Holdings: New approaches to drug discovery

New approaches to drug discovery:

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Bibliographic Details
Other Authors:	Nielsch, Ulrich (Editor), Fuhrmann, Ulrike 1970- (Editor), Jaroch, Stefan (Editor)
Format:	Electronic eBook
Language:	English
Published:	Cham Springer 2016 2016
Edition:	2016
Series:	Handbook of Experimental Pharmacology 232
Subjects:	Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin
Online Access:	BTU01 FUBA2 HTW01 UBR01 Volltext Inhaltsverzeichnis Abstract
Physical Description:	1 Online-Ressource (VIII, 341 p. 100 illus., 63 illus. in color)
ISBN:	9783319289144 9783319289120
ISSN:	0171-2004
DOI:	10.1007/978-3-319-28914-4

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MARC


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Record in the Search Index

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adam_text	NEW APPROACHES TO DRUG DISCOVERY / : 2016 TABLE OF CONTENTS / INHALTSVERZEICHNIS PREFACE PART 1. HISTORICAL VIEW DRUG DISCOVERY IN THE PAST AND TODAY.PART 2. TARGET DISCOVERY EMERGING TARGET FAMILIES: INTRACTABLE TARGETS. IN VIVO TARGET VALIDATION ESPECIALLY FOR BIOLOGICAL TARGETS. HR RNAI/HIGH CONTENT ANALYSIS PART 3. LEAD GENERATION AND OPTIMIZATION SOURCES FOR LEADS: NATURAL PRODUCTS, LIBRARIES. SCREENING: ASSAYS, READOUT, TECHNOLOGY. IMPACT OF STRUCTURAL BIOLOGY, FRAGMENT BASED SCREENING/VIRTUAL SCREENING. PREDICTIVE IN SILICO TOOLS OF COMPOUND PROPERTIES. HIGH THROUGHPUT SYNTHESIS. NEW COMPOUND CLASSES: PROTEIN-PROTEIN INTERACTION. SOURCES FOR BIOLOGICAL LEADS/SCREENING OF BIOLOGICALS PART 4. TEST SYSTEMS FOR EFFICACY AND SAFETY IN VITRO / CELL BASED ASSAYS. PHARMACODYNAMIC. PHARMACOKINETIC. SAFETY AND TOXICOLOGY. IMPACT OF BIOMARKERS/PERSONALIZED MEDICINE. SIMULATING IN VIVO DRUG EFFECTS DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT. NEW APPROACHES TO DRUG DISCOVERY / : 2016 ABSTRACT / INHALTSTEXT THIS VOLUME GIVES AN OVERVIEW OF STATE OF THE ART TECHNOLOGIES AND FUTURE DEVELOPMENTS IN THE FIELD OF PRECLINICAL PHARMACEUTICAL RESEARCH. A BALANCED MIX OF EXPERTS FROM ACADEMIA AND INDUSTRY GIVE INSIGHT IN SELECTED NEW DEVELOPMENTS IN THE DRUG DISCOVERY PATHWAY. THE TOPICS COVER THE DIFFERENT PARTS OF THE DRUG DISCOVERY PROCESS, STARTING WITH NEW DEVELOPMENTS IN THE TARGET IDENTIFICATION AND VALIDATION AREA. THE LEAD GENERATION PART AS A NEXT STEP FOCUSES ON THE REQUIREMENTS AND TECHNOLOGIES TO IDENTIFY NEW SMALL MOLECULES AS LEAD COMPOUNDS FOR FURTHER OPTIMIZATION; IN A SECOND SECTION THE TECHNOLOGIES TO IDENTIFY BIOLOGICS AS LEADS ARE ADDRESSED. THE FINAL PART FOCUSES ON THE PHARMACOLOGICAL MODELS AND TECHNOLOGIES TO CHARACTERIZE NEW COMPOUNDS AND THE IMPACT OF BIOMARKERS TO FACILITATE THE TRANSFER OF DRUG CANDIDATES INTO THE DEVELOPMENT PHASE DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
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author2	Nielsch, Ulrich Fuhrmann, Ulrike 1970- Jaroch, Stefan
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dewey-ones	615 - Pharmacology and therapeutics
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dewey-tens	610 - Medicine and health
discipline	Medizin
doi_str_mv	10.1007/978-3-319-28914-4
edition	2016
format	Electronic eBook
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indexdate	2024-07-10T07:28:32Z
institution	BVB
isbn	9783319289144 9783319289120
issn	0171-2004
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series2	Handbook of Experimental Pharmacology
spelling	New approaches to drug discovery edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch 2016 Cham Springer 2016 1 Online-Ressource (VIII, 341 p. 100 illus., 63 illus. in color) txt rdacontent c rdamedia cr rdacarrier Handbook of Experimental Pharmacology 232 0171-2004 Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin Nielsch, Ulrich edt Fuhrmann, Ulrike 1970- (DE-588)121865746 edt Jaroch, Stefan edt https://doi.org/10.1007/978-3-319-28914-4 Verlag URL des Erstveröffentlichers Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962463&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962463&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract
spellingShingle	New approaches to drug discovery Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin
title	New approaches to drug discovery
title_auth	New approaches to drug discovery
title_exact_search	New approaches to drug discovery
title_full	New approaches to drug discovery edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch
title_fullStr	New approaches to drug discovery edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch
title_full_unstemmed	New approaches to drug discovery edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch
title_short	New approaches to drug discovery
title_sort	new approaches to drug discovery
topic	Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin
topic_facet	Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin
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