression, or Reverse DSP? 28
3. Selection of Study Participants 29
4. Trial Duration 31
5. Study End Points 33
6. Core Labs and Training 35
7. intervention 35
8. Study Conduct 36
9. Streamlined Ethics and Contracts Process 37
10. Summary 37
References 38
v
vi
Contents
Section II
New Models of Diabetic Neuropathy
4. An Introduction to the History and Controversies
of Animal Models of Diabetic Neuropathy 45
N.A. Calcutt and P. Fernyhough
1. Why Use Animal Models? 45
2. What Species? 46
3. What Diabetogenic Insult? 48
4. STZ Toxicity 49
5. Novel Models 50
References 50
5. Can Diabetic Neuropathy Be Modeled In Vitro? 53
NJ. Gardiner and OJ. Freeman
1. Introduction 54
2. Diabetic Neuropathy 56
3. The Somatosensory Nervous System 56
4. Can We Model Diabetic Neuropathy In Vitro? 62
5. Conclusions 79
Acknowledgments 79
References 79
6. Alternatives to the Streptozotocin-Diabetic Rodent 89
M.A. Yorek
1. Introduction 90
2. Rodent Models of Obesity 91
3. Rodent Models of Type 2 Diabetes 93
4. Rodent Models of Type 1 Diabetes 101
5. Other Animal Models 103
6. Conclusions 103
References 104
Section III
Mechanisms and Therapies
7. An Introduction to the History and Controversies of the
Pathogenesis of Diabetic Neuropathy 115
P. Fernyhough and N.A. Calcutt
Contents
vii
8. Glucotoxic Mechanisms and Related Therapeutic
Approaches 121
S. Yagihashi
1. Introduction 122
2. Glucose-Metabolizing Pathways Relevant to DPN 124
3. Polyol (AR or Sorbitol-Fructose) Pathway 125
4. Nonenzymatic Glycation and AGEs 131
5. Oxidative Stress 135
6. PKC Activity 138
7. Glycosylation 139
8. Conclusion 141
Acknowledgments 141
References 141
9. Sensory Neurodegeneration in Diabetes:
Beyond Glucotoxicity 151
D.W. Zochodne
1. Terminals at Risk: Sensory Neurodegeneration in Diabetes 152
2. Not Necessarily a Microvascular Disease 154
3. Altered Insulin Signaling 156
4. Ongoing Growth: Other Forms of Support 160
5. Neurons on Edge” 162
6. Diabetes, Neurons, and Epigenetics 165
7. A Regeneration Strategy 169
8. Conclusions 174
Acknowledgments 174
References 174
10. Promoting Neuronal Tolerance of Diabetic Stress:
Modulating Molecular Chaperones 181
S.M. Emery and R.T. Dobrowsky
1. Introduction 182
2. Molecular Chaperones 183
3. Extracellular Hsp70 185
4. Intracellular Hsp70 189
5. DPN and Modulating Hsp7G 197
6. Concluding Remarks 201
Acknowledgments 201
References 201
viii
Contents
11. Painful Diabetic Neuropathy: Prevention or Suppression? 211
S.M. Todorovic
1. Introduction 212
2. Nociceptive Ion Channels Control Neuronal Excitability 213
3. Alterations of Voltage-Gated and Ligand-Gated Ion Channels
in Sensory Neurons in Animal Models of Type 1 Diabetes 215
4. Alterations of Cav3.2 T-Type Channels in Nociceptive Sensory
Neurons in Animal Models of Type 2 Diabetes with Painful PDN 217
5. Posttranslational Modification of Pronociceptive Ion Channels in PDN 217
6. Diminished Inhibitory Drive in the Spinal Cord May Also Contribute
to Painful PDN 221
7. Conclusions 221
Acknowledgments 222
References 223
Section IV
Translating Science into Medicine
12. New Directions in Diabetic Neuropathy: Evolution
or Extinction? 229
P. Fernyhough and N.A. Calcutt
1. NCV as an Endpoint in Animal Models 230
2. Treatment Paradigms 230
3. Insanity: Doing the Same Thing Over and Over Again and
Expecting a Different Result 231
References 232
13. Alternative Quantitative Tools in the Assessment
of Diabetic Peripheral and Autonomic Neuropathy 235
A.I. Vinik, C. Casellini, and M.-L. Nevoret
1. Introduction 236
2. Diabetic Peripheral Neuropathy 238
3. Diabetic Autonomic Neuropathy 245
4. Measuring Diabetic Neuropathy: Established and
Innovative Approaches 253
5. Concluding Remarks 270
References 271
Contents
ix
14. Wherefore Art Thou, O Treatment for Diabetic Neuropathy? 287
R.A. Malik
1. The Problem 288
2. What Can We Do? 291
3. Diagnostic Tests are Not Necessarily Good Surrogate End Points 293
4. Clinical Trials in Diabetic Neuropathy 294
5. Can We Ever Succeed? 306
References 309
Index 319
Contents of Recent Volumes 329
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| indexdate | 2024-07-10T07:29:25Z |
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| isbn | 9780128039151 |
| language | English |
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| spelling | Controversies in diabetic neuropathy edited by Nigel A. Calcutt, Paul Fernyhough First edition Amsterdam ; Heidelberg Elsevier 2016 xvi, 375 Seiten Illustrationen txt rdacontent n rdamedia nc rdacarrier International review of neurobiology Volume 127 Calcutt, Nigel A. edt Fernyhough, Paul edt International review of neurobiology Volume 127 (DE-604)BV002534817 127 Digitalisierung UB Regensburg - ADAM Catalogue Enrichment application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028996411&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis |
| spellingShingle | Controversies in diabetic neuropathy International review of neurobiology |
| title | Controversies in diabetic neuropathy |
| title_auth | Controversies in diabetic neuropathy |
| title_exact_search | Controversies in diabetic neuropathy |
| title_full | Controversies in diabetic neuropathy edited by Nigel A. Calcutt, Paul Fernyhough |
| title_fullStr | Controversies in diabetic neuropathy edited by Nigel A. Calcutt, Paul Fernyhough |
| title_full_unstemmed | Controversies in diabetic neuropathy edited by Nigel A. Calcutt, Paul Fernyhough |
| title_short | Controversies in diabetic neuropathy |
| title_sort | controversies in diabetic neuropathy |
| url | http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028996411&sequence=000002&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA |
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