Physics at the Biomolecular Interface: Fundamentals for Molecular Targeted Therapy
Saved in:
| Main Author: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cham
Springer
[2016]
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| Series: | Soft and Biological Matter
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| Subjects: | |
| Online Access: | TUM01 UBT01 Volltext Inhaltsverzeichnis Abstract |
| Physical Description: | 1 Online-Ressource (XV, 483 p. 295 illus., 208 illus. in color) |
| ISBN: | 9783319308524 |
| DOI: | 10.1007/978-3-319-30852-4 |
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| 245 | 1 | 0 | |a Physics at the Biomolecular Interface |b Fundamentals for Molecular Targeted Therapy |c Ariel Fernández |
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| 650 | 4 | |a Molecular Medicine | |
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Record in the Search Index
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| adam_text | PHYSICS AT THE BIOMOLECULAR INTERFACE
/ FERNANDEZ, ARIEL
: 2016
TABLE OF CONTENTS / INHALTSVERZEICHNIS
CHAPTER 1 INTERFACIAL PHYSICS FOR WATER IN BIOLOGY
CHAPTER 2 DIELECTRIC STRUCTURE OF AQUEOUS INTERFACES: FROM CLASSICAL
NON-DEBYE ELECTROSTATICS TO A QUANTUM THEORY OF INTERFACIAL TENSION
CHAPTER 3 SOLUTION TO THE PROTEIN FOLDING PROBLEM
CHAPTER 4 EPISTRUCTURAL DYNAMICS OF BIOLOGICAL WATER
CHAPTER 5 DEHYDRON-RICH PROTEINS IN THE ORDER-DISORDER TWILIGHT ZONE
CHAPTER 6 DEHYDRON AS A MARKER FOR MOLECULAR EVOLUTION: LESSONS FOR THE
DRUG DESIGNER
CHAPTER 7 CATALYTIC ROLE OF DEHYDRONS IN SOLUBLE PROTEINS: BIOLOGICAL
CHEMISTRY OF FRUSTRATED INTERFACIAL WATER
CHAPTER 8 EPISTRUCTURAL SELECTIVITY FILTERS FOR MOLECULAR TARGETED
THERAPY
CHAPTER 9 EPISTRUCTURAL RE-ENGINEERING OFIMATINIB TO ELIMINATE ADVERSE
SIDE EFFECTS
CHAPTER 10 EPISTRUCTURAL INFORMATICS FOR THE DRUG DESIGNER
CHAPTER 11 DRUG-TARGET ASSOCIATIONS INDUCING PROTEIN FOLDING
CHAPTER 12 COMBINATION THERAPIES TO EDIT OUT SIDE EFFECTS AND RESISTANCE
TO INHIBITION OF DRUG RESISTANCE
CHAPTER 13 EPISTRUCTURE-BASED DESIGN OF DRUGS WITH CONTROLLED
PROMISCUITY
CHAPTER 14 SYNERGIZING ENGINEERED IMMUNOTHERAPY WITH MOLECULARLY
TARGETED CANCER TREATMENT
CHAPTER 15 QUANTUM MECHANICAL CONCEPTS FOR EPISTRUCTURAL DRUG DESIGN
CHAPTER 16 STRUCTURE-BASED DRUG DISCOVERY WITHOUT STRUCTURE: WORKING
AROUND THE PARADOX TO DISRUPT PROTEIN-PROTEIN ASSOCIATIONS
CHAPTER 17 EPISTRUCTURAL DRUG DESIGN TO TREAT CANCER METASTASIS AND THE
ASSOCIATED DRUG RESISTANCE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
PHYSICS AT THE BIOMOLECULAR INTERFACE
/ FERNANDEZ, ARIEL
: 2016
ABSTRACT / INHALTSTEXT
THIS BOOK FOCUSES PRIMARILY ON THE ROLE OF INTERFACIAL FORCES IN
UNDERSTANDING BIOLOGICAL PHENOMENA AT THE MOLECULAR SCALE. BY PROVIDING
A SUITABLE STATISTICAL MECHANICAL APPARATUS TO HANDLE THE BIOMOLECULAR
INTERFACE, THE BOOK BECOMES UNIQUELY POSITIONED TO ADDRESS CORE PROBLEMS
IN MOLECULAR BIOPHYSICS. IT HIGHLIGHTS THE IMPORTANCE OF INTERFACIAL
TENSION IN DELINEATING A SOLUTION TO THE PROTEIN FOLDING PROBLEM, IN
UNRAVELLING THE PHYSICO-CHEMICAL BASIS OF ENZYME CATALYSIS AND PROTEIN
ASSOCIATIONS, AND IN RATIONALLY DESIGNING MOLECULAR TARGETED THERAPIES.
