New approaches to drug discovery:
Gespeichert in:
| Weitere Verfasser: | , , |
|---|---|
| Format: | Elektronisch E-Book |
| Sprache: | English |
| Veröffentlicht: |
Cham
Springer
2016
2016 |
| Ausgabe: | 2016 |
| Schriftenreihe: | Handbook of Experimental Pharmacology
232 |
| Schlagworte: | |
| Online-Zugang: | BTU01 FUBA2 HTW01 UBR01 Volltext Inhaltsverzeichnis Abstract |
| Beschreibung: | 1 Online-Ressource (VIII, 341 p. 100 illus., 63 illus. in color) |
| ISBN: | 9783319289144 9783319289120 |
| ISSN: | 0171-2004 |
| DOI: | 10.1007/978-3-319-28914-4 |
Internformat
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Datensatz im Suchindex
| _version_ | 1804176208698540032 |
|---|---|
| adam_text | NEW APPROACHES TO DRUG DISCOVERY
/
: 2016
TABLE OF CONTENTS / INHALTSVERZEICHNIS
PREFACE
PART 1. HISTORICAL VIEW
DRUG DISCOVERY IN THE PAST AND TODAY.PART 2. TARGET DISCOVERY
EMERGING TARGET FAMILIES: INTRACTABLE TARGETS. IN VIVO TARGET VALIDATION
ESPECIALLY FOR BIOLOGICAL TARGETS. HR RNAI/HIGH CONTENT ANALYSIS
PART 3. LEAD GENERATION AND OPTIMIZATION
SOURCES FOR LEADS: NATURAL PRODUCTS, LIBRARIES. SCREENING: ASSAYS,
READOUT, TECHNOLOGY. IMPACT OF STRUCTURAL BIOLOGY, FRAGMENT BASED
SCREENING/VIRTUAL SCREENING. PREDICTIVE IN SILICO TOOLS OF COMPOUND
PROPERTIES. HIGH THROUGHPUT SYNTHESIS. NEW COMPOUND CLASSES:
PROTEIN-PROTEIN INTERACTION. SOURCES FOR BIOLOGICAL LEADS/SCREENING OF
BIOLOGICALS
PART 4. TEST SYSTEMS FOR EFFICACY AND SAFETY
IN VITRO / CELL BASED ASSAYS. PHARMACODYNAMIC. PHARMACOKINETIC. SAFETY
AND TOXICOLOGY. IMPACT OF BIOMARKERS/PERSONALIZED MEDICINE. SIMULATING
IN VIVO DRUG EFFECTS
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
NEW APPROACHES TO DRUG DISCOVERY
/
: 2016
ABSTRACT / INHALTSTEXT
THIS VOLUME GIVES AN OVERVIEW OF STATE OF THE ART TECHNOLOGIES AND
FUTURE DEVELOPMENTS IN THE FIELD OF PRECLINICAL PHARMACEUTICAL RESEARCH.
A BALANCED MIX OF EXPERTS FROM ACADEMIA AND INDUSTRY GIVE INSIGHT IN
SELECTED NEW DEVELOPMENTS IN THE DRUG DISCOVERY PATHWAY. THE TOPICS
COVER THE DIFFERENT PARTS OF THE DRUG DISCOVERY PROCESS, STARTING WITH
NEW DEVELOPMENTS IN THE TARGET IDENTIFICATION AND VALIDATION AREA. THE
LEAD GENERATION PART AS A NEXT STEP FOCUSES ON THE REQUIREMENTS AND
TECHNOLOGIES TO IDENTIFY NEW SMALL MOLECULES AS LEAD COMPOUNDS FOR
FURTHER OPTIMIZATION; IN A SECOND SECTION THE TECHNOLOGIES TO IDENTIFY
BIOLOGICS AS LEADS ARE ADDRESSED. THE FINAL PART FOCUSES ON THE
PHARMACOLOGICAL MODELS AND TECHNOLOGIES TO CHARACTERIZE NEW COMPOUNDS
AND THE IMPACT OF BIOMARKERS TO FACILITATE THE TRANSFER OF DRUG
CANDIDATES INTO THE DEVELOPMENT PHASE
DIESES SCHRIFTSTUECK WURDE MASCHINELL ERZEUGT.
|
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| dewey-full | 615 |
| dewey-hundreds | 600 - Technology (Applied sciences) |
| dewey-ones | 615 - Pharmacology and therapeutics |
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| edition | 2016 |
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| indexdate | 2024-07-10T07:28:32Z |
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| isbn | 9783319289144 9783319289120 |
| issn | 0171-2004 |
| language | English |
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| spelling | New approaches to drug discovery edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch 2016 Cham Springer 2016 1 Online-Ressource (VIII, 341 p. 100 illus., 63 illus. in color) txt rdacontent c rdamedia cr rdacarrier Handbook of Experimental Pharmacology 232 0171-2004 Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin Nielsch, Ulrich edt Fuhrmann, Ulrike 1970- (DE-588)121865746 edt Jaroch, Stefan edt https://doi.org/10.1007/978-3-319-28914-4 Verlag URL des Erstveröffentlichers Volltext Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962463&sequence=000001&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA Inhaltsverzeichnis Springer Fremddatenuebernahme application/pdf http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&local_base=BVB01&doc_number=028962463&sequence=000003&line_number=0002&func_code=DB_RECORDS&service_type=MEDIA Abstract |
| spellingShingle | New approaches to drug discovery Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin |
| title | New approaches to drug discovery |
| title_auth | New approaches to drug discovery |
| title_exact_search | New approaches to drug discovery |
| title_full | New approaches to drug discovery edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch |
| title_fullStr | New approaches to drug discovery edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch |
| title_full_unstemmed | New approaches to drug discovery edited by Ulrich Nielsch, Ulrike Fuhrmann, Stefan Jaroch |
| title_short | New approaches to drug discovery |
| title_sort | new approaches to drug discovery |
| topic | Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin |
| topic_facet | Medicine Pharmacology Medical biochemistry Pharmacy Metabolism Biomedicine Pharmacology/Toxicology Drug Safety and Pharmacovigilance Medical Biochemistry Metabolomics Medizin |
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