THUS GROUNDED IN FUNDAMENTAL SCIENCE, THE BOOK DEVELOPS A POWERFUL
TECHNOLOGICAL PLATFORM FOR DRUG DISCOVERY, WHILE IT IS SET TO INSPIRE
SCIENTISTS AT ANY LEVEL IN THEIR CAREERS DETERMINED TO ADDRESS THE MAJOR
CHALLENGES IN MOLECULAR BIOPHYSICS. THE ACKNOWLEDGMENT OF HOW
EXQUISITELY THE STRUCTURE AND DYNAMICS OF PROTEINS AND THEIR AQUEOUS
ENVIRONMENT ARE RELATED ATTESTS TO THE OVERDUE RECOGNITION THAT
BIOMOLECULAR PHENOMENA CANNOT BE EFFECTIVELY UNDERSTOOD WITHOUT DEALING
WITH INTERFACIAL BEHAVIOUR. THERE IS AN URGE TO GRASP HOW BIOLOGICALLY
RELEVANT BEHAVIOUR IS SHAPED BY THE STRUCTURING OF BIOMOLECULAR
INTERFACES AND HOW INTERFACIAL TENSION AFFECTS THE MOLECULAR EVENTS THAT
TAKE PLACE IN THE CELL. THIS BOOK SQUARELY ADDRESSES THESE NEEDS FROM A
PHYSICIST PERSPECTIVE. THE BOOK MAY SERVE AS A MONOGRAPH FOR
PRACTITIONERS AND, ALTERNATIVELY, AS AN ADVANCED TEXTBOOK. FRUITFUL
READING REQUIRES A BACKGROUND IN PHYSICAL CHEMISTRY AND SOME BASICS IN
BIOPHYSICS. THE SELECTED PROBLEMS AT THE END OF THE CHAPTERS AND THE
PROGRESSION IN CONCEPTUAL DIFFICULTY MAKE IT A SUITABLE TEXTBOOK FOR A
GRADUATE LEVEL COURSE OR AN ELECTIVE COURSE FOR SENIORS MAJORING IN
CHEMISTRY, PHYSICS, BIOMEDICAL ENGINEERING OR RELATED DISCIPLINES
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
| any_adam_object | 1 |
| author | Fernández, Ariel |
| author_facet | Fernández, Ariel |
| author_role | aut |
| author_sort | Fernández, Ariel |
| author_variant | a f af |
| building | Verbundindex |
| bvnumber | BV043579457 |
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| collection | ZDB-2-PHA |
| ctrlnum | (ZDB-2-PHA)978-3-319-30852-4 (OCoLC)951065617 (DE-599)BVBBV043579457 |
| dewey-full | 571.4 |
| dewey-hundreds | 500 - Natural sciences and mathematics |
| dewey-ones | 571 - Physiology & related subjects |
| dewey-raw | 571.4 |
| dewey-search | 571.4 |
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| dewey-tens | 570 - Biology |
| discipline | Physik Biologie |
| doi_str_mv | 10.1007/978-3-319-30852-4 |
| format | Electronic eBook |
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| indexdate | 2024-07-10T07:29:21Z |
| institution | BVB |
| isbn | 9783319308524 |
| language | English |
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| spelling | Fernández, Ariel Verfasser aut Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy Ariel Fernández Cham Springer [2016] 1 Online-Ressource (XV, 483 p. 295 illus., 208 illus. in color) txt rdacontent c rdamedia cr rdacarrier Soft and Biological Matter Physics Molecular biology Pharmaceutical technology Physical chemistry Proteins Biophysics Biological physics Statistical physics Dynamical systems Biophysics and Biological Physics Physical Chemistry Pharmaceutical Sciences/Technology Protein Structure Molecular Medicine Statistical Physics, Dynamical Systems and Complexity Erscheint auch als Druckausgabe 978-3-319-30851-7 https://doi.org/10.1007/978-3-319-30852-4 Verlag URL des Erstveröffentlichers Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028994129&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028994129&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | Fernández, Ariel Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy Physics Molecular biology Pharmaceutical technology Physical chemistry Proteins Biophysics Biological physics Statistical physics Dynamical systems Biophysics and Biological Physics Physical Chemistry Pharmaceutical Sciences/Technology Protein Structure Molecular Medicine Statistical Physics, Dynamical Systems and Complexity |
| title | Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy |
| title_auth | Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy |
| title_exact_search | Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy |
| title_full | Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy Ariel Fernández |
| title_fullStr | Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy Ariel Fernández |
| title_full_unstemmed | Physics at the Biomolecular Interface Fundamentals for Molecular Targeted Therapy Ariel Fernández |
| title_short | Physics at the Biomolecular Interface |
| title_sort | physics at the biomolecular interface fundamentals for molecular targeted therapy |
| title_sub | Fundamentals for Molecular Targeted Therapy |
| topic | Physics Molecular biology Pharmaceutical technology Physical chemistry Proteins Biophysics Biological physics Statistical physics Dynamical systems Biophysics and Biological Physics Physical Chemistry Pharmaceutical Sciences/Technology Protein Structure Molecular Medicine Statistical Physics, Dynamical Systems and Complexity |
| topic_facet | Physics Molecular biology Pharmaceutical technology Physical chemistry Proteins Biophysics Biological physics Statistical physics Dynamical systems Biophysics and Biological Physics Physical Chemistry Pharmaceutical Sciences/Technology Protein Structure Molecular Medicine Statistical Physics, Dynamical Systems and Complexity |
| url | https://doi.org/10.1007/978-3-319-30852-4 http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028994129&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028994129&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA |
